JP2018512862A5 - - Google Patents
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- Publication number
- JP2018512862A5 JP2018512862A5 JP2017554311A JP2017554311A JP2018512862A5 JP 2018512862 A5 JP2018512862 A5 JP 2018512862A5 JP 2017554311 A JP2017554311 A JP 2017554311A JP 2017554311 A JP2017554311 A JP 2017554311A JP 2018512862 A5 JP2018512862 A5 JP 2018512862A5
- Authority
- JP
- Japan
- Prior art keywords
- polynucleotide
- multivalent antigen
- antigen
- sample
- multivalent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000427 antigen Substances 0.000 claims description 106
- 102000036639 antigens Human genes 0.000 claims description 106
- 108091007433 antigens Proteins 0.000 claims description 106
- 239000002157 polynucleotide Substances 0.000 claims description 85
- 108091033319 polynucleotide Proteins 0.000 claims description 83
- 102000040430 polynucleotide Human genes 0.000 claims description 83
- 238000000034 method Methods 0.000 claims description 61
- 239000000126 substance Substances 0.000 claims description 35
- 230000003321 amplification Effects 0.000 claims description 15
- 238000003199 nucleic acid amplification method Methods 0.000 claims description 15
- 238000001514 detection method Methods 0.000 claims description 11
- 230000000295 complement effect Effects 0.000 claims description 9
- 206010028980 Neoplasm Diseases 0.000 claims description 7
- 108091093088 Amplicon Proteins 0.000 claims description 6
- 210000004369 blood Anatomy 0.000 claims description 5
- 239000008280 blood Substances 0.000 claims description 5
- 229940127073 nucleoside analogue Drugs 0.000 claims description 5
- 239000002773 nucleotide Substances 0.000 claims description 5
- 125000003729 nucleotide group Chemical group 0.000 claims description 5
- 208000023275 Autoimmune disease Diseases 0.000 claims description 4
- 239000003153 chemical reaction reagent Substances 0.000 claims description 4
- 238000003752 polymerase chain reaction Methods 0.000 claims description 4
- 108020004414 DNA Proteins 0.000 claims description 3
- 208000030159 metabolic disease Diseases 0.000 claims description 3
- 239000011230 binding agent Substances 0.000 claims description 2
- 230000015556 catabolic process Effects 0.000 claims description 2
- 238000006731 degradation reaction Methods 0.000 claims description 2
- 208000016097 disease of metabolism Diseases 0.000 claims description 2
- 230000028993 immune response Effects 0.000 claims description 2
- 208000015181 infectious disease Diseases 0.000 claims description 2
- 208000027866 inflammatory disease Diseases 0.000 claims description 2
- 238000011901 isothermal amplification Methods 0.000 claims description 2
- 238000011002 quantification Methods 0.000 claims description 2
- 239000002131 composite material Substances 0.000 claims 1
- 238000004132 cross linking Methods 0.000 claims 1
- 230000009826 neoplastic cell growth Effects 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
- 239000007787 solid Substances 0.000 description 4
- 108060003951 Immunoglobulin Proteins 0.000 description 3
- 201000011510 cancer Diseases 0.000 description 3
- 102000018358 immunoglobulin Human genes 0.000 description 3
- 108020004635 Complementary DNA Proteins 0.000 description 2
- 210000001124 body fluid Anatomy 0.000 description 2
- 239000010839 body fluid Substances 0.000 description 2
- 208000035269 cancer or benign tumor Diseases 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 210000003608 fece Anatomy 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 210000004408 hybridoma Anatomy 0.000 description 2
