JP2018504122A - 免疫調節特性が増加した細胞ならびにその使用および製造のための方法 - Google Patents

免疫調節特性が増加した細胞ならびにその使用および製造のための方法 Download PDF

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JP2018504122A
JP2018504122A JP2017539018A JP2017539018A JP2018504122A JP 2018504122 A JP2018504122 A JP 2018504122A JP 2017539018 A JP2017539018 A JP 2017539018A JP 2017539018 A JP2017539018 A JP 2017539018A JP 2018504122 A JP2018504122 A JP 2018504122A
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cells
population
pge
cell
hematopoietic
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JP2018504122A5 (enExample
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デイビッド ロビンス,
デイビッド ロビンス,
ベッツィー レズナー,
ベッツィー レズナー,
リー ミッチェル,
リー ミッチェル,
リサ ゲレタズ,
リサ ゲレタズ,
フィリップ アレサンドロ パロネ,
フィリップ アレサンドロ パロネ,
ロバート スティーブン タケ,
ロバート スティーブン タケ,
ケビン ライ,
ケビン ライ,
バーラム バラマール,
バーラム バラマール,
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フェイト セラピューティクス,インコーポレイテッド
フェイト セラピューティクス,インコーポレイテッド
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Publication of JP2018504122A publication Critical patent/JP2018504122A/ja
Publication of JP2018504122A5 publication Critical patent/JP2018504122A5/ja
Priority to JP2020201293A priority Critical patent/JP7304844B2/ja
Priority to JP2023025696A priority patent/JP2023062155A/ja
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JP2017539018A 2015-01-26 2016-01-26 免疫調節特性が増加した細胞ならびにその使用および製造のための方法 Withdrawn JP2018504122A (ja)

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JP2020201293A JP7304844B2 (ja) 2015-01-26 2020-12-03 免疫調節特性が増加した細胞ならびにその使用および製造のための方法
JP2023025696A JP2023062155A (ja) 2015-01-26 2023-02-22 免疫調節特性が増加した細胞ならびにその使用および製造のための方法

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US201562107517P 2015-01-26 2015-01-26
US62/107,517 2015-01-26
US201562112653P 2015-02-06 2015-02-06
US62/112,653 2015-02-06
PCT/US2016/014942 WO2016123117A1 (en) 2015-01-26 2016-01-26 Cells with increased immuno-regulatory properties and methods for their use and manufacture

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JP2020201294A Division JP2021050220A (ja) 2015-01-26 2020-12-03 免疫調節特性が増加した細胞ならびにその使用および製造のための方法

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JP2020201293A Active JP7304844B2 (ja) 2015-01-26 2020-12-03 免疫調節特性が増加した細胞ならびにその使用および製造のための方法
JP2020201294A Pending JP2021050220A (ja) 2015-01-26 2020-12-03 免疫調節特性が増加した細胞ならびにその使用および製造のための方法
JP2023010327A Pending JP2023052658A (ja) 2015-01-26 2023-01-26 免疫調節特性が増加した細胞ならびにその使用および製造のための方法
JP2023025696A Pending JP2023062155A (ja) 2015-01-26 2023-02-22 免疫調節特性が増加した細胞ならびにその使用および製造のための方法

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JP2020201294A Pending JP2021050220A (ja) 2015-01-26 2020-12-03 免疫調節特性が増加した細胞ならびにその使用および製造のための方法
JP2023010327A Pending JP2023052658A (ja) 2015-01-26 2023-01-26 免疫調節特性が増加した細胞ならびにその使用および製造のための方法
JP2023025696A Pending JP2023062155A (ja) 2015-01-26 2023-02-22 免疫調節特性が増加した細胞ならびにその使用および製造のための方法

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US (6) US20180112180A1 (enExample)
EP (2) EP3250682A4 (enExample)
JP (5) JP2018504122A (enExample)
CN (2) CN112481211B (enExample)
AU (3) AU2016211688A1 (enExample)
CA (1) CA2974903A1 (enExample)
WO (1) WO2016123117A1 (enExample)

