JP2018511616A5 - - Google Patents
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- Publication number
- JP2018511616A5 JP2018511616A5 JP2017553122A JP2017553122A JP2018511616A5 JP 2018511616 A5 JP2018511616 A5 JP 2018511616A5 JP 2017553122 A JP2017553122 A JP 2017553122A JP 2017553122 A JP2017553122 A JP 2017553122A JP 2018511616 A5 JP2018511616 A5 JP 2018511616A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- aryl
- compound according
- unsubstituted
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000000217 alkyl group Chemical group 0.000 claims 24
- -1 R 21 Chemical compound 0.000 claims 22
- 150000001875 compounds Chemical class 0.000 claims 14
- 125000003118 aryl group Chemical group 0.000 claims 13
- 229910052757 nitrogen Inorganic materials 0.000 claims 12
- 229910052739 hydrogen Inorganic materials 0.000 claims 11
- 239000001257 hydrogen Substances 0.000 claims 9
- 125000006413 ring segment Chemical group 0.000 claims 9
- 125000002877 alkyl aryl group Chemical group 0.000 claims 8
- 150000002431 hydrogen Chemical class 0.000 claims 8
- 125000003710 aryl alkyl group Chemical group 0.000 claims 6
- 125000004093 cyano group Chemical group *C#N 0.000 claims 6
- 125000000018 nitroso group Chemical group N(=O)* 0.000 claims 6
- YTPLMLYBLZKORZ-UHFFFAOYSA-N Divinylene sulfide Natural products C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 claims 4
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims 4
- 125000004414 alkyl thio group Chemical group 0.000 claims 4
- 125000001072 heteroaryl group Chemical group 0.000 claims 4
- 125000000623 heterocyclic group Chemical group 0.000 claims 4
- 229910052760 oxygen Inorganic materials 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 229940124530 sulfonamide Drugs 0.000 claims 4
- 150000003456 sulfonamides Chemical class 0.000 claims 4
- 229910052717 sulfur Inorganic materials 0.000 claims 4
- 125000004448 alkyl carbonyl group Chemical group 0.000 claims 3
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 3
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 claims 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 3
- 229930192474 thiophene Natural products 0.000 claims 3
- XFXPMWWXUTWYJX-UHFFFAOYSA-N Cyanide Chemical compound N#[C-] XFXPMWWXUTWYJX-UHFFFAOYSA-N 0.000 claims 2
- 229910019142 PO4 Inorganic materials 0.000 claims 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 2
- FZWLAAWBMGSTSO-UHFFFAOYSA-N Thiazole Chemical compound C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 claims 2
- 125000002252 acyl group Chemical group 0.000 claims 2
- 125000004423 acyloxy group Chemical group 0.000 claims 2
- 125000003342 alkenyl group Chemical group 0.000 claims 2
- 125000003302 alkenyloxy group Chemical group 0.000 claims 2
- 125000003545 alkoxy group Chemical group 0.000 claims 2
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 2
- 125000003282 alkyl amino group Chemical group 0.000 claims 2
- 125000005115 alkyl carbamoyl group Chemical group 0.000 claims 2
- 125000005277 alkyl imino group Chemical group 0.000 claims 2
- 125000004644 alkyl sulfinyl group Chemical group 0.000 claims 2
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims 2
- 125000000304 alkynyl group Chemical group 0.000 claims 2
- 125000005133 alkynyloxy group Chemical group 0.000 claims 2
- 125000001769 aryl amino group Chemical group 0.000 claims 2
- 125000005116 aryl carbamoyl group Chemical group 0.000 claims 2
- 125000005129 aryl carbonyl group Chemical group 0.000 claims 2
