JP2018511627A5 - - Google Patents
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- Publication number
- JP2018511627A5 JP2018511627A5 JP2017553877A JP2017553877A JP2018511627A5 JP 2018511627 A5 JP2018511627 A5 JP 2018511627A5 JP 2017553877 A JP2017553877 A JP 2017553877A JP 2017553877 A JP2017553877 A JP 2017553877A JP 2018511627 A5 JP2018511627 A5 JP 2018511627A5
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- pyrido
- oxo
- trifluoromethyl
- pyrazol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 claims 33
- 150000003839 salts Chemical class 0.000 claims 31
- 125000000217 alkyl group Chemical group 0.000 claims 29
- 229910052739 hydrogen Inorganic materials 0.000 claims 12
- 239000001257 hydrogen Substances 0.000 claims 12
- 125000001475 halogen functional group Chemical group 0.000 claims 10
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 9
- AUQDITHEDVOTCU-UHFFFAOYSA-N cyclopropyl cyanide Chemical compound N#CC1CC1 AUQDITHEDVOTCU-UHFFFAOYSA-N 0.000 claims 9
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 9
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 8
- 125000004353 pyrazol-1-yl group Chemical group [H]C1=NN(*)C([H])=C1[H] 0.000 claims 8
- 125000004093 cyano group Chemical group *C#N 0.000 claims 7
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 5
- -1 3-chloro-5- (trifluoromethyl) pyrazol-1-yl Chemical group 0.000 claims 4
- 206010010904 Convulsion Diseases 0.000 claims 4
- 125000003545 alkoxy group Chemical group 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 125000003226 pyrazolyl group Chemical group 0.000 claims 4
- 201000000980 schizophrenia Diseases 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 3
- 150000002431 hydrogen Chemical class 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 208000024827 Alzheimer disease Diseases 0.000 claims 2
- 208000020406 Creutzfeldt Jacob disease Diseases 0.000 claims 2
- 208000003407 Creutzfeldt-Jakob Syndrome Diseases 0.000 claims 2
- 208000010859 Creutzfeldt-Jakob disease Diseases 0.000 claims 2
- 208000023105 Huntington disease Diseases 0.000 claims 2
- 206010065390 Inflammatory pain Diseases 0.000 claims 2
- 208000019022 Mood disease Diseases 0.000 claims 2
- 208000002193 Pain Diseases 0.000 claims 2
- 208000018737 Parkinson disease Diseases 0.000 claims 2
- 208000006011 Stroke Diseases 0.000 claims 2
- 208000030886 Traumatic Brain injury Diseases 0.000 claims 2
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 206010013663 drug dependence Diseases 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 206010015037 epilepsy Diseases 0.000 claims 2
