JP2018510190A5 - - Google Patents
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- JP2018510190A5 JP2018510190A5 JP2017551331A JP2017551331A JP2018510190A5 JP 2018510190 A5 JP2018510190 A5 JP 2018510190A5 JP 2017551331 A JP2017551331 A JP 2017551331A JP 2017551331 A JP2017551331 A JP 2017551331A JP 2018510190 A5 JP2018510190 A5 JP 2018510190A5
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- JP
- Japan
- Prior art keywords
- nhq
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- same
- alkyl
- nhc
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000001875 compounds Chemical class 0.000 claims 31
- 239000008194 pharmaceutical composition Substances 0.000 claims 12
- 229910052757 nitrogen Inorganic materials 0.000 claims 9
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 9
- 125000000623 heterocyclic group Chemical group 0.000 claims 8
- 229920006395 saturated elastomer Polymers 0.000 claims 8
- 125000003118 aryl group Chemical group 0.000 claims 6
- 208000035143 Bacterial infection Diseases 0.000 claims 5
- 208000022362 bacterial infectious disease Diseases 0.000 claims 5
- 229910052739 hydrogen Inorganic materials 0.000 claims 5
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 5
- 239000000203 mixture Substances 0.000 claims 5
- -1 β-lactam compounds Chemical class 0.000 claims 5
- 230000002265 prevention Effects 0.000 claims 4
- 241000894006 Bacteria Species 0.000 claims 3
- 230000000845 anti-microbial effect Effects 0.000 claims 3
- 125000001963 4 membered heterocyclic group Chemical group 0.000 claims 2
- 125000002373 5 membered heterocyclic group Chemical group 0.000 claims 2
- 125000004070 6 membered heterocyclic group Chemical group 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 229910052731 fluorine Inorganic materials 0.000 claims 2
- 125000001153 fluoro group Chemical group F* 0.000 claims 2
- 125000005842 heteroatom Chemical group 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 150000003952 β-lactams Chemical class 0.000 claims 2
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 1
- IZXIZTKNFFYFOF-UHFFFAOYSA-N 2-Oxazolidone Chemical class O=C1NCCO1 IZXIZTKNFFYFOF-UHFFFAOYSA-N 0.000 claims 1
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 claims 1
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims 1
- 229930186147 Cephalosporin Natural products 0.000 claims 1
- 108090000204 Dipeptidase 1 Proteins 0.000 claims 1
- 108010015899 Glycopeptides Proteins 0.000 claims 1
- 102000002068 Glycopeptides Human genes 0.000 claims 1
- 108010028921 Lipopeptides Proteins 0.000 claims 1
- 229930182555 Penicillin Natural products 0.000 claims 1
- 108010040201 Polymyxins Proteins 0.000 claims 1
- 108010034396 Streptogramins Proteins 0.000 claims 1
- 239000004098 Tetracycline Substances 0.000 claims 1
- 229940126575 aminoglycoside Drugs 0.000 claims 1
- 230000000844 anti-bacterial effect Effects 0.000 claims 1
- 102000006635 beta-lactamase Human genes 0.000 claims 1
- 229940041011 carbapenems Drugs 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims 1
- ORFOPKXBNMVMKC-DWVKKRMSSA-N ceftazidime Chemical compound S([C@@H]1[C@@H](C(N1C=1C([O-])=O)=O)NC(=O)\C(=N/OC(C)(C)C(O)=O)C=2N=C(N)SC=2)CC=1C[N+]1=CC=CC=C1 ORFOPKXBNMVMKC-DWVKKRMSSA-N 0.000 claims 1
- 229960000484 ceftazidime Drugs 0.000 claims 1
- 229940124587 cephalosporin Drugs 0.000 claims 1
- 150000001780 cephalosporins Chemical class 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 125000003709 fluoroalkyl group Chemical group 0.000 claims 1
