JP2018503691A5 - - Google Patents
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- Publication number
- JP2018503691A5 JP2018503691A5 JP2017558605A JP2017558605A JP2018503691A5 JP 2018503691 A5 JP2018503691 A5 JP 2018503691A5 JP 2017558605 A JP2017558605 A JP 2017558605A JP 2017558605 A JP2017558605 A JP 2017558605A JP 2018503691 A5 JP2018503691 A5 JP 2018503691A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- uric acid
- purine
- dihydro
- chloro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- LEHOTFFKMJEONL-UHFFFAOYSA-N Uric Acid Chemical compound N1C(=O)NC(=O)C2=C1NC(=O)N2 LEHOTFFKMJEONL-UHFFFAOYSA-N 0.000 claims description 18
- TVWHNULVHGKJHS-UHFFFAOYSA-N Uric acid Natural products N1C(=O)NC(=O)C2NC(=O)NC21 TVWHNULVHGKJHS-UHFFFAOYSA-N 0.000 claims description 18
- 229940116269 uric acid Drugs 0.000 claims description 18
- 201000005569 Gout Diseases 0.000 claims description 7
- 150000001875 compounds Chemical class 0.000 claims description 7
- 201000001431 Hyperuricemia Diseases 0.000 claims description 6
- 206010046337 Urate nephropathy Diseases 0.000 claims description 5
- 239000008194 pharmaceutical composition Substances 0.000 claims description 5
- 206010061218 Inflammation Diseases 0.000 claims description 4
- 230000004054 inflammatory process Effects 0.000 claims description 4
- 208000002193 Pain Diseases 0.000 claims description 3
- 150000003839 salts Chemical class 0.000 claims description 3
- 239000012453 solvate Substances 0.000 claims description 3
- 230000002485 urinary effect Effects 0.000 claims description 2
- 201000010099 disease Diseases 0.000 claims 13
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 13
- 239000003814 drug Substances 0.000 claims 9
- 229940124597 therapeutic agent Drugs 0.000 claims 9
- 230000000069 prophylactic effect Effects 0.000 claims 7
- 125000004093 cyano group Chemical group *C#N 0.000 claims 6
- 125000005843 halogen group Chemical group 0.000 claims 6
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 claims 4
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 4
- CGAMDQCXAAOFSR-UHFFFAOYSA-N 8-chloro-3-pentyl-7h-purine-2,6-dione Chemical compound O=C1NC(=O)N(CCCCC)C2=C1NC(Cl)=N2 CGAMDQCXAAOFSR-UHFFFAOYSA-N 0.000 claims 4
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical class [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 4
- 229910052739 hydrogen Inorganic materials 0.000 claims 4
- 239000001257 hydrogen Substances 0.000 claims 4
- 125000001972 isopentyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])C([H])([H])* 0.000 claims 3
- IXKIATZUIFUKIE-UHFFFAOYSA-N 3-butyl-8-chloro-1-methyl-7h-purine-2,6-dione Chemical compound O=C1N(C)C(=O)N(CCCC)C2=C1NC(Cl)=N2 IXKIATZUIFUKIE-UHFFFAOYSA-N 0.000 claims 2
- IWPBNHSYRXVLEI-UHFFFAOYSA-N 3-butyl-8-chloro-7h-purine-2,6-dione Chemical compound O=C1NC(=O)N(CCCC)C2=C1NC(Cl)=N2 IWPBNHSYRXVLEI-UHFFFAOYSA-N 0.000 claims 2
- IRKQPAMTLHYJDE-UHFFFAOYSA-N 8-chloro-1-methyl-3-pentyl-7h-purine-2,6-dione Chemical compound O=C1N(C)C(=O)N(CCCCC)C2=C1NC(Cl)=N2 IRKQPAMTLHYJDE-UHFFFAOYSA-N 0.000 claims 2
- GCRUYCXLSLIMAO-UHFFFAOYSA-N 8-chloro-3-(2-methylpropyl)-7H-purine-2,6-dione Chemical compound ClC1=NC=2N(C(NC(C=2N1)=O)=O)CC(C)C GCRUYCXLSLIMAO-UHFFFAOYSA-N 0.000 claims 2
- NCLSUDNPUAQNGG-UHFFFAOYSA-N 8-chloro-3-(3-methylbutyl)-7h-purine-2,6-dione Chemical compound O=C1NC(=O)N(CCC(C)C)C2=C1NC(Cl)=N2 NCLSUDNPUAQNGG-UHFFFAOYSA-N 0.000 claims 2
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 2
