JP2018514204A5 - - Google Patents
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- JP2018514204A5 JP2018514204A5 JP2017554350A JP2017554350A JP2018514204A5 JP 2018514204 A5 JP2018514204 A5 JP 2018514204A5 JP 2017554350 A JP2017554350 A JP 2017554350A JP 2017554350 A JP2017554350 A JP 2017554350A JP 2018514204 A5 JP2018514204 A5 JP 2018514204A5
- Authority
- JP
- Japan
- Prior art keywords
- domain
- cell
- car
- signaling domain
- intracellular signaling
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1507368.7A GB201507368D0 (en) | 2015-04-30 | 2015-04-30 | Cell |
| GB1507368.7 | 2015-04-30 | ||
| PCT/GB2016/051235 WO2016174461A1 (en) | 2015-04-30 | 2016-04-29 | T cell which expresses a gamma-delta t cell receptor (tcr) and a chimeric antigen receptor (car) |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018514204A JP2018514204A (ja) | 2018-06-07 |
| JP2018514204A5 true JP2018514204A5 (https=) | 2019-06-06 |
| JP6986449B2 JP6986449B2 (ja) | 2021-12-22 |
Family
ID=53488907
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017554350A Expired - Fee Related JP6986449B2 (ja) | 2015-04-30 | 2016-04-29 | ガンマデルタt細胞受容体(tcr)とキメラ抗原受容体(car)とを発現するt細胞 |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US20180125890A1 (https=) |
| EP (1) | EP3288567B1 (https=) |
| JP (1) | JP6986449B2 (https=) |
| KR (1) | KR20180020140A (https=) |
| CN (1) | CN107771215A (https=) |
| AU (1) | AU2016255611B2 (https=) |
| BR (1) | BR112017023409A2 (https=) |
| CA (1) | CA2982532C (https=) |
| EA (1) | EA201792042A1 (https=) |
| ES (1) | ES3018558T3 (https=) |
| GB (1) | GB201507368D0 (https=) |
| HK (1) | HK1252235A1 (https=) |
| IL (1) | IL255186B (https=) |
| SG (1) | SG11201708402UA (https=) |
| WO (1) | WO2016174461A1 (https=) |
| ZA (1) | ZA201706923B (https=) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2948544A4 (en) | 2013-01-28 | 2016-08-03 | St Jude Childrens Res Hospital | CHIMERIC RECEPTOR WITH NKG2D SPECIFICITY FOR CELL THERAPY AGAINST CANCER AND INFECTION DISEASES |
| DK3143134T3 (da) | 2014-05-15 | 2021-01-04 | Nat Univ Singapore | Modificerede, naturlige dræberceller og anvendelser deraf |
| GB201506423D0 (en) * | 2015-04-15 | 2015-05-27 | Tc Biopharm Ltd | Gamma delta T cells and uses thereof |
| GB201507368D0 (en) | 2015-04-30 | 2015-06-17 | Ucl Business Plc | Cell |
| CA3057838A1 (en) * | 2017-03-24 | 2018-09-27 | Lentigen Technology, Inc. | Compositions and methods for treating cancer with anti-cd33 immunotherapy |
| BR112019019917A2 (pt) | 2017-03-27 | 2020-04-22 | Nat Univ Singapore | receptores quiméricos nkg2d truncados e seus usos em imunoterapia de células exterminadoras naturais |
| CA3056591A1 (en) | 2017-03-27 | 2018-10-04 | National University Of Singapore | Stimulatory cell lines for ex vivo expansion and activation of natural killer cells |
| US20210130775A1 (en) * | 2017-08-02 | 2021-05-06 | Autolus Limited | Cells expressing a chimeric antigen receptor or engineered tcr and comprising a nucleotide sequence which is selectively expressed |
| WO2019067249A1 (en) * | 2017-09-27 | 2019-04-04 | Ohio State Innovation Foundation | CAR-NK CELL THERAPY AND TISSUE FACTOR TARGETING T-CARD |
