JP2018510917A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2018510917A5 JP2018510917A5 JP2018504078A JP2018504078A JP2018510917A5 JP 2018510917 A5 JP2018510917 A5 JP 2018510917A5 JP 2018504078 A JP2018504078 A JP 2018504078A JP 2018504078 A JP2018504078 A JP 2018504078A JP 2018510917 A5 JP2018510917 A5 JP 2018510917A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- cancer
- composition according
- isoty
- capcna
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- 206010028980 Neoplasm Diseases 0.000 claims 4
- 201000011510 cancer Diseases 0.000 claims 4
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 108050006400 Cyclin Proteins 0.000 claims 1
- 206010029260 Neuroblastoma Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 102000009339 Proliferating Cell Nuclear Antigen Human genes 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 239000000969 carrier Substances 0.000 claims 1
- 230000004663 cell proliferation Effects 0.000 claims 1
- 230000000973 chemotherapeutic effect Effects 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 229940127089 cytotoxic agent Drugs 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000006260 foam Substances 0.000 claims 1
- 230000003211 malignant effect Effects 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14/684,259 US10420840B2 (en) | 2015-04-10 | 2015-04-10 | Anticancer therapeutic agents |
| US14/684,259 | 2015-04-10 | ||
| PCT/US2016/026619 WO2016164707A1 (en) | 2015-04-10 | 2016-04-08 | Anticancer therapeutic agents |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018510917A JP2018510917A (ja) | 2018-04-19 |
| JP2018510917A5 true JP2018510917A5 (https=) | 2019-05-09 |
| JP6748704B2 JP6748704B2 (ja) | 2020-09-02 |
Family
ID=57072079
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018504078A Active JP6748704B2 (ja) | 2015-04-10 | 2016-04-08 | 抗癌治療剤 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US10420840B2 (https=) |
| EP (2) | EP3280261B1 (https=) |
| JP (1) | JP6748704B2 (https=) |
| CN (1) | CN107404876B (https=) |
| AU (1) | AU2016245886B2 (https=) |
| BR (1) | BR122023024844A2 (https=) |
| CA (1) | CA2978965C (https=) |
| ES (1) | ES2991018T3 (https=) |
| FI (1) | FI3878444T3 (https=) |
| PL (2) | PL3878444T3 (https=) |
| PT (1) | PT3878444T (https=) |
| WO (1) | WO2016164707A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20250171404A1 (en) * | 2022-03-07 | 2025-05-29 | City Of Hope | Pcna inhibitors and uses thereof |
| WO2025054318A1 (en) * | 2023-09-06 | 2025-03-13 | City Of Hope | Pcna inhibitors and uses thereof |
| WO2025184571A1 (en) * | 2024-03-01 | 2025-09-04 | City Of Hope | Pcna inhibitors for the treatment of myc family associated cancers |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5627165A (en) | 1990-06-13 | 1997-05-06 | Drug Innovation & Design, Inc. | Phosphorous prodrugs and therapeutic delivery systems using same |
| US20050037090A1 (en) | 1998-12-23 | 2005-02-17 | Mckearn John P. | Combination therapy including a cyclooxygenase-2 inhibitor and an antineoplastic agent |
| MX2007013584A (es) | 2005-04-27 | 2008-04-22 | Univ Indiana Res & Tech Corp | Anticuerpos de isoforma de cspcna y sus usos. |
| AU2006261856B2 (en) * | 2005-06-27 | 2012-07-05 | Indiana University Research And Technology Corporation | csPCNA isoform modifications and uses thereof |
| CA2638866C (en) * | 2006-02-17 | 2015-11-10 | Indiana University Research And Technology Corporation | Peptide based inhibition of capcna protein-protein interactions in cancer |