- 125000002541 furyl group Chemical group 0.000 claims 2
- 125000002883 imidazolyl group Chemical group 0.000 claims 2
- 208000028867 ischemia Diseases 0.000 claims 2
- 230000001404 mediated effect Effects 0.000 claims 2
- 206010027175 memory impairment Diseases 0.000 claims 2
- 208000004296 neuralgia Diseases 0.000 claims 2
- 230000004770 neurodegeneration Effects 0.000 claims 2
- 208000021722 neuropathic pain Diseases 0.000 claims 2
- 208000033808 peripheral neuropathy Diseases 0.000 claims 2
- 208000028173 post-traumatic stress disease Diseases 0.000 claims 2
- 125000000168 pyrrolyl group Chemical group 0.000 claims 2
- 208000011117 substance-related disease Diseases 0.000 claims 2
- 125000001544 thienyl group Chemical group 0.000 claims 2
- 230000009529 traumatic brain injury Effects 0.000 claims 2
- CMWBJBAILPBLIB-WCBMZHEXSA-N (1R,2R)-2-[2-[[5-chloro-3-(trifluoromethyl)pyrazol-1-yl]methyl]-7-fluoro-4-oxopyrido[1,2-a]pyrimidin-6-yl]cyclopropane-1-carbonitrile Chemical compound ClC1=CC(=NN1CC=1N=C2N(C(C=1)=O)C(=C(C=C2)F)[C@H]1[C@@H](C1)C#N)C(F)(F)F CMWBJBAILPBLIB-WCBMZHEXSA-N 0.000 claims 1
- CANODGNUGMXXDV-GXSJLCMTSA-N (1R,2R)-2-[2-[[5-chloro-3-(trifluoromethyl)pyrazol-1-yl]methyl]-7-methoxy-4-oxopyrido[1,2-a]pyrimidin-6-yl]cyclopropane-1-carbonitrile Chemical compound ClC1=CC(=NN1CC=1N=C2N(C(C=1)=O)C(=C(C=C2)OC)[C@H]1[C@@H](C1)C#N)C(F)(F)F CANODGNUGMXXDV-GXSJLCMTSA-N 0.000 claims 1
- PXLJMGCNGCDJTO-CMPLNLGQSA-N (1R,2R)-2-[2-[[5-chloro-3-(trifluoromethyl)pyrazol-1-yl]methyl]-7-methyl-4-oxopyrido[1,2-a]pyrimidin-6-yl]cyclopropane-1-carbonitrile Chemical compound ClC1=CC(=NN1CC=1N=C2N(C(C=1)=O)C(=C(C=C2)C)[C@H]1[C@@H](C1)C#N)C(F)(F)F PXLJMGCNGCDJTO-CMPLNLGQSA-N 0.000 claims 1
- XSISCWOKUQLCCR-CMPLNLGQSA-N (1R,2R)-2-[2-[[5-chloro-3-(trifluoromethyl)pyrazol-1-yl]methyl]-8-methyl-4-oxopyrido[1,2-a]pyrimidin-6-yl]cyclopropane-1-carbonitrile Chemical compound ClC1=CC(=NN1CC=1N=C2N(C(C=1)=O)C(=CC(=C2)C)[C@H]1[C@@H](C1)C#N)C(F)(F)F XSISCWOKUQLCCR-CMPLNLGQSA-N 0.000 claims 1
- 125000004206 2,2,2-trifluoroethyl group Chemical group [H]C([H])(*)C(F)(F)F 0.000 claims 1
- GIQLLIHHXCSFFX-UHFFFAOYSA-N 2-[(3-chloro-2-fluorophenyl)methyl]-3-fluoro-N,7-dimethyl-4-oxopyrido[1,2-a]pyrimidine-6-carboxamide Chemical compound ClC=1C(=C(C=CC=1)CC=1N=C2N(C(C=1F)=O)C(=C(C=C2)C)C(=O)NC)F GIQLLIHHXCSFFX-UHFFFAOYSA-N 0.000 claims 1
- YVDINJMRPDBYBO-UHFFFAOYSA-N 2-[(3-chloro-2-fluorophenyl)methyl]-N,7-dimethyl-4-oxopyrido[1,2-a]pyrimidine-6-carboxamide Chemical compound ClC=1C(=C(C=CC=1)CC=1N=C2N(C(C=1)=O)C(=C(C=C2)C)C(=O)NC)F YVDINJMRPDBYBO-UHFFFAOYSA-N 0.000 claims 1
