JP2018502577A5 - - Google Patents
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- Publication number
- JP2018502577A5 JP2018502577A5 JP2017536325A JP2017536325A JP2018502577A5 JP 2018502577 A5 JP2018502577 A5 JP 2018502577A5 JP 2017536325 A JP2017536325 A JP 2017536325A JP 2017536325 A JP2017536325 A JP 2017536325A JP 2018502577 A5 JP2018502577 A5 JP 2018502577A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- antigen
- atcc
- variant
- derivative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000004408 hybridoma Anatomy 0.000 claims 27
- 239000012634 fragment Substances 0.000 claims 23
- 239000000427 antigen Substances 0.000 claims 21
- 102000036639 antigens Human genes 0.000 claims 21
- 108091007433 antigens Proteins 0.000 claims 21
- 238000004113 cell culture Methods 0.000 claims 7
- 229940126619 mouse monoclonal antibody Drugs 0.000 claims 6
- 239000013598 vector Substances 0.000 claims 6
- 210000004748 cultured cell Anatomy 0.000 claims 5
- 102000039446 nucleic acids Human genes 0.000 claims 5
- 108020004707 nucleic acids Proteins 0.000 claims 5
- 150000007523 nucleic acids Chemical class 0.000 claims 5
- 102000016622 Dipeptidyl Peptidase 4 Human genes 0.000 claims 4
- 108010067722 Dipeptidyl Peptidase 4 Proteins 0.000 claims 4
- 230000008520 organization Effects 0.000 claims 4
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims 3
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims 2
- 239000002202 Polyethylene glycol Substances 0.000 claims 2
- 210000000628 antibody-producing cell Anatomy 0.000 claims 2
- 229920001223 polyethylene glycol Polymers 0.000 claims 2
- 102000040430 polynucleotide Human genes 0.000 claims 2
- 108091033319 polynucleotide Proteins 0.000 claims 2
- 239000002157 polynucleotide Substances 0.000 claims 2
- 229920001184 polypeptide Polymers 0.000 claims 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims 2
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims 1
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims 1
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims 1
- KJTLSVCANCCWHF-UHFFFAOYSA-N Ruthenium Chemical compound [Ru] KJTLSVCANCCWHF-UHFFFAOYSA-N 0.000 claims 1
- 229960002685 biotin Drugs 0.000 claims 1
- 235000020958 biotin Nutrition 0.000 claims 1
- 239000011616 biotin Substances 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 239000013522 chelant Substances 0.000 claims 1
- 150000002632 lipids Chemical class 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 229910052707 ruthenium Inorganic materials 0.000 claims 1
- 230000000087 stabilizing effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562101697P | 2015-01-09 | 2015-01-09 | |
| US62/101,697 | 2015-01-09 | ||
| PCT/US2016/012603 WO2016112261A2 (en) | 2015-01-09 | 2016-01-08 | Assay to detect human dpp-4 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018502577A JP2018502577A (ja) | 2018-02-01 |
| JP2018502577A5 true JP2018502577A5 (https=) | 2019-02-14 |
Family
ID=56356576
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017536325A Pending JP2018502577A (ja) | 2015-01-09 | 2016-01-08 | ヒトｄｐｐ−４を検出するためのアッセイ |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US10351630B2 (https=) |
| EP (1) | EP3242686B1 (https=) |
| JP (1) | JP2018502577A (https=) |
| KR (1) | KR20170098941A (https=) |
| CN (1) | CN107206079A (https=) |
| AU (1) | AU2016205188A1 (https=) |
| BR (1) | BR112017011724A2