- 229940124307 fluoroquinolone Drugs 0.000 claims 1
- 239000003835 ketolide antibiotic agent Substances 0.000 claims 1
- 229940041028 lincosamides Drugs 0.000 claims 1
- 239000003120 macrolide antibiotic agent Substances 0.000 claims 1
- 229940041033 macrolides Drugs 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 229940041009 monobactams Drugs 0.000 claims 1
- 150000002961 penems Chemical class 0.000 claims 1
- 150000002960 penicillins Chemical class 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000006239 protecting group Chemical group 0.000 claims 1
- 150000007660 quinolones Chemical class 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 229940041030 streptogramins Drugs 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 125000004434 sulfur atom Chemical group 0.000 claims 1
- ILMRJRBKQSSXGY-UHFFFAOYSA-N tert-butyl(dimethyl)silicon Chemical compound C[Si](C)C(C)(C)C ILMRJRBKQSSXGY-UHFFFAOYSA-N 0.000 claims 1
- 125000001981 tert-butyldimethylsilyl group Chemical group [H]C([H])([H])[Si]([H])(C([H])([H])[H])[*]C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
- 125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
- 125000001302 tertiary amino group Chemical group 0.000 claims 1
- 235000019364 tetracycline Nutrition 0.000 claims 1
- 150000003522 tetracyclines Chemical class 0.000 claims 1
- 229940040944 tetracyclines Drugs 0.000 claims 1
- FPZLLRFZJZRHSY-HJYUBDRYSA-N tigecycline Chemical class C([C@H]1C2)C3=C(N(C)C)C=C(NC(=O)CNC(C)(C)C)C(O)=C3C(=O)C1=C(O)[C@@]1(O)[C@@H]2[C@H](N(C)C)C(O)=C(C(N)=O)C1=O FPZLLRFZJZRHSY-HJYUBDRYSA-N 0.000 claims 1
- 229960004089 tigecycline Drugs 0.000 claims 1
- 0 C[C@@](C(CC(C1)N2O*)=*)N1C2=O Chemical compound C[C@@](C(CC(C1)N2O*)=*)N1C2=O 0.000 description 5
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15305479.6 | 2015-03-31 | ||
| EP15305479.6A EP3075734A1 (en) | 2015-03-31 | 2015-03-31 | Heterocyclic compounds and their use in preventing or treating bacterial infections |
| EP16305059.4 | 2016-01-22 | ||
| EP16305059 | 2016-01-22 | ||
| PCT/EP2016/056845 WO2016156346A1 (en) | 2015-03-31 | 2016-03-30 | Heterocyclic compounds and their use in preventing or treating bacterial infections |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018510190A JP2018510190A (ja) | 2018-04-12 |
| JP2018510190A5 true JP2018510190A5 (https=) | 2019-04-11 |
Family
ID=55642466
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017551331A Pending JP2018510190A (ja) | 2015-03-31 | 2016-03-30 | 複素環式化合物及びそれらの細菌感染症の予防または治療のための使用 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US10570131B2 (https=) |
| EP (1) | EP3277685B1 (https=) |
| JP (1) | JP2018510190A (https=) |
| KR (1) | KR20170131687A (https=) |
| CN (1) | CN107438610A (https=) |
| AU (1) | AU2016239207A1 (https=) |
| BR (1) | BR112017020826A2 (https=) |
| CA (1) | CA2980109A1 (https=) |
| CL (1) | CL2017002449A1 (https=) |
| HK (1) | HK1244791A1 (https=) |
| MX (1) | MX2017012539A (https=) |
| RU (1) | RU2715058C2 (https=) |
| TW (1) | TW201639853A (https=) |
| WO (2) | WO2016156344A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3300736B1 (en) * | 2016-09-30 | 2021-05-05 | Mutabilis | Composition comprising antibiotic compound and an heterocyclic compound and their use in preventing or treating bacterial infections |
| EP3357924A1 (en) | 2017-02-06 | 2018-08-08 | Mutabilis | Novel heterocyclic compounds and their use in preventing or treating bacterial infections |
