HK1249030A1 - 化合物及在治療衰老相關病症中的用途 - Google Patents

化合物及在治療衰老相關病症中的用途

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Publication number
HK1249030A1
HK1249030A1 HK18108744.2A HK18108744A HK1249030A1 HK 1249030 A1 HK1249030 A1 HK 1249030A1 HK 18108744 A HK18108744 A HK 18108744A HK 1249030 A1 HK1249030 A1 HK 1249030A1
Authority
HK
Hong Kong
Prior art keywords
conditons
senescence
compounds
treatment
associated conditons
Prior art date
Application number
HK18108744.2A
Other languages
English (en)
Inventor
Nathaniel David
Remi-Martin Laberge
Original Assignee
Unity Biotechnology Inc
Buck Inst Res Aging
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Unity Biotechnology Inc, Buck Inst Res Aging filed Critical Unity Biotechnology Inc
Publication of HK1249030A1 publication Critical patent/HK1249030A1/zh

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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/66Phosphorus compounds
    • A61K31/675Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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  • Dermatology (AREA)
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  • Rheumatology (AREA)
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  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
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HK18108744.2A 2015-02-06 2018-07-06 化合物及在治療衰老相關病症中的用途 HK1249030A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562113227P 2015-02-06 2015-02-06
PCT/US2016/016894 WO2016127135A1 (en) 2015-02-06 2016-02-05 Compounds and uses in treatment of senescence-associated conditons

Publications (1)

Publication Number Publication Date
HK1249030A1 true HK1249030A1 (zh) 2018-10-26

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HK18108744.2A HK1249030A1 (zh) 2015-02-06 2018-07-06 化合物及在治療衰老相關病症中的用途

Country Status (8)

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US (2) US20170266211A1 (zh)
EP (1) EP3253387A4 (zh)
JP (1) JP2018508569A (zh)
CN (1) CN108025006A (zh)
AU (1) AU2016215035A1 (zh)
CA (1) CA2981753A1 (zh)
HK (1) HK1249030A1 (zh)
WO (1) WO2016127135A1 (zh)

