|
US4634665A
(en)
|
1980-02-25 |
1987-01-06 |
The Trustees Of Columbia University In The City Of New York |
Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
|
|
US4399216A
(en)
|
1980-02-25 |
1983-08-16 |
The Trustees Of Columbia University |
Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
|
|
US5179017A
(en)
|
1980-02-25 |
1993-01-12 |
The Trustees Of Columbia University In The City Of New York |
Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
|
|
US4656134A
(en)
|
1982-01-11 |
1987-04-07 |
Board Of Trustees Of Leland Stanford Jr. University |
Gene amplification in eukaryotic cells
|
|
US5149636A
(en)
|
1982-03-15 |
1992-09-22 |
Trustees Of Columbia University In The City Of New York |
Method for introducing cloned, amplifiable genes into eucaryotic cells and for producing proteinaceous products
|
|
GB8601597D0
(en)
|
1986-01-23 |
1986-02-26 |
Wilson R H |
Nucleotide sequences
|
|
US4956288A
(en)
|
1988-04-22 |
1990-09-11 |
Biogen, Inc. |
Method for producing cells containing stably integrated foreign DNA at a high copy number, the cells produced by this method, and the use of these cells to produce the polypeptides coded for by the foreign DNA
|
|
US5047335A
(en)
|
1988-12-21 |
1991-09-10 |
The Regents Of The University Of Calif. |
Process for controlling intracellular glycosylation of proteins
|
|
US5096816A
(en)
|
1990-06-05 |
1992-03-17 |
Cetus Corporation |
In vitro management of ammonia's effect on glycosylation of cell products through pH control
|
|
FR2672895B1
(fr)
|
1991-02-15 |
1995-05-12 |
Transgene Sa |
Procede de purification d'une proteine fortement glycosylee.
|
|
WO1992022320A1
(en)
*
|
1991-06-14 |
1992-12-23 |
Genentech, Inc. |
C1 inhibitor variants and treating inflammatory response with c1 inhibitor
|
|
US5705364A
(en)
|
1995-06-06 |
1998-01-06 |
Genentech, Inc. |
Mammalian cell culture process
|
|
US6277375B1
(en)
|
1997-03-03 |
2001-08-21 |
Board Of Regents, The University Of Texas System |
Immunoglobulin-like domains with increased half-lives
|
|
US6528286B1
(en)
|
1998-05-29 |
2003-03-04 |
Genentech, Inc. |
Mammalian cell culture process for producing glycoproteins
|
|
JP5179689B2
(ja)
*
|
2000-02-11 |
2013-04-10 |
メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング |
抗体ベース融合タンパク質の循環系内半減期の増強
|
|
US6926898B2
(en)
*
|
2000-04-12 |
2005-08-09 |
Human Genome Sciences, Inc. |
Albumin fusion proteins
|
|
EP1355919B1
(en)
*
|
2000-12-12 |
2010-11-24 |
MedImmune, LLC |
Molecules with extended half-lives, compositions and uses thereof
|
|
CA2492267C
(en)
|
2002-07-15 |
2013-09-10 |
Immunex Corporation |
Methods and media for controlling sialylation of proteins produced by mammalian cells
|
|
US8524477B2
(en)
|
2002-10-29 |
2013-09-03 |
Crucell Holland B.V. |
Methods to obtain recombinant proteins with increased sialylation from cells that express adenovirus E1A protein, and proteins obtained thereby
|
|
US7384754B2
(en)
|
2003-10-31 |
2008-06-10 |
Agilent Technologies, Inc. |
Enrichment and tagging of glycosylated proteins
|
|
EA200700391A1
(ru)
*
|
2004-08-03 |
2007-10-26 |
Байорексис Текнолоджи, Инк. |
Комбинированное лечение с применением слитых белков трансферрина, содержащих glp-1
|
|
GB0507123D0
(en)
|
2005-04-08 |
2005-05-11 |
Isis Innovation |
Method
|
|
WO2006130834A2
(en)
|
2005-05-31 |
2006-12-07 |
Board Of Regents, The University Of Texas System |
IGGl ANTIBODIES WITH MUTATED FC PORTION FOR INCREASED BINDING TO FCRN RECEPTOR AND USES THEREOF
|
|
EP3026109B1
(en)
|
2005-12-08 |
2022-03-09 |
Amgen Inc. |
Improved production of glycoproteins using manganese
|
|
US20070249014A1
(en)
|
2006-02-10 |
2007-10-25 |
Invitrogen Corporation |
Labeling and detection of post translationally modified proteins
|
|
US20100056428A1
(en)
|
2006-09-01 |
2010-03-04 |
Novo Nordisk Health Care Ag |
Modified proteins
|
|
IL182956A0
(en)
|
2007-05-03 |
2008-01-20 |
Yeda Res & Dev |
Glycan modified soluble receptors and binding proteins and their use
|
|
DK2195444T3
(en)
|
2007-10-12 |
2015-08-24 |
Sigma Aldrich Co Llc |
Cell line and methods for enhanced sialylation of glycoprotein.