| GB201715918D0 (en) * | 2017-09-29 | 2017-11-15 | Tc Biopharm Ltd | Modified CAR-T |
| GB201720949D0 (en) | 2017-12-15 | 2018-01-31 | Autolus Ltd | Cell |
| EP3749685A4 (en) | 2018-02-09 | 2021-12-22 | National University of Singapore | ACTIVATOR CHEMERIC RECEPTORS AND THEIR USES IN NATURAL KILLING CELL IMMUNOTHERAPY |
| GB201804701D0 (en) * | 2018-03-23 | 2018-05-09 | Gammadelta Therapeutics Ltd | Lymphocytes expressing heterologous targeting constructs |
| JP7334985B2 (ja) | 2018-04-02 | 2023-08-29 | ナショナル ユニヴァーシティー オブ シンガポール | 免疫細胞で発現される膜結合抗サイトカイン非シグナル伝達バインダーによるヒトサイトカインの中和 |
| WO2019192526A1 (zh) * | 2018-04-04 | 2019-10-10 | 达仁生物科技有限公司 | 嵌合抗原受体和其治疗癌症的方法 |
| JP7436383B2 (ja) * | 2018-04-18 | 2024-02-21 | ユーシーエル ビジネス リミテッド | 操作された調節性t細胞 |
| CN108588023B (zh) | 2018-05-09 | 2020-02-14 | 河北森朗生物科技有限公司 | 一种生产嵌合抗原受体修饰的γδT细胞的方法 |
| CN110577932A (zh) * | 2018-06-07 | 2019-12-17 | 亘喜生物科技(上海)有限公司 | 一种脐带血来源的嵌合抗原受体t细胞 |
| SG11202008731XA (en) * | 2018-06-19 | 2020-10-29 | Nanjing Legend Biotech Co Ltd | Engineered cells and uses thereof |
| CA3102641A1 (en) * | 2018-06-22 | 2019-12-26 | Kite Pharma, Inc. | Chimeric transmembrane proteins and uses thereof |
| EP3831936A4 (en) | 2018-07-31 | 2022-04-13 | Thyas Co. Ltd. | METHOD FOR PRODUCING A REGENERATED T LYMPHOCYTE POPULATION USING IPS CELLS |
| US12156888B2 (en) | 2018-08-07 | 2024-12-03 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | CAR T-cells for the treatment of bone metastatic cancer |
| US12569507B2 (en) | 2018-08-07 | 2026-03-10 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | CAR T-cells for the treatment of bone metastatic cancer |
| CN112567025B (zh) * | 2018-08-10 | 2025-01-17 | 国立大学法人京都大学 | Cd3阳性细胞的制造方法 |
| EP3844186A4 (en) | 2018-08-29 | 2022-08-17 | National University of Singapore | METHOD OF SPECIFIC STIMULATION OF SURVIVAL AND EXPANSION OF GENETICALLY MODIFIED IMMUNE CELLS |
| AU2019344300A1 (en) * | 2018-09-19 | 2021-04-22 | LAVA Therapeutics N.V. | Dual acting CD1D immunoglobulin |
| CN109234236A (zh) * | 2018-09-29 | 2019-01-18 | 吉林大学第医院 | 一种嵌合抗原受体γδT细胞的制备方法 |
| SG11202103234RA (en) * | 2018-10-01 | 2021-04-29 | Adicet Bio Inc | COMPOSITIONS AND METHODS REGARDING ENGINEERED AND NON-ENGINEERED γδ -T CELLS FOR TREATMENT OF SOLID TUMORS |
| US20210388100A1 (en) * | 2018-10-01 | 2021-12-16 | Adicet Bio, Inc. | Compositions and methods regarding engineered and non-engineered gamma delta t-cells for treatment of hematological tumors |
| CA3120563A1 (en) | 2018-11-26 | 2020-06-04 | Nkarta, Inc. | Methods for the simultaneous expansion of multiple immune cell types, related compositions and uses of same in cancer immunotherapy |
| WO2020156335A1 (zh) | 2019-01-29 | 2020-08-06 | 上海交通大学 | 一种嵌合抗原受体及其应用 |
| WO2020172555A1 (en) * | 2019-02-21 | 2020-08-27 | Regents Of The University Of Minnesota | Genetically modified gamma delta t cells and methods of making and using |
| EP3773918A4 (en) | 2019-03-05 | 2022-01-05 | Nkarta, Inc. | CD19 DIRECTED CHIMERIC ANTIGEN RECEPTORS AND THEIR USES IN IMMUNOTHERAPY |
| SG11202109051PA (en) * | 2019-04-12 | 2021-10-28 | Phanes Therapeutics Inc | Humanized anti-folate receptor 1 chimeric antigen receptors and uses thereof |
