JP2018512397A - 癌治療の有効性を高めるための組成物及び方法 - Google Patents

癌治療の有効性を高めるための組成物及び方法 Download PDF

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JP2018512397A
JP2018512397A JP2017547001A JP2017547001A JP2018512397A JP 2018512397 A JP2018512397 A JP 2018512397A JP 2017547001 A JP2017547001 A JP 2017547001A JP 2017547001 A JP2017547001 A JP 2017547001A JP 2018512397 A JP2018512397 A JP 2018512397A
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ctla4
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ゴフ，マイケル
クリッテンデン，マルカ
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プロビデンス ヘルス アンド サービシーズ−オレゴン
プロビデンス ヘルス アンド サービシーズ−オレゴン
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    • G—PHYSICS
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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JP2017547001A 2015-03-11 2016-03-09 癌治療の有効性を高めるための組成物及び方法 Pending JP2018512397A (ja)

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US201562131562P 2015-03-11 2015-03-11
US62/131,562 2015-03-11
PCT/US2016/021486 WO2016145030A1 (en) 2015-03-11 2016-03-09 Compositions and methods for enhancing the efficacy of cancer therapy

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JP2018512397A5 JP2018512397A5 (https=) 2019-04-18

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US (1) US20180044428A1 (https=)
EP (1) EP3268387A4 (https=)
JP (1) JP2018512397A (https=)
KR (1) KR20180002597A (https=)
CN (1) CN107531773A (https=)
AU (1) AU2016229810A1 (https=)
CA (1) CA2978318A1 (https=)
HK (1) HK1247630A1 (https=)
IL (1) IL254103A0 (https=)
RU (1) RU2017134104A (https=)
SG (1) SG11201706958SA (https=)
WO (1) WO2016145030A1 (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022511096A (ja) * 2018-12-08 2022-01-28 ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム がんおよび他の疾患の診断および処置のための腫瘍促進がん関連線維芽細胞の同定および標的化
JP2023525140A (ja) * 2020-05-13 2023-06-14 アンセルム（アンスティチュート・ナシオナル・ドゥ・ラ・サンテ・エ・ドゥ・ラ・ルシェルシュ・メディカル） Ｏｘ４０活性化特性を有する組換えタンパク質
US12473598B2 (en) 2018-03-28 2025-11-18 Board Of Regents, The University Of Texas System Identification of epigenetic alterations in DNA isolated from exosomes

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2984794A1 (en) 2015-05-07 2016-11-10 Agenus Inc. Anti-ox40 antibodies and methods of use thereof
US20160347848A1 (en) * 2015-05-28 2016-12-01 Medimmune Limited Therapeutic combinations and methods for treating neoplasia
EP3331917A1 (en) * 2015-08-04 2018-06-13 GlaxoSmithKline Intellectual Property Development Limited Combination treatments and uses and methods thereof
IL299072A (en) 2015-12-02 2023-02-01 Memorial Sloan Kettering Cancer Center Antibodies and methods for using them
MA46770A (fr) 2016-11-09 2019-09-18 Agenus Inc Anticorps anti-ox40, anticorps anti-gitr, et leurs procédés d'utilisation
US20190375847A1 (en) * 2017-02-15 2019-12-12 Glaxosmithkline Intellectual Property Development Limited Combination treatment for cancer
CN112007149A (zh) * 2019-05-29 2020-12-01 思格(苏州)生物科技有限公司 一种新型复合免疫佐剂及其应用
WO2021062332A1 (en) * 2019-09-27 2021-04-01 Icahn School Of Medicine At Mount Sinai Combination of inhibitors of il4 signaling and immune checkpoints for treating cancer
WO2021098851A1 (en) * 2019-11-20 2021-05-27 Eucure (Beijing) Biopharma Co., Ltd Anti-ctla4/ox40 bispecific antibodies and uses thereof
WO2021098750A1 (en) * 2019-11-21 2021-05-27 Beigene (Beijing) Co., Ltd. Methods of cancer treatment with anti-ox40 antibody in comibinaiton with tlr agonists
CN113045655A (zh) * 2019-12-27 2021-06-29 高诚生物医药(香港)有限公司 抗ox40抗体及其用途
CN116249715A (zh) 2020-06-11 2023-06-09 南特生物科学公司 抗ctla4单克隆抗体和嵌合抗原受体
JP2024546904A (ja) * 2021-12-15 2024-12-26 ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム 腫瘍マイクロバイオームを変化させるための方法および組成物

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012533619A (ja) * 2009-07-20 2012-12-27 ブリストル−マイヤーズ スクイブ カンパニー 増殖性疾患の相乗的処置のための抗ｃｔｌａ４抗体と多様な治療レジメンとの組み合わせ