- 230000001154 acute effect Effects 0.000 claims 2
- 125000000304 alkynyl group Chemical group 0.000 claims 2
- 206010003246 arthritis Diseases 0.000 claims 2
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 2
- 229910052801 chlorine Inorganic materials 0.000 claims 2
- 125000001309 chloro group Chemical group Cl* 0.000 claims 2
- 230000001684 chronic effect Effects 0.000 claims 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
- 229910052731 fluorine Inorganic materials 0.000 claims 2
- 125000001153 fluoro group Chemical group F* 0.000 claims 2
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 125000001147 pentyl group Chemical group C(CCCC)* 0.000 claims 2
- 230000003449 preventive effect Effects 0.000 claims 2
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 2
- IQAOHTRPZVQICW-UHFFFAOYSA-N 8-chloro-1-methyl-3-(3-methylbutyl)-7H-purine-2,6-dione Chemical compound ClC1=NC=2N(C(N(C(C=2N1)=O)C)=O)CCC(C)C IQAOHTRPZVQICW-UHFFFAOYSA-N 0.000 claims 1
- 206010018634 Gouty Arthritis Diseases 0.000 claims 1
- 201000001509 acute urate nephropathy Diseases 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 238000007920 subcutaneous administration Methods 0.000 claims 1
- 208000026101 uric acid urolithiasis Diseases 0.000 claims 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000002253 acid Substances 0.000 description 1
- 208000017169 kidney disease Diseases 0.000 description 1
- -1 xanthine derivative compound Chemical class 0.000 description 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510048096 | 2015-01-30 | ||
| CN201510048096.3 | 2015-01-30 | ||
| CN201510080714.2 | 2015-02-13 | ||
| CN201510079809 | 2015-02-13 | ||
| CN201510079809.2 | 2015-02-13 | ||
| CN201510080714 | 2015-02-13 | ||
| CN201510216089.X | 2015-04-30 | ||
| CN201510216089 | 2015-04-30 | ||
| PCT/CN2016/000061 WO2016119570A1 (zh) | 2015-01-30 | 2016-01-28 | 尿酸性或痛风性疾病的预防或治疗 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018503691A JP2018503691A (ja) | 2018-02-08 |
| JP2018503691A5 true JP2018503691A5 (https=) | 2019-03-07 |
| JP6678685B2 JP6678685B2 (ja) | 2020-04-08 |
Family
ID=56542370
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017558605A Active JP6678685B2 (ja) | 2015-01-30 | 2016-01-28 | 尿酸性または痛風性疾患の予防または治療 |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US10322132B2 (https=) |
| EP (1) | EP3251675B1 (https=) |
| JP (1) | JP6678685B2 (https=) |
| KR (1) | KR102128810B1 (https=) |
| CN (1) | CN107206002B (https=) |
| AU (1) | AU2016212625B2 (https=) |
| BR (1) | BR112017016065A2 (https=) |
| CA (1) | CA2973746C (https=) |
| CY (1) | CY1124383T1 (https=) |
| DK (1) | DK3251675T3 (https=) |
| EA (1) | EA034139B1 (https=) |
| ES (1) | ES2881872T3 (https=) |
| HR (1) | HRP20211007T1 (https=) |
| HU (1) | HUE054741T2 (https=) |
| IL (1) | IL253726B2 (https=) |
| LT (1) | LT3251675T (https=) |
| MA (1) | MA41431B1 (https=) |
| MX (1) | MX380301B (https=) |
| PL (1) | PL3251675T3 (https=) |
| PT (1) | PT3251675T (https=) |
| SG (2) | SG11201705889VA (https=) |
| SI (1) | SI3251675T1 (https=) |
| SM (1) | SMT202100359T1 (https=) |
| TW (1) | TWI680761B (https=) |
| WO (1) | WO2016119570A1 (https=) |
| ZA (1) | ZA201704600B (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12566174B2 (en) | 2017-05-11 | 2026-03-03 | The Research Foundation For The State University Of New York | Method and kit for determining the presence of monosodium urate crystals in joint synovial fluid |