- YWGSSNMKHUMLIP-UHFFFAOYSA-N 2-[(3-cyano-2-fluorophenyl)methyl]-3-fluoro-N,7-dimethyl-4-oxopyrido[1,2-a]pyrimidine-6-carboxamide Chemical compound C(#N)C=1C(=C(C=CC=1)CC=1N=C2N(C(C=1F)=O)C(=C(C=C2)C)C(=O)NC)F YWGSSNMKHUMLIP-UHFFFAOYSA-N 0.000 claims 1
- STKYLRPMWSTXMJ-UHFFFAOYSA-N 2-[(3-cyano-2-fluorophenyl)methyl]-N,7-dimethyl-4-oxopyrido[1,2-a]pyrimidine-6-carboxamide Chemical compound C(#N)C=1C(=C(C=CC=1)CC=1N=C2N(C(C=1)=O)C(=C(C=C2)C)C(=O)NC)F STKYLRPMWSTXMJ-UHFFFAOYSA-N 0.000 claims 1
- NRDLZVPGNJRUOL-UHFFFAOYSA-N 2-[(3-cyano-2-fluorophenyl)methyl]-N-ethyl-4-oxopyrido[1,2-a]pyrimidine-6-carboxamide Chemical compound C(#N)C=1C(=C(C=CC=1)CC=1N=C2N(C(C=1)=O)C(=CC=C2)C(=O)NCC)F NRDLZVPGNJRUOL-UHFFFAOYSA-N 0.000 claims 1
- YHUHKPPRXXNFCO-UHFFFAOYSA-N 2-[(3-cyano-2-fluorophenyl)methyl]-N-ethyl-7-methyl-4-oxopyrido[1,2-a]pyrimidine-6-carboxamide Chemical compound C(#N)C=1C(=C(C=CC=1)CC=1N=C2N(C(C=1)=O)C(=C(C=C2)C)C(=O)NCC)F YHUHKPPRXXNFCO-UHFFFAOYSA-N 0.000 claims 1
- AASFYRNWSHXWIV-UHFFFAOYSA-N 2-[(3-cyclopropyl-2-fluorophenyl)methyl]-N,7-dimethyl-4-oxopyrido[1,2-a]pyrimidine-6-carboxamide Chemical compound C1(CC1)C=1C(=C(C=CC=1)CC=1N=C2N(C(C=1)=O)C(=C(C=C2)C)C(=O)NC)F AASFYRNWSHXWIV-UHFFFAOYSA-N 0.000 claims 1
- CIGNVKNVEPJEIV-UHFFFAOYSA-N 2-[(5-chloro-3-methylpyrazol-1-yl)methyl]-7-methoxy-6-(2-methylcyclopropyl)pyrido[1,2-a]pyrimidin-4-one Chemical compound COC1=C(C2CC2C)N2C(=O)C=C(CN3N=C(C)C=C3Cl)N=C2C=C1 CIGNVKNVEPJEIV-UHFFFAOYSA-N 0.000 claims 1
- ZLJBQEHZSARYSF-UHFFFAOYSA-N 2-[(N-ethyl-4-fluoroanilino)methyl]-4-oxopyrido[1,2-a]pyrimidine-6-carbonitrile Chemical compound C(C)N(C1=CC=C(C=C1)F)CC=1N=C2N(C(C=1)=O)C(=CC=C2)C#N ZLJBQEHZSARYSF-UHFFFAOYSA-N 0.000 claims 1
- ISEBYYVBBPZCKS-UHFFFAOYSA-N 2-[(N-ethyl-4-fluoroanilino)methyl]-6-(furan-2-yl)pyrido[1,2-a]pyrimidin-4-one Chemical compound C(C)N(C1=CC=C(C=C1)F)CC=1N=C2N(C(C=1)=O)C(=CC=C2)C=1OC=CC=1 ISEBYYVBBPZCKS-UHFFFAOYSA-N 0.000 claims 1
- UNZMBGODSMYNAC-UHFFFAOYSA-N 2-[(N-ethyl-4-fluoroanilino)methyl]-6-methoxy-7-methylpyrido[1,2-a]pyrimidin-4-one Chemical compound C(C)N(C1=CC=C(C=C1)F)CC=1N=C2N(C(C=1)=O)C(=C(C=C2)C)OC UNZMBGODSMYNAC-UHFFFAOYSA-N 0.000 claims 1
- BKAKLMTUIIEBQN-UHFFFAOYSA-N 2-[(N-ethyl-4-fluoroanilino)methyl]-6-methoxypyrido[1,2-a]pyrimidin-4-one Chemical compound C(C)N(C1=CC=C(C=C1)F)CC=1N=C2N(C(C=1)=O)C(=CC=C2)OC BKAKLMTUIIEBQN-UHFFFAOYSA-N 0.000 claims 1