| WO2020216238A1 (en) * | 2019-04-22 | 2020-10-29 | Nanjing Legend Biotech Co., Ltd. | Engineered cells and uses thereof |
| CN113939302A (zh) | 2019-06-14 | 2022-01-14 | 赛雅思株式会社 | 医药组合物 |
| US20220259281A1 (en) * | 2019-06-21 | 2022-08-18 | Shattuck Labs, Inc. | Chimeric protein expressing t-cells |
| GB201909283D0 (en) * | 2019-06-27 | 2019-08-14 | Cancer Research Tech Ltd | Fusion proteins with enzyme activity |
| CN110981972B (zh) * | 2019-12-25 | 2022-09-30 | 华夏源(上海)细胞基因工程股份有限公司 | 一种分泌双特异性抗体的嵌合抗原受体及其表达载体和应用 |
| CN115485369A (zh) * | 2020-03-03 | 2022-12-16 | 詹森生物科技公司 | γδT细胞及其用途 |
| US20230203125A1 (en) | 2020-05-22 | 2023-06-29 | Chongqing Precision Biotech Co., Ltd. | Fusion protein for reversing tumor microenvironment and use thereof |
| EP4182338A1 (en) | 2020-07-17 | 2023-05-24 | Instil Bio (Uk) Limited | Receptors providing targeted costimulation for adoptive cell therapy |
| US12012441B2 (en) | 2020-10-26 | 2024-06-18 | Neptune Biosciences Llc | Engineered human IL-21 cytokines and methods for using the same |
| WO2022266192A1 (en) | 2021-06-16 | 2022-12-22 | Instil Bio, Inc. | Receptors providing targeted costimulation for adoptive cell therapy |
| EP4370213A4 (en) | 2021-07-16 | 2025-06-04 | Instil Bio (Uk) Limited | Chimeric molecules for targeted costimulation for adoptive cell therapy |
| CN113528455A (zh) * | 2021-07-19 | 2021-10-22 | 广州百暨基因科技有限公司 | 表达嵌合抗原受体的γδT细胞 |
| US20240408139A1 (en) * | 2021-10-06 | 2024-12-12 | Dana-Farber Cancer Institute, Inc. | Engineered cytokine receptors for tunable adoptive cell therapy |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1147186A4 (en) | 1999-01-28 | 2002-05-15 | Palmetto Health Alliance D B A | In vitro activated gamma delta lymphocytes |
| ES2336302T3 (es) | 2000-04-03 | 2010-04-12 | Therapure Biopharma Inc. | Produccion de celulas ttcr gamma delta. |
| DE60115069T2 (de) | 2000-09-11 | 2006-08-03 | Chiron Corp., Emeryville | Chinolinonderivate als tyrosin-kinase inhibitoren |
| WO2006006720A1 (ja) | 2004-07-13 | 2006-01-19 | Medinet., Co.Ltd | γδT細胞の培養方法、γδT細胞及び治療・予防剤 |
| DE602005022728D1 (de) | 2004-08-19 | 2010-09-16 | Univ Cardiff | Präparation antigenpräsentierender menschlicher gamma delta t-zellen und verwendung in der immuntherapie |
| JPWO2008152822A1 (ja) | 2007-06-15 | 2010-08-26 | 株式会社メディネット | 医薬 |
| PH12013501201A1 (en) | 2010-12-09 | 2013-07-29 | Univ Pennsylvania | Use of chimeric antigen receptor-modified t cells to treat cancer |
| WO2013033626A2 (en) * | 2011-08-31 | 2013-03-07 | Trustees Of Dartmouth College | Nkp30 receptor targeted therapeutics |
| CA2861491C (en) * | 2012-02-13 | 2020-08-25 | Seattle Children's Hospital D/B/A Seattle Children's Research Institute | Bispecific chimeric antigen receptors and therapeutic uses thereof |
| WO2013174404A1 (en) * | 2012-05-23 | 2013-11-28 | Ganymed Pharmaceuticals Ag | Combination therapy involving antibodies against claudin 18.2 for treatment of cancer |
| WO2014055657A1 (en) | 2012-10-05 | 2014-04-10 | The Trustees Of The University Of Pennsylvania | Use of a trans-signaling approach in chimeric antigen receptors |
| CN113005091A (zh) | 2013-02-06 | 2021-06-22 | 细胞基因公司 | 具有改进特异性的修饰的t淋巴细胞 |