- 125000004467 aryl imino group Chemical group 0.000 claims 2
- 125000005161 aryl oxy carbonyl group Chemical group 0.000 claims 2
- 125000005163 aryl sulfanyl group Chemical group 0.000 claims 2
- 125000005135 aryl sulfinyl group Chemical group 0.000 claims 2
- 125000004391 aryl sulfonyl group Chemical group 0.000 claims 2
- 125000005110 aryl thio group Chemical group 0.000 claims 2
- 125000004104 aryloxy group Chemical group 0.000 claims 2
- 125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 claims 2
- 239000004202 carbamide Substances 0.000 claims 2
- 235000013877 carbamide Nutrition 0.000 claims 2
- 125000002579 carboxylato group Chemical group [O-]C(*)=O 0.000 claims 2
- 150000002170 ethers Chemical class 0.000 claims 2
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims 2
- 125000001475 halogen functional group Chemical group 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 125000001841 imino group Chemical group [H]N=* 0.000 claims 2
- 125000001261 isocyanato group Chemical group *N=C=O 0.000 claims 2
- 125000002462 isocyano group Chemical group *[N+]#[C-] 0.000 claims 2
- 125000001810 isothiocyanato group Chemical group *N=C=S 0.000 claims 2
- RIFHJAODNHLCBH-UHFFFAOYSA-N methanethione Chemical group S=[CH] RIFHJAODNHLCBH-UHFFFAOYSA-N 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 2
- 125000001181 organosilyl group Chemical group [SiH3]* 0.000 claims 2
- FVZVCSNXTFCBQU-UHFFFAOYSA-N phosphanyl Chemical group [PH2] FVZVCSNXTFCBQU-UHFFFAOYSA-N 0.000 claims 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 2
- 239000010452 phosphate Substances 0.000 claims 2
- 125000000394 phosphonato group Chemical group [O-]P([O-])(*)=O 0.000 claims 2
- 125000001476 phosphono group Chemical group [H]OP(*)(=O)O[H] 0.000 claims 2
- 150000003014 phosphoric acid esters Chemical class 0.000 claims 2
- 125000000020 sulfo group Chemical group O=S(=O)([*])O[H] 0.000 claims 2
- 125000001273 sulfonato group Chemical group [O-]S(*)(=O)=O 0.000 claims 2
- 125000003396 thiol group Chemical group [H]S* 0.000 claims 2
- 150000003577 thiophenes Chemical class 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- ZCQWOFVYLHDMMC-UHFFFAOYSA-N Oxazole Chemical compound C1=COC=N1 ZCQWOFVYLHDMMC-UHFFFAOYSA-N 0.000 claims 1
- 235000018936 Vitellaria paradoxa Nutrition 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims 1
- 125000001651 cyanato group Chemical group [*]OC#N 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 125000004366 heterocycloalkenyl group Chemical group 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims 1
- 150000003557 thiazoles Chemical class 0.000 claims 1
- 0 *C1=C([N+](*)(*)[O-])OC2=*C(C3=NC=C*3)=I=*C(*)=C12 Chemical compound *C1=C([N+](*)(*)[O-])OC2=*C(C3=NC=C*3)=I=*C(*)=C12 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562147305P | 2015-04-14 | 2015-04-14 | |
| US62/147,305 | 2015-04-14 | ||
| PCT/US2016/027549 WO2016168472A1 (en) | 2015-04-14 | 2016-04-14 | Compositions and methods of modulating short-chain dehydrogenase activity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018511616A JP2018511616A (ja) | 2018-04-26 |
| JP2018511616A5 true JP2018511616A5 (https=) | 2019-05-30 |
Family
ID=57127188
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017553122A Pending JP2018511616A (ja) | 2015-04-14 | 2016-04-14 | 短鎖デヒドロゲナーゼ活性を調節する組成物および方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (4) | US20180118756A1 (https=) |
| EP (1) | EP3283074A4 (https=) |
| JP (1) | JP2018511616A (https=) |