- YLRNIDSUDPFNPF-UHFFFAOYSA-N 2-[(N-ethyl-4-fluoroanilino)methyl]-6-methylpyrido[1,2-a]pyrimidin-4-one Chemical compound C(C)N(C1=CC=C(C=C1)F)CC=1N=C2N(C(C=1)=O)C(=CC=C2)C YLRNIDSUDPFNPF-UHFFFAOYSA-N 0.000 claims 1
- PHQKAKFTYMJGCJ-UHFFFAOYSA-N 2-[(N-ethyl-4-fluoroanilino)methyl]-6-pyrimidin-5-ylpyrido[1,2-a]pyrimidin-4-one Chemical compound C(C)N(C1=CC=C(C=C1)F)CC=1N=C2N(C(C=1)=O)C(=CC=C2)C=1C=NC=NC=1 PHQKAKFTYMJGCJ-UHFFFAOYSA-N 0.000 claims 1
- RNWMPZDONLVVMQ-UHFFFAOYSA-N 2-[(N-ethyl-4-fluoroanilino)methyl]-7-methylpyrido[1,2-a]pyrimidin-4-one Chemical compound C(C)N(C1=CC=C(C=C1)F)CC=1N=C2N(C(C=1)=O)C=C(C=C2)C RNWMPZDONLVVMQ-UHFFFAOYSA-N 0.000 claims 1
- VMUKPRRMMBFZCX-UHFFFAOYSA-N 2-[(N-ethyl-4-fluoroanilino)methyl]-N,7-dimethyl-4-oxopyrido[1,2-a]pyrimidine-6-carboxamide Chemical compound C(C)N(C1=CC=C(C=C1)F)CC=1N=C2N(C(C=1)=O)C(=C(C=C2)C)C(=O)NC VMUKPRRMMBFZCX-UHFFFAOYSA-N 0.000 claims 1
- OLPHYKMWWHKMQS-UHFFFAOYSA-N 2-[(n-ethylanilino)methyl]-7-methylpyrido[1,2-a]pyrimidin-4-one Chemical compound C=1C(=O)N2C=C(C)C=CC2=NC=1CN(CC)C1=CC=CC=C1 OLPHYKMWWHKMQS-UHFFFAOYSA-N 0.000 claims 1
- VZDHZXIHFSANFG-UHFFFAOYSA-N 2-[2-[[3-chloro-5-(trifluoromethyl)pyrazol-1-yl]methyl]-7-fluoro-4-oxopyrido[1,2-a]pyrimidin-6-yl]cyclopropane-1-carbonitrile Chemical compound ClC1=NN(C(=C1)C(F)(F)F)CC=1N=C2N(C(C=1)=O)C(=C(C=C2)F)C1C(C1)C#N VZDHZXIHFSANFG-UHFFFAOYSA-N 0.000 claims 1
- ULUNRUNZUDWLFA-UHFFFAOYSA-N 2-[2-[[3-chloro-5-(trifluoromethyl)pyrazol-1-yl]methyl]-7-methyl-4-oxopyrido[1,2-a]pyrimidin-6-yl]cyclopropane-1-carbonitrile Chemical compound ClC1=NN(C(=C1)C(F)(F)F)CC=1N=C2N(C(C=1)=O)C(=C(C=C2)C)C1C(C1)C#N ULUNRUNZUDWLFA-UHFFFAOYSA-N 0.000 claims 1
- HVBJXKGBBYZTEF-UHFFFAOYSA-N 2-[2-[[3-chloro-5-(trifluoromethyl)pyrazol-1-yl]methyl]-8-methyl-4-oxopyrido[1,2-a]pyrimidin-6-yl]cyclopropane-1-carbonitrile Chemical compound ClC1=NN(C(=C1)C(F)(F)F)CC=1N=C2N(C(C=1)=O)C(=CC(=C2)C)C1C(C1)C#N HVBJXKGBBYZTEF-UHFFFAOYSA-N 0.000 claims 1
- CUVYQEMREGRGID-UHFFFAOYSA-N 2-[[2-fluoro-3-(trifluoromethyl)phenyl]methyl]-N,7-dimethyl-4-oxopyrido[1,2-a]pyrimidine-6-carboxamide Chemical compound FC1=C(C=CC=C1C(F)(F)F)CC=1N=C2N(C(C=1)=O)C(=C(C=C2)C)C(=O)NC CUVYQEMREGRGID-UHFFFAOYSA-N 0.000 claims 1
- OYOFREMAXAPKEG-UHFFFAOYSA-N 2-[[3-cyclopropyl-5-(trifluoromethyl)pyrazol-1-yl]methyl]-N,7-dimethyl-4-oxopyrido[1,2-a]pyrimidine-6-carboxamide Chemical compound C1(CC1)C1=NN(C(=C1)C(F)(F)F)CC=1N=C2N(C(C=1)=O)C(=C(C=C2)C)C(=O)NC OYOFREMAXAPKEG-UHFFFAOYSA-N 0.000 claims 1
- HHUOPRJFKHUDCY-UHFFFAOYSA-N 2-[[3-cyclopropyl-5-(trifluoromethyl)pyrazol-1-yl]methyl]-N-ethyl-7-methyl-4-oxopyrido[1,2-a]pyrimidine-6-carboxamide Chemical compound C1(CC1)C1=NN(C(=C1)C(F)(F)F)CC=1N=C2N(C(C=1)=O)C(=C(C=C2)C)C(=O)NCC HHUOPRJFKHUDCY-UHFFFAOYSA-N 0.000 claims 1
