JP2018512397A5 - - Google Patents
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- JP2018512397A5 JP2018512397A5 JP2017547001A JP2017547001A JP2018512397A5 JP 2018512397 A5 JP2018512397 A5 JP 2018512397A5 JP 2017547001 A JP2017547001 A JP 2017547001A JP 2017547001 A JP2017547001 A JP 2017547001A JP 2018512397 A5 JP2018512397 A5 JP 2018512397A5
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- JP
- Japan
- Prior art keywords
- composition
- subject
- agonist
- administering
- chemotherapy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 claims description 65
- 101710165473 Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 claims description 42
- 102100022153 Tumor necrosis factor receptor superfamily member 4 Human genes 0.000 claims description 42
- 239000000556 agonist Substances 0.000 claims description 38
- 238000002512 chemotherapy Methods 0.000 claims description 34
- 206010028980 Neoplasm Diseases 0.000 claims description 27
- 230000005855 radiation Effects 0.000 claims description 26
- 208000029742 colonic neoplasm Diseases 0.000 claims description 12
- 230000004069 differentiation Effects 0.000 claims description 12
- 210000002540 macrophage Anatomy 0.000 claims description 12
- 206010009944 Colon cancer Diseases 0.000 claims description 10
- 238000001959 radiotherapy Methods 0.000 claims description 10
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 6
- 210000004027 cell Anatomy 0.000 claims description 6
- 230000002708 enhancing effect Effects 0.000 claims description 6
- 238000005259 measurement Methods 0.000 claims description 5
- 206010052747 Adenocarcinoma pancreas Diseases 0.000 claims description 4
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims description 4
- 108020001507 fusion proteins Proteins 0.000 claims description 4
- 102000037865 fusion proteins Human genes 0.000 claims description 4
- 210000002865 immune cell Anatomy 0.000 claims description 4
- 230000002163 immunogen Effects 0.000 claims description 4
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims description 4
- 201000002094 pancreatic adenocarcinoma Diseases 0.000 claims description 4
- 201000002528 pancreatic cancer Diseases 0.000 claims description 4
- 208000008443 pancreatic carcinoma Diseases 0.000 claims description 4
- 230000004083 survival effect Effects 0.000 claims description 4
- 238000002560 therapeutic procedure Methods 0.000 claims description 4
- 229950007217 tremelimumab Drugs 0.000 claims description 4
- 230000004614 tumor growth Effects 0.000 claims description 3
- 102000004452 Arginase Human genes 0.000 claims description 2
- 108700024123 Arginases Proteins 0.000 claims description 2
- 238000009175 antibody therapy Methods 0.000 claims description 2
- SDUQYLNIPVEERB-QPPQHZFASA-N gemcitabine Chemical compound O=C1N=C(N)C=CN1[C@H]1C(F)(F)[C@H](O)[C@@H](CO)O1 SDUQYLNIPVEERB-QPPQHZFASA-N 0.000 claims description 2
- 229960005277 gemcitabine Drugs 0.000 claims description 2
- 230000001413 cellular effect Effects 0.000 claims 1
- 238000011260 co-administration Methods 0.000 claims 1
- 210000004102 animal cell Anatomy 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000005021 gait Effects 0.000 description 1
- 230000012010 growth Effects 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- 210000004962 mammalian cell Anatomy 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000010369 molecular cloning Methods 0.000 description 1
- 238000002515 oligonucleotide synthesis Methods 0.000 description 1
- 238000003752 polymerase chain reaction Methods 0.000 description 1
- 108091033319 polynucleotide Proteins 0.000 description 1
- 102000040430 polynucleotide Human genes 0.000 description 1
- 239000002157 polynucleotide Substances 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000010188 recombinant method Methods 0.000 description 1
- 239000013598 vector Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562131562P | 2015-03-11 | 2015-03-11 | |
| US62/131,562 | 2015-03-11 | ||
| PCT/US2016/021486 WO2016145030A1 (en) | 2015-03-11 | 2016-03-09 | Compositions and methods for enhancing the efficacy of cancer therapy |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018512397A JP2018512397A (ja) | 2018-05-17 |
| JP2018512397A5 true JP2018512397A5 (https=) | 2019-04-18 |
Family
ID=56880519
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017547001A Pending JP2018512397A (ja) | 2015-03-11 | 2016-03-09 | 癌治療の有効性を高めるための組成物及び方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20180044428A1 (https=) |
| EP (1) | EP3268387A4 (https=) |
| JP (1) | JP2018512397A (https=) |
| KR (1) | KR20180002597A (https=) |
| CN (1) | CN107531773A (https=) |
| AU (1) | AU2016229810A1 (https=) |