|
|
JP5781308B2
(ja)
|
2008-02-19 |
2015-09-16 |
バイオコン・リミテッドBiocon Limited |
異種タンパク質を得る方法およびインスリン類似体
|
|
EP2166085A1
(en)
|
2008-07-16 |
2010-03-24 |
Suomen Punainen Risti Veripalvelu |
Divalent modified cells
|
|
CN102317309A
(zh)
|
2009-02-26 |
2012-01-11 |
巴特勒能源同盟有限公司 |
通过不同的翻译后修饰改变和调节蛋白质活性
|
|
EP2504360B1
(en)
|
2009-11-23 |
2018-08-15 |
Amgen Inc. |
Monomeric antibody fc
|
|
EP2543730B1
(en)
*
|
2010-03-04 |
2018-10-31 |
Chugai Seiyaku Kabushiki Kaisha |
Antibody constant region variant
|
|
WO2011116291A1
(en)
*
|
2010-03-18 |
2011-09-22 |
Thrombolytic Science International |
Production of human c1 inhibitor in human cells
|
|
US20120010013A1
(en)
*
|
2010-06-19 |
2012-01-12 |
Fellows Edwin E |
Swing assistant device
|
|
JP2013537416A
(ja)
|
2010-08-13 |
2013-10-03 |
メディミューン リミテッド |
変異型Fc領域を含むモノマーポリペプチド及び使用方法
|
|
AU2011349049B2
(en)
*
|
2010-12-22 |
2016-08-11 |
Teva Pharmaceuticals Australia Pty Ltd |
Modified antibody with improved half-life
|
|
KR20140114276A
(ko)
|
2011-02-10 |
2014-09-26 |
라이덴 유니버시티 메디컬 센터 |
코튼을 포함하는 정지상을 이용하는 크로마토그래피에 의한 글리칸 및/또는 글리코컨쥬게이트의 정제 방법
|
|
US8580922B2
(en)
|
2011-03-04 |
2013-11-12 |
Shire Human Genetic Therapies, Inc. |
Peptide linkers for polypeptide compositions and methods for using same
|
|
LT2691417T
(lt)
*
|
2011-03-29 |
2018-10-25 |
Roche Glycart Ag |
Antikūno fc variantai
|
|
SMT201900520T1
(it)
*
|
2011-06-28 |
2019-11-13 |
Inhibrx Lp |
Polipeptidi di fusione serpinici e relativi metodi d'uso
|
|
JP6280499B2
(ja)
|
2011-07-08 |
2018-02-14 |
メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. |
Fc融合タンパク質の精製方法
|
|
CN102890790B
(zh)
*
|
2011-07-22 |
2014-04-30 |
鸿富锦精密工业(深圳)有限公司 |
扩展卡
|
|
AU2012340501A1
(en)
|
2011-12-19 |
2013-07-11 |
Grifols, S.A. |
Compositions, methods, and kits for preparing sialylated recombinant proteins
|
|
WO2013093027A1
(en)
*
|
2011-12-22 |
2013-06-27 |
Csl Behring Gmbh |
Use of c1-inhibitor for the treatment of secondary edema of the central nervous system
|
|
EP2623110A1
(en)
*
|
2012-01-31 |
2013-08-07 |
CSL Behring GmbH |
Factor XII inhibitors for the treatment of neurological inflammatory disorders
|
|
WO2013138643A1
(en)
|
2012-03-16 |
2013-09-19 |
The United States Of America, As Represented By The Secretary, Department Of Health & Human Services |
Soluble engineered monomeric fc
|
|
ES2664095T3
(es)
|
2012-12-07 |
2018-04-18 |
Pfizer Inc. |
Fragmentos de anticuerpos monoméricos diseñados mediante ingeniería genética
|
|
WO2014135694A1
(en)
*
|
2013-03-08 |
2014-09-12 |
Csl Behring Ag |
Treatment and prevention of remote ischemia-reperfusion injury
|
|
WO2014152940A1
(en)
*
|
2013-03-14 |
2014-09-25 |
Shire Human Genetic Therapies, Inc. |
Mrna therapeutic compositions and use to treat diseases and disorders
|
|
EP2796145B1
(en)
*
|
2013-04-22 |
2017-11-01 |
CSL Ltd. |
A covalent complex of von willebrand factor and faktor viii linked by a disulphide bridge
|