DK3251675T3 - Forebyggelse eller behandling af urinsyresygdom eller gigtsygdom - Google Patents

Forebyggelse eller behandling af urinsyresygdom eller gigtsygdom Download PDF

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Publication number
DK3251675T3
DK3251675T3 DK16742632.9T DK16742632T DK3251675T3 DK 3251675 T3 DK3251675 T3 DK 3251675T3 DK 16742632 T DK16742632 T DK 16742632T DK 3251675 T3 DK3251675 T3 DK 3251675T3
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DK
Denmark
Prior art keywords
disease
uricanic
prevention
treatment
arthritic
Prior art date
Application number
DK16742632.9T
Other languages
Danish (da)
English (en)
Inventor
Qian Zhang
Zhenhua Huang
Jinrong Liu
Shuangshuang Chi
Original Assignee
Shanton Pharma Pte Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shanton Pharma Pte Ltd filed Critical Shanton Pharma Pte Ltd
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Publication of DK3251675T3 publication Critical patent/DK3251675T3/da

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • A61K31/41881,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52Purines, e.g. adenine
    • A61K31/522Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/04Drugs for disorders of the urinary system for urolithiasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/06Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D473/00Heterocyclic compounds containing purine ring systems
    • C07D473/02Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D473/00Heterocyclic compounds containing purine ring systems
    • C07D473/02Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D473/00Heterocyclic compounds containing purine ring systems
    • C07D473/02Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • C07D473/08Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK16742632.9T 2015-01-30 2016-01-28 Forebyggelse eller behandling af urinsyresygdom eller gigtsygdom DK3251675T3 (da)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CN201510048096 2015-01-30
CN201510079809 2015-02-13
CN201510080714 2015-02-13
CN201510216089 2015-04-30
PCT/CN2016/000061 WO2016119570A1 (zh) 2015-01-30 2016-01-28 尿酸性或痛风性疾病的预防或治疗

Publications (1)

Publication Number Publication Date
DK3251675T3 true DK3251675T3 (da) 2021-06-28

Family

ID=56542370

Family Applications (1)

Application Number Title Priority Date Filing Date
DK16742632.9T DK3251675T3 (da) 2015-01-30 2016-01-28 Forebyggelse eller behandling af urinsyresygdom eller gigtsygdom

Country Status (26)

