JP2018503599A - 体重を管理するための乳清タンパク質ミセルとペクチンの複合体の使用 - Google Patents
体重を管理するための乳清タンパク質ミセルとペクチンの複合体の使用 Download PDFInfo
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Abstract
Description
タンパク質4重量%、pH5.89の乳清タンパク質分離物(Prolacta 90)の分散液を85℃/15分で熱処理し、精密濾過により総固形分22重量%まで濃縮し、噴霧乾燥して、乳清タンパク質ミセル粉末(WPM)を調製した。
表面電荷
粒子の電気泳動移動度に対応する表面電荷(ゼータ(ζ)電位)を粒子移動度分布計(Zetasizer Nanoseries、Malvern,UK)を用いて測定した。1M HCl及びNaOHの滴定液を用いる多目的滴定装置(MPT2、Malvern)を使用して、増分0.5及びpH精度目標0.3で、pHを8から2まで変化させた。セルDTS1060Cを使用し、25℃で測定を行った。15mLの0.1重量%溶液を用いた。データ処理は自動で行った。
Mastersizer Sロングベンチ(Malvern,UK)による多角度静的光散乱を使用して、粒径分布を測定した。分散相の屈折率1.36、連続相の屈折率1.33及び後方散乱係数0.1(3JHD表示)を計算に使用した。残りの値は常に1.5未満であった。使用した分散相の屈折率及び数学モデル(粒子は球状であると仮定)の任意選択を考慮すると、本測定値は、粒径の定量的測定ではなく、系の凝集の定性的指標のみを提供する。
I.WPM/ペクチン静電的複合体の形成を可能にするpH条件の特定
WPM及びペクチンの表面電荷(ゼータ電位)をpHとの関数として図1に示す。pHが2から8に上がるにつれて、ペクチンのゼータ電位は、中性から−45mVに下がった。この変化は、ペクチン主鎖上のカルボキシル基に関係する可能性があり、低いpHでは、これらの基が中和されて、ゼータ電位値がゼロに近づいた。WPMの場合、ゼータ電位は、pH2からpH3.8で20mVから40mVまで変化し、pH8で−45mVまで減少し、pH4.6で電気的中性が測定された。後者は、WPMの主要構成タンパク質であるβ−ラクトグロブリンの等電点に関係する可能性がある。
WPMへのペクチンの添加によって生じる変化を評価するために、粒径分布を測定した。図2及び3は、WPM:ペクチンの重量比が10:1〜1:1に相当する、1重量%のWPMを含み、ペクチンの量を0.1重量%から1重量%まで増加させた系について得られた結果を示す。
発明者らは、健康なミニブタにおける無作為化二重盲検交差試験にて、血漿アミノ酸濃度の食後応答を観察した。2つの食事の間には少なくとも6日のウォッシュアウト期間を設け、この間は通常の食餌をミニブタに与えた。
Claims (15)
- 肥満又は過体重の治療又は予防における使用のための、乳清タンパク質ミセルとペクチンの複合体を含む組成物であって、前記組成物における乳清タンパク質ミセルのペクチンに対する重量比は、30:1〜0.8:1であり、前記乳清タンパク質ミセルは、乳清タンパク質水溶液のpHを3.0〜8.0の間の値に調節し、前記水溶液を80〜98℃の間の温度に供することによって得ることができる、組成物。
- 前記組成物が食事と組み合わせて投与される、請求項1に記載の使用のための組成物。
- 前記食事が、乳清タンパク質分離物、天然若しくは加水分解された乳タンパク質、遊離アミノ酸又はこれらの組み合わせを含む、請求項2に記載の使用のための組成物。
- 前記組成物が子供又は大人のヒトに投与される、請求項1〜3のいずれか一項に記載の使用のための組成物。
- 前記組成物がペットに投与される、請求項1〜4のいずれか一項に記載の使用のための組成物。
- 前記組成物が1kg体重あたり0.1g〜2.0gの乾燥重量の乳清タンパク質ミセル及びペクチンを供給するような一日量で投与される、請求項1〜5のいずれか一項に記載の使用のための組成物。
- 前記組成物が飲料、栄養組成物、バー、フレークの形態又はペレット状である、請求項1〜6のいずれか一項に記載の使用のための組成物。
- 前記組成物が経口栄養補助食品である、請求項1〜7のいずれか一項に記載の使用のための組成物。
- 前記組成物が熱処理した液体である、請求項1〜8のいずれか一項に記載の使用のための組成物。
- 前記組成物が流動性食事代替物である、請求項1〜9のいずれか一項に記載の使用のための組成物。
- 前記流動性食事代替物が経腸経管栄養法に適した形態である、請求項10に記載の使用のための組成物。
- 前記組成物中の乳清タンパク質ミセルの総含有量が少なくとも5重量%である、請求項1〜11のいずれか一項に記載の使用のための組成物。
- 対象の満腹感及び/又は食後エネルギー消費を増加させるための、乳清タンパク質ミセルとペクチンの複合体を含む組成物の非治療的使用であって、前記組成物における乳清タンパク質ミセルのペクチンに対する重量比は、30:1〜0.8:1であり、前記乳清タンパク質ミセルは、乳清タンパク質水溶液のpHを3.0〜8.0の間の値に調節し、前記水溶液を80〜98℃の間の温度に供することによって得ることができる、組成物の非治療的使用。
- 除脂肪体重を増加させ、及び/又は体脂肪量を減少させる、請求項13に記載の非治療的使用。
- 体重減少後の健康な体組成の維持に役立つ、請求項13又は14に記載の非治療的使用。
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PCT/EP2015/076087 WO2016078954A1 (en) | 2014-11-19 | 2015-11-09 | Use of complexes of whey protein micelles and pectin for managing body weight |
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EP (1) | EP3220754B1 (ja) |
JP (1) | JP2018503599A (ja) |
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FR1453815A (fr) * | 1965-01-22 | 1966-07-22 | Genvrain Sa | Procédé permettant d'augmenter le rendement dans la fabrication des fromages |
CN1273030C (zh) * | 1998-10-16 | 2006-09-06 | 雀巢制品公司 | 缓慢消化的蛋白质及其用途 |
RU2005141151A (ru) * | 2003-05-28 | 2006-06-10 | Юнилевер Н.В. (Nl) | Пищевые продукты, усиливающие чувство насыщения |
EP1839492B1 (en) * | 2006-03-27 | 2011-09-14 | Nestec S.A. | Whey protein micelles |
MY153295A (en) * | 2004-09-29 | 2015-01-29 | Nestec Sa | Nanoparticulated whey proteins |
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US20110045160A1 (en) * | 2008-04-30 | 2011-02-24 | Nestec S.A. | Satiety inducing food composition |
TR201902631T4 (tr) * | 2008-10-17 | 2019-03-21 | Nestec Sa | Peyniraltı Suyu Proteini Bileşimlerini ve Bu Yolla Elde Edilebilir Bileşimi Üretme Yöntemi. |
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WO2011078654A1 (en) * | 2009-12-24 | 2011-06-30 | N.V. Nutricia | Low-caloric high-protein nutritional composition for the stimulation of muscle protein synthesis |
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