JP2018510198A5 - - Google Patents
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- Publication number
- JP2018510198A5 JP2018510198A5 JP2017551690A JP2017551690A JP2018510198A5 JP 2018510198 A5 JP2018510198 A5 JP 2018510198A5 JP 2017551690 A JP2017551690 A JP 2017551690A JP 2017551690 A JP2017551690 A JP 2017551690A JP 2018510198 A5 JP2018510198 A5 JP 2018510198A5
- Authority
- JP
- Japan
- Prior art keywords
- nhq
- nhc
- group
- compound
- heterocyclic ring
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 42
- 229910052739 hydrogen Inorganic materials 0.000 claims 21
- 125000003118 aryl group Chemical group 0.000 claims 20
- 125000002373 5 membered heterocyclic group Chemical group 0.000 claims 17
- 125000004070 6 membered heterocyclic group Chemical group 0.000 claims 17
- 239000001257 hydrogen Substances 0.000 claims 15
- 229920006395 saturated elastomer Polymers 0.000 claims 15
- 229910052757 nitrogen Inorganic materials 0.000 claims 14
- 239000008194 pharmaceutical composition Substances 0.000 claims 14
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 11
- 125000005842 heteroatom Chemical group 0.000 claims 9
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 9
- 229910052717 sulfur Inorganic materials 0.000 claims 8
- 125000001963 4 membered heterocyclic group Chemical group 0.000 claims 7
- 125000000623 heterocyclic group Chemical group 0.000 claims 7
- -1 unsaturated Chemical group 0.000 claims 7
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 6
- 229910052760 oxygen Inorganic materials 0.000 claims 5
- 229910052799 carbon Inorganic materials 0.000 claims 4
- 150000002431 hydrogen Chemical class 0.000 claims 4
- 238000011282 treatment Methods 0.000 claims 4
- 208000035143 Bacterial infection Diseases 0.000 claims 3
- 230000000845 anti-microbial effect Effects 0.000 claims 3
- 208000022362 bacterial infectious disease Diseases 0.000 claims 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 238000011321 prophylaxis Methods 0.000 claims 3
- 241000894006 Bacteria Species 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- ORFOPKXBNMVMKC-DWVKKRMSSA-N ceftazidime Chemical compound S([C@@H]1[C@@H](C(N1C=1C([O-])=O)=O)NC(=O)\C(=N/OC(C)(C)C(O)=O)C=2N=C(N)SC=2)CC=1C[N+]1=CC=CC=C1 ORFOPKXBNMVMKC-DWVKKRMSSA-N 0.000 claims 2
- 229960000484 ceftazidime Drugs 0.000 claims 2
- 229910052731 fluorine Inorganic materials 0.000 claims 2
- 125000001153 fluoro group Chemical group F* 0.000 claims 2
- 230000003287 optical effect Effects 0.000 claims 2
- 150000003952 β-lactams Chemical class 0.000 claims 2
- IZXIZTKNFFYFOF-UHFFFAOYSA-N 2-Oxazolidone Chemical class O=C1NCCO1 IZXIZTKNFFYFOF-UHFFFAOYSA-N 0.000 claims 1
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 claims 1
- 229930186147 Cephalosporin Natural products 0.000 claims 1
- 108090000204 Dipeptidase 1 Proteins 0.000 claims 1
- 108010015899 Glycopeptides Proteins 0.000 claims 1
- 102000002068 Glycopeptides Human genes 0.000 claims 1
- 108010028921 Lipopeptides Proteins 0.000 claims 1
- 229930182555 Penicillin Natural products 0.000 claims 1
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 claims 1
- 108010040201 Polymyxins Proteins 0.000 claims 1
- 108010034396 Streptogramins Proteins 0.000 claims 1
- 239000004098 Tetracycline Substances 0.000 claims 1
- 229940126575 aminoglycoside Drugs 0.000 claims 1
- 239000004599 antimicrobial Substances 0.000 claims 1
- WZPBZJONDBGPKJ-VEHQQRBSSA-N aztreonam Chemical compound O=C1N(S([O-])(=O)=O)[C@@H](C)[C@@H]1NC(=O)C(=N/OC(C)(C)C(O)=O)\C1=CSC([NH3+])=N1 WZPBZJONDBGPKJ-VEHQQRBSSA-N 0.000 claims 1
- 229960003644 aztreonam Drugs 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 102000006635 beta-lactamase Human genes 0.000 claims 1
- 229940041011 carbapenems Drugs 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims 1
- 229940124587 cephalosporin Drugs 0.000 claims 1