- QXIFDJHYBCLIKQ-UHFFFAOYSA-N 2-[[5-chloro-3-(trifluoromethyl)pyrazol-1-yl]methyl]pyrido[1,2-a]pyrimidin-4-one Chemical compound ClC1=CC(=NN1CC=1N=C2N(C(C=1)=O)C=CC=C2)C(F)(F)F QXIFDJHYBCLIKQ-UHFFFAOYSA-N 0.000 claims 1
- GWRFUZNYFIIXBN-UHFFFAOYSA-N 2-[[5-cyclopropyl-3-(trifluoromethyl)pyrazol-1-yl]methyl]-N,7-dimethyl-4-oxopyrido[1,2-a]pyrimidine-6-carboxamide Chemical compound C1(CC1)C1=CC(=NN1CC=1N=C2N(C(C=1)=O)C(=C(C=C2)C)C(=O)NC)C(F)(F)F GWRFUZNYFIIXBN-UHFFFAOYSA-N 0.000 claims 1
- DOOUMSLVIZLSHU-UHFFFAOYSA-N 2-[[5-cyclopropyl-3-(trifluoromethyl)pyrazol-1-yl]methyl]-N-ethyl-4-oxopyrido[1,2-a]pyrimidine-6-carboxamide Chemical compound C1(CC1)C1=CC(=NN1CC=1N=C2N(C(C=1)=O)C(=CC=C2)C(=O)NCC)C(F)(F)F DOOUMSLVIZLSHU-UHFFFAOYSA-N 0.000 claims 1
- KJEBDDULKDJINE-UHFFFAOYSA-N 2-[[5-cyclopropyl-3-(trifluoromethyl)pyrazol-1-yl]methyl]-N-ethyl-7-methyl-4-oxopyrido[1,2-a]pyrimidine-6-carboxamide Chemical compound C1(CC1)C1=CC(=NN1CC=1N=C2N(C(C=1)=O)C(=C(C=C2)C)C(=O)NCC)C(F)(F)F KJEBDDULKDJINE-UHFFFAOYSA-N 0.000 claims 1
- LLPFYDIOVSDPQX-UHFFFAOYSA-N 2-[[5-cyclopropyl-3-(trifluoromethyl)pyrazol-1-yl]methyl]-N-ethyl-8-methyl-4-oxopyrido[1,2-a]pyrimidine-6-carboxamide Chemical compound C1(CC1)C1=CC(=NN1CC=1N=C2N(C(C=1)=O)C(=CC(=C2)C)C(=O)NCC)C(F)(F)F LLPFYDIOVSDPQX-UHFFFAOYSA-N 0.000 claims 1
- SVYFCSMXVAIKBD-UHFFFAOYSA-N 6-acetyl-2-[[3-chloro-5-(trifluoromethyl)pyrazol-1-yl]methyl]-7-methylpyrido[1,2-a]pyrimidin-4-one Chemical compound C(C)(=O)C1=C(C=CC=2N1C(C=C(N=2)CN1N=C(C=C1C(F)(F)F)Cl)=O)C SVYFCSMXVAIKBD-UHFFFAOYSA-N 0.000 claims 1
- CVNZOKKGYMPHLM-UHFFFAOYSA-N 6-acetyl-2-[[5-chloro-3-(trifluoromethyl)pyrazol-1-yl]methyl]-7-methylpyrido[1,2-a]pyrimidin-4-one Chemical compound C(C)(=O)C1=C(C=CC=2N1C(C=C(N=2)CN1N=C(C=C1Cl)C(F)(F)F)=O)C CVNZOKKGYMPHLM-UHFFFAOYSA-N 0.000 claims 1
- DLJUZBHJTMNLHY-UHFFFAOYSA-N 6-acetyl-2-[[5-chloro-3-(trifluoromethyl)pyrazol-1-yl]methyl]pyrido[1,2-a]pyrimidin-4-one Chemical compound C(C)(=O)C1=CC=CC=2N1C(C=C(N=2)CN1N=C(C=C1Cl)C(F)(F)F)=O DLJUZBHJTMNLHY-UHFFFAOYSA-N 0.000 claims 1
- RMLZDOOSPFUMBW-UHFFFAOYSA-N 6-bromo-2-[(N-ethyl-4-fluoroanilino)methyl]pyrido[1,2-a]pyrimidin-4-one Chemical compound BrC1=CC=CC=2N1C(C=C(N=2)CN(C1=CC=C(C=C1)F)CC)=O RMLZDOOSPFUMBW-UHFFFAOYSA-N 0.000 claims 1
- CAZZSJVYBYNVAH-UHFFFAOYSA-N 6-chloro-2-[[5-chloro-3-(trifluoromethyl)pyrazol-1-yl]methyl]-8-(trifluoromethyl)pyrido[1,2-a]pyrimidin-4-one Chemical compound ClC1=CC(=CC=2N1C(C=C(N=2)CN1N=C(C=C1Cl)C(F)(F)F)=O)C(F)(F)F CAZZSJVYBYNVAH-UHFFFAOYSA-N 0.000 claims 1