- 229940099472 immunoglobulin a Drugs 0.000 description 2
- 229940027941 immunoglobulin g Drugs 0.000 description 2
- 244000052769 pathogen Species 0.000 description 2
- 230000001717 pathogenic effect Effects 0.000 description 2
- 210000004915 pus Anatomy 0.000 description 2
- 210000003296 saliva Anatomy 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- 210000004243 sweat Anatomy 0.000 description 2
- 210000001138 tear Anatomy 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 210000002700 urine Anatomy 0.000 description 2
- 206010006187 Breast cancer Diseases 0.000 description 1
- 208000026310 Breast neoplasm Diseases 0.000 description 1
- 206010009944 Colon cancer Diseases 0.000 description 1
- 102000012410 DNA Ligases Human genes 0.000 description 1
- 108010061982 DNA Ligases Proteins 0.000 description 1
- 102000004533 Endonucleases Human genes 0.000 description 1
- 108010042407 Endonucleases Proteins 0.000 description 1
- 102000003960 Ligases Human genes 0.000 description 1
- 108090000364 Ligases Proteins 0.000 description 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 description 1
- 206010060862 Prostate cancer Diseases 0.000 description 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 description 1
- 208000005718 Stomach Neoplasms Diseases 0.000 description 1
- 208000024770 Thyroid neoplasm Diseases 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 208000029742 colonic neoplasm Diseases 0.000 description 1
- 230000000593 degrading effect Effects 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 206010017758 gastric cancer Diseases 0.000 description 1
- 201000007270 liver cancer Diseases 0.000 description 1
- 208000014018 liver neoplasm Diseases 0.000 description 1
- 201000005202 lung cancer Diseases 0.000 description 1
- 208000020816 lung neoplasm Diseases 0.000 description 1
- 208000012111 paraneoplastic syndrome Diseases 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 238000003753 real-time PCR Methods 0.000 description 1
- 201000011549 stomach cancer Diseases 0.000 description 1
- 201000002510 thyroid cancer Diseases 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562149324P | 2015-04-17 | 2015-04-17 | |
| US62/149,324 | 2015-04-17 | ||
| PCT/US2016/027906 WO2016168711A1 (en) | 2015-04-17 | 2016-04-15 | Methods for detecting agglutination and compositions for use in practicing the same |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018512862A JP2018512862A (ja) | 2018-05-24 |
| JP2018512862A5 true JP2018512862A5 (https=) | 2019-05-23 |
| JP6822973B2 JP6822973B2 (ja) | 2021-01-27 |
Family
ID=57127062
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017554311A Active JP6822973B2 (ja) | 2015-04-17 | 2016-04-15 | 凝集の検出方法及びその方法を実施する際に使用する組成物 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US11149296B2 (https=) |
| EP (2) | EP3283638B1 (https=) |
| JP (1) | JP6822973B2 (https=) |
| CN (1) | CN107614699A (https=) |
| AU (1) | AU2016249392A1 (https=) |
| BR (1) | BR112017022329A2 (https=) |
| CA (1) | CA2982998A1 (https=) |
| EA (1) | EA201792289A1 (https=) |
| WO (1) | WO2016168711A1 (https=) |
| ZA (1) | ZA201707114B (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106591436A (zh) * | 2016-11-24 | 2017-04-26 | 湖南大学 | 用于检测人体内低丰度抗体的邻位连接核酸探针与试剂盒及其制备方法 |
| CN110869514A (zh) * | 2017-03-30 | 2020-03-06 | 小利兰·斯坦福大学托管委员会 | 多重同型特异性抗体检测 |