- 150000001780 cephalosporins Chemical class 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 125000003709 fluoroalkyl group Chemical group 0.000 claims 1
- 229940124307 fluoroquinolone Drugs 0.000 claims 1
- 208000027096 gram-negative bacterial infections Diseases 0.000 claims 1
- 208000027136 gram-positive bacterial infections Diseases 0.000 claims 1
- 239000003835 ketolide antibiotic agent Substances 0.000 claims 1
- 229940041028 lincosamides Drugs 0.000 claims 1
- 239000003120 macrolide antibiotic agent Substances 0.000 claims 1
- 229940041033 macrolides Drugs 0.000 claims 1
- 150000002961 penems Chemical class 0.000 claims 1
- 229940049954 penicillin Drugs 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 229940041153 polymyxins Drugs 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 125000006239 protecting group Chemical group 0.000 claims 1
- 150000007660 quinolones Chemical class 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 229940041030 streptogramins Drugs 0.000 claims 1
- 125000004434 sulfur atom Chemical group 0.000 claims 1
- ILMRJRBKQSSXGY-UHFFFAOYSA-N tert-butyl(dimethyl)silicon Chemical compound C[Si](C)C(C)(C)C ILMRJRBKQSSXGY-UHFFFAOYSA-N 0.000 claims 1
- 125000001981 tert-butyldimethylsilyl group Chemical group [H]C([H])([H])[Si]([H])(C([H])([H])[H])[*]C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
- 125000001302 tertiary amino group Chemical group 0.000 claims 1
- 235000019364 tetracycline Nutrition 0.000 claims 1
- 150000003522 tetracyclines Chemical class 0.000 claims 1
- 229940040944 tetracyclines Drugs 0.000 claims 1
- FPZLLRFZJZRHSY-HJYUBDRYSA-N tigecycline Chemical class C([C@H]1C2)C3=C(N(C)C)C=C(NC(=O)CNC(C)(C)C)C(O)=C3C(=O)C1=C(O)[C@@]1(O)[C@@H]2[C@H](N(C)C)C(O)=C(C(N)=O)C1=O FPZLLRFZJZRHSY-HJYUBDRYSA-N 0.000 claims 1
- 229960004089 tigecycline Drugs 0.000 claims 1
- 0 CC(CCC=O)=C(C(*)*(CC1*2*)C2=O)C1=CCC=C Chemical compound CC(CCC=O)=C(C(*)*(CC1*2*)C2=O)C1=CCC=C 0.000 description 3
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15305508.2 | 2015-04-03 | ||
| EP15305508.2A EP3075381A1 (en) | 2015-04-03 | 2015-04-03 | Heterocyclic compounds and their use in preventing or treating bacterial infections |
| EP16305069 | 2016-01-26 | ||
| EP16305069.3 | 2016-01-26 | ||
| PCT/EP2016/057274 WO2016156597A1 (en) | 2015-04-03 | 2016-04-01 | Heterocyclic compounds and their use in preventing or treating bacterial infections |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018510198A JP2018510198A (ja) | 2018-04-12 |
| JP2018510198A5 true JP2018510198A5 (https=) | 2019-04-18 |
Family
ID=55646608
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017551690A Pending JP2018510198A (ja) | 2015-04-03 | 2016-04-01 | 複素環式化合物及びそれらの細菌感染症の予防または治療のための使用 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US10501481B2 (https=) |
| EP (1) | EP3277277B1 (https=) |
| JP (1) | JP2018510198A (https=) |
| KR (1) | KR20170132316A (https=) |
| CN (1) | CN107438614B (https=) |
| AU (1) | AU2016239861A1 (https=) |
| BR (1) | BR112017020935A2 (https=) |
| CA (1) | CA2980395A1 (https=) |
| CL (1) | CL2017002482A1 (https=) |
| MX (1) | MX2017012545A (https=) |
| RU (1) | RU2714197C2 (https=) |
| TW (1) | TW201639854A (https=) |
| WO (1) | WO2016156597A1 (https=) |
| ZA (1) | ZA201706348B (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX373103B (es) | 2014-02-13 | 2020-04-17 | Incyte Holdings Corp | Ciclopropilaminas como inhibidores de desmetilasa específica de lisina 1 (lsd1). |
| US9527835B2 (en) | 2014-02-13 | 2016-12-27 | Incyte Corporation | Cyclopropylamines as LSD1 inhibitors |
| SI3105218T1 (sl) | 2014-02-13 | 2019-11-29 | Incyte Corp | Ciklopropilamini kot inhibitorji LSD1 |
| WO2016007722A1 (en) | 2014-07-10 | 2016-01-14 | Incyte Corporation | Triazolopyridines and triazolopyrazines as lsd1 inhibitors |
| TWI687419B (zh) | 2014-07-10 | 2020-03-11 | 美商英塞特公司 | 作為ｌｓｄ１抑制劑之咪唑并吡啶及咪唑并吡嗪 |