| JP6647868B2 (ja) * | 2013-02-20 | 2020-02-14 | ノバルティス アーゲー | ヒト化抗EGFRvIIIキメラ抗原受容体を用いたがんの処置 |
| UY35468A (es) * | 2013-03-16 | 2014-10-31 | Novartis Ag | Tratamiento de cáncer utilizando un receptor quimérico de antígeno anti-cd19 |
| EP3783098A1 (en) * | 2013-05-14 | 2021-02-24 | Board Of Regents, The University Of Texas System | Human application of engineered chimeric antigen receptor (car) t-cells |
| EP3925618A1 (en) * | 2013-07-29 | 2021-12-22 | 2seventy bio, Inc. | Multipartite signaling proteins and uses thereof |
| EP3060059A4 (en) | 2013-10-25 | 2017-11-01 | Board of Regents, The University of Texas System | Polyclonal gamma delta t cells for immunotherapy |
| WO2015066262A1 (en) * | 2013-11-04 | 2015-05-07 | Trustees Of Dartmouth College | Methods for preventing toxicity of adoptive cell therapy |
| MX373687B (es) * | 2013-11-21 | 2020-07-07 | Ucl Business Ltd | Célula natural (nk) |
| KR102375998B1 (ko) | 2014-02-14 | 2022-03-21 | 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 | 키메라 항원 수용체 및 제조방법 |
| GB201403972D0 (en) * | 2014-03-06 | 2014-04-23 | Ucl Business Plc | Chimeric antigen receptor |
| US20170335281A1 (en) | 2014-03-15 | 2017-11-23 | Novartis Ag | Treatment of cancer using chimeric antigen receptor |
| CA2945388A1 (en) * | 2014-04-23 | 2015-10-29 | Board Of Regents, The University Of Texas System | Chimeric antigen receptors (car) for use in therapy and methods for making the same |
| GB201506423D0 (en) * | 2015-04-15 | 2015-05-27 | Tc Biopharm Ltd | Gamma delta T cells and uses thereof |
| CN107075480A (zh) | 2014-07-09 | 2017-08-18 | Tc生物制药有限公司 | γδT细胞及其用途 |
| IL297773B2 (en) | 2014-11-17 | 2024-07-01 | Adicet Bio Inc | Engineered gamma delta t-cells |
| GB201507368D0 (en) | 2015-04-30 | 2015-06-17 | Ucl Business Plc | Cell |
| CN105158466B (zh) | 2015-05-05 | 2017-12-22 | 中国科学院广州生物医药与健康研究院 | 一种检测抗cd19的嵌合抗原受体t细胞对白血病细胞抑制作用的方法 |
-
2015
- 2015-04-30 GB GBGB1507368.7A patent/GB201507368D0/en not_active Ceased
-
2016
- 2016-04-29 AU AU2016255611A patent/AU2016255611B2/en active Active
- 2016-04-29 US US15/567,165 patent/US20180125890A1/en not_active Abandoned
- 2016-04-29 EA EA201792042A patent/EA201792042A1/ru unknown
- 2016-04-29 KR KR1020177034648A patent/KR20180020140A/ko not_active Ceased
- 2016-04-29 EP EP16720532.7A patent/EP3288567B1/en active Active
- 2016-04-29 JP JP2017554350A patent/JP6986449B2/ja not_active Expired - Fee Related
- 2016-04-29 WO PCT/GB2016/051235 patent/WO2016174461A1/en not_active Ceased
- 2016-04-29 SG SG11201708402UA patent/SG11201708402UA/en unknown
- 2016-04-29 HK HK18111473.3A patent/HK1252235A1/zh unknown
- 2016-04-29 BR BR112017023409-2A patent/BR112017023409A2/en not_active Application Discontinuation
- 2016-04-29 CN CN201680024237.0A patent/CN107771215A/zh active Pending
- 2016-04-29 ES ES16720532T patent/ES3018558T3/es active Active
- 2016-04-29 CA CA2982532A patent/CA2982532C/en active Active
-
2017
- 2017-10-12 ZA ZA2017/06923A patent/ZA201706923B/en unknown
- 2017-10-22 IL IL255186A patent/IL255186B/en unknown
-
2021
- 2021-11-17 US US17/528,836 patent/US12331316B2/en active Active
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