| CN (1) | CN108012528A (https=) |
| AU (1) | AU2016248080A1 (https=) |
| CA (1) | CA2982784A1 (https=) |
| HK (1) | HK1250651A1 (https=) |
| WO (1) | WO2016168472A1 (https=) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11690847B2 (en) | 2016-11-30 | 2023-07-04 | Case Western Reserve University | Combinations of 15-PGDH inhibitors with corticosteroids and/or TNF inhibitors and uses thereof |
| US11718589B2 (en) | 2017-02-06 | 2023-08-08 | Case Western Reserve University | Compositions and methods of modulating short-chain dehydrogenase |
| US12336982B2 (en) | 2018-11-21 | 2025-06-24 | Rodeo Therapeutics Corporation | Compositions and methods of modulating short-chain dehydrogenase activity |
| US12616681B2 (en) | 2022-08-22 | 2026-05-05 | Case Western Reserve University | Compositions and methods for treating renal injury |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9801863B2 (en) | 2012-04-16 | 2017-10-31 | Case Western Reserve University | Inhibitors of short-chain dehydrogenase activity for modulating hematopoietic stem cells and hematopoiesis |
| DK2838533T3 (da) | 2012-04-16 | 2017-11-27 | Univ Case Western Reserve | Sammensætninger og fremgangsmåder til at modulere 15-pgdh-aktivitet |
| AU2014342811B2 (en) | 2013-10-15 | 2019-01-03 | Board Of Regents Of The University Of Texas System | Compositions and methods of modulating short-chain dehydrogenase activity |
| CN107921025A (zh) | 2015-03-08 | 2018-04-17 | 卡斯西部储备大学 | 用于治疗纤维症的短链脱氢酶活性的抑制剂 |
| US20190275014A1 (en) * | 2016-07-18 | 2019-09-12 | Case Western Reserve University | Inhibitors of short-chain dehydrogenase activity for promoting neurogenesis and inhibiting cell death |
| WO2018187810A1 (en) * | 2017-04-07 | 2018-10-11 | Case Western Reserve University | Inhibitors of short-chain dehydrogenase activity for treating coronary disorders |
| JP7426941B2 (ja) * | 2018-04-04 | 2024-02-02 | ケース ウエスタン リザーブ ユニバーシティ | 腎傷害を治療するための組成物および方法 |
| TWI834795B (zh) | 2019-01-08 | 2024-03-11 | 日商杏林製藥股份有限公司 | 15-pgdh抑制劑 |
| EP3917911A1 (en) | 2019-01-31 | 2021-12-08 | Kyorin Pharmaceutical Co., Ltd. | 15-pgdh inhibitors |
| EP3982957A4 (en) * | 2019-06-11 | 2023-06-21 | The Board of Trustees of the Leland Stanford Junior University | METHODS OF REJUVENATING AGED TISSUE BY INHIBITION OF 15-HYDROXYPROSTAGLANDINE DEHYDROGENASE (15-PGDH) |
| JP2023515081A (ja) * | 2020-02-21 | 2023-04-12 | ケース ウエスタン リザーブ ユニバーシティ | 腎損傷を治療するための組成物および方法 |
| AU2021275122A1 (en) | 2020-05-20 | 2022-12-15 | Board Of Regents Of The University Of Texas System | Compositions and methods of modulating short-chain dehydrogenase activity |
| CN117377668A (zh) * | 2020-10-15 | 2024-01-09 | 迈欧伏特治疗公司 | Pgdh抑制剂的吸入制剂及其使用方法 |
| US20240000758A1 (en) * | 2020-10-23 | 2024-01-04 | The Board Of Trustees Of The Leland Stanford Junior University | Elevation of mitochondrial biogenesis and function by inhibition of prostaglandin degrading enzyme 15-pgdh |
| CA3200394A1 (en) * | 2020-12-09 | 2022-06-16 | Helen M. Blau | Inhibition of prostaglandin degrading enzyme 15-pgdh to improve joint structure and function |
| CA3243368A1 (en) * | 2022-01-28 | 2025-01-16 | Scinnohub Pharmaceutical Co., Ltd. | COMPOUND FOR REGULATING AND CONTROLLING THE ACTIVITY OF 15-PGDH AND ITS PREPARATION PROCESS |
| US20250250283A1 (en) * | 2022-04-13 | 2025-08-07 | Scinnohub Pharmaceutical Co., Ltd. | Compound capable of regulating and controlling activity of 15-pgdh, and preparation method therefor |
| TW202419452A (zh) * | 2022-11-11 | 2024-05-16 | 大陸商賽諾哈勃藥業（成都）有限公司 | 調控１５－ｐｇｄｈ活性的化合物、其藥物組合物及其用途 |
