CA2981753A1 - Compounds and uses in treatment of senescence-associated conditions - Google Patents
Compounds and uses in treatment of senescence-associated conditions Download PDFInfo
- Publication number
- CA2981753A1 CA2981753A1 CA2981753A CA2981753A CA2981753A1 CA 2981753 A1 CA2981753 A1 CA 2981753A1 CA 2981753 A CA2981753 A CA 2981753A CA 2981753 A CA2981753 A CA 2981753A CA 2981753 A1 CA2981753 A1 CA 2981753A1
- Authority
- CA
- Canada
- Prior art keywords
- compound
- salt
- alkyl
- disease
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- 0 CCC*[C@](C)C(**C1C2)*C(C)C12C(C1)C1=*C*C(CC(C)*(CC1)CC1(C)*(CCC)C=C)=C Chemical compound CCC*[C@](C)C(**C1C2)*C(C)C12C(C1)C1=*C*C(CC(C)*(CC1)CC1(C)*(CCC)C=C)=C 0.000 description 7
Classifications
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurology (AREA)
- Diabetes (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Neurosurgery (AREA)
- Ophthalmology & Optometry (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Child & Adolescent Psychology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562113227P | 2015-02-06 | 2015-02-06 | |
| US62/113,227 | 2015-02-06 | ||
| PCT/US2016/016894 WO2016127135A1 (en) | 2015-02-06 | 2016-02-05 | Compounds and uses in treatment of senescence-associated conditons |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2981753A1 true CA2981753A1 (en) | 2016-08-11 |
Family
ID=56564790
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2981753A Abandoned CA2981753A1 (en) | 2015-02-06 | 2016-02-05 | Compounds and uses in treatment of senescence-associated conditions |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US20170266211A1 (https=) |
| EP (1) | EP3253387A4 (https=) |
| JP (1) | JP2018508569A (https=) |
| CN (1) | CN108025006A (https=) |
| AU (1) | AU2016215035A1 (https=) |
| CA (1) | CA2981753A1 (https=) |
| HK (1) | HK1249030A1 (https=) |
| WO (1) | WO2016127135A1 (https=) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL286427B2 (en) | 2014-01-28 | 2024-08-01 | Mayo Found Medical Education & Res | Inhibitors bcl-2 anti-apoptotic protein family members for treatment of non cancer pulmonary disease or an opthalmic disease |
| US20170216286A1 (en) | 2014-01-28 | 2017-08-03 | Mayo Foundation For Medical Education And Research | Killing senescent cells and treating senescence-associated conditions using a src inhibitor and a flavonoid |
| TW201613576A (en) | 2014-06-26 | 2016-04-16 | Novartis Ag | Intermittent dosing of MDM2 inhibitor |
| WO2018092020A1 (en) | 2016-11-15 | 2018-05-24 | Novartis Ag | Dose and regimen for hdm2-p53 interaction inhibitors |
| BR102018007822A2 (pt) | 2017-04-20 | 2018-11-06 | Gilead Sciences, Inc. | composto, métodos para inibir pd-1, pd-l1 e/ou interação de pd-1/pd-l1 e para tratamento de câncer, composição farmacêutica, e, kit para tratamento de ou prevenção de câncer ou uma doença ou condição |
| US11419883B2 (en) | 2017-05-05 | 2022-08-23 | The Regents Of The University Of California | Inhibiting senescent processes in beta cells for the prevention of type 1 diabetes |
| WO2019033122A1 (en) * | 2017-08-11 | 2019-02-14 | Unity Biotechnology, Inc. | TREATMENT OF PULMONARY DISEASES USING PHARMACEUTICAL AGENTS THAT ELIMINATE SENESCENT CELLS |
