JP2018510637A5 - - Google Patents
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- JP2018510637A5 JP2018510637A5 JP2017549757A JP2017549757A JP2018510637A5 JP 2018510637 A5 JP2018510637 A5 JP 2018510637A5 JP 2017549757 A JP2017549757 A JP 2017549757A JP 2017549757 A JP2017549757 A JP 2017549757A JP 2018510637 A5 JP2018510637 A5 JP 2018510637A5
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- JP
- Japan
- Prior art keywords
- amino acid
- acid sequence
- polypeptide
- protein complex
- interaction pair
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 125000003275 alpha amino acid group Chemical group 0.000 claims description 111
- 230000003993 interaction Effects 0.000 claims description 80
- 102000004169 proteins and genes Human genes 0.000 claims description 75
- 108090000623 proteins and genes Proteins 0.000 claims description 75
- 229920001184 polypeptide Polymers 0.000 claims description 62
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 62
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 62
- 230000004927 fusion Effects 0.000 claims description 13
- 108060003951 Immunoglobulin Proteins 0.000 claims description 12
- 102000018358 immunoglobulin Human genes 0.000 claims description 12
- 102000016970 Follistatin Human genes 0.000 claims description 10
- 108010014612 Follistatin Proteins 0.000 claims description 10
- 108010059616 Activins Proteins 0.000 claims description 9
- 102100026818 Inhibin beta E chain Human genes 0.000 claims description 9
- 239000000488 activin Substances 0.000 claims description 9
- 150000001413 amino acids Chemical class 0.000 claims description 7
- 102100039939 Growth/differentiation factor 8 Human genes 0.000 claims description 6
- 239000000825 pharmaceutical preparation Substances 0.000 claims description 6
- 102100040898 Growth/differentiation factor 11 Human genes 0.000 claims description 4
- 101000893545 Homo sapiens Growth/differentiation factor 11 Proteins 0.000 claims description 4
- 108010023079 activin B Proteins 0.000 claims description 4
- 230000004071 biological effect Effects 0.000 claims description 4
- 239000003446 ligand Substances 0.000 claims description 4
- 108010023082 activin A Proteins 0.000 claims description 3
- 239000000539 dimer Substances 0.000 claims description 3
- 210000002966 serum Anatomy 0.000 claims description 3
- 108091026890 Coding region Proteins 0.000 claims description 2
- 241000699670 Mus sp. Species 0.000 claims description 2
- 238000000423 cell based assay Methods 0.000 claims description 2
- 108020001507 fusion proteins Proteins 0.000 claims description 2
- 102000037865 fusion proteins Human genes 0.000 claims description 2
- 239000000833 heterodimer Substances 0.000 claims description 2
- 108020004707 nucleic acids Proteins 0.000 claims description 2
- 102000039446 nucleic acids Human genes 0.000 claims description 2
- 150000007523 nucleic acids Chemical class 0.000 claims description 2
- 230000011664 signaling Effects 0.000 claims description 2
- 101000803329 Homo sapiens WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2 Proteins 0.000 claims 18
- 108010056852 Myostatin Proteins 0.000 claims 4
- 101710087237 Whey acidic protein Proteins 0.000 claims 3
- 239000012634 fragment Substances 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 239000000710 homodimer Substances 0.000 claims 1
- 101000886562 Homo sapiens Growth/differentiation factor 8 Proteins 0.000 description 2
- 239000000203 mixture Substances 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021037388A JP2021097697A (ja) | 2015-03-26 | 2021-03-09 | フォリスタチン関連融合タンパク質およびその使用 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562138886P | 2015-03-26 | 2015-03-26 | |
| US62/138,886 | 2015-03-26 | ||
| PCT/US2016/024368 WO2016154601A1 (en) | 2015-03-26 | 2016-03-25 | Follistatin-related fusion proteins and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021037388A Division JP2021097697A (ja) | 2015-03-26 | 2021-03-09 | フォリスタチン関連融合タンパク質およびその使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018510637A JP2018510637A (ja) | 2018-04-19 |
| JP2018510637A5 true JP2018510637A5 (cg-RX-API-DMAC10.html) | 2019-05-09 |
Family
ID=56978700
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017549757A Pending JP2018510637A (ja) | 2015-03-26 | 2016-03-25 | フォリスタチン関連融合タンパク質およびその使用 |
