JP2018516537A5 - - Google Patents
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- JP2018516537A5 JP2018516537A5 JP2017552827A JP2017552827A JP2018516537A5 JP 2018516537 A5 JP2018516537 A5 JP 2018516537A5 JP 2017552827 A JP2017552827 A JP 2017552827A JP 2017552827 A JP2017552827 A JP 2017552827A JP 2018516537 A5 JP2018516537 A5 JP 2018516537A5
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- Prior art keywords
- amino acid
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- seq
- acid sequence
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- 239000000427 antigen Substances 0.000 claims description 62
- 102000036639 antigens Human genes 0.000 claims description 62
- 108091007433 antigens Proteins 0.000 claims description 62
- 229920001184 polypeptide Polymers 0.000 claims description 50
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 50
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 50
- 125000003275 alpha amino acid group Chemical group 0.000 claims 69
- 238000000034 method Methods 0.000 claims 21
- 230000004048 modification Effects 0.000 claims 19
- 238000012986 modification Methods 0.000 claims 19
- 102000000844 Cell Surface Receptors Human genes 0.000 claims 17
- 108010001857 Cell Surface Receptors Proteins 0.000 claims 17
- 239000001601 sodium adipate Substances 0.000 claims 12
- 238000006467 substitution reaction Methods 0.000 claims 11
- 102100022153 Tumor necrosis factor receptor superfamily member 4 Human genes 0.000 claims 10
- 101710165473 Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 claims 10
- 150000001413 amino acids Chemical class 0.000 claims 9
- 210000004027 cell Anatomy 0.000 claims 9
- 230000004540 complement-dependent cytotoxicity Effects 0.000 claims 6
- 239000012636 effector Substances 0.000 claims 6
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 5
- 102000003688 G-Protein-Coupled Receptors Human genes 0.000 claims 4
- 108090000045 G-Protein-Coupled Receptors Proteins 0.000 claims 4
- 108060008683 Tumor Necrosis Factor Receptor Proteins 0.000 claims 4
- 238000012217 deletion Methods 0.000 claims 4
- 230000037430 deletion Effects 0.000 claims 4
- 230000001404 mediated effect Effects 0.000 claims 4
- 102000005962 receptors Human genes 0.000 claims 4
- 108020003175 receptors Proteins 0.000 claims 4
- 102000003298 tumor necrosis factor receptor Human genes 0.000 claims 4
- 239000000556 agonist Substances 0.000 claims 3
- 230000000694 effects Effects 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- 239000013598 vector Substances 0.000 claims 3
- 101100481408 Danio rerio tie2 gene Proteins 0.000 claims 2
- 101000851370 Homo sapiens Tumor necrosis factor receptor superfamily member 9 Proteins 0.000 claims 2
- 101100481410 Mus musculus Tek gene Proteins 0.000 claims 2
- 230000001270 agonistic effect Effects 0.000 claims 2
- 125000000539 amino acid group Chemical group 0.000 claims 2
- 230000003042 antagnostic effect Effects 0.000 claims 2
- 230000015572 biosynthetic process Effects 0.000 claims 2
- 230000003247 decreasing effect Effects 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 230000013595 glycosylation Effects 0.000 claims 2
- 238000006206 glycosylation reaction Methods 0.000 claims 2
- 230000019491 signal transduction Effects 0.000 claims 2
