JP2018512863A5 - - Google Patents
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- Publication number
- JP2018512863A5 JP2018512863A5 JP2017554329A JP2017554329A JP2018512863A5 JP 2018512863 A5 JP2018512863 A5 JP 2018512863A5 JP 2017554329 A JP2017554329 A JP 2017554329A JP 2017554329 A JP2017554329 A JP 2017554329A JP 2018512863 A5 JP2018512863 A5 JP 2018512863A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- fragment
- binding
- hiv
- binding molecule
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562149460P | 2015-04-17 | 2015-04-17 | |
| US62/149,460 | 2015-04-17 | ||
| PCT/US2016/027979 WO2016168758A1 (en) | 2015-04-17 | 2016-04-15 | Multi-valent human immunodeficiency virus antigen binding molecules and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018512863A JP2018512863A (ja) | 2018-05-24 |
| JP2018512863A5 true JP2018512863A5 (cg-RX-API-DMAC10.html) | 2019-05-23 |
| JP6811723B2 JP6811723B2 (ja) | 2021-01-13 |
Family
ID=57126939
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017554329A Expired - Fee Related JP6811723B2 (ja) | 2015-04-17 | 2016-04-15 | 多価ヒト免疫不全ウイルス抗原結合分子およびその使用方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US10570191B2 (cg-RX-API-DMAC10.html) |
| EP (1) | EP3283112A4 (cg-RX-API-DMAC10.html) |
| JP (1) | JP6811723B2 (cg-RX-API-DMAC10.html) |
| CN (1) | CN107847591B (cg-RX-API-DMAC10.html) |
| AU (1) | AU2016249404B2 (cg-RX-API-DMAC10.html) |
| CA (1) | CA2983034A1 (cg-RX-API-DMAC10.html) |
| HK (1) | HK1245675A1 (cg-RX-API-DMAC10.html) |
| WO (1) | WO2016168758A1 (cg-RX-API-DMAC10.html) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105722855B (zh) | 2013-09-05 | 2021-04-23 | Igm生物科学股份有限公司 | 恒定链经修饰的双特异性五价和六价Ig-M抗体 |
| WO2015120474A1 (en) | 2014-02-10 | 2015-08-13 | Igm Biosciences, Inc. | Iga multi-specific binding molecules |
| EP4011910A1 (en) | 2014-04-03 | 2022-06-15 | IGM Biosciences, Inc. | Modified j-chain |
| PT3247728T (pt) | 2015-01-20 | 2020-07-16 | Igm Biosciences Inc | Moléculas de ligação do recetor da superfamília do fator de necrose tumoral (fnt) e utilização das mesmas |
| KR102357312B1 (ko) | 2015-03-04 | 2022-02-03 | 아이쥐엠 바이오사이언스 인코포레이티드 | Ｃｄ20 결합 분자 및 그의 용도 |
| WO2016154593A1 (en) | 2015-03-25 | 2016-09-29 | Igm Biosciences, Inc. | Multi-valent hepatitis b virus antigen binding molecules and uses thereof |
| AU2016249404B2 (en) * | 2015-04-17 | 2021-01-21 | Igm Biosciences, Inc. | Multi-valent human immunodeficiency virus antigen binding molecules and uses thereof |
| ES2819870T3 (es) | 2015-09-30 | 2021-04-19 | Igm Biosciences Inc | Moléculas de unión con cadena J modificada |
| PT3355913T (pt) | 2015-09-30 | 2024-12-18 | Igm Biosciences Inc | Moléculas de ligação com cadeia j modificada |
| WO2017196867A1 (en) | 2016-05-09 | 2017-11-16 | Igm Biosciences, Inc. | Anti-pd-l1 antibodies |
| CA3055790A1 (en) | 2017-04-07 | 2018-10-11 | Igm Biosciences, Inc. | Modified human igm constant regions for modulation of complement-dependent cytolysis effector function |
| JP7009517B2 (ja) | 2017-06-21 | 2022-01-25 | ギリアード サイエンシーズ， インコーポレイテッド | Ｈｉｖ ｇｐ１２０およびｃｄ３を標的とする多重特異性抗体 |
