JP2018508513A5 - - Google Patents
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- Publication number
- JP2018508513A5 JP2018508513A5 JP2017545300A JP2017545300A JP2018508513A5 JP 2018508513 A5 JP2018508513 A5 JP 2018508513A5 JP 2017545300 A JP2017545300 A JP 2017545300A JP 2017545300 A JP2017545300 A JP 2017545300A JP 2018508513 A5 JP2018508513 A5 JP 2018508513A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- unsubstituted
- nhc
- alkyl
- nhnr
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000000217 alkyl group Chemical group 0.000 claims 63
- 229910052739 hydrogen Inorganic materials 0.000 claims 53
- 239000001257 hydrogen Substances 0.000 claims 53
- 229910052736 halogen Inorganic materials 0.000 claims 49
- 150000002367 halogens Chemical class 0.000 claims 49
- 150000002431 hydrogen Chemical class 0.000 claims 48
- 125000005343 heterocyclic alkyl group Chemical group 0.000 claims 46
- 125000001072 heteroaryl group Chemical group 0.000 claims 44
- 125000003118 aryl group Chemical group 0.000 claims 41
- 125000004404 heteroalkyl group Chemical group 0.000 claims 41
- 125000000753 cycloalkyl group Chemical group 0.000 claims 35
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 18
- 239000008194 pharmaceutical composition Substances 0.000 claims 17
- 150000001875 compounds Chemical class 0.000 claims 10
- 125000000623 heterocyclic group Chemical group 0.000 claims 6
- 125000005346 substituted cycloalkyl group Chemical group 0.000 claims 6
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 5
- 210000004027 cell Anatomy 0.000 claims 4
- 238000006243 chemical reaction Methods 0.000 claims 4
- 230000000694 effects Effects 0.000 claims 4
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 3
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 3
- 239000000460 chlorine Substances 0.000 claims 3
- 229910052801 chlorine Inorganic materials 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 229910052731 fluorine Inorganic materials 0.000 claims 3
- 239000011737 fluorine Substances 0.000 claims 3
- 229910052757 nitrogen Inorganic materials 0.000 claims 3
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 3
- 102000005962 receptors Human genes 0.000 claims 3
- 108020003175 receptors Proteins 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 125000001424 substituent group Chemical group 0.000 claims 3
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims 2
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims 2
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims 2
- 229910052794 bromium Inorganic materials 0.000 claims 2
- 239000011630 iodine Substances 0.000 claims 2
- 229910052740 iodine Inorganic materials 0.000 claims 2
- 239000000018 receptor agonist Substances 0.000 claims 2
- 229940044601 receptor agonist Drugs 0.000 claims 2
- 102200016458 rs104894274 Human genes 0.000 claims 2
- 102220060025 rs141586345 Human genes 0.000 claims 2
- 102200025788 rs179363875 Human genes 0.000 claims 2
- 102220024746 rs199473444 Human genes 0.000 claims 2
- 102200078752 rs201827340 Human genes 0.000 claims 2
- 102200084288 rs375181336 Human genes 0.000 claims 2
- 102200001405 rs377584435 Human genes 0.000 claims 2
- 239000000443 aerosol Substances 0.000 claims 1
- 206010003246 arthritis Diseases 0.000 claims 1
- 210000000845 cartilage Anatomy 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 210000001612 chondrocyte Anatomy 0.000 claims 1
- 239000011248 coating agent Substances 0.000 claims 1
- 238000000576 coating method Methods 0.000 claims 1
- 239000006071 cream Substances 0.000 claims 1
- 230000007850 degeneration Effects 0.000 claims 1
- 239000000839 emulsion Substances 0.000 claims 1
- 239000004744 fabric Substances 0.000 claims 1
- 239000000499 gel Substances 0.000 claims 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 claims 1
- 235000015110 jellies Nutrition 0.000 claims 1
- 239000008274 jelly Substances 0.000 claims 1
- 239000002674 ointment Substances 0.000 claims 1
- 239000006072 paste Substances 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
- 230000000699 topical effect Effects 0.000 claims 1
- 230000037317 transdermal delivery Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562126010P | 2015-02-27 | 2015-02-27 | |
| US62/126,010 | 2015-02-27 | ||
| PCT/US2016/020126 WO2016138533A2 (en) | 2015-02-27 | 2016-02-29 | Small molecules that enable cartilage rejuvanation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018508513A JP2018508513A (ja) | 2018-03-29 |
| JP2018508513A5 true JP2018508513A5 (OSRAM) | 2019-04-25 |
Family
ID=56789264
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017545300A Pending JP2018508513A (ja) | 2015-02-27 | 2016-02-29 | 軟骨若返りを可能とする小分子 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US11072592B2 (OSRAM) |
| EP (1) | EP3262040A4 (OSRAM) |
| JP (1) | JP2018508513A (OSRAM) |