| US11905286B2 (en) | 2018-08-09 | 2024-02-20 | Antabio Sas | Diazabicyclooctanones as inhibitors of serine beta-lactamases |
| SG11202101255UA (en) | 2018-08-09 | 2021-03-30 | Antabio Sas | Diazabicyclooctanones as inhibitors of serine beta-lactamases |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2533826T3 (es) | 2008-01-18 | 2015-04-15 | Merck Sharp & Dohme Corp. | Inhibidores de beta-lactamasa |
| RU2578370C2 (ru) | 2011-08-27 | 2016-03-27 | Вокхардт Лимитед | Производные 1,6- диазабицикло [3,2,1] октан-7-она и их применение при лечении бактериальных инфекционных болезней |
| MX340533B (es) * | 2011-08-30 | 2016-07-13 | Wockhardt Ltd | Derivados de 1,6- diazabiciclo [3,2,1] octan-7-ona y su uso en el tratamiento de infecciones bacterianas. |
| AR090539A1 (es) | 2012-04-02 | 2014-11-19 | Astrazeneca Ab | COMPUESTOS INHIBIDORES DE b LACTAMASA |
| RU2693898C2 (ru) | 2012-05-30 | 2019-07-05 | Мейдзи Сейка Фарма Ко., Лтд. | НОВЫЙ ИНГИБИТОР бета-ЛАКТАМАЗЫ И СПОСОБ ЕГО ПОЛУЧЕНИЯ |
| US9271446B2 (en) * | 2012-06-28 | 2016-03-01 | Forage Innovations B.V. | Self-aligning apparatus and methods for gathering bales |
| BR112015003592B1 (pt) * | 2012-08-25 | 2020-04-14 | Wockhardt Ltd | derivados de 1,6-diazabiciclo[3,2,1]octan-7-ona e seu uso no tratamento de infecções bacterianas |
| WO2014122468A1 (en) * | 2013-02-06 | 2014-08-14 | Astrazeneca Ab | Combination therapy for the treatment of nosocomial pneumonia |
| WO2014141132A1 (en) | 2013-03-14 | 2014-09-18 | Naeja Pharmaceutical Inc. | NEW HETEROCYCLIC COMPOUNDS AND THEIR USE AS ANTIBACTERIAL AGENTS AND β-LACTAMASE INHIBITORS |
| GB201505585D0 (en) | 2015-03-31 | 2015-05-13 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides and scaffolds for use in immunotherapy against renal cell carinoma (RCC) and other cancers |
| EP3075733A1 (en) | 2015-03-31 | 2016-10-05 | Mutabilis | Novel heterocyclic compounds and their use in preventing or treating bacterial infections |
| EP3075734A1 (en) * | 2015-03-31 | 2016-10-05 | Mutabilis | Heterocyclic compounds and their use in preventing or treating bacterial infections |
| MX378262B (es) | 2015-03-31 | 2025-03-10 | Laboratorios Bago S A | Procedimiento de elaboración de pellets entéricos que contienen un inhibidor de la bomba protónica y composiciones farmacéuticas multiparticuladas que los contienen. |
| MA41850A (fr) | 2015-03-31 | 2018-02-06 | Takeda Pharmaceuticals Co | Nouvelles utilisations pharmaceutiques |
-
2016
- 2016-03-30 TW TW105110155A patent/TW201639853A/zh unknown
- 2016-03-30 CA CA2980109A patent/CA2980109A1/en not_active Abandoned
- 2016-03-30 AU AU2016239207A patent/AU2016239207A1/en not_active Abandoned
- 2016-03-30 RU RU2017133745A patent/RU2715058C2/ru active
- 2016-03-30 MX MX2017012539A patent/MX2017012539A/es unknown
- 2016-03-30 HK HK18104010.8A patent/HK1244791A1/zh unknown
- 2016-03-30 CN CN201680020427.5A patent/CN107438610A/zh active Pending
- 2016-03-30 WO PCT/EP2016/056842 patent/WO2016156344A1/en not_active Ceased
- 2016-03-30 JP JP2017551331A patent/JP2018510190A/ja active Pending
- 2016-03-30 BR BR112017020826-1A patent/BR112017020826A2/pt not_active Application Discontinuation
- 2016-03-30 WO PCT/EP2016/056845 patent/WO2016156346A1/en not_active Ceased
- 2016-03-30 US US15/563,483 patent/US10570131B2/en active Active
- 2016-03-30 KR KR1020177031506A patent/KR20170131687A/ko not_active Withdrawn
- 2016-03-30 EP EP16712866.9A patent/EP3277685B1/en active Active
-
2017
- 2017-09-28 CL CL2017002449A patent/CL2017002449A1/es unknown
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