| WO2019123262A1 (en) * | 2017-12-18 | 2019-06-27 | VIIV Healthcare UK (No.5) Limited | Antigen binding polypeptides |
| CN111787951B (zh) | 2018-03-01 | 2025-06-17 | Igm生物科学股份有限公司 | 影响IgM血清半衰期的IgM Fc和J链突变 |
| EP3794027A4 (en) * | 2018-05-18 | 2022-02-09 | MacroGenics, Inc. | OPTIMIZED GP41 BINDING MOLECULES AND THEIR USES |
| IL317993B2 (en) | 2018-07-03 | 2025-11-01 | Gilead Sciences Inc | Antibodies directed against HIV gp120 and methods of use |
| WO2020023827A1 (en) * | 2018-07-27 | 2020-01-30 | International Aids Vaccine Initiative | Engineered antibodies to hiv env |
| WO2020056383A1 (en) * | 2018-09-13 | 2020-03-19 | Children's National Medical Center | Cells comprising antibodies against human immunodeficiency virus and methods of preparing and using the same |
| US12365722B2 (en) | 2018-10-19 | 2025-07-22 | University Of Maryland, College Park | Multispecific antibodies targeting multiple epitopes on the HIV-1 envelope |
| WO2020105700A1 (ja) * | 2018-11-22 | 2020-05-28 | 富士レビオ株式会社 | 抗体コンジュゲート |
| CN109776683B (zh) * | 2019-03-19 | 2020-04-07 | 益科思特(北京)医药科技发展有限公司 | 一种双特异性抗体及其制备方法与应用 |
| WO2021007285A1 (en) * | 2019-07-08 | 2021-01-14 | California Institute Of Technology | Anti-hiv vaccine antibodies with reduced polyreactivity |
| JP2022544405A (ja) | 2019-08-15 | 2022-10-18 | アイジーエム バイオサイエンシズ インコーポレイテッド | 免疫刺激性多量体型結合分子 |
| BR112022005666A2 (pt) * | 2019-09-26 | 2022-06-21 | Univ Minnesota | Compostos engatadores de nk que se ligam a antígenos virais e métodos de uso |
| JP2023522962A (ja) | 2020-04-22 | 2023-06-01 | アイジーエム バイオサイエンシズ インコーポレイテッド | Ｐｄ－１アゴニスト多量体結合分子 |
| JP7518286B2 (ja) * | 2020-08-25 | 2024-07-17 | ギリアード サイエンシーズ， インコーポレイテッド | Ｈｉｖを標的とする多重特異性抗原結合分子及び使用方法 |
| EP4205761A4 (en) * | 2020-08-27 | 2024-05-29 | Cellid Co., Ltd | NOVEL RECOMBINANT CORONAVIRUS SPIKE PROTEIN, POLYNUCLEOTIDE, VECTOR WITH POLYNUCLEOTIDE AND VACCINE FOR PREVENTING OR TREATING CORONAVIRUS INFECTION WITH VECTOR |
| CN113461811A (zh) * | 2021-06-30 | 2021-10-01 | 复旦大学 | 一种双特异性抗hiv-1抗体 |
| US12600801B2 (en) | 2022-07-11 | 2026-04-14 | Fred Hutchinson Cancer Center | Single-domain antibodies that bind ROR1 |
| CN116589566A (zh) * | 2022-11-18 | 2023-08-15 | 昆明医科大学第一附属医院 | 一种HIV-1中和抗体的改造重组单克隆IgM抗体及其应用 |
| WO2025178915A1 (en) * | 2024-02-23 | 2025-08-28 | Icahn School Of Medicine At Mount Sinai | Multivalent protein complexes und uses thereof |
| CN122444879A (zh) * | 2025-01-22 | 2026-07-24 | 复旦大学 | 一种预防和/或治疗hiv感染的多特异性和/或多价结合蛋白 |
| CN121537523B (zh) * | 2026-01-19 | 2026-04-21 | 武汉睿欣和生物科技有限公司 | 一种用于胃蛋白酶原i检测的pgi单克隆抗体组合及其应用 |
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| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US5892019A (en) | 1987-07-15 | 1999-04-06 | The United States Of America, As Represented By The Department Of Health And Human Services | Production of a single-gene-encoded immunoglobulin |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| EP1690935A3 (en) | 1990-01-12 | 2008-07-30 | Abgenix, Inc. | Generation of xenogeneic antibodies |
| TW505656B (en) | 1995-12-18 | 2002-10-11 | Otsuka Pharma Co Ltd | Sugar-chain-recognizing antibodies and pharmaceutical composition for HIV infectious diseases |