- 230000011664 signaling Effects 0.000 claims 2
- 239000002131 composite material Substances 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000013604 expression vector Substances 0.000 claims 1
- 230000009878 intermolecular interaction Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 description 5
- BUROJSBIWGDYCN-GAUTUEMISA-N AP 23573 Chemical compound C1C[C@@H](OP(C)(C)=O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 BUROJSBIWGDYCN-GAUTUEMISA-N 0.000 description 4
- 108091007960 PI3Ks Proteins 0.000 description 4
- 102000003993 Phosphatidylinositol 3-kinases Human genes 0.000 description 4
- 108090000430 Phosphatidylinositol 3-kinases Proteins 0.000 description 4
- CWHUFRVAEUJCEF-UHFFFAOYSA-N BKM120 Chemical compound C1=NC(N)=CC(C(F)(F)F)=C1C1=CC(N2CCOCC2)=NC(N2CCOCC2)=N1 CWHUFRVAEUJCEF-UHFFFAOYSA-N 0.000 description 3
- CBPNZQVSJQDFBE-FUXHJELOSA-N Temsirolimus Chemical compound C1C[C@@H](OC(=O)C(C)(CO)CO)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 CBPNZQVSJQDFBE-FUXHJELOSA-N 0.000 description 3
- KDGFLJKFZUIJMX-UHFFFAOYSA-N alectinib Chemical compound CCC1=CC=2C(=O)C(C3=CC=C(C=C3N3)C#N)=C3C(C)(C)C=2C=C1N(CC1)CCC1N1CCOCC1 KDGFLJKFZUIJMX-UHFFFAOYSA-N 0.000 description 3
- 229960003445 idelalisib Drugs 0.000 description 3
- YKLIKGKUANLGSB-HNNXBMFYSA-N idelalisib Chemical compound C1([C@@H](NC=2[C]3N=CN=C3N=CN=2)CC)=NC2=CC=CC(F)=C2C(=O)N1C1=CC=CC=C1 YKLIKGKUANLGSB-HNNXBMFYSA-N 0.000 description 3
- 229960001302 ridaforolimus Drugs 0.000 description 3
- GRZXWCHAXNAUHY-NSISKUIASA-N (2S)-2-(4-chlorophenyl)-1-[4-[(5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]-1-piperazinyl]-3-(propan-2-ylamino)-1-propanone Chemical compound C1([C@H](C(=O)N2CCN(CC2)C=2C=3[C@H](C)C[C@@H](O)C=3N=CN=2)CNC(C)C)=CC=C(Cl)C=C1 GRZXWCHAXNAUHY-NSISKUIASA-N 0.000 description 2
- DWZAEMINVBZMHQ-UHFFFAOYSA-N 1-[4-[4-(dimethylamino)piperidine-1-carbonyl]phenyl]-3-[4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl]urea Chemical compound C1CC(N(C)C)CCN1C(=O)C(C=C1)=CC=C1NC(=O)NC1=CC=C(C=2N=C(N=C(N=2)N2CCOCC2)N2CCOCC2)C=C1 DWZAEMINVBZMHQ-UHFFFAOYSA-N 0.000 description 2
- BEUQXVWXFDOSAQ-UHFFFAOYSA-N 2-methyl-2-[4-[2-(5-methyl-2-propan-2-yl-1,2,4-triazol-3-yl)-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl]pyrazol-1-yl]propanamide Chemical compound CC(C)N1N=C(C)N=C1C1=CN(CCOC=2C3=CC=C(C=2)C2=CN(N=C2)C(C)(C)C(N)=O)C3=N1 BEUQXVWXFDOSAQ-UHFFFAOYSA-N 0.000 description 2
- 102100033793 ALK tyrosine kinase receptor Human genes 0.000 description 2
- 101710168331 ALK tyrosine kinase receptor Proteins 0.000 description 2
- HKVAMNSJSFKALM-GKUWKFKPSA-N Everolimus Chemical compound C1C[C@@H](OCCO)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 HKVAMNSJSFKALM-GKUWKFKPSA-N 0.000 description 2
- 229960001611 alectinib Drugs 0.000 description 2
- 229950003628 buparlisib Drugs 0.000 description 2
- 229950006418 dactolisib Drugs 0.000 description 2
- JOGKUKXHTYWRGZ-UHFFFAOYSA-N dactolisib Chemical compound O=C1N(C)C2=CN=C3C=CC(C=4C=C5C=CC=CC5=NC=4)=CC3=C2N1C1=CC=C(C(C)(C)C#N)C=C1 JOGKUKXHTYWRGZ-UHFFFAOYSA-N 0.000 description 2
- 229960005167 everolimus Drugs 0.000 description 2
- LHNIIDJUOCFXAP-UHFFFAOYSA-N pictrelisib Chemical compound C1CN(S(=O)(=O)C)CCN1CC1=CC2=NC(C=3C=4C=NNC=4C=CC=3)=NC(N3CCOCC3)=C2S1 LHNIIDJUOCFXAP-UHFFFAOYSA-N 0.000 description 2
- ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 description 2
- 229960002930 sirolimus Drugs 0.000 description 2
- QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 description 2
- 229950001269 taselisib Drugs 0.000 description 2
- 229960000235 temsirolimus Drugs 0.000 description 2
- STUWGJZDJHPWGZ-LBPRGKRZSA-N (2S)-N1-[4-methyl-5-[2-(1,1,1-trifluoro-2-methylpropan-2-yl)-4-pyridinyl]-2-thiazolyl]pyrrolidine-1,2-dicarboxamide Chemical compound S1C(C=2C=C(N=CC=2)C(C)(C)C(F)(F)F)=C(C)N=C1NC(=O)N1CCC[C@H]1C(N)=O STUWGJZDJHPWGZ-LBPRGKRZSA-N 0.000 description 1
- YOVVNQKCSKSHKT-HNNXBMFYSA-N (2s)-1-[4-[[2-(2-aminopyrimidin-5-yl)-7-methyl-4-morpholin-4-ylthieno[3,2-d]pyrimidin-6-yl]methyl]piperazin-1-yl]-2-hydroxypropan-1-one Chemical compound C1CN(C(=O)[C@@H](O)C)CCN1CC1=C(C)C2=NC(C=3C=NC(N)=NC=3)=NC(N3CCOCC3)=C2S1 YOVVNQKCSKSHKT-HNNXBMFYSA-N 0.000 description 1
- GYLDXIAOMVERTK-UHFFFAOYSA-N 5-(4-amino-1-propan-2-yl-3-pyrazolo[3,4-d]pyrimidinyl)-1,3-benzoxazol-2-amine Chemical compound C12=C(N)N=CN=C2N(C(C)C)N=C1C1=CC=C(OC(N)=N2)C2=C1 GYLDXIAOMVERTK-UHFFFAOYSA-N 0.000 description 1
- KVLFRAWTRWDEDF-IRXDYDNUSA-N AZD-8055 Chemical compound C1=C(CO)C(OC)=CC=C1C1=CC=C(C(=NC(=N2)N3[C@H](COCC3)C)N3[C@H](COCC3)C)C2=N1 KVLFRAWTRWDEDF-IRXDYDNUSA-N 0.000 description 1
- BMMXYEBLEBULND-UHFFFAOYSA-N BGT226 free base Chemical compound C1=NC(OC)=CC=C1C1=CC=C(N=CC2=C3N(C=4C=C(C(N5CCNCC5)=CC=4)C(F)(F)F)C(=O)N2C)C3=C1 BMMXYEBLEBULND-UHFFFAOYSA-N 0.000 description 1
- KGPGFQWBCSZGEL-ZDUSSCGKSA-N GSK690693 Chemical compound C=12N(CC)C(C=3C(=NON=3)N)=NC2=C(C#CC(C)(C)O)N=CC=1OC[C@H]1CCCNC1 KGPGFQWBCSZGEL-ZDUSSCGKSA-N 0.000 description 1
- 239000002146 L01XE16 - Crizotinib Substances 0.000 description 1
- 229940124640 MK-2206 Drugs 0.000 description 1
- 239000012823 PI3K/mTOR inhibitor Substances 0.000 description 1
- 229940124639 Selective inhibitor Drugs 0.000 description 1
- 102000013530 TOR Serine-Threonine Kinases Human genes 0.000 description 1
- 108010065917 TOR Serine-Threonine Kinases Proteins 0.000 description 1
- 229950010482 alpelisib Drugs 0.000 description 1
- JROFGZPOBKIAEW-HAQNSBGRSA-N chembl3120215 Chemical compound N1C=2C(OC)=CC=CC=2C=C1C(=C1C(N)=NC=NN11)N=C1[C@H]1CC[C@H](C(O)=O)CC1 JROFGZPOBKIAEW-HAQNSBGRSA-N 0.000 description 1
- 229960005061 crizotinib Drugs 0.000 description 1
- KTEIFNKAUNYNJU-GFCCVEGCSA-N crizotinib Chemical compound O([C@H](C)C=1C(=C(F)C=CC=1Cl)Cl)C(C(=NC=1)N)=CC=1C(=C1)C=NN1C1CCNCC1 KTEIFNKAUNYNJU-GFCCVEGCSA-N 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 229950008209 gedatolisib Drugs 0.000 description 1
- 229950006331 ipatasertib Drugs 0.000 description 1
- 229950000846 onartuzumab Drugs 0.000 description 1
- SZFPYBIJACMNJV-UHFFFAOYSA-N perifosine Chemical compound CCCCCCCCCCCCCCCCCCOP([O-])(=O)OC1CC[N+](C)(C)CC1 SZFPYBIJACMNJV-UHFFFAOYSA-N 0.000 description 1
- 229950004941 pictilisib Drugs 0.000 description 1
- 229950009216 sapanisertib Drugs 0.000 description 1
- QFJCIRLUMZQUOT-UHFFFAOYSA-N temsirolimus Natural products C1CC(O)C(OC)CC1CC(C)C1OC(=O)C2CCCCN2C(=O)C(=O)C(O)(O2)C(C)CCC2CC(OC)C(C)=CC=CC=CC(C)CC(C)C(=O)C(OC)C(O)C(C)=CC(C)C(=O)C1 QFJCIRLUMZQUOT-UHFFFAOYSA-N 0.000 description 1