Cited By (2)

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Publication number Priority date Publication date Assignee Title
JP2022512658A (ja) * 2018-10-10 2022-02-07 ノース カロライナ ステート ユニバーシティ Pd-l1提示血小板は、新たに発症する1型糖尿病を逆転させる
JP2022539249A (ja) * 2019-07-05 2022-09-07 ケース ウェスタン リザーブ ユニバーシティ 幹細胞培養及び幹細胞治療用プライム化培地及びプライム化方法

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US10626372B1 (en) 2015-01-26 2020-04-21 Fate Therapeutics, Inc. Methods and compositions for inducing hematopoietic cell differentiation
BR112018001232A2 (pt) 2015-07-21 2018-09-25 The Children's Medical Center Corporation pd-l1 que expressa células-tronco hematopoéticas e usos
CN122146606A (zh) 2015-11-04 2026-06-05 菲特治疗公司 用于诱导造血细胞分化的方法和组合物
US12642852B1 (en) 2015-11-04 2026-06-02 Fate Therapeutics, Inc. Genomic engineering of pluripotent cells
JP7653759B2 (ja) 2016-01-20 2025-03-31 フェイト セラピューティクス,インコーポレイテッド 養子免疫療法における免疫細胞調節のための組成物および方法
AU2017210031C1 (en) 2016-01-20 2020-11-26 Fate Therapeutics, Inc. Compositions and methods for immune cell modulation in adoptive immunotherapies
EP4538365A3 (en) 2016-03-04 2025-07-30 The Board Of Trustees Of The Leland Stanford Junior University Compositions and methods for muscle regeneration using prostaglandin e2
US11932870B2 (en) 2016-12-05 2024-03-19 Fate Therapeutics, Inc. Compositions and methods for immune cell modulation in adoptive immunotherapies
GB2578539B (en) 2017-06-09 2022-08-10 Univ Leland Stanford Junior Compositions and methods for preventing or treating muscle conditions
WO2019060708A1 (en) 2017-09-22 2019-03-28 The Children's Medical Center Corporation TREATMENT OF TYPE 1 DIABETES AND AUTOIMMUNE DISEASES OR DISORDERS
CN107714717A (zh) * 2017-10-11 2018-02-23 刘志强 聚肌胞苷酸在制备治疗或预防结肠炎的药物中的应用
WO2019158712A1 (en) * 2018-02-16 2019-08-22 Nextcell Pharma Ab Allogeneic composition
MX2021004140A (es) * 2018-10-12 2021-08-05 Salk Inst For Biological Studi Celulas, isletas y organoides que evaden la deteccion inmunitaria y la autoinmunidad, metodos de produccion y usos de los mismos.
CN109706180A (zh) * 2019-01-11 2019-05-03 杭州荣泽生物科技有限公司 一种脐带间充质干细胞过表达ido增强免疫抑制的方法及应用
CA3128871A1 (en) * 2019-02-09 2020-08-13 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Genetically modified hematopoietic stem and progenitor cells (hspcs) and mesenchymal cells as a platform to reduce or prevent metastasis, treat autoimmune and inflammatory disorders, and rebalance the immune milieu_and dysregulated niches
WO2021167770A1 (en) * 2020-02-18 2021-08-26 Octagon Therapeutics, Inc. Immune cell modulators
US20240024361A1 (en) * 2020-06-26 2024-01-25 The Children's Medical Center Corporation Methods and compositions for treating multiple sclerosis
US20230270085A1 (en) * 2020-07-08 2023-08-31 The Jackson Laboratory Transgenic mouse model expressing human hla-a201 restriction gene
WO2022202352A1 (ja) 2021-03-24 2022-09-29 キヤノン株式会社 虚像光学系、それを備える虚像表示装置及び車載システム
KR20220162394A (ko) * 2021-06-01 2022-12-08 에스씨엠생명과학 주식회사 기능강화 줄기세포 및 조절 t 세포를 포함하는 아토피 피부염 예방 또는 치료용 병용투여 조성물
WO2025043075A1 (en) * 2023-08-24 2025-02-27 The Johns Hopkins University Methods of treating myocardial infarction, ischemia, and ischemia reperfusion injury
WO2025199431A1 (en) * 2024-03-22 2025-09-25 Colorado State University Research Foundation Innate immune pathway activated mesenchymal stromal cells for treatment of musculoskeletal disorders or conditions