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CN106163557B (zh) 2014-01-28 2020-07-14 巴克老龄化研究所 用于杀死衰老细胞和用于治疗衰老相关疾病和病症的方法和组合物
TW201613576A (en) 2014-06-26 2016-04-16 Novartis Ag Intermittent dosing of MDM2 inhibitor
PL3541387T3 (pl) 2016-11-15 2021-10-25 Novartis Ag Dawka i schemat dla inhibitorów interakcji hdm2-p53
US11419883B2 (en) 2017-05-05 2022-08-23 The Regents Of The University Of California Inhibiting senescent processes in beta cells for the prevention of type 1 diabetes
EP4234025A3 (en) 2017-08-11 2024-04-24 Unity Biotechnology, Inc. Treatment of diabetic retinopathy using pharmaceutical agents that eliminate senescent cells
WO2019033122A1 (en) * 2017-08-11 2019-02-14 Unity Biotechnology, Inc. TREATMENT OF PULMONARY DISEASES USING PHARMACEUTICAL AGENTS THAT ELIMINATE SENESCENT CELLS
US20200354336A9 (en) * 2017-08-11 2020-11-12 Unity Biotechnology, Inc. Treatment of Lung Diseases Using Pharmaceutical Agents that Eliminate Senescent Cells
US10588916B2 (en) 2017-10-31 2020-03-17 Unity Biotechnology, Inc. Technology to inhibit vascular changes that lead to vision loss in the eye
WO2019133988A1 (en) 2017-12-30 2019-07-04 Unity Biotechnology, Inc. Peptide-based proteasome inhibitors for treating conditions mediated by senescent cells and for treating cancer
KR20200108302A (ko) 2018-01-10 2020-09-17 리커리엄 아이피 홀딩스, 엘엘씨 벤즈아미드 화합물
AU2019222644B2 (en) 2018-02-13 2021-04-01 Gilead Sciences, Inc. PD-1/PD-L1 inhibitors
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CA3056878C (en) 2018-04-30 2021-03-30 Unity Biotechnology Phospholidines that are bcl family antagonists for use in clinical management of conditions caused or mediated by senescent cells and for treating cancer
WO2019213160A1 (en) 2018-04-30 2019-11-07 Unity Biotechnology Acyl phosphonamidates and acyl benzylamines that are bcl family antagonists for use in clinical management of conditions caused or mediated by senescent cells and for treating cancer
US10738042B2 (en) 2018-04-30 2020-08-11 Unity Biotechnology, Inc. Phosphonamidates that are Bcl family antagonists for use in clinical management of conditions caused or mediated by senescent cells and for treating cancer
US10717722B2 (en) 2018-06-13 2020-07-21 Unity Biotechnology, Inc. Acyl sulfonamides that are Bcl family antagonists for use in clinical management of conditions caused or mediated by senescent cells and for treating cancer
EP3809983A4 (en) 2018-06-22 2021-09-01 Mayo Foundation for Medical Education and Research METHODS AND MATERIALS FOR IMPROVING THE MATURATION OF ARTERIOVENOUS FISTULA AND MAINTAINING THE FUNCTIONALITY OF ARTERIOVENOUS FISTULA
WO2020014409A1 (en) * 2018-07-11 2020-01-16 Rubedo Life Sciences, Inc. Senolytic compositions and uses thereof
JP7105359B2 (ja) 2018-07-13 2022-07-22 ギリアード サイエンシーズ, インコーポレイテッド Pd-1/pd-l1阻害剤
AU2019366355B2 (en) 2018-10-24 2022-10-13 Gilead Sciences, Inc. PD-1/PD-L1 inhibitors
WO2020092117A2 (en) * 2018-10-30 2020-05-07 Unity Biotechnology, Inc. Killing senescent cells and treating senescence-associated diseases or disorders using a combination of a bcl inhibitor and an mcl-1 inhibitor
US11872237B2 (en) 2018-12-28 2024-01-16 Ascentage Pharma (Suzhou) Co., Ltd. Pharmaceutical composition and preparation method thereof
EP4014040A4 (en) * 2019-08-15 2023-12-27 Mayo Foundation for Medical Education and Research METHODS AND MATERIALS FOR ASSESSMENT AND TREATMENT OF HYPERTENSIVE DISEASES
WO2021092061A1 (en) * 2019-11-08 2021-05-14 Unity Biotechnology, Inc. Combination treatment for senescence-associated diseases
CN113509475A (zh) * 2020-04-10 2021-10-19 苏州亚盛药业有限公司 Bcl-2/bcl-xl抑制剂的组合及相关用途
WO2022012481A1 (en) * 2020-07-13 2022-01-20 Ascentage Pharma (Suzhou) Co., Ltd. Crystalline or Amorphous form of Bcl-2/Bcl-xL inhibitor compound or its salts
CN114053288A (zh) * 2020-07-31 2022-02-18 苏州亚盛药业有限公司 肺部疾病治疗的组合物和方法
CN114073703B (zh) * 2020-08-21 2022-12-30 苏州亚盛药业有限公司 用于治疗非酒精性脂肪肝炎的组合物和方法
CN115837022B (zh) * 2023-02-20 2023-04-25 中山大学附属第八医院(深圳福田) 1,2,4三唑并4,3-b哒嗪衍生物在制备抗衰老药物中的应用

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CA2981753A1 (en) 2016-08-11
CN108025006A (zh) 2018-05-11
AU2016215035A1 (en) 2017-09-28
US20200338097A1 (en) 2020-10-29
US20170266211A1 (en) 2017-09-21
EP3253387A1 (en) 2017-12-13
WO2016127135A1 (en) 2016-08-11
EP3253387A4 (en) 2018-12-19
JP2018508569A (ja) 2018-03-29

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