| CN109142730B (zh) * | 2018-06-14 | 2021-04-23 | 郑州大学第一附属医院 | 一种肺癌标志物抗-psip1自身抗体及其应用 |
| DE202020006093U1 (de) * | 2019-05-06 | 2025-04-09 | The Regents Of The University Of California | Nicht-HLA-Marker der Transplantatabstoßung |
| CN111323590B (zh) * | 2020-03-19 | 2022-04-22 | 福建省立医院 | 抗TIF1γ-IgA与抗TIF1γ-IgG作为联合诊断标志物在肺癌诊断中的应用 |
| CN111398584A (zh) * | 2020-03-20 | 2020-07-10 | 北京良芯生物科技发展有限公司 | 一种用于检测人类免疫缺陷病毒hiv1/2抗体的蛋白芯片及其制备方法 |
| CN111499724A (zh) * | 2020-04-15 | 2020-08-07 | 上海领潮生物新材料有限公司 | 一种s-腺苷同型半胱氨酸-鸡卵白蛋白偶联物的制备方法 |
| EP4138915A4 (en) * | 2020-04-24 | 2024-04-24 | Siemens Healthcare Diagnostics, Inc. | Compositions, kits, and methods for anti-microbial serology assays using anti-human immunoglobulin antibody |
| WO2023081029A2 (en) * | 2021-11-08 | 2023-05-11 | Summit Biolabs, Inc. | Devices and methods for nucleic acid extraction-free sti pathogen testing |
| CN114316016B (zh) * | 2021-12-14 | 2023-11-10 | 江苏浩欧博生物医药股份有限公司 | 一种Jo-1抗原生物素化的方法及抗Jo-1抗体检测试剂盒 |
| CN115060912B (zh) * | 2022-06-23 | 2024-02-02 | 南京浦光生物科技有限公司 | 检测目标抗体的试剂组合、试剂盒、检测系统及检测方法 |
| EP4389913A1 (en) * | 2022-12-23 | 2024-06-26 | Universität Heidelberg | A pcr-elisa analogous antibody-free method for detecting a target nucleic acid in a sample |
| CN116125076A (zh) * | 2022-12-30 | 2023-05-16 | 广州医科大学 | 检测桥粒蛋白的试剂在制备肝纤维化的检测产品中的应用 |
| CN118667920B (zh) * | 2024-07-30 | 2024-11-12 | 北京华诺奥美基因生物科技有限公司 | 一种基于微流控的低丰度生物标志物的检测试剂盒、检测方法及其应用 |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4292403A (en) * | 1978-08-24 | 1981-09-29 | Akzona Incorporated | Detection and/or determination of IgM, IgA, IgD and IgE immunoglobulins |
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US4965188A (en) | 1986-08-22 | 1990-10-23 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4883867A (en) | 1985-11-01 | 1989-11-28 | Becton, Dickinson And Company | Detection of reticulocytes, RNA or DNA |
| US4800159A (en) | 1986-02-07 | 1989-01-24 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences |
| WO1992001814A2 (en) | 1990-07-24 | 1992-02-06 | F. Hoffmann-La-Roche Ag | The reduction of non-specific amplification during in vitro nucleic acid amplification using modified nucleic acid bases |
| WO1993006482A1 (en) | 1991-09-16 | 1993-04-01 | Molecular Probes, Inc. | Dimers of unsymmetrical cyanine dyes |
| US5321130A (en) | 1992-02-10 | 1994-06-14 | Molecular Probes, Inc. | Unsymmetrical cyanine dyes with a cationic side chain |
| SG41929A1 (en) | 1992-09-25 | 1997-08-15 | Commw Scient Ind Res Org | Target binding polypeptide |
| US5410030A (en) | 1993-04-05 | 1995-04-25 | Molecular Probes, Inc. | Dimers of unsymmetrical cyanine dyes containing pyridinium moieties |
| US5658751A (en) | 1993-04-13 | 1997-08-19 | Molecular Probes, Inc. | Substituted unsymmetrical cyanine dyes with selected permeability |
| US5436134A (en) | 1993-04-13 | 1995-07-25 | Molecular Probes, Inc. | Cyclic-substituted unsymmetrical cyanine dyes |
| US5512462A (en) | 1994-02-25 | 1996-04-30 | Hoffmann-La Roche Inc. | Methods and reagents for the polymerase chain reaction amplification of long DNA sequences |
| US20030104361A1 (en) | 1997-09-29 | 2003-06-05 | Susan Weininger | Method of detection of nucleic acids with a specific sequence composition |
| AUPO591797A0 (en) | 1997-03-27 | 1997-04-24 | Commonwealth Scientific And Industrial Research Organisation | High avidity polyvalent and polyspecific reagents |
| SE504798C2 (sv) * | 1995-06-16 | 1997-04-28 | Ulf Landegren | Immunanalys och testkit med två reagens som kan tvärbindas om de adsorberats till analyten |