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010508818A (ja) * 2006-11-03 2010-03-25 アストロム バイオサイエンシーズ, インコーポレイテッド 組織修復のための混合細胞集団および細胞処理のための単離技術
US20140234373A1 (en) * 2011-09-16 2014-08-21 Georfia Regents University Methods of Promoting Immune Tolerance

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US5061620A (en) 1990-03-30 1991-10-29 Systemix, Inc. Human hematopoietic stem cell
US5635387A (en) 1990-04-23 1997-06-03 Cellpro, Inc. Methods and device for culturing human hematopoietic cells and their precursors
US5460964A (en) 1992-04-03 1995-10-24 Regents Of The University Of Minnesota Method for culturing hematopoietic cells
US5409813A (en) 1993-09-30 1995-04-25 Systemix, Inc. Method for mammalian cell separation from a mixture of cell populations
US5677136A (en) 1994-11-14 1997-10-14 Systemix, Inc. Methods of obtaining compositions enriched for hematopoietic stem cells, compositions derived therefrom and methods of use thereof
US5854033A (en) 1995-11-21 1998-12-29 Yale University Rolling circle replication reporter systems
AU2183900A (en) 1998-12-24 2000-07-31 Alcon Laboratories, Inc. Ep4 receptor agonists for treatment of dry eye
ATE327751T1 (de) 2000-01-31 2006-06-15 Pfizer Prod Inc Verwendung von aktivatoren des prostaglandinrezeptores 4 zur behandlung von akuter oder chronischer niereninsuffizienz
US20020013294A1 (en) 2000-03-31 2002-01-31 Delong Mitchell Anthony Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives
US20060292618A1 (en) * 2002-04-12 2006-12-28 Mellor Andrew L Antigen-presenting cell populations and their use as reagents for enhancing or reducing immune tolerance
EP1501918A4 (en) * 2002-04-12 2006-03-29 Med College Georgia Res Inst ANTIGEN PRESENTING CELL POPULATIONS AND THEIR USE AS REAGENTS TO INCREASE OR REDUCE IMMUNO TOLERANCE
US6747037B1 (en) 2003-06-06 2004-06-08 Allergan, Inc. Piperidinyl prostaglandin E analogs
WO2005040391A1 (en) 2003-10-27 2005-05-06 Murdoch Childrens Research Institute Compositions and methods for differentiating stem cells
WO2005047524A2 (en) 2003-11-10 2005-05-26 The Scripps Research Institute Compositions and methods for inducing cell dedifferentiation
US7682828B2 (en) 2003-11-26 2010-03-23 Whitehead Institute For Biomedical Research Methods for reprogramming somatic cells
DE102005062741A1 (de) 2005-12-22 2007-06-28 Bayer Schering Pharma Ag Fluorene und Carbazole als Liganden des EP2 Rezeptors
MX348010B (es) 2007-04-07 2017-05-23 Whitehead Inst Biomedical Res Reprogramacion de celulas somaticas.
EP2578677A1 (en) * 2007-08-09 2013-04-10 Genzyme Corporation Method of treating autoimmune disease with mesenchymal stem cells
WO2009032194A1 (en) 2007-08-31 2009-03-12 Whitehead Institute For Biomedical Research Wnt pathway stimulation in reprogramming somatic cells
JP5951254B2 (ja) 2008-03-17 2016-07-13 ザ スクリプス リサーチ インスティテュート 人工多能性幹細胞を作製するための化学的手法と遺伝的手法の組み合わせ法
MX340972B (es) * 2008-10-08 2016-08-02 Intrexon Corp Celulas manipuladas por ingenieria que expresan multiples inmunomoduladores, y uso de las mismas.
EP3031907B1 (en) 2008-11-06 2021-01-06 Indiana University Research and Technology Corporation Materials and methods to enhance hematopoietic stem cells engraftment procedures
SG172160A1 (en) 2008-12-17 2011-07-28 Scripps Research Inst Generation and maintenance of stem cells
EP3533445A1 (en) 2009-03-19 2019-09-04 Fate Therapeutics, Inc. Compositions comprising cyclic amp enhancers and/or ep ligands, and methods of preparing and using the same
EP2456786B2 (en) * 2009-07-24 2017-04-19 Immune Design Corp Lentiviral vectors pseudotyped with a sindbis virus envelope glycoprotein
MX389666B (es) 2009-10-16 2025-03-19 Scripps Research Inst Induccion de celulas pluripotentes.
CA2780572A1 (en) * 2009-11-13 2011-05-19 The United States Of America, As Represented By The Secretary, Departmen T Of Health And Human Services Modulated programmed death ligand-1
DK2510084T3 (da) * 2009-12-08 2020-04-27 The Board Of Trustees Of The Univ Of Illionis Stamcelleimmunmoduleringsanvendelsesfremgangsmåder og apparat
EP2550359B1 (en) * 2010-03-23 2017-08-09 Intrexon Corporation Vectors conditionally expressing therapeutic proteins, host cells comprising the vectors, and uses thereof
CN103119054B (zh) * 2010-03-26 2017-01-18 达特茅斯大学理事会 Vista调节性t细胞介体蛋白、vista结合剂及其用途
CN103167876B (zh) * 2010-08-12 2016-08-31 菲特治疗公司 改进的造血干细胞和祖细胞疗法
CN104066837B (zh) * 2011-12-02 2020-12-08 菲特治疗公司 增强的干细胞组合物
US20150139994A1 (en) * 2013-11-12 2015-05-21 The Regents Of The University Of California Compositions and methods for preventing allogeneic immune rejection
BR112018001232A2 (pt) * 2015-07-21 2018-09-25 The Children's Medical Center Corporation pd-l1 que expressa células-tronco hematopoéticas e usos