- BVFJRDSRDWIVBV-UHFFFAOYSA-N 6-ethoxy-2-[(N-ethyl-4-fluoroanilino)methyl]-7-methylpyrido[1,2-a]pyrimidin-4-one Chemical compound C(C)OC1=C(C=CC=2N1C(C=C(N=2)CN(C1=CC=C(C=C1)F)CC)=O)C BVFJRDSRDWIVBV-UHFFFAOYSA-N 0.000 claims 1
- MWYSJIYXSXMVPH-UHFFFAOYSA-N 6-ethoxy-2-[(N-ethyl-4-fluoroanilino)methyl]pyrido[1,2-a]pyrimidin-4-one Chemical compound C(C)OC1=CC=CC=2N1C(C=C(N=2)CN(C1=CC=C(C=C1)F)CC)=O MWYSJIYXSXMVPH-UHFFFAOYSA-N 0.000 claims 1
- JIQNNJMGUPDLAN-UHFFFAOYSA-N 6-ethyl-2-[(N-ethyl-4-fluoroanilino)methyl]pyrido[1,2-a]pyrimidin-4-one Chemical compound C(C)C1=CC=CC=2N1C(C=C(N=2)CN(C1=CC=C(C=C1)F)CC)=O JIQNNJMGUPDLAN-UHFFFAOYSA-N 0.000 claims 1
- XIULPRIKVVTTOE-UHFFFAOYSA-N 6-ethyl-2-[(N-ethylanilino)methyl]pyrido[1,2-a]pyrimidin-4-one Chemical compound C(C)C1=CC=CC=2N1C(C=C(N=2)CN(C1=CC=CC=C1)CC)=O XIULPRIKVVTTOE-UHFFFAOYSA-N 0.000 claims 1
- ZBURIMVPAULINH-UHFFFAOYSA-N 7-methyl-2-[(n-methylanilino)methyl]pyrido[1,2-a]pyrimidin-4-one Chemical compound C=1C(=O)N2C=C(C)C=CC2=NC=1CN(C)C1=CC=CC=C1 ZBURIMVPAULINH-UHFFFAOYSA-N 0.000 claims 1
- MDIPIFAXDQKSGJ-CMPLNLGQSA-N CC(F)(F)C1=NN(CC2=CC(=O)N3C(C=CC=C3[C@@H]3C[C@H]3C#N)=N2)C(Cl)=C1 Chemical compound CC(F)(F)C1=NN(CC2=CC(=O)N3C(C=CC=C3[C@@H]3C[C@H]3C#N)=N2)C(Cl)=C1 MDIPIFAXDQKSGJ-CMPLNLGQSA-N 0.000 claims 1
- ZIQAAZNDFSSJJV-PWSUYJOCSA-N ClC1=CC(=NN1CC=1N=C2N(C(C=1)=O)C(=C(C=C2)C)[C@@H]1[C@H](C1)CO)C(F)(F)F Chemical compound ClC1=CC(=NN1CC=1N=C2N(C(C=1)=O)C(=C(C=C2)C)[C@@H]1[C@H](C1)CO)C(F)(F)F ZIQAAZNDFSSJJV-PWSUYJOCSA-N 0.000 claims 1
- ZIQAAZNDFSSJJV-CMPLNLGQSA-N ClC1=CC(=NN1CC=1N=C2N(C(C=1)=O)C(=C(C=C2)C)[C@H]1[C@@H](C1)CO)C(F)(F)F Chemical compound ClC1=CC(=NN1CC=1N=C2N(C(C=1)=O)C(=C(C=C2)C)[C@H]1[C@@H](C1)CO)C(F)(F)F ZIQAAZNDFSSJJV-CMPLNLGQSA-N 0.000 claims 1
- CMWBJBAILPBLIB-SCZZXKLOSA-N ClC1=CC(=NN1CC=1N=C2N(C(C=1)=O)C(=C(C=C2)F)[C@@H]1[C@H](C1)C#N)C(F)(F)F Chemical compound ClC1=CC(=NN1CC=1N=C2N(C(C=1)=O)C(=C(C=C2)F)[C@@H]1[C@H](C1)C#N)C(F)(F)F CMWBJBAILPBLIB-SCZZXKLOSA-N 0.000 claims 1
- CANODGNUGMXXDV-KOLCDFICSA-N ClC1=CC(=NN1CC=1N=C2N(C(C=1)=O)C(=C(C=C2)OC)[C@@H]1[C@H](C1)C#N)C(F)(F)F Chemical compound ClC1=CC(=NN1CC=1N=C2N(C(C=1)=O)C(=C(C=C2)OC)[C@@H]1[C@H](C1)C#N)C(F)(F)F CANODGNUGMXXDV-KOLCDFICSA-N 0.000 claims 1
- XSISCWOKUQLCCR-PWSUYJOCSA-N ClC1=CC(=NN1CC=1N=C2N(C(C=1)=O)C(=CC(=C2)C)[C@@H]1[C@H](C1)C#N)C(F)(F)F Chemical compound ClC1=CC(=NN1CC=1N=C2N(C(C=1)=O)C(=CC(=C2)C)[C@@H]1[C@H](C1)C#N)C(F)(F)F XSISCWOKUQLCCR-PWSUYJOCSA-N 0.000 claims 1