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2007228943B2 (en) * 2006-03-22 2012-03-22 Apogenix Gmbh Antibody specific for human IL-4 for the treament of cancer
CA2647282A1 (en) * 2006-04-05 2007-10-11 Pfizer Products Inc. Ctla4 antibody combination therapy
US20100136030A1 (en) * 2007-02-27 2010-06-03 Lamhamedi-Cherradi Salah-Eddine Antagonist ox40 antibodies and their use in the treatment of inflammatory and autoimmune diseases
WO2010014784A2 (en) * 2008-08-01 2010-02-04 Bristol-Myers Squibb Company Combination of anti-ctla4 antibody with diverse therapeutic regimens for the synergistic treatment of proliferative diseases
EP2571577A1 (en) * 2010-05-17 2013-03-27 Bristol-Myers Squibb Company Improved immunotherapeutic dosing regimens and combinations thereof
GB201116092D0 (en) * 2011-09-16 2011-11-02 Bioceros B V Antibodies and uses thereof
KR20140126357A (ko) * 2012-02-01 2014-10-30 컴퓨젠 엘티디. C1orf32 항체 및 이의 암 치료를 위한 용도
WO2017134292A1 (en) * 2016-02-04 2017-08-10 Glenmark Pharmaceuticals S.A. Anti-ox40 antagonistic antibodies for the treatment of atopic dermatitis

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012533619A (ja) * 2009-07-20 2012-12-27 ブリストル−マイヤーズ スクイブ カンパニー 増殖性疾患の相乗的処置のための抗ｃｔｌａ４抗体と多様な治療レジメンとの組み合わせ

Non-Patent Citations (11)

* Cited by examiner, † Cited by third party
Title
DEWAN MZ ET AL.: "Fractionated but not single-dose radiotherapy induces an immune-mediated abscopal effect when combin", CLINICAL CANCER RESEARCH, vol. 15, no. 17, JPN6020013296, 1 September 2009 (2009-09-01), pages 5379 - 5388, ISSN: 0004249595 *
FRIEDMAN DJ ET AL.: "Preparative immunotherapy with anti-OX40 and anti-CTLA4 improves the response to chemotherapy", JOURNAL FOR IMMUNOTHERAPY OF CANCER, vol. Vol.2, Suppl.3, JPN6020013291, 2014, pages 207, ISSN: 0004399463 *
GOUGH MJ ET AL.: "Adjuvant therapy with agonistic antibodies to CD134 (OX40) increases local control after surgical or", JOURNAL OF IMMUNOTHERAPY, vol. 33, no. 8, JPN6020013302, October 2010 (2010-10-01), pages 798 - 809, ISSN: 0004249598 *
HIRSCHHORN-CYMERMAN D ET AL.: "OX40 engagement and chemotherapy combination provides potent antitumor immunity with concomitant reg", THE JOURNAL OF EXPERIMENTAL MEDICINE, vol. 206, no. 5, JPN6020013299, 11 May 2009 (2009-05-11), pages 1103 - 1116, ISSN: 0004399466 *
JURE-KUNKEL M ET AL.: "Synergy between chemotherapeutic agents and CTLA-4 blockade in preclinical tumor models", CANCER IMMUNOLOGY, IMMUNOTHERAPY, vol. 62, no. 9, JPN6020013293, 2013, pages 1533 - 1545, ISSN: 0004399464 *
PICONESE S ET AL.: "OX40 triggering blocks suppression by regulatory T cells and facilitates tumor rejection", THE JOURNAL OF EXPERIMENTAL MEDICINE, vol. 205, no. 4, JPN6020013306, 14 April 2008 (2008-04-14), pages 825 - 839, ISSN: 0004249600 *
REDMOND WL ET AL.: "Combined targeting of costimulatory (OX40) and coinhibitory (CTLA-4) pathways elicits potent effecto", CANCER IMMUNOLOGY RESEARCH, vol. 2, no. 2, JPN6020013297, February 2014 (2014-02-01), pages 142 - 153, ISSN: 0004399465 *
SADUN RE ET AL.: "Fc-mOX40L fusion protein produces complete remission and enhanced survival in 2 murine tumor models", JOURNAL OF IMMUNOTHERAPY, vol. 31, no. 3, JPN6020013308, April 2008 (2008-04-01), pages 235 - 245, ISSN: 0004249601 *
YOKOUCHI H ET AL.: "Anti-OX40 monoclonal antibody therapy in combination with radiotherapy results in therapeutic antitu", CANCER SCIENCE, vol. 99, no. 2, JPN6020013304, February 2008 (2008-02-01), pages 361 - 367, ISSN: 0004249599 *
がんの冊子 各種がんシリーズ 大腸がん［ONLINE］, vol. 第２版, JPN6020013311, March 2012 (2012-03-01), ISSN: 0004249602 *
松島 綱治 ほか: "腫瘍会合性マクロファージ", 実験医学, vol. 第３１巻，第１２号, JPN6020013312, 2013, pages 1872 - 1876, ISSN: 0004249603 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12473598B2 (en) 2018-03-28 2025-11-18 Board Of Regents, The University Of Texas System Identification of epigenetic alterations in DNA isolated from exosomes
JP2022511096A (ja) * 2018-12-08 2022-01-28 ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム がんおよび他の疾患の診断および処置のための腫瘍促進がん関連線維芽細胞の同定および標的化
JP2023525140A (ja) * 2020-05-13 2023-06-14 アンセルム（アンスティチュート・ナシオナル・ドゥ・ラ・サンテ・エ・ドゥ・ラ・ルシェルシュ・メディカル） Ｏｘ４０活性化特性を有する組換えタンパク質

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CA2978318A1 (en) 2016-09-15
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