- 229940100411 torisel Drugs 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021162634A JP2022020049A (ja) | 2015-04-07 | 2021-10-01 | アゴニスト性の活性を有する抗原結合複合体及びその使用方法 |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562144237P | 2015-04-07 | 2015-04-07 | |
| US62/144,237 | 2015-04-07 | ||
| US201562207315P | 2015-08-19 | 2015-08-19 | |
| US62/207,315 | 2015-08-19 | ||
| US201562387485P | 2015-12-23 | 2015-12-23 | |
| US62/387,485 | 2015-12-23 | ||
| PCT/US2016/026245 WO2016164480A1 (en) | 2015-04-07 | 2016-04-06 | Antigen binding complex having agonistic activity and methods of use |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021162634A Division JP2022020049A (ja) | 2015-04-07 | 2021-10-01 | アゴニスト性の活性を有する抗原結合複合体及びその使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018516537A JP2018516537A (ja) | 2018-06-28 |
| JP2018516537A5 true JP2018516537A5 (OSRAM) | 2019-05-16 |
| JP6955445B2 JP6955445B2 (ja) | 2021-10-27 |
Family
ID=55802475
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017552827A Active JP6955445B2 (ja) | 2015-04-07 | 2016-04-06 | アゴニスト性の活性を有する抗原結合複合体及びその使用方法 |
| JP2021162634A Pending JP2022020049A (ja) | 2015-04-07 | 2021-10-01 | アゴニスト性の活性を有する抗原結合複合体及びその使用方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021162634A Pending JP2022020049A (ja) | 2015-04-07 | 2021-10-01 | アゴニスト性の活性を有する抗原結合複合体及びその使用方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US10865248B2 (OSRAM) |
| EP (1) | EP3280736A1 (OSRAM) |
| JP (2) | JP6955445B2 (OSRAM) |
| KR (1) | KR20180002653A (OSRAM) |
| CN (1) | CN107709364A (OSRAM) |
| AU (1) | AU2016246695A1 (OSRAM) |
| CA (1) | CA2981183A1 (OSRAM) |
| HK (1) | HK1249532A1 (OSRAM) |
| IL (1) | IL254717A0 (OSRAM) |
| MX (1) | MX2017012805A (OSRAM) |
| TW (1) | TW201710295A (OSRAM) |
| WO (1) | WO2016164480A1 (OSRAM) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA201591495A1 (ru) | 2013-03-18 | 2016-05-31 | Биосерокс Продактс Б.В. | Гуманизированные антитела против cd134 (ox40) и применения указанных антител |
| JP6588461B2 (ja) | 2014-03-31 | 2019-10-09 | ジェネンテック， インコーポレイテッド | 抗血管新生剤及びｏｘ４０結合アゴニストを含む併用療法 |
| MA41460A (fr) | 2015-02-03 | 2017-12-12 | Oncomed Pharm Inc | Agents de liaison à la tnfrsf et leurs utilisations |
| KR20180053674A (ko) | 2015-10-02 | 2018-05-23 | 에프. 호프만-라 로슈 아게 | 공자극 tnf 수용체에 특이적인 이중특이성 항체 |
| JP7464389B2 (ja) | 2016-08-02 | 2024-04-09 | ビステラ， インコーポレイテッド | 操作されたポリペプチドおよびその使用 |
| JP2019530434A (ja) | 2016-08-05 | 2019-10-24 | ジェネンテック， インコーポレイテッド | アゴニスト活性を有する多価及び多重エピトープ抗体ならびに使用方法 |
| CA3033665A1 (en) * | 2016-08-12 | 2018-02-15 | Janssen Biotech, Inc. | Fc engineered anti-tnfr superfamily member antibodies having enhanced agonistic activity and methods of using them |
| EP4342912A3 (en) | 2016-09-23 | 2024-05-22 | Merus N.V. | Binding molecules that modulate a biological activity expressed by a cell |
| KR20190070977A (ko) * | 2016-11-01 | 2019-06-21 | 젠맵 비. 브이 | 폴리펩티드 변이체 및 그의 용도 |
| CA3047059A1 (en) * | 2016-12-19 | 2018-06-28 | Glenmark Pharmaceuticals S.A. | Novel tnfr agonists and uses thereof |
| CA3049163A1 (en) * | 2017-01-06 | 2018-07-12 | Iovance Biotherapeutics, Inc. | Expansion of tumor infiltrating lymphocytes (tils) with tumor necrosis factor receptor superfamily (tnfrsf) agonists and therapeutic combinations of tils and tnfrsf agonists |