- DOWVTWKIXIRDDR-KOLCDFICSA-N ClC1=CC(=NN1CC=1N=C2N(C(C=1)=O)C(=CC=C2)[C@@H]1[C@H](C1)C#N)C(F)(F)F Chemical compound ClC1=CC(=NN1CC=1N=C2N(C(C=1)=O)C(=CC=C2)[C@@H]1[C@H](C1)C#N)C(F)(F)F DOWVTWKIXIRDDR-KOLCDFICSA-N 0.000 claims 1
- GPMGDUIAVSFGGH-SCZZXKLOSA-N ClC=1C=CC=2N(C(C=C(N=2)CN2N=C(C=C2Cl)C(F)(F)F)=O)C=1[C@@H]1[C@H](C1)C#N Chemical compound ClC=1C=CC=2N(C(C=C(N=2)CN2N=C(C=C2Cl)C(F)(F)F)=O)C=1[C@@H]1[C@H](C1)C#N GPMGDUIAVSFGGH-SCZZXKLOSA-N 0.000 claims 1
- SLYSEOQRBVATEA-UHFFFAOYSA-N N-ethyl-2-[(4-fluorophenoxy)methyl]-7-methyl-4-oxopyrido[1,2-a]pyrimidine-6-carboxamide Chemical compound C(C)NC(=O)C1=C(C=CC=2N1C(C=C(N=2)COC1=CC=C(C=C1)F)=O)C SLYSEOQRBVATEA-UHFFFAOYSA-N 0.000 claims 1
- IUHQWCRWYUQNIU-UHFFFAOYSA-N N-ethyl-7-methyl-4-oxo-2-[[3-(trifluoromethyl)pyrazol-1-yl]methyl]pyrido[1,2-a]pyrimidine-6-carboxamide Chemical compound C(C)NC(=O)C1=C(C=CC=2N1C(C=C(N=2)CN1N=C(C=C1)C(F)(F)F)=O)C IUHQWCRWYUQNIU-UHFFFAOYSA-N 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- NYJWYCAHJRGKMI-UHFFFAOYSA-N pyrido[1,2-a]pyrimidin-4-one Chemical compound C1=CC=CN2C(=O)C=CN=C21 NYJWYCAHJRGKMI-UHFFFAOYSA-N 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- 125000004943 pyrimidin-6-yl group Chemical group N1=CN=CC=C1* 0.000 claims 1
- HKSQZEGSMBFHGC-UHFFFAOYSA-N pyrimidine-4-carboxamide Chemical compound NC(=O)C1=CC=NC=N1 HKSQZEGSMBFHGC-UHFFFAOYSA-N 0.000 claims 1
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 1
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| CNPCT/CN2015/076617 | 2015-04-15 | ||
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| PCT/EP2016/057962 WO2016166078A1 (en) | 2015-04-15 | 2016-04-12 | Pyridopyrimidinones and their use as nmda receptor modulators |
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| JP (2) | JP6847851B2 (OSRAM) |
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| RS58047B1 (sr) | 2013-10-11 | 2019-02-28 | Hoffmann La Roche | Tiazolopirimidinoni kao modulatori aktivnosti nmda receptora |
| MX373162B (es) | 2015-04-15 | 2020-04-21 | Hoffmann La Roche | Piridopirimidinonas y utilización de las mismas como moduladores de receptores de n-metil-d-aspartato (nmda). |
| HRP20201522T1 (hr) | 2015-12-09 | 2020-12-11 | Cadent Therapeutics, Inc. | Heteroaromatski nmda receptor modulatori i njihove uporabe |
| EP3558318B1 (en) | 2016-12-22 | 2023-12-20 | Novartis AG | Nmda receptor modulators and uses thereof |
| CU24647B1 (es) | 2018-08-03 | 2023-02-13 | Cadent Therapeutics Inc | Moduladores del receptor nmda heteroaromático |