Country Link
US (1) US10322132B2 (https=)
EP (1) EP3251675B1 (https=)
JP (1) JP6678685B2 (https=)
KR (1) KR102128810B1 (https=)
CN (1) CN107206002B (https=)
AU (1) AU2016212625B2 (https=)
BR (1) BR112017016065A2 (https=)
CA (1) CA2973746C (https=)
CY (1) CY1124383T1 (https=)
DK (1) DK3251675T3 (https=)
EA (1) EA034139B1 (https=)
ES (1) ES2881872T3 (https=)
HR (1) HRP20211007T1 (https=)
HU (1) HUE054741T2 (https=)
IL (1) IL253726B2 (https=)
LT (1) LT3251675T (https=)
MA (1) MA41431B1 (https=)
MX (1) MX380301B (https=)
PL (1) PL3251675T3 (https=)
PT (1) PT3251675T (https=)
SG (2) SG11201705889VA (https=)
SI (1) SI3251675T1 (https=)
SM (1) SMT202100359T1 (https=)
TW (1) TWI680761B (https=)
WO (1) WO2016119570A1 (https=)
ZA (1) ZA201704600B (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12566174B2 (en) 2017-05-11 2026-03-03 The Research Foundation For The State University Of New York Method and kit for determining the presence of monosodium urate crystals in joint synovial fluid
US20260035370A1 (en) 2023-02-27 2026-02-05 Shanton Pharma Pte. Ltd. Crystal form of 8-chloro-3-pentyl-3,7-dihydro-1h-purin-2,6-dione compound and preparation method therefor
CN116650490B (zh) * 2023-06-07 2025-05-20 中国人民解放军海军军医大学 化合物mt-1207在降低尿酸方面的应用
EP4497439A1 (en) * 2023-07-28 2025-01-29 Universitat de les Illes Balears Compounds for the treatment or prevention of gout
TWI902254B (zh) * 2024-05-16 2025-10-21 新加坡商珊頓醫藥科技新加坡公司 化合物8-氯-3-戊基-3,7-二氫-1h-嘌呤-2,6-二酮的晶型及其製備方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8906792D0 (en) 1989-03-23 1989-05-10 Beecham Wuelfing Gmbh & Co Kg Treatment and compounds
WO1993016699A1 (en) * 1992-02-21 1993-09-02 Smithkline Beecham Corporation Tnf inhibitors
AR015966A1 (es) 1997-10-17 2001-05-30 Smithkline Beecham Corp Uso de un compuesto inhibidor de pde4 para la preparacion de un medicamento util para el tratamiento de prurito
CN101103030B (zh) 2004-02-14 2010-10-13 史密丝克莱恩比彻姆公司 具有hm74a受体活性的药物
CN101479273B (zh) * 2006-06-23 2011-11-30 英赛特股份有限公司 作为hm74a激动剂的嘌呤酮衍生物
KR20090025262A (ko) * 2006-06-23 2009-03-10 인사이트 코포레이션 Hm74a 아고니스트로서 푸리논 유도체
WO2010071865A1 (en) 2008-12-19 2010-06-24 Nuon Therapeutics, Inc. Pharmaceutical compositions and methods for treating hyperuricemia and related disorders
US20110136835A1 (en) * 2009-09-14 2011-06-09 Nuon Therapeutics, Inc. Combination formulations of tranilast and allopurinol and methods related thereto
WO2011057110A1 (en) 2009-11-06 2011-05-12 Ruprecht-Karls-Universitat-Heidelberg Gpr109a agonists for the treatment of cerebral ischemia

Also Published As

Publication number Publication date
JP6678685B2 (ja) 2020-04-08
ZA201704600B (en) 2020-07-29
SG11201705889VA (en) 2017-08-30
ES2881872T3 (es) 2021-11-30
LT3251675T (lt) 2021-07-12
PT3251675T (pt) 2021-05-25
CN107206002B (zh) 2019-07-16
WO2016119570A1 (zh) 2016-08-04
MA41431A (fr) 2017-12-06
CN107206002A (zh) 2017-09-26
AU2016212625A1 (en) 2017-07-27
EA201791714A1 (ru) 2017-11-30
BR112017016065A2 (pt) 2018-04-03
SI3251675T1 (sl) 2021-08-31
HK1244434A1 (zh) 2018-08-10
TW201628623A (zh) 2016-08-16
IL253726A0 (en) 2017-09-28
JP2018503691A (ja) 2018-02-08
CA2973746C (en) 2020-03-24
HK1245146A1 (en) 2018-08-24
HRP20211007T1 (hr) 2021-09-17
EP3251675B1 (en) 2021-04-21
MX2017009853A (es) 2017-11-01
EP3251675A1 (en) 2017-12-06
MX380301B (es) 2025-03-12
US10322132B2 (en) 2019-06-18
SMT202100359T1 (it) 2021-07-12
HUE054741T2 (hu) 2021-09-28
US20170326148A1 (en) 2017-11-16
MA41431B1 (fr) 2021-05-31
KR102128810B1 (ko) 2020-07-02
TWI680761B (zh) 2020-01-01
AU2016212625B2 (en) 2020-03-26
EA034139B1 (ru) 2020-01-09
SG10201907026RA (en) 2019-09-27
IL253726B1 (en) 2023-03-01
IL253726B2 (en) 2023-07-01
CY1124383T1 (el) 2022-07-22
CA2973746A1 (en) 2016-08-04
PL3251675T3 (pl) 2021-11-02
KR20170106485A (ko) 2017-09-20
EP3251675A4 (en) 2018-06-20

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