JP2018509890A - 人工多能性幹細胞(iPSC)の生産を再プログラムする方法 - Google Patents

人工多能性幹細胞(iPSC)の生産を再プログラムする方法 Download PDF

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JP2018509890A
JP2018509890A JP2017540262A JP2017540262A JP2018509890A JP 2018509890 A JP2018509890 A JP 2018509890A JP 2017540262 A JP2017540262 A JP 2017540262A JP 2017540262 A JP2017540262 A JP 2017540262A JP 2018509890 A JP2018509890 A JP 2018509890A
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δ133p53β
isoform
cells
δ133p53γ
ipsc
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JP2018509890A5 (enExample
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ルー ピエール
ピエール ルー
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センター ナショナル ド ラ ルシェルシュ サイエンティフィーク
センター ナショナル ド ラ ルシェルシュ サイエンティフィーク
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JP2017540262A 2015-01-30 2016-02-01 人工多能性幹細胞(iPSC)の生産を再プログラムする方法 Pending JP2018509890A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP15305145 2015-01-30
EP15305145.3 2015-01-30
PCT/EP2016/052085 WO2016120493A1 (en) 2015-01-30 2016-02-01 Reprogramming method for producing induced pluripotent stem cells (ipsc)

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US (1) US10767165B2 (enExample)
EP (1) EP3250679B1 (enExample)
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022534295A (ja) * 2019-05-30 2022-07-28 イミュノルクス インターナショナル コーポレーション ワクチン接種及び疾患治療法のための自己人工多能性幹細胞とのポックスウイルスの使用

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11845960B2 (en) 2016-09-12 2023-12-19 President And Fellows Of Harvard College Transcription factors controlling differentiation of stem cells
WO2018064460A1 (en) * 2016-09-30 2018-04-05 Mayo Foundation For Medical Education And Research Viral vectors for nuclear reprogramming
WO2018204262A1 (en) * 2017-05-01 2018-11-08 President And Fellows Of Harvard College Transcription factors controlling differentiation of stem cells
GB2564437B (en) * 2017-07-10 2020-11-04 Univ Brunel Method of testing a gene therapy vector using induced pluripotent stem cells
WO2019108894A1 (en) 2017-12-01 2019-06-06 President And Fellows Of Harvard College Methods and compositions for the production of oligodendrocyte progenitor cells
US11788131B2 (en) 2018-04-06 2023-10-17 President And Fellows Of Harvard College Methods of identifying combinations of transcription factors
GB201909975D0 (en) * 2019-07-11 2019-08-28 Babraham Inst Novel reprogramming method
US20220273591A1 (en) * 2019-07-26 2022-09-01 The Board Of Trustees Of The Leland Stanford Junior University Methods for determining risk of developing insulin resistance
CN114736872A (zh) * 2022-05-06 2022-07-12 中国科学院动物研究所 提高多能干细胞性能的组合物、方法及其应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012531606A (ja) * 2009-06-30 2012-12-10 サントル、ナショナール、ド、ラ、ルシェルシュ、シアンティフィク、(セーエヌエルエス) Δ133p53βを用いた転移癌を有する素因があると思われる被験体の検査方法
JP2013541951A (ja) * 2010-10-01 2013-11-21 アメリカ合衆国 p53アイソフォームによる幹細胞機能の操作
JP2018506278A (ja) * 2015-01-30 2018-03-08 センター ナショナル ド ラ ルシェルシュ サイエンティフィーク デルタ133p53ベータおよびデルタ133p53ガンマアイソフォームはがん幹細胞のバイオマーカーである

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2690554T3 (es) * 2008-03-17 2018-11-21 The Scripps Research Institute Enfoques químicos y genéticos combinados para la generación de células madre pluripotentes inducidas
KR101606943B1 (ko) * 2008-06-27 2016-03-28 고쿠리츠 다이가쿠 호진 교토 다이가쿠 유도된 다능성 줄기 세포의 효율적인 확립 방법
WO2010033991A2 (en) * 2008-09-22 2010-03-25 Children's Medical Center Corporation Detection of human somatic cell reprogramming
WO2011016588A1 (en) * 2009-08-07 2011-02-10 Kyoto University Method of efficiently establishing induced pluripotent stem cells

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012531606A (ja) * 2009-06-30 2012-12-10 サントル、ナショナール、ド、ラ、ルシェルシュ、シアンティフィク、(セーエヌエルエス) Δ133p53βを用いた転移癌を有する素因があると思われる被験体の検査方法
JP2013541951A (ja) * 2010-10-01 2013-11-21 アメリカ合衆国 p53アイソフォームによる幹細胞機能の操作
JP2018506278A (ja) * 2015-01-30 2018-03-08 センター ナショナル ド ラ ルシェルシュ サイエンティフィーク デルタ133p53ベータおよびデルタ133p53ガンマアイソフォームはがん幹細胞のバイオマーカーである

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
ARSIC N. ET AL., STEM CELL REPORTS, vol. Vol.4 [Epub 2015 Mar 5], JPN6020011440, pages 531 - 540, ISSN: 0004240066 *
BOURDON J. ET AL., GENES & DEVELOPMENT, vol. 19 (2005), JPN6020011439, pages 2122 - 2137, ISSN: 0004446041 *
MAHERALI N. ET AL., CELL STEM CELL, vol. 3 (2008), JPN6020011438, pages 595 - 605, ISSN: 0004446042 *
MONTSERRAT N. ET AL., J. BIOL. CHEM., vol. Vol.287 No.29 (2012), JPN6021004853, pages 24131 - 24138, ISSN: 0004446043 *
POPOWSKI M. ET AL., STEM CELL REPORTS, vol. Vol.2 (2014), JPN6021004858, pages 26 - 35, ISSN: 0004446044 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022534295A (ja) * 2019-05-30 2022-07-28 イミュノルクス インターナショナル コーポレーション ワクチン接種及び疾患治療法のための自己人工多能性幹細胞とのポックスウイルスの使用

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US10767165B2 (en) 2020-09-08
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WO2016120493A1 (en) 2016-08-04
EP3250679B1 (en) 2020-08-19

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