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| US5834597A (en) | 1996-05-20 | 1998-11-10 | Protein Design Labs, Inc. | Mutated nonactivating IgG2 domains and anti CD3 antibodies incorporating the same |
| DE19622088A1 (de) * | 1996-05-31 | 1997-12-04 | Boehringer Mannheim Gmbh | Anti-HIV-Antikörper als Kontrollproben |
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| CN101016543A (zh) * | 2000-11-17 | 2007-08-15 | 罗切斯特大学 | 筛选编码抗原特异性免疫球蛋白分子或其抗原特异性片段的多核苷酸的方法 |
| ATE423141T1 (de) | 2002-07-01 | 2009-03-15 | Inst Nagoya Ind Science Res | Humaner igm-antikörper, der in hiv-infizierten zellen apoptose induziert, und mittel gegen hiv- infektion |
| EP1615946B1 (en) * | 2003-03-26 | 2020-05-06 | Sudhir Paul | Proteolytic and covalent antibodies |
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| US7513893B2 (en) * | 2004-03-12 | 2009-04-07 | Abraham Ebbie Soroudi | Device and method for treatment of eyelid diseases |
| KR20070041781A (ko) * | 2004-08-11 | 2007-04-19 | 트루비온 파마슈티칼스, 인코포레이티드 | 결합 도메인 융합 단백질 |
| US20080038280A1 (en) | 2004-10-14 | 2008-02-14 | Government Of The United States Of America | A32 Monoclonal Antibody Fusion Proteins For Use As Hiv Inhibitors And Vaccines |
| AU2005304973A1 (en) | 2004-11-05 | 2006-05-18 | Palingen, Inc. | Antibody induced cell membrane wounding |
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| AU2009297095A1 (en) | 2008-09-25 | 2010-04-01 | Duke University | A method of detecting antibodies and antibody-HIV virion complexes |
| CA2767063A1 (en) * | 2009-07-03 | 2011-01-06 | Bionor Immuno As | Novel therapeutic and diagnostic means |
| WO2011035205A2 (en) | 2009-09-18 | 2011-03-24 | Calmune Corporation | Antibodies against candida, collections thereof and methods of use |
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| AU2011215684A1 (en) * | 2010-02-12 | 2012-08-30 | Research Corporation Technologies | Multimeric proteins comprising immunoglobulin constant domains |
| WO2012106578A1 (en) * | 2011-02-04 | 2012-08-09 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | HIV NEUTRALIZING ANTIBODIES HAVING MUTATIONS IN CONSTANT DOMAIN (Fc) |
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| EP2807181A1 (en) * | 2012-01-26 | 2014-12-03 | Institut National de la Santé et de la Recherche Médicale (INSERM) | Vaccine compositions for hiv prevention and treatment |
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| US20150044137A1 (en) | 2012-03-23 | 2015-02-12 | The United States of America, as represented by the Secretary, Dep. of Health Care Human Services | Neutralizing antibodies to hiv-1 and their use |
| CA2879814A1 (en) * | 2012-08-02 | 2014-02-06 | Jn Biosciences Llc | Antibodies or fusion proteins multimerized via cysteine mutation and a mu tailpiece |
| EP2882455A4 (en) * | 2012-08-08 | 2016-03-23 | Network Immunology Inc | PROCESS FOR INDUCING AN IMMUNE RESPONSE |
| JP2014124186A (ja) * | 2012-12-26 | 2014-07-07 | Industrial Technology Research Institute | 多価抗体フラグメントおよびその三量体化複合体 |
| CN105722855B (zh) | 2013-09-05 | 2021-04-23 | Igm生物科学股份有限公司 | 恒定链经修饰的双特异性五价和六价Ig-M抗体 |
| SG10201806025TA (en) | 2014-01-16 | 2018-08-30 | Mario Umberto Francesco Mondelli | Neutralizing human monoclonal antibodies against hepatitis b virus surface antigen |