| KR (1) | KR20170122788A (OSRAM) |
| CN (1) | CN107531687A (OSRAM) |
| AU (1) | AU2016224975B2 (OSRAM) |
| CA (1) | CA2977401A1 (OSRAM) |
| WO (1) | WO2016138533A2 (OSRAM) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2977401A1 (en) | 2015-02-27 | 2016-09-01 | The Regents Of The University Of California | Small molecules that enable cartilage rejuvenation |
| EP3493803A4 (en) * | 2016-08-05 | 2020-04-22 | The Regents of The University of California | GP130 MODULATORS |
| US10828289B2 (en) | 2016-08-26 | 2020-11-10 | The Regents Of The University Of California | Hair follicle stem cell activation and hair growth |
| EP3758700B1 (en) * | 2018-02-28 | 2024-07-31 | University of Southern California | Compositions for modulating inflammatory and degenerative disorders |
| CN112877283A (zh) * | 2021-02-10 | 2021-06-01 | 安徽农业大学 | 一种鸡原代软骨细胞分离培养及鉴定的方法 |
| CN114276999A (zh) * | 2022-03-03 | 2022-04-05 | 中日友好医院(中日友好临床医学研究所) | 黑素瘤细胞株及其制备方法 |
| EP4511378A1 (en) * | 2022-04-20 | 2025-02-26 | Carthronix, Inc. | Small molecule modulators of gp130 signaling pathways |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4911920A (en) | 1986-07-30 | 1990-03-27 | Alcon Laboratories, Inc. | Sustained release, comfort formulation for glaucoma therapy |
| FR2588189B1 (fr) | 1985-10-03 | 1988-12-02 | Merck Sharp & Dohme | Composition pharmaceutique de type a transition de phase liquide-gel |
| JP2594486B2 (ja) | 1991-01-15 | 1997-03-26 | アルコン ラボラトリーズ インコーポレイテッド | 局所的眼薬組成物 |
| US5212162A (en) | 1991-03-27 | 1993-05-18 | Alcon Laboratories, Inc. | Use of combinations gelling polysaccharides and finely divided drug carrier substrates in topical ophthalmic compositions |
| US6309853B1 (en) | 1994-08-17 | 2001-10-30 | The Rockfeller University | Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof |
| US7105550B2 (en) | 2000-03-01 | 2006-09-12 | Christopher Love | 2,4-disubstituted thiazolyl derivatives |
| JP2002020286A (ja) | 2000-06-30 | 2002-01-23 | Sumitomo Pharmaceut Co Ltd | 骨・軟骨疾患治療剤 |
| NZ530950A (en) * | 2001-08-13 | 2006-03-31 | Janssen Pharmaceutica Nv | 2-amino-4,5-trisubstituted thiazolyl derivatives and their use against autoimmune diseases |
| MXPA05012281A (es) * | 2003-05-14 | 2006-05-19 | Torreypines Therapeutics Inc | Compuestos y uso de los mismos en la modulacion beta amiloide. |
| US8067608B2 (en) * | 2003-09-29 | 2011-11-29 | The Johns Hopkins University | Hedgehog pathway antagonists |
| CA2602609A1 (en) * | 2005-03-16 | 2006-09-21 | Junichi Yokotani | Novel anthranilic acid derivative or salt thereof |
| WO2006122011A2 (en) * | 2005-05-09 | 2006-11-16 | Achillion Pharmaceuticals, Inc. | Thiazole compounds and methods of use |
| EP1893607A4 (en) * | 2005-06-09 | 2010-07-21 | Merck Sharp & Dohme | CHECKPOINT KINASE INHIBITORS |
| ES2632940T3 (es) * | 2005-09-13 | 2017-09-18 | Janssen Pharmaceutica Nv | Derivados de tiazol sustituidos con 2-anilin-4-arilo |
| JP4882076B2 (ja) * | 2005-11-22 | 2012-02-22 | 国立大学法人 東京大学 | インターロイキン−６（ｉｌ−６）シグナル伝達阻害剤スクリーニング方法 |
| US8217037B2 (en) * | 2006-04-07 | 2012-07-10 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Thiazole and thiophene analogues, and their use in treating autoimmune diseases and cancers |
| US8183263B2 (en) | 2007-05-22 | 2012-05-22 | Achillion Pharmaceuticals, Inc. | Heteroaryl substituted thiazoles |
| US9315449B2 (en) * | 2008-05-15 | 2016-04-19 | Duke University | Substituted pyrazoles as heat shock transcription factor activators |
| WO2013056679A1 (en) * | 2011-10-21 | 2013-04-25 | Beijing Hanmi Pharmaceutical Co., Ltd | Novel heteroaryl-amino derivatives |
| CN103130792B (zh) * | 2011-11-30 | 2016-05-04 | 正大天晴药业集团股份有限公司 | 一种2-氨基噻唑类化合物 |
| JP6488239B2 (ja) * | 2013-01-18 | 2019-03-20 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | Ｒｏｃｋ阻害剤としてのフタラジノンおよびイソキノリノン |
| US20150045353A1 (en) | 2013-08-09 | 2015-02-12 | Neurogenetic Pharmaceuticals, Inc. | Formulations containing gamma secretase modulators, methods for preparation and delivery thereof |
| CA2977401A1 (en) | 2015-02-27 | 2016-09-01 | The Regents Of The University Of California | Small molecules that enable cartilage rejuvenation |
-
2016
- 2016-02-29 CA CA2977401A patent/CA2977401A1/en not_active Abandoned
- 2016-02-29 EP EP16756554.8A patent/EP3262040A4/en not_active Withdrawn
- 2016-02-29 AU AU2016224975A patent/AU2016224975B2/en active Active
- 2016-02-29 JP JP2017545300A patent/JP2018508513A/ja active Pending
- 2016-02-29 WO PCT/US2016/020126 patent/WO2016138533A2/en not_active Ceased
- 2016-02-29 CN CN201680024174.9A patent/CN107531687A/zh active Pending
- 2016-02-29 KR KR1020177027191A patent/KR20170122788A/ko not_active Withdrawn
- 2016-02-29 US US15/553,353 patent/US11072592B2/en active Active
-
2018
- 2018-12-07 US US16/213,958 patent/US11247974B2/en active Active
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