JP2018508569A - 老化関連状態の治療における化合物および使用 - Google Patents

老化関連状態の治療における化合物および使用 Download PDF

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JP2018508569A
JP2018508569A JP2017559779A JP2017559779A JP2018508569A JP 2018508569 A JP2018508569 A JP 2018508569A JP 2017559779 A JP2017559779 A JP 2017559779A JP 2017559779 A JP2017559779 A JP 2017559779A JP 2018508569 A JP2018508569 A JP 2018508569A
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salt
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JP2018508569A5 (https=
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ナサニエル デビッド
ナサニエル デビッド
レミ‐マーティン ラバージ
レミ‐マーティン ラバージ
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ユニティ バイオテクノロジー インコーポレイテッド
ユニティ バイオテクノロジー インコーポレイテッド
バック インスティテュート フォー リサーチ オン エイジング
バック インスティテュート フォー リサーチ オン エイジング
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JP2017559779A 2015-02-06 2016-02-05 老化関連状態の治療における化合物および使用 Pending JP2018508569A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562113227P 2015-02-06 2015-02-06
US62/113,227 2015-02-06
PCT/US2016/016894 WO2016127135A1 (en) 2015-02-06 2016-02-05 Compounds and uses in treatment of senescence-associated conditons

Publications (2)

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JP2018508569A true JP2018508569A (ja) 2018-03-29
JP2018508569A5 JP2018508569A5 (https=) 2019-03-14

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JP2017559779A Pending JP2018508569A (ja) 2015-02-06 2016-02-05 老化関連状態の治療における化合物および使用

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US (2) US20170266211A1 (https=)
EP (1) EP3253387A4 (https=)
JP (1) JP2018508569A (https=)
CN (1) CN108025006A (https=)
AU (1) AU2016215035A1 (https=)
CA (1) CA2981753A1 (https=)
HK (1) HK1249030A1 (https=)
WO (1) WO2016127135A1 (https=)

Cited By (4)

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JPWO2021132628A1 (https=) * 2019-12-26 2021-07-01
JP2021522270A (ja) * 2018-04-30 2021-08-30 ユニティ バイオテクノロジー インコーポレイテッド 老化細胞によって引き起こされるかまたは媒介される状態の臨床管理における使用のためおよびがんを治療するための、Ｂｃｌファミリーアンタゴニストであるホスホノアミダート
JP2021528392A (ja) * 2018-06-13 2021-10-21 ユニティ バイオテクノロジー インコーポレイテッド 老化細胞によって引き起こされるかまたは媒介される状態の臨床管理における使用のためおよびがんを治療するための、Ｂｃｌファミリーアンタゴニストであるアシルスルホンアミド
JP2023547959A (ja) * 2020-11-10 2023-11-14 ユニティ バイオテクノロジー インコーポレイテッド Ｂｃｌの結晶性固体メグルミン塩阻害物質、並びに前記阻害物質を作製及び使用する方法

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US20170216286A1 (en) 2014-01-28 2017-08-03 Mayo Foundation For Medical Education And Research Killing senescent cells and treating senescence-associated conditions using a src inhibitor and a flavonoid
TW201613576A (en) 2014-06-26 2016-04-16 Novartis Ag Intermittent dosing of MDM2 inhibitor
MX388093B (es) 2016-11-15 2025-03-19 Novartis Ag Dosis y regimen para inhibidores de la interaccion hdm2-p53.
BR102018007822A2 (pt) 2017-04-20 2018-11-06 Gilead Sciences, Inc. composto, métodos para inibir pd-1, pd-l1 e/ou interação de pd-1/pd-l1 e para tratamento de câncer, composição farmacêutica, e, kit para tratamento de ou prevenção de câncer ou uma doença ou condição
WO2018204830A2 (en) * 2017-05-05 2018-11-08 The Regents Of The University Of California Inhibiting senescent processes in beta cells for the prevention of type 1 diabetes
EP3441069B1 (en) 2017-08-11 2023-04-05 Unity Biotechnology, Inc. Treatment of diabetic retinopathy using pharmaceutical agents that eliminate senescent cells
WO2019033122A1 (en) * 2017-08-11 2019-02-14 Unity Biotechnology, Inc. TREATMENT OF PULMONARY DISEASES USING PHARMACEUTICAL AGENTS THAT ELIMINATE SENESCENT CELLS
US10588916B2 (en) 2017-10-31 2020-03-17 Unity Biotechnology, Inc. Technology to inhibit vascular changes that lead to vision loss in the eye
CA3043103C (en) 2017-12-30 2021-02-09 Unity Biotechnology Peptide-based proteasome inhibitors for treating conditions mediated by senescent cells and for treating cancer
EP3737681A4 (en) 2018-01-10 2022-01-12 Recurium IP Holdings, LLC BENZAMIDE COMPOUNDS
TWI707849B (zh) 2018-02-13 2020-10-21 美商基利科學股份有限公司 Pd‐1/pd‐l1抑制劑
KR102591947B1 (ko) 2018-04-19 2023-10-25 길리애드 사이언시즈, 인코포레이티드 Pd-1/pd-l1 억제제
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CA3056878C (en) 2018-04-30 2021-03-30 Unity Biotechnology Phospholidines that are bcl family antagonists for use in clinical management of conditions caused or mediated by senescent cells and for treating cancer
US10717722B2 (en) 2018-06-13 2020-07-21 Unity Biotechnology, Inc. Acyl sulfonamides that are Bcl family antagonists for use in clinical management of conditions caused or mediated by senescent cells and for treating cancer
EP3809983B1 (en) 2018-06-22 2025-08-27 Mayo Foundation for Medical Education and Research Methods and materials for improving arteriovenous fistula maturation and maintaining arteriovenous fistula functionality
IL312612A (en) * 2018-07-11 2024-07-01 Rubedo Life Sciences Inc Senolytic compositions and uses thereof
EP3820572B1 (en) 2018-07-13 2023-08-16 Gilead Sciences, Inc. Pd-1/pd-l1 inhibitors
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