| CU20220065A7 (es) | 2020-05-04 | 2023-06-13 | Amgen Inc | Compuestos heterocíclicos como agonistas del receptor de activación expresado en las células mieloides 2 |
| TW202208355A (zh) | 2020-05-04 | 2022-03-01 | 美商安進公司 | 作為骨髓細胞觸發受體2促效劑之雜環化合物及使用方法 |
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| US6951875B2 (en) * | 2001-10-29 | 2005-10-04 | Hoffmann-La Roche Inc. | Conjugated aromatic compounds with a pyridine substituent |
| US7148226B2 (en) | 2003-02-21 | 2006-12-12 | Agouron Pharmaceuticals, Inc. | Inhibitors of hepatitis C virus RNA-dependent RNA polymerase, and compositions and treatments using the same |
| ATE458735T1 (de) * | 2003-06-20 | 2010-03-15 | Novartis Vaccines & Diagnostic | Pyridino[1,2-a pyrimidin-4-onverbindungen als mittel gegen krebs |
| NL2000397C2 (nl) | 2006-01-05 | 2007-10-30 | Pfizer Prod Inc | Bicyclische heteroarylverbindingen als PDE10 inhibitoren. |
| JP2010518026A (ja) * | 2007-02-05 | 2010-05-27 | ゼノン・ファーマシューティカルズ・インコーポレイテッド | ナトリウムチャネルが介在する疾患または状態の治療に有用なピリドピリミジノン化合物 |
| JP6130061B2 (ja) * | 2013-06-19 | 2017-05-17 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | インドリン−２−オン又はピロロ−ピリジン／ピリミジン−２−オン誘導体 |
| RS58047B1 (sr) * | 2013-10-11 | 2019-02-28 | Hoffmann La Roche | Tiazolopirimidinoni kao modulatori aktivnosti nmda receptora |
| MX373162B (es) | 2015-04-15 | 2020-04-21 | Hoffmann La Roche | Piridopirimidinonas y utilización de las mismas como moduladores de receptores de n-metil-d-aspartato (nmda). |
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- 2016-04-12 WO PCT/EP2016/057962 patent/WO2016166078A1/en not_active Ceased
- 2016-04-12 JP JP2017553877A patent/JP6847851B2/ja active Active
- 2016-04-12 RU RU2017139254A patent/RU2717665C2/ru active
- 2016-04-12 CN CN201680021960.3A patent/CN107531696B/zh active Active
- 2016-04-12 CA CA2982217A patent/CA2982217A1/en not_active Abandoned
- 2016-04-12 AU AU2016248886A patent/AU2016248886B2/en not_active Ceased
- 2016-04-12 PE PE2017002006A patent/PE20180316A1/es unknown
- 2016-04-12 BR BR112017021083-5A patent/BR112017021083A2/pt not_active IP Right Cessation
- 2016-04-12 CR CR20170462A patent/CR20170462A/es unknown
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2017
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- 2017-10-13 PH PH12017501876A patent/PH12017501876A1/en unknown
- 2017-10-13 US US15/783,373 patent/US10280165B2/en active Active
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2020
- 2020-12-03 JP JP2020200946A patent/JP2021046428A/ja active Pending
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