| CN118027057A (zh) * | 2022-11-14 | 2024-05-14 | 武汉人福创新药物研发中心有限公司 | 抑制15-pgdh的化合物及其用途 |
| CN121443609A (zh) * | 2023-05-19 | 2026-01-30 | 赛诺哈勃药业（成都）有限公司 | 一种调控15-pgdh活性的化合物及其制备方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4904672A (en) * | 1987-01-30 | 1990-02-27 | Merck & Co., Inc. | Derivatives of 3-hydroxyazabenzo[b]thiophene useful as 5-lipoxygenase inhibitors |
| US6281227B1 (en) * | 1996-12-13 | 2001-08-28 | Aventis Pharma Deutschland Gmbh | Sulfonic acid sulfonylamino n-(heteroaralkyl)-azaheterocyclylamide compounds |
| EP1491541B1 (en) * | 2001-03-30 | 2007-01-24 | Pfizer Products Inc. | Pyridazinone aldose reductase inhibitors |
| EP1558252B1 (en) * | 2002-08-02 | 2007-10-10 | Merck & Co., Inc. | Substituted furo [2,3-b]pyridine derivatives |
| WO2006019832A1 (en) * | 2004-07-22 | 2006-02-23 | Ptc Therapeutics, Inc. | Thienopyridines for treating hepatitis c |
| TW200801012A (en) * | 2006-04-26 | 2008-01-01 | Piramed Ltd | Phosphoinositide 3-kinase inhibitor compounds and methods of use |
| US20100093764A1 (en) * | 2008-10-13 | 2010-04-15 | Devraj Chakravarty | AMINES AND SULFOXIDES OF THIENO[2,3-d]PYRIMIDINE AND THEIR USE AS ADENOSINE A2a RECEPTOR ANTAGONISTS |
| KR101172638B1 (ko) * | 2008-12-30 | 2012-08-08 | 조선대학교산학협력단 | 신규한 티아졸리딘디온 유도체 및 그의 용도 |
| DK2838533T3 (da) * | 2012-04-16 | 2017-11-27 | Univ Case Western Reserve | Sammensætninger og fremgangsmåder til at modulere 15-pgdh-aktivitet |
| US9801863B2 (en) * | 2012-04-16 | 2017-10-31 | Case Western Reserve University | Inhibitors of short-chain dehydrogenase activity for modulating hematopoietic stem cells and hematopoiesis |
| AU2014342811B2 (en) * | 2013-10-15 | 2019-01-03 | Board Of Regents Of The University Of Texas System | Compositions and methods of modulating short-chain dehydrogenase activity |
| CN107921025A (zh) * | 2015-03-08 | 2018-04-17 | 卡斯西部储备大学 | 用于治疗纤维症的短链脱氢酶活性的抑制剂 |
| JP2019078488A (ja) * | 2017-10-25 | 2019-05-23 | ダイキン工業株式会社 | 空気調和装置 |
-
2016
- 2016-04-14 AU AU2016248080A patent/AU2016248080A1/en not_active Abandoned
- 2016-04-14 JP JP2017553122A patent/JP2018511616A/ja active Pending
- 2016-04-14 EP EP16780752.8A patent/EP3283074A4/en not_active Withdrawn
- 2016-04-14 US US15/566,637 patent/US20180118756A1/en not_active Abandoned
- 2016-04-14 CN CN201680034932.5A patent/CN108012528A/zh active Pending
- 2016-04-14 CA CA2982784A patent/CA2982784A1/en not_active Abandoned
- 2016-04-14 HK HK18110182.7A patent/HK1250651A1/zh unknown
- 2016-04-14 WO PCT/US2016/027549 patent/WO2016168472A1/en not_active Ceased
-
2020
- 2020-05-08 US US16/869,879 patent/US20210094968A1/en not_active Abandoned
-
2023
- 2023-10-05 US US18/481,787 patent/US20240174688A1/en not_active Abandoned
-
2024
- 2024-10-23 US US18/924,696 patent/US20250243217A1/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11690847B2 (en) | 2016-11-30 | 2023-07-04 | Case Western Reserve University | Combinations of 15-PGDH inhibitors with corticosteroids and/or TNF inhibitors and uses thereof |
| US11718589B2 (en) | 2017-02-06 | 2023-08-08 | Case Western Reserve University | Compositions and methods of modulating short-chain dehydrogenase |
| US12336982B2 (en) | 2018-11-21 | 2025-06-24 | Rodeo Therapeutics Corporation | Compositions and methods of modulating short-chain dehydrogenase activity |
| US12616681B2 (en) | 2022-08-22 | 2026-05-05 | Case Western Reserve University | Compositions and methods for treating renal injury |
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