| TW201613925A (en) | 2014-07-10 | 2016-04-16 | Incyte Corp | Imidazopyrazines as LSD1 inhibitors |
| EP3277689B1 (en) | 2015-04-03 | 2019-09-04 | Incyte Corporation | Heterocyclic compounds as lsd1 inhibitors |
| LT3334709T (lt) | 2015-08-12 | 2025-03-10 | Incyte Holdings Corporation | Lsd1 inhibitoriaus druskos |
| JOP20190061A1 (ar) * | 2016-09-28 | 2019-03-26 | Novartis Ag | مثبطات بيتا-لاكتاماز |
| EP3300736B1 (en) * | 2016-09-30 | 2021-05-05 | Mutabilis | Composition comprising antibiotic compound and an heterocyclic compound and their use in preventing or treating bacterial infections |
| EP3357924A1 (en) | 2017-02-06 | 2018-08-08 | Mutabilis | Novel heterocyclic compounds and their use in preventing or treating bacterial infections |
| EP3604315A1 (en) * | 2018-07-30 | 2020-02-05 | Mutabilis | Heterocyclic compounds and their use in preventing or treating bacterial infections |
| EP3833665B1 (en) | 2018-08-09 | 2023-07-19 | Antabio SAS | Diazabicyclooctanones as inhibitors of serine beta-lactamases |
| US11905286B2 (en) | 2018-08-09 | 2024-02-20 | Antabio Sas | Diazabicyclooctanones as inhibitors of serine beta-lactamases |
| WO2020047198A1 (en) | 2018-08-31 | 2020-03-05 | Incyte Corporation | Salts of an lsd1 inhibitor and processes for preparing the same |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU1107541A1 (ru) | 1982-12-03 | 1995-10-20 | Институт Тонкой Органической Химии Им.А.Л.Мнджояна | 10-нитро-1,6,8-триазатрицикло [6,3,1,1] тридекан-2,5-дион |
| CZ282567B6 (cs) | 1993-12-29 | 1997-08-13 | Pfizer Inc. | Diazabicyklické sloučeniny a farmaceutické prostředky na jejich bázi |
| FR2825705B1 (fr) | 2001-06-08 | 2005-05-20 | Aventis Pharma Sa | Nouveaux composes heterocycliques, leur preparation et leur utilisation comme medicaments, notamment comme anti-bacteriens |
| US20040009234A1 (en) * | 2002-07-10 | 2004-01-15 | Meisel Gerard M. | Gastrointestinal compositions |
| BRPI0614874A2 (pt) * | 2005-08-22 | 2011-04-19 | Targacept Inc | diazatricicloalcanos substituìdos com heteroarila, métodos para sua preparação e uso dos mesmos |
| EP1972629A1 (en) * | 2007-03-23 | 2008-09-24 | Mutabilis SA | New imidazolo-heteroaryl derivatives with antibacterial properties |
| FR2936798B1 (fr) | 2008-10-03 | 2012-09-28 | Novexel | Nouveaux composes heterocycliques azotes, leur preparation et leur utilisation comme medicaments antibacteriens. |
| FR2937034B1 (fr) * | 2008-10-10 | 2012-11-23 | Novexel | Nouveaux composes heterocycliques azotes, leur preparation et leur utilisation comme medicaments antibacteriens |
| AR090539A1 (es) * | 2012-04-02 | 2014-11-19 | Astrazeneca Ab | COMPUESTOS INHIBIDORES DE b LACTAMASA |
| WO2014141132A1 (en) | 2013-03-14 | 2014-09-18 | Naeja Pharmaceutical Inc. | NEW HETEROCYCLIC COMPOUNDS AND THEIR USE AS ANTIBACTERIAL AGENTS AND β-LACTAMASE INHIBITORS |
-
2016
- 2016-04-01 WO PCT/EP2016/057274 patent/WO2016156597A1/en not_active Ceased
- 2016-04-01 AU AU2016239861A patent/AU2016239861A1/en not_active Abandoned
- 2016-04-01 BR BR112017020935A patent/BR112017020935A2/pt not_active Application Discontinuation
- 2016-04-01 KR KR1020177031671A patent/KR20170132316A/ko not_active Withdrawn
- 2016-04-01 US US15/563,889 patent/US10501481B2/en active Active
- 2016-04-01 JP JP2017551690A patent/JP2018510198A/ja active Pending
- 2016-04-01 CN CN201680020682.XA patent/CN107438614B/zh active Active
- 2016-04-01 MX MX2017012545A patent/MX2017012545A/es unknown
- 2016-04-01 RU RU2017134055A patent/RU2714197C2/ru active
- 2016-04-01 TW TW105110646A patent/TW201639854A/zh unknown
- 2016-04-01 EP EP16713469.1A patent/EP3277277B1/en active Active
- 2016-04-01 CA CA2980395A patent/CA2980395A1/en not_active Abandoned
-
2017
- 2017-09-20 ZA ZA201706348A patent/ZA201706348B/en unknown
- 2017-10-02 CL CL2017002482A patent/CL2017002482A1/es unknown
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