JP2018508513A5 - - Google Patents
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- Publication number
- JP2018508513A5 JP2018508513A5 JP2017545300A JP2017545300A JP2018508513A5 JP 2018508513 A5 JP2018508513 A5 JP 2018508513A5 JP 2017545300 A JP2017545300 A JP 2017545300A JP 2017545300 A JP2017545300 A JP 2017545300A JP 2018508513 A5 JP2018508513 A5 JP 2018508513A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- unsubstituted
- nhc
- alkyl
- nhnr
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562126010P | 2015-02-27 | 2015-02-27 | |
| US62/126,010 | 2015-02-27 | ||
| PCT/US2016/020126 WO2016138533A2 (en) | 2015-02-27 | 2016-02-29 | Small molecules that enable cartilage rejuvanation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018508513A JP2018508513A (ja) | 2018-03-29 |
| JP2018508513A5 true JP2018508513A5 (https=) | 2019-04-25 |
Family
ID=56789264
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017545300A Pending JP2018508513A (ja) | 2015-02-27 | 2016-02-29 | 軟骨若返りを可能とする小分子 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US11072592B2 (https=) |
| EP (1) | EP3262040A4 (https=) |
| JP (1) | JP2018508513A (https=) |
| KR (1) | KR20170122788A (https=) |
| CN (1) | CN107531687A (https=) |
| AU (1) | AU2016224975B2 (https=) |
| CA (1) | CA2977401A1 (https=) |
| WO (1) | WO2016138533A2 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016138533A2 (en) | 2015-02-27 | 2016-09-01 | The Regents Of The University Of California | Small molecules that enable cartilage rejuvanation |
| EP3493803A4 (en) * | 2016-08-05 | 2020-04-22 | The Regents of The University of California | GP130 MODULATORS |
| KR20190058494A (ko) * | 2016-08-26 | 2019-05-29 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | 모낭 줄기 세포 활성화 및 모발 성장 |
| EP3758700B1 (en) | 2018-02-28 | 2024-07-31 | University of Southern California | Compositions for modulating inflammatory and degenerative disorders |
| CN112877283A (zh) * | 2021-02-10 | 2021-06-01 | 安徽农业大学 | 一种鸡原代软骨细胞分离培养及鉴定的方法 |
| CN114276999A (zh) * | 2022-03-03 | 2022-04-05 | 中日友好医院(中日友好临床医学研究所) | 黑素瘤细胞株及其制备方法 |
| EP4511378A4 (en) * | 2022-04-20 | 2026-03-11 | Carthronix Inc | GP130 Small Molecule Modulators for Signaling Channels |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4911920A (en) | 1986-07-30 | 1990-03-27 | Alcon Laboratories, Inc. | Sustained release, comfort formulation for glaucoma therapy |
| FR2588189B1 (fr) | 1985-10-03 | 1988-12-02 | Merck Sharp & Dohme | Composition pharmaceutique de type a transition de phase liquide-gel |
| ATE141502T1 (de) | 1991-01-15 | 1996-09-15 | Alcon Lab Inc | Verwendung von karrageenan in topischen ophthalmologischen zusammensetzungen |
| US5212162A (en) | 1991-03-27 | 1993-05-18 | Alcon Laboratories, Inc. | Use of combinations gelling polysaccharides and finely divided drug carrier substrates in topical ophthalmic compositions |
| US6309853B1 (en) | 1994-08-17 | 2001-10-30 | The Rockfeller University | Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof |
| AU2001237401B2 (en) | 2000-03-01 | 2006-11-09 | Janssen Pharmaceutica N.V. | 2,4-disubstituted thiazolyl derivatives |
| JP2002020286A (ja) | 2000-06-30 | 2002-01-23 | Sumitomo Pharmaceut Co Ltd | 骨・軟骨疾患治療剤 |
| KR100979988B1 (ko) * | 2001-08-13 | 2010-09-03 | 얀센 파마슈티카 엔.브이. | 2-아미노-4,5-삼치환 티아졸릴 유도체 |
| JP4847868B2 (ja) * | 2003-05-14 | 2011-12-28 | ニューロジェネティック ファーマシューティカルズ、 インコーポレイテッド | 化合物、及び、アミロイドベータの調節におけるその使用 |
| US8067608B2 (en) * | 2003-09-29 | 2011-11-29 | The Johns Hopkins University | Hedgehog pathway antagonists |
| ES2395952T3 (es) * | 2005-03-16 | 2013-02-18 | Toyama Chemical Co., Ltd. | Nuevo derivado del ácido antranílico o una sal del mismo |
| NZ563866A (en) | 2005-05-09 | 2011-03-31 | Achillion Pharmaceuticals Inc | Thiazole compounds and methods of use |
| AU2006258101A1 (en) * | 2005-06-09 | 2006-12-21 | Merck Sharp & Dohme Corp. | Inhibitors of checkpoint kinases |
| NZ566036A (en) * | 2005-09-13 | 2010-06-25 | Janssen Pharmaceutica Nv | 2-Aniline-4-aryl substituted thiazole derivatives that modulate the alpha7 nicotinic receptor |
| JP4882076B2 (ja) * | 2005-11-22 | 2012-02-22 | 国立大学法人 東京大学 | インターロイキン−６（ｉｌ−６）シグナル伝達阻害剤スクリーニング方法 |
| WO2007118149A2 (en) | 2006-04-07 | 2007-10-18 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical Lollege | Thiazole and thiophene analogues, and their use in treating autoimmune diseases and cancers |
| US8183263B2 (en) * | 2007-05-22 | 2012-05-22 | Achillion Pharmaceuticals, Inc. | Heteroaryl substituted thiazoles |
| US9315449B2 (en) * | 2008-05-15 | 2016-04-19 | Duke University | Substituted pyrazoles as heat shock transcription factor activators |
| WO2013056679A1 (en) * | 2011-10-21 | 2013-04-25 | Beijing Hanmi Pharmaceutical Co., Ltd | Novel heteroaryl-amino derivatives |
| CN103130792B (zh) * | 2011-11-30 | 2016-05-04 | 正大天晴药业集团股份有限公司 | 一种2-氨基噻唑类化合物 |
| JP6488239B2 (ja) | 2013-01-18 | 2019-03-20 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | Ｒｏｃｋ阻害剤としてのフタラジノンおよびイソキノリノン |
| US20150045353A1 (en) | 2013-08-09 | 2015-02-12 | Neurogenetic Pharmaceuticals, Inc. | Formulations containing gamma secretase modulators, methods for preparation and delivery thereof |
| WO2016138533A2 (en) | 2015-02-27 | 2016-09-01 | The Regents Of The University Of California | Small molecules that enable cartilage rejuvanation |
-
2016
- 2016-02-29 WO PCT/US2016/020126 patent/WO2016138533A2/en not_active Ceased
- 2016-02-29 EP EP16756554.8A patent/EP3262040A4/en not_active Withdrawn
- 2016-02-29 AU AU2016224975A patent/AU2016224975B2/en active Active
- 2016-02-29 CA CA2977401A patent/CA2977401A1/en not_active Abandoned
- 2016-02-29 JP JP2017545300A patent/JP2018508513A/ja active Pending
- 2016-02-29 CN CN201680024174.9A patent/CN107531687A/zh active Pending
- 2016-02-29 US US15/553,353 patent/US11072592B2/en active Active
- 2016-02-29 KR KR1020177027191A patent/KR20170122788A/ko not_active Withdrawn
-
2018
- 2018-12-07 US US16/213,958 patent/US11247974B2/en active Active
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