| US20090123487A1 (en) | 2007-09-19 | 2009-05-14 | Katia Rothhaar | Precursors and enzymes associated with post translational modification of proteins implicated in isoform generation of PCNA |
| WO2009079451A2 (en) | 2007-12-14 | 2009-06-25 | The Cleveland Clinic Foundation | Compositions and methods of promoting wound healing |
| GB0808282D0 (en) | 2008-05-07 | 2008-06-11 | Medical Res Council | Compounds for use in stabilizing p53 mutants |
| CA3023068C (en) * | 2008-07-24 | 2022-06-21 | Indiana University Research And Technology Corporation | Cancer peptide therapeutics |
| US20120195978A1 (en) * | 2009-10-07 | 2012-08-02 | Indiana University Research And Technology Corpora | Capcna peptide therapeutics for cancer |
| CN103619331A (zh) * | 2011-03-23 | 2014-03-05 | 印第安纳大学研究及科技公司 | 抗癌治疗剂 |
| EP3349754B9 (en) * | 2015-09-17 | 2025-10-22 | City of Hope | Pcna inhibitors |
-
2015
- 2015-04-10 US US14/684,259 patent/US10420840B2/en active Active
-
2016
- 2016-04-08 BR BR122023024844-9A patent/BR122023024844A2/pt not_active Application Discontinuation
- 2016-04-08 FI FIEP20216249.1T patent/FI3878444T3/fi active
- 2016-04-08 CN CN201680018509.6A patent/CN107404876B/zh active Active
- 2016-04-08 WO PCT/US2016/026619 patent/WO2016164707A1/en not_active Ceased
- 2016-04-08 AU AU2016245886A patent/AU2016245886B2/en active Active
- 2016-04-08 EP EP16777344.9A patent/EP3280261B1/en active Active
- 2016-04-08 PT PT202162491T patent/PT3878444T/pt unknown
- 2016-04-08 ES ES20216249T patent/ES2991018T3/es active Active
- 2016-04-08 CA CA2978965A patent/CA2978965C/en active Active
- 2016-04-08 PL PL20216249.1T patent/PL3878444T3/pl unknown
- 2016-04-08 PL PL16777344T patent/PL3280261T3/pl unknown
- 2016-04-08 EP EP20216249.1A patent/EP3878444B1/en active Active
- 2016-04-08 JP JP2018504078A patent/JP6748704B2/ja active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2014221779A5 (https=) | ||
| WO2014152389A8 (en) | Imaging agent for detection of diseased cells | |
| EA202090530A1 (ru) | Производные 1-бензил-2-имино-4-фенил-5-оксоимидазолидина как ингибиторы протеазы вич | |
| MX380928B (es) | Inhibidores de kras g12c. | |
| CN109415406A (zh) | 羊毛甾醇前药化合物及其制备方法和应用 | |
| MX363347B (es) | Sal de omecamtiv mecarbilo y proceso para preparar la sal. | |
| JP2013509429A5 (https=) | ||
| JP2017524735A5 (https=) | ||
| JP2012255026A5 (https=) | ||
| MX2024009886A (es) | Derivados de quinolina como inhibidores de integrina alfa4beta7. | |
| JP2016515561A5 (https=) | ||
| JP2011102304A5 (https=) | ||
| MA37206B1 (fr) | Nouveaux derives de pyrrole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent | |
| BR112012027743A2 (pt) | ciclopropil dicarboxamidas e análogos exibindo atividades anticâncer e antiproliferativas | |
| JP2014508804A5 (https=) | ||
| JP2019520343A5 (https=) | ||
| JP2017517565A5 (https=) | ||
| JP2015516427A5 (https=) | ||
| WO2016098054A9 (en) | Processes for preparing oxathiazin-like compounds | |
| JO3619B1 (ar) | صياغات مثبطة للمناعة | |
| RU2018101431A (ru) | Ингибиторы индоламин-2,3-диоксигеназы | |
| MX394624B (es) | Inhibidores selectivos hdac6, métodos de preparación y aplicación de los mismos. | |
| JO3610B1 (ar) | مشتقات كربوكساميد | |
| RU2017141536A (ru) | Замещенные производные индол-5-ола и их терапевтические применения | |
| CN109689652A (zh) | 稠杂环类衍生物、其制备方法及其在医学上的应用 |