| US20260035370A1 (en) | 2023-02-27 | 2026-02-05 | Shanton Pharma Pte. Ltd. | Crystal form of 8-chloro-3-pentyl-3,7-dihydro-1h-purin-2,6-dione compound and preparation method therefor |
| CN116650490B (zh) * | 2023-06-07 | 2025-05-20 | 中国人民解放军海军军医大学 | 化合物mt-1207在降低尿酸方面的应用 |
| EP4497439A1 (en) * | 2023-07-28 | 2025-01-29 | Universitat de les Illes Balears | Compounds for the treatment or prevention of gout |
| TWI902254B (zh) * | 2024-05-16 | 2025-10-21 | 新加坡商珊頓醫藥科技新加坡公司 | 化合物8-氯-3-戊基-3,7-二氫-1h-嘌呤-2,6-二酮的晶型及其製備方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8906792D0 (en) | 1989-03-23 | 1989-05-10 | Beecham Wuelfing Gmbh & Co Kg | Treatment and compounds |
| WO1993016699A1 (en) * | 1992-02-21 | 1993-09-02 | Smithkline Beecham Corporation | Tnf inhibitors |
| AR015966A1 (es) | 1997-10-17 | 2001-05-30 | Smithkline Beecham Corp | Uso de un compuesto inhibidor de pde4 para la preparacion de un medicamento util para el tratamiento de prurito |
| CN101103030B (zh) | 2004-02-14 | 2010-10-13 | 史密丝克莱恩比彻姆公司 | 具有hm74a受体活性的药物 |
| CN101479273B (zh) * | 2006-06-23 | 2011-11-30 | 英赛特股份有限公司 | 作为hm74a激动剂的嘌呤酮衍生物 |
| KR20090025262A (ko) * | 2006-06-23 | 2009-03-10 | 인사이트 코포레이션 | Ｈｍ７４ａ 아고니스트로서 푸리논 유도체 |
| WO2010071865A1 (en) | 2008-12-19 | 2010-06-24 | Nuon Therapeutics, Inc. | Pharmaceutical compositions and methods for treating hyperuricemia and related disorders |
| US20110136835A1 (en) * | 2009-09-14 | 2011-06-09 | Nuon Therapeutics, Inc. | Combination formulations of tranilast and allopurinol and methods related thereto |
| WO2011057110A1 (en) | 2009-11-06 | 2011-05-12 | Ruprecht-Karls-Universitat-Heidelberg | Gpr109a agonists for the treatment of cerebral ischemia |
-
2016
- 2016-01-28 CA CA2973746A patent/CA2973746C/en active Active
- 2016-01-28 KR KR1020177024392A patent/KR102128810B1/ko active Active
- 2016-01-28 SI SI201631264T patent/SI3251675T1/sl unknown
- 2016-01-28 DK DK16742632.9T patent/DK3251675T3/da active
- 2016-01-28 EA EA201791714A patent/EA034139B1/ru unknown
- 2016-01-28 SG SG11201705889VA patent/SG11201705889VA/en unknown
- 2016-01-28 SG SG10201907026RA patent/SG10201907026RA/en unknown
- 2016-01-28 PL PL16742632T patent/PL3251675T3/pl unknown
- 2016-01-28 EP EP16742632.9A patent/EP3251675B1/en active Active
- 2016-01-28 ES ES16742632T patent/ES2881872T3/es active Active
- 2016-01-28 SM SM20210359T patent/SMT202100359T1/it unknown
- 2016-01-28 AU AU2016212625A patent/AU2016212625B2/en active Active
- 2016-01-28 MA MA41431A patent/MA41431B1/fr unknown
- 2016-01-28 HU HUE16742632A patent/HUE054741T2/hu unknown
- 2016-01-28 BR BR112017016065-0A patent/BR112017016065A2/pt not_active Application Discontinuation
- 2016-01-28 LT LTEP16742632.9T patent/LT3251675T/lt unknown
- 2016-01-28 CN CN201680001581.8A patent/CN107206002B/zh active Active
- 2016-01-28 MX MX2017009853A patent/MX380301B/es unknown
- 2016-01-28 JP JP2017558605A patent/JP6678685B2/ja active Active
- 2016-01-28 US US15/512,412 patent/US10322132B2/en active Active
- 2016-01-28 HR HRP20211007TT patent/HRP20211007T1/hr unknown
- 2016-01-28 PT PT167426329T patent/PT3251675T/pt unknown
- 2016-01-28 WO PCT/CN2016/000061 patent/WO2016119570A1/zh not_active Ceased
- 2016-01-29 TW TW105102935A patent/TWI680761B/zh active
-
2017
- 2017-07-07 ZA ZA2017/04600A patent/ZA201704600B/en unknown
- 2017-07-30 IL IL253726A patent/IL253726B2/en unknown
-
2021
- 2021-06-22 CY CY20211100551T patent/CY1124383T1/el unknown
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