| WO2018145075A1 (en) * | 2017-02-06 | 2018-08-09 | Dana-Farber Cancer Institute, Inc. | Compositions and methods for augmenting antibody mediated receptor signaling |
| KR20250140128A (ko) | 2017-02-10 | 2025-09-24 | 젠맵 비. 브이 | 폴리펩티드 변이체 및 그의 용도 |
| JP7205995B2 (ja) * | 2017-03-29 | 2023-01-17 | エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト | 共刺激性ｔｎｆ受容体に対する二重特異性抗原結合分子 |
| RS64419B1 (sr) | 2017-08-03 | 2023-09-29 | Alector Llc | Anti-trem2 antitela i postupci za njihovu upotrebu |
| CN111247171A (zh) * | 2017-10-14 | 2020-06-05 | 西托姆克斯治疗公司 | 抗体、可活化抗体、双特异性抗体和双特异性可活化抗体及其使用方法 |
| US20200339681A1 (en) * | 2017-11-16 | 2020-10-29 | Orum Therapeutics Inc. | Antibody inhibiting activated ras in cell by internalizing into cytosol of cell, and use thereof |
| EP3743440A1 (en) * | 2018-01-24 | 2020-12-02 | Genmab B.V. | Polypeptide variants and uses thereof |
| JP7551499B2 (ja) * | 2018-03-21 | 2024-09-17 | デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド | Ｆｃバリアント組成物およびその使用方法 |
| AU2019264217A1 (en) * | 2018-05-03 | 2020-12-17 | Genmab B.V. | Antibody variant combinations and uses thereof |
| CN113286824A (zh) | 2018-08-03 | 2021-08-20 | 中外制药株式会社 | 包含两个彼此连接的抗原结合结构域的抗原结合分子 |
| US12331320B2 (en) | 2018-10-10 | 2025-06-17 | The Research Foundation For The State University Of New York | Genome edited cancer cell vaccines |
| EP3883968A4 (en) * | 2018-11-22 | 2022-08-17 | Agency for Science, Technology and Research | MODIFIED FC REGION |
| KR20210145254A (ko) * | 2019-03-29 | 2021-12-01 | 유니베르시태트 취리히 | 구획, 특히 cns로의 국소 전달을 위한 fc 변형 생물학적 제제 |
| US20230072197A1 (en) * | 2020-01-29 | 2023-03-09 | Korea University Research And Business Foundation | Ph-sensitive fc variants |
| WO2021165417A1 (en) * | 2020-02-19 | 2021-08-26 | Adivo Gmbh | Modified fc regions |
| US20230105415A1 (en) * | 2020-02-21 | 2023-04-06 | Arizona Board Of Regentson Behalf Of Arizona State University | IgG VARIANTS FOR INDUCTION OF IMMUNE RESPONSE WITHOUT ADJUVANT |
| JP2023516028A (ja) * | 2020-02-28 | 2023-04-17 | ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッド | 多重特異性抗体を介したトランスフォーミング増殖因子ベータスーパーファミリーシグナル伝達の選択的調節 |
| KR20220151189A (ko) | 2020-03-09 | 2022-11-14 | 브리스톨-마이어스 스큅 컴퍼니 | 증진된 효능제 활성을 갖는 cd40에 대한 항체 |
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-
2016
- 2016-04-06 KR KR1020177031885A patent/KR20180002653A/ko not_active Withdrawn
- 2016-04-06 CA CA2981183A patent/CA2981183A1/en not_active Abandoned
- 2016-04-06 WO PCT/US2016/026245 patent/WO2016164480A1/en not_active Ceased
- 2016-04-06 JP JP2017552827A patent/JP6955445B2/ja active Active
- 2016-04-06 CN CN201680032985.3A patent/CN107709364A/zh active Pending
- 2016-04-06 MX MX2017012805A patent/MX2017012805A/es unknown
- 2016-04-06 EP EP16717751.8A patent/EP3280736A1/en not_active Withdrawn
- 2016-04-06 HK HK18109024.1A patent/HK1249532A1/zh unknown
- 2016-04-06 AU AU2016246695A patent/AU2016246695A1/en not_active Abandoned
- 2016-04-07 TW TW105110958A patent/TW201710295A/zh unknown
-
2017
- 2017-09-26 IL IL254717A patent/IL254717A0/en unknown
- 2017-10-04 US US15/725,208 patent/US10865248B2/en active Active
-
2020
- 2020-10-27 US US17/081,784 patent/US20210147562A1/en not_active Abandoned
-
2021
- 2021-10-01 JP JP2021162634A patent/JP2022020049A/ja active Pending
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