| WO2019033119A1 (en) * | 2017-08-11 | 2019-02-14 | Unity Biotechnology, Inc. | TREATMENT OF OPHTHALMIC CONDITIONS SUCH AS MACULAR DEGENERATION, GLAUCOMA AND DIABETIC RETINOPATHY USING PHARMACEUTICAL AGENTS THAT ELIMINATE SENESCENT CELLS |
| US20200354336A9 (en) * | 2017-08-11 | 2020-11-12 | Unity Biotechnology, Inc. | Treatment of Lung Diseases Using Pharmaceutical Agents that Eliminate Senescent Cells |
| US10588916B2 (en) | 2017-10-31 | 2020-03-17 | Unity Biotechnology, Inc. | Technology to inhibit vascular changes that lead to vision loss in the eye |
| AU2018357829B2 (en) | 2017-12-30 | 2019-09-26 | Unity Biotechnology, Inc. | Peptide-based proteasome inhibitors for treating conditions mediated by senescent cells and for treating cancer |
| KR20200108301A (ko) | 2018-01-10 | 2020-09-17 | 리커리엄 아이피 홀딩스, 엘엘씨 | 벤즈아미드 화합물 |
| CR20200347A (es) | 2018-02-13 | 2020-09-23 | Gilead Sciences Inc | Inhibidores pd-1/pd-l1 |
| TWI712412B (zh) | 2018-04-19 | 2020-12-11 | 美商基利科學股份有限公司 | Pd‐1/pd‐l1抑制劑 |
| US10738042B2 (en) | 2018-04-30 | 2020-08-11 | Unity Biotechnology, Inc. | Phosphonamidates that are Bcl family antagonists for use in clinical management of conditions caused or mediated by senescent cells and for treating cancer |
| CN117866015A (zh) | 2018-04-30 | 2024-04-12 | 联合生物科技公司 | 一种临床管理中使用的化合物及其用途 |
| CA3056878C (en) | 2018-04-30 | 2021-03-30 | Unity Biotechnology | Phospholidines that are bcl family antagonists for use in clinical management of conditions caused or mediated by senescent cells and for treating cancer |
| US10717722B2 (en) | 2018-06-13 | 2020-07-21 | Unity Biotechnology, Inc. | Acyl sulfonamides that are Bcl family antagonists for use in clinical management of conditions caused or mediated by senescent cells and for treating cancer |
| EP3809983B1 (en) | 2018-06-22 | 2025-08-27 | Mayo Foundation for Medical Education and Research | Methods and materials for improving arteriovenous fistula maturation and maintaining arteriovenous fistula functionality |
| US11026963B2 (en) * | 2018-07-11 | 2021-06-08 | Rubedo Life Sciences, Inc. | Senolytic compositions and uses thereof |
| SG11202012425QA (en) | 2018-07-13 | 2021-01-28 | Gilead Sciences Inc | Pd-1/pd-l1 inhibitors |
| WO2020086556A1 (en) | 2018-10-24 | 2020-04-30 | Gilead Sciences, Inc. | Pd-1/pd-l1 inhibitors |
| US20210379078A1 (en) * | 2018-10-30 | 2021-12-09 | Unity Biotechnology, Inc. | Killing Senescent Cells And Treating Senescence-Associated Conditions Using A Bcl Inhibitor And An Mcl-1 Inhibitor |
| US11872237B2 (en) * | 2018-12-28 | 2024-01-16 | Ascentage Pharma (Suzhou) Co., Ltd. | Pharmaceutical composition and preparation method thereof |
| WO2021030655A1 (en) * | 2019-08-15 | 2021-02-18 | Mayo Foundation For Medical Education And Research | Methods and materials for assessing and treating hypertensive disorders |
| WO2021092061A1 (en) * | 2019-11-08 | 2021-05-14 | Unity Biotechnology, Inc. | Combination treatment for senescence-associated diseases |
| WO2021132628A1 (ja) * | 2019-12-26 | 2021-07-01 | 東レ株式会社 | 酸化セリウムのナノ粒子、分散体、酸化剤、抗酸化剤および酸化セリウムのナノ粒子の製造方法 |