| CA (1) | CA2978318A1 (https=) |
| HK (1) | HK1247630A1 (https=) |
| IL (1) | IL254103A0 (https=) |
| RU (1) | RU2017134104A (https=) |
| SG (1) | SG11201706958SA (https=) |
| WO (1) | WO2016145030A1 (https=) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG11201708804WA (en) | 2015-05-07 | 2017-11-29 | Agenus Inc | Anti-ox40 antibodies and methods of use thereof |
| US20160347848A1 (en) * | 2015-05-28 | 2016-12-01 | Medimmune Limited | Therapeutic combinations and methods for treating neoplasia |
| EP3331917A1 (en) * | 2015-08-04 | 2018-06-13 | GlaxoSmithKline Intellectual Property Development Limited | Combination treatments and uses and methods thereof |
| CN108883173B (zh) | 2015-12-02 | 2022-09-06 | 阿吉纳斯公司 | 抗体和其使用方法 |
| MA46770A (fr) | 2016-11-09 | 2019-09-18 | Agenus Inc | Anticorps anti-ox40, anticorps anti-gitr, et leurs procédés d'utilisation |
| US20190375847A1 (en) * | 2017-02-15 | 2019-12-12 | Glaxosmithkline Intellectual Property Development Limited | Combination treatment for cancer |
| EP3775258A4 (en) | 2018-03-28 | 2022-01-26 | Board of Regents, The University of Texas System | IDENTIFICATION OF EPIGENETIC ALTERATIONS IN DNA ISOLATED FROM EXOSOMES |
| EP3890802A4 (en) * | 2018-12-08 | 2023-03-22 | Board of Regents, The University of Texas System | IDENTIFICATION AND TARGETING OF TUMOR-FOMOTING CARCINOMA ASSOCIATED WITH FIBROBLAST FOR DIAGNOSIS AND TREATMENT OF CANCER AND OTHER DISEASES |
| CN112007149A (zh) * | 2019-05-29 | 2020-12-01 | 思格(苏州)生物科技有限公司 | 一种新型复合免疫佐剂及其应用 |
| WO2021062332A1 (en) * | 2019-09-27 | 2021-04-01 | Icahn School Of Medicine At Mount Sinai | Combination of inhibitors of il4 signaling and immune checkpoints for treating cancer |
| WO2021098851A1 (en) * | 2019-11-20 | 2021-05-27 | Eucure (Beijing) Biopharma Co., Ltd | Anti-ctla4/ox40 bispecific antibodies and uses thereof |
| JP2023503031A (ja) * | 2019-11-21 | 2023-01-26 | ベイジーン（ベイジン）カンパニー リミテッド | 化学療法剤との組合せでの抗ｏｘ４０抗体による癌治療の方法 |
| CN113045655A (zh) * | 2019-12-27 | 2021-06-29 | 高诚生物医药(香港)有限公司 | 抗ox40抗体及其用途 |
| US20230183366A1 (en) * | 2020-05-13 | 2023-06-15 | Inserm (Institut National De La Santé Et De La Recherch Médicale) | Recombinant proteins with ox40 activating properties |
| WO2021250594A1 (en) | 2020-06-11 | 2021-12-16 | Nantbio, Inc. | Anti-ctla4 monoclonal antibodies and chimeric antigen receptors |
| EP4448111A4 (en) * | 2021-12-15 | 2026-03-18 | Univ Texas | METHODS AND COMPOSITIONS FOR MODIFYING A TUMOR MICROBIOME |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2646626A1 (en) * | 2006-03-22 | 2007-09-27 | Apogenix Gmbh | Antibody specific for human il-4 for the treatment of cancer |
| WO2007113648A2 (en) * | 2006-04-05 | 2007-10-11 | Pfizer Products Inc. | Ctla4 antibody combination therapy |
| KR20100014588A (ko) * | 2007-02-27 | 2010-02-10 | 제넨테크, 인크. | 길항제 ｏｘ40 항체 및 염증성 및 자가면역 질환의 치료에서의 이의 용도 |
| WO2010014784A2 (en) * | 2008-08-01 | 2010-02-04 | Bristol-Myers Squibb Company | Combination of anti-ctla4 antibody with diverse therapeutic regimens for the synergistic treatment of proliferative diseases |
| PT2769737T (pt) * | 2009-07-20 | 2017-06-29 | Bristol Myers Squibb Co | Combinação de um anticorpo anti-ctla4 com etopósido para o tratamento sinérgico de doenças proliferativas |
| WO2011146382A1 (en) * | 2010-05-17 | 2011-11-24 | Bristol-Myers Squibb Company | Improved immunotherapeutic dosing regimens and combinations thereof |
| GB201116092D0 (en) * | 2011-09-16 | 2011-11-02 | Bioceros B V | Antibodies and uses thereof |
| CA2848985A1 (en) * | 2012-02-01 | 2013-08-08 | Compugen Ltd. | C10rf32 antibodies, and uses thereof for treatment of cancer |
| WO2017134292A1 (en) * | 2016-02-04 | 2017-08-10 | Glenmark Pharmaceuticals S.A. | Anti-ox40 antagonistic antibodies for the treatment of atopic dermatitis |
-
2016
- 2016-03-09 WO PCT/US2016/021486 patent/WO2016145030A1/en not_active Ceased
- 2016-03-09 RU RU2017134104A patent/RU2017134104A/ru not_active Application Discontinuation
- 2016-03-09 US US15/556,864 patent/US20180044428A1/en not_active Abandoned
- 2016-03-09 JP JP2017547001A patent/JP2018512397A/ja active Pending
- 2016-03-09 SG SG11201706958SA patent/SG11201706958SA/en unknown
- 2016-03-09 HK HK18107203.8A patent/HK1247630A1/zh unknown
- 2016-03-09 KR KR1020177025629A patent/KR20180002597A/ko not_active Withdrawn
- 2016-03-09 CN CN201680014559.7A patent/CN107531773A/zh active Pending
- 2016-03-09 CA CA2978318A patent/CA2978318A1/en not_active Abandoned
- 2016-03-09 AU AU2016229810A patent/AU2016229810A1/en not_active Abandoned
- 2016-03-09 EP EP16762392.5A patent/EP3268387A4/en not_active Withdrawn
-
2017
- 2017-08-22 IL IL254103A patent/IL254103A0/en unknown
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