| WO2015120474A1 (en) | 2014-02-10 | 2015-08-13 | Igm Biosciences, Inc. | Iga multi-specific binding molecules |
| EP4011910A1 (en) | 2014-04-03 | 2022-06-15 | IGM Biosciences, Inc. | Modified j-chain |
| PT3247728T (pt) | 2015-01-20 | 2020-07-16 | Igm Biosciences Inc | Moléculas de ligação do recetor da superfamília do fator de necrose tumoral (fnt) e utilização das mesmas |
| KR102357312B1 (ko) | 2015-03-04 | 2022-02-03 | 아이쥐엠 바이오사이언스 인코포레이티드 | Ｃｄ20 결합 분자 및 그의 용도 |
| WO2016154593A1 (en) | 2015-03-25 | 2016-09-29 | Igm Biosciences, Inc. | Multi-valent hepatitis b virus antigen binding molecules and uses thereof |
| AU2016249404B2 (en) * | 2015-04-17 | 2021-01-21 | Igm Biosciences, Inc. | Multi-valent human immunodeficiency virus antigen binding molecules and uses thereof |
| PT3355913T (pt) | 2015-09-30 | 2024-12-18 | Igm Biosciences Inc | Moléculas de ligação com cadeia j modificada |
| ES2819870T3 (es) | 2015-09-30 | 2021-04-19 | Igm Biosciences Inc | Moléculas de unión con cadena J modificada |
| WO2017196867A1 (en) | 2016-05-09 | 2017-11-16 | Igm Biosciences, Inc. | Anti-pd-l1 antibodies |
| CA3030659A1 (en) | 2016-07-20 | 2018-01-25 | Igm Biosciences, Inc. | Multimeric gitr binding molecules and uses thereof |
| US20190330374A1 (en) | 2016-07-20 | 2019-10-31 | Igm Biosciences, Inc. | Multimeric ox40 binding molecules and uses thereof |
| US20190338041A1 (en) | 2016-07-20 | 2019-11-07 | Igm Biosciences, Inc. | Multimeric cd40 binding molecules and uses thereof |
| AU2017299608A1 (en) | 2016-07-20 | 2019-02-07 | Igm Biosciences, Inc. | Multimeric CD137/4-1BB binding molecules and uses thereof |
| CA3055790A1 (en) | 2017-04-07 | 2018-10-11 | Igm Biosciences, Inc. | Modified human igm constant regions for modulation of complement-dependent cytolysis effector function |
| EP3759229A4 (en) | 2018-02-26 | 2021-12-29 | IGM Biosciences Inc. | Use of a multimeric anti-dr5 binding molecule in combination with a chemotherapeutic agent for treating cancer |
| CN111787951B (zh) | 2018-03-01 | 2025-06-17 | Igm生物科学股份有限公司 | 影响IgM血清半衰期的IgM Fc和J链突变 |
| AU2019368289A1 (en) | 2018-10-23 | 2021-04-29 | Igm Biosciences, Inc. | Multivalent IgM- and IgA-Fc-based binding molecules |
| US20220106398A1 (en) | 2019-02-08 | 2022-04-07 | Igm Biosciences, Inc. | Anti-gitr antigen-binding domains and uses thereof |
-
2016
- 2016-04-15 AU AU2016249404A patent/AU2016249404B2/en not_active Ceased
- 2016-04-15 CN CN201680035419.8A patent/CN107847591B/zh not_active Expired - Fee Related
- 2016-04-15 HK HK18105481.5A patent/HK1245675A1/zh unknown
- 2016-04-15 EP EP16780944.1A patent/EP3283112A4/en not_active Withdrawn
- 2016-04-15 US US15/566,485 patent/US10570191B2/en active Active
- 2016-04-15 CA CA2983034A patent/CA2983034A1/en active Pending
- 2016-04-15 WO PCT/US2016/027979 patent/WO2016168758A1/en not_active Ceased
- 2016-04-15 JP JP2017554329A patent/JP6811723B2/ja not_active Expired - Fee Related
-
2020
- 2020-01-07 US US16/736,327 patent/US11192941B2/en not_active Expired - Fee Related
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