| JP2021037388A Pending JP2021097697A (ja) | 2015-03-26 | 2021-03-09 | フォリスタチン関連融合タンパク質およびその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021037388A Pending JP2021097697A (ja) | 2015-03-26 | 2021-03-09 | フォリスタチン関連融合タンパク質およびその使用 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US9975934B2 (cg-RX-API-DMAC10.html) |
| EP (1) | EP3274457A4 (cg-RX-API-DMAC10.html) |
| JP (2) | JP2018510637A (cg-RX-API-DMAC10.html) |
| KR (1) | KR20170129233A (cg-RX-API-DMAC10.html) |
| CN (1) | CN107636154A (cg-RX-API-DMAC10.html) |
| AU (2) | AU2016238254B2 (cg-RX-API-DMAC10.html) |
| CA (1) | CA2980757A1 (cg-RX-API-DMAC10.html) |
| WO (1) | WO2016154601A1 (cg-RX-API-DMAC10.html) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2315602A4 (en) | 2008-06-26 | 2011-11-02 | Acceleron Pharma Inc | METHOD OF DOSING AN ACTRIIB ANTAGONIST AND MONITORING TREATED PATIENTS |
| JP6568110B2 (ja) * | 2014-06-04 | 2019-08-28 | アクセルロン ファーマ， インコーポレイテッド | フォリスタチンポリペプチドによる障害の処置のための方法および組成物 |
| US10010498B2 (en) | 2014-06-04 | 2018-07-03 | Acceleron Pharma Inc. | Methods for treatment of amyotrophic lateral sclerosis with follistatin fusion proteins |
| CA2980757A1 (en) * | 2015-03-26 | 2016-09-29 | Acceleron Pharma Inc. | Follistatin-related fusion proteins and uses thereof |
| MA41919A (fr) | 2015-04-06 | 2018-02-13 | Acceleron Pharma Inc | Hétéromultimères alk4:actriib et leurs utilisations |
| CN113683708A (zh) | 2015-04-06 | 2021-11-23 | 阿塞勒隆制药公司 | 单臂i型和ii型受体融合蛋白和其用途 |
| US20170306027A1 (en) | 2016-04-06 | 2017-10-26 | Acceleron Pharma Inc. | Alk7 antagonists and uses thereof |
| CN110678195A (zh) | 2016-10-05 | 2020-01-10 | 阿塞勒隆制药公司 | ALK4:ActRIIB异多聚体及其用途 |
| EP3522912A4 (en) * | 2016-10-05 | 2020-10-14 | Acceleron Pharma Inc. | HETEROMULTIMERS OF TYPE I AND TYPE II RECEIVERS OF THE TGF-BETA SUPERFAMILY AND THEIR USES |
| WO2018067740A1 (en) * | 2016-10-05 | 2018-04-12 | Acceleron Pharma, Inc. | Compositions and method for treating kidney disease |
| CN110846400A (zh) * | 2019-10-30 | 2020-02-28 | 吉林大学 | 人外周血循环FST mRNA检测试剂盒及其用途 |
| WO2022067028A1 (en) * | 2020-09-25 | 2022-03-31 | Bigelow Laboratory For Ocean Sciences | Engineered perkinsus marinus cells |
| CA3197104A1 (en) * | 2020-11-11 | 2022-05-19 | Hq Han | Bifunctional antagonists of activin/tgf-beta and rankl and uses thereof |
| US20220380422A1 (en) * | 2021-05-28 | 2022-12-01 | Lirsamax, Inc. | Method for treating muscle atrophy and/or obesity and composition for use in said method |
| CA3259309A1 (en) * | 2022-06-15 | 2023-12-21 | UCB Biopharma SRL | Fusion protein for the prevention, treatment or improvement of kidney disease |
| KR20250024825A (ko) * | 2022-06-15 | 2025-02-19 | 유씨비 바이오파마 에스알엘 | 폴리스타틴-fc 융합 단백질 |
| KR102971166B1 (ko) * | 2022-12-09 | 2026-06-01 | (주)케어젠 | 연골 재생용 펩타이드 및 이의 용도 |
| CN116358954B (zh) * | 2023-02-22 | 2024-08-09 | 深圳市昭蓝生物科技有限公司 | 复合质控品及其制备方法和产前筛查试剂盒 |
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| CN1993048A (zh) | 2002-02-21 | 2007-07-04 | 惠氏公司 | 包含促滤泡素抑制素结构域的蛋白质 |
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| BR0307907A2 (pt) * | 2002-02-21 | 2011-07-05 | Wyeth Corp | gasp1: proteìna contendo domìnio de folistatina |
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| US10010498B2 (en) | 2014-06-04 | 2018-07-03 | Acceleron Pharma Inc. | Methods for treatment of amyotrophic lateral sclerosis with follistatin fusion proteins |
| JP6568110B2 (ja) * | 2014-06-04 | 2019-08-28 | アクセルロン ファーマ， インコーポレイテッド | フォリスタチンポリペプチドによる障害の処置のための方法および組成物 |
| CN104293834B (zh) * | 2014-10-11 | 2018-03-23 | 上海兴迪金生物技术有限公司 | GLP‑1或其类似物与抗体Fc片段融合蛋白的制备方法 |
| CA2980757A1 (en) * | 2015-03-26 | 2016-09-29 | Acceleron Pharma Inc. | Follistatin-related fusion proteins and uses thereof |
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2016
- 2016-03-25 CA CA2980757A patent/CA2980757A1/en active Pending
- 2016-03-25 KR KR1020177029984A patent/KR20170129233A/ko not_active Abandoned
- 2016-03-25 AU AU2016238254A patent/AU2016238254B2/en not_active Ceased
- 2016-03-25 JP JP2017549757A patent/JP2018510637A/ja active Pending
- 2016-03-25 US US15/081,629 patent/US9975934B2/en active Active
- 2016-03-25 EP EP16769819.0A patent/EP3274457A4/en active Pending
- 2016-03-25 WO PCT/US2016/024368 patent/WO2016154601A1/en not_active Ceased
- 2016-03-25 CN CN201680030289.9A patent/CN107636154A/zh active Pending
-
2018
- 2018-04-19 US US15/957,026 patent/US11001614B2/en active Active
-
2021
- 2021-03-09 JP JP2021037388A patent/JP2021097697A/ja active Pending
-
2022
- 2022-04-14 AU AU2022202514A patent/AU2022202514A1/en not_active Abandoned