| WO2021204060A1 (en) * | 2020-04-10 | 2021-10-14 | Ascentage Pharma (Suzhou) Co., Ltd. | Combinations of bcl-2/bcl-xl inhibitors and related uses |
| CN113929715A (zh) * | 2020-07-13 | 2022-01-14 | 苏州亚盛药业有限公司 | Bcl-2/Bcl-xL抑制剂化合物或其盐的结晶形式或无定形形式 |
| WO2022022706A1 (en) * | 2020-07-31 | 2022-02-03 | Ascentage Pharma (Suzhou) Co., Ltd. | Compositions and methods for treating lung diseases |
| CN114073703B (zh) * | 2020-08-21 | 2022-12-30 | 苏州亚盛药业有限公司 | 用于治疗非酒精性脂肪肝炎的组合物和方法 |
| KR20230145313A (ko) * | 2020-11-10 | 2023-10-17 | 유니티 바이오테크놀로지, 인크. | Bcl의 결정성 고체 메글루민 염 억제제 및 이의 제조 방법 및 이의 사용 방법 |
| EP4649499A1 (en) * | 2023-01-12 | 2025-11-19 | Koninklijke Philips N.V. | Model-guided imaging for mechanical ventilation |
| WO2024164543A1 (zh) * | 2023-02-09 | 2024-08-15 | 中山大学附属第八医院（深圳福田） | [1,2,4]三唑并[4,3-b]哒嗪衍生物在衰老及衰老相关性疾病防治中的应用 |
| CN115837022B (zh) * | 2023-02-20 | 2023-04-25 | 中山大学附属第八医院（深圳福田） | 1,2,4三唑并4,3-b哒嗪衍生物在制备抗衰老药物中的应用 |
| EP4719408A1 (en) * | 2023-05-30 | 2026-04-08 | Ascentage Pharma (Suzhou) Co., Ltd. | Bcl-2/bcl-xl protein degrader and use thereof |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6228873B1 (en) * | 1994-12-09 | 2001-05-08 | The Regents Of The University Of California | Method for enhancing outflow of aqueous humor in treatment of glaucoma |
| JP5277168B2 (ja) * | 2006-09-05 | 2013-08-28 | アボット・ラボラトリーズ | 血小板過剰を治療するｂｃｌインヒビター |
| EP2668180B1 (en) * | 2011-01-25 | 2018-08-01 | The Regents of The University of Michigan | Bcl-2/bcl-xl inhibitors for use in the treatment of cancer |
| EP3689886A1 (en) * | 2013-01-16 | 2020-08-05 | The Regents of The University of Michigan | Bcl-2/bcl-xl inhibitors and their use in the treatment of cancer |
| RU2015149680A (ru) * | 2013-04-21 | 2017-05-24 | Йеда Ресеарч Энд Девелопмент Ко. Лтд. | Агенты для подавления активности и/или снижения количества bcl-xl и/или bcl-w |
| IL286427B2 (en) * | 2014-01-28 | 2024-08-01 | Mayo Found Medical Education & Res | Inhibitors bcl-2 anti-apoptotic protein family members for treatment of non cancer pulmonary disease or an opthalmic disease |
-
2016
- 2016-02-05 WO PCT/US2016/016894 patent/WO2016127135A1/en not_active Ceased
- 2016-02-05 JP JP2017559779A patent/JP2018508569A/ja active Pending
- 2016-02-05 HK HK18108744.2A patent/HK1249030A1/zh unknown
- 2016-02-05 EP EP16747391.7A patent/EP3253387A4/en not_active Withdrawn
- 2016-02-05 AU AU2016215035A patent/AU2016215035A1/en not_active Abandoned
- 2016-02-05 CA CA2981753A patent/CA2981753A1/en not_active Abandoned
- 2016-02-05 CN CN201680020353.5A patent/CN108025006A/zh active Pending
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2017
- 2017-06-01 US US15/611,589 patent/US20170266211A1/en not_active Abandoned
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2020
- 2020-06-11 US US16/899,401 patent/US20200338097A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU2016215035A1 (en) | 2017-09-28 |
| HK1249030A1 (zh) | 2018-10-26 |
| CN108025006A (zh) | 2018-05-11 |
| JP2018508569A (ja) | 2018-03-29 |
| WO2016127135A1 (en) | 2016-08-11 |
| US20200338097A1 (en) | 2020-10-29 |
| EP3253387A4 (en) | 2018-12-19 |
| US20170266211A1 (en) | 2017-09-21 |
| EP3253387A1 (en) | 2017-12-13 |
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