| EP1006197A1 (en) * | 1998-12-04 | 2000-06-07 | Transgene S.A. | Use of an immuno complex for the preparation of a therapeutic composition useful for transfecting a polynucleotide into macropinocyte cells |
| SE516272C2 (sv) | 2000-02-18 | 2001-12-10 | Ulf Landegren | Metoder och kit för analytdetektion mha proximitets-probning |
| US6511809B2 (en) * | 2000-06-13 | 2003-01-28 | E. I. Du Pont De Nemours And Company | Method for the detection of an analyte by means of a nucleic acid reporter |
| US8013134B2 (en) * | 2001-11-23 | 2011-09-06 | Olink Ab | Kit for proximity probing with multivalent proximity probes |
| US7399590B2 (en) | 2002-02-21 | 2008-07-15 | Asm Scientific, Inc. | Recombinase polymerase amplification |
| AU2004232976B2 (en) * | 2003-04-18 | 2011-02-10 | Becton, Dickinson And Company | Immuno-amplification |
| US7198900B2 (en) | 2003-08-29 | 2007-04-03 | Applera Corporation | Multiplex detection compositions, methods, and kits |
| US20050095627A1 (en) | 2003-09-03 | 2005-05-05 | The Salk Institute For Biological Studies | Multiple antigen detection assays and reagents |
| EP1692514A4 (en) * | 2003-11-07 | 2008-04-09 | Hepgenics Pty Ltd | BINDING ASSAY COMPONENTS |
| US7914987B2 (en) * | 2004-06-14 | 2011-03-29 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for use in analyte detection using proximity probes |
| DE602005023529D1 (de) * | 2004-11-03 | 2010-10-21 | Iris Molecular Diagnostics Inc | Homogener nachweis von analyten |
| US8673567B2 (en) | 2006-03-08 | 2014-03-18 | Atila Biosystems, Inc. | Method and kit for nucleic acid sequence detection |
| US20070281367A1 (en) * | 2006-05-03 | 2007-12-06 | Applera Corporation | Methods, Compositions, and Kits for Quantitating Antibodies |
| WO2008066483A1 (en) * | 2006-11-27 | 2008-06-05 | Mohammad Alimohammadi | Use of nalp5 in methods for diagnosis and therapy of parathyroid related disorders |
| JP2010226986A (ja) * | 2009-03-26 | 2010-10-14 | Kaneka Corp | 抗原または抗体の検出方法 |
| WO2011062933A2 (en) * | 2009-11-18 | 2011-05-26 | Raybiotech, Inc. | Array-based proximity ligation association assays |
| US8993347B2 (en) | 2009-12-17 | 2015-03-31 | Cornell University | Methods for detecting antibodies in mucosal samples and device for sampling mucosal material |
| GB201108678D0 (en) | 2011-05-24 | 2011-07-06 | Olink Ab | Multiplexed proximity ligation assay |
| WO2013073932A1 (en) * | 2011-11-15 | 2013-05-23 | Erasmus University Medical Center Rotterdam | Methods and kits for detecting ige-expressing b cells |
-
2016
- 2016-04-15 WO PCT/US2016/027906 patent/WO2016168711A1/en not_active Ceased
- 2016-04-15 CN CN201680031621.3A patent/CN107614699A/zh active Pending
- 2016-04-15 EA EA201792289A patent/EA201792289A1/ru unknown
- 2016-04-15 AU AU2016249392A patent/AU2016249392A1/en not_active Abandoned
- 2016-04-15 US US15/566,594 patent/US11149296B2/en active Active
- 2016-04-15 JP JP2017554311A patent/JP6822973B2/ja active Active
- 2016-04-15 BR BR112017022329A patent/BR112017022329A2/pt not_active IP Right Cessation
- 2016-04-15 CA CA2982998A patent/CA2982998A1/en not_active Abandoned
- 2016-04-15 EP EP16780915.1A patent/EP3283638B1/en active Active
- 2016-04-15 EP EP22177391.4A patent/EP4123031A1/en active Pending
-
2017
- 2017-10-19 ZA ZA2017/07114A patent/ZA201707114B/en unknown
-
2021
- 2021-09-14 US US17/474,424 patent/US12054768B2/en active Active
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