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010508818A (ja) * 2006-11-03 2010-03-25 アストロム バイオサイエンシーズ, インコーポレイテッド 組織修復のための混合細胞集団および細胞処理のための単離技術
US20140234373A1 (en) * 2011-09-16 2014-08-21 Georfia Regents University Methods of Promoting Immune Tolerance

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
CELL STEM CELL, vol. 9, JPN6019042815, 2011, pages 119 - 130, ISSN: 0004318676 *
EXPERIMENTAL AND MOLECULAR MEDICINE, vol. 43, no. 8, JPN6019042819, 2011, pages 446 - 454, ISSN: 0004318678 *
IMMUNOBIOLOGY, vol. 215, JPN6019042812, 2010, pages 452 - 457, ISSN: 0004318675 *
JOURNAL OF LEUKOCYTE BIOLOGY, vol. 88, JPN6019042817, 2010, pages 1241 - 1249, ISSN: 0004318677 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022512658A (ja) * 2018-10-10 2022-02-07 ノース カロライナ ステート ユニバーシティ Pd-l1提示血小板は、新たに発症する1型糖尿病を逆転させる
JP2022539249A (ja) * 2019-07-05 2022-09-07 ケース ウェスタン リザーブ ユニバーシティ 幹細胞培養及び幹細胞治療用プライム化培地及びプライム化方法
JP7668781B2 (ja) 2019-07-05 2025-04-25 ケース ウェスタン リザーブ ユニバーシティ 幹細胞培養及び幹細胞治療用プライム化培地及びプライム化方法
JP2025108591A (ja) * 2019-07-05 2025-07-23 ケース ウェスタン リザーブ ユニバーシティ 幹細胞培養及び幹細胞治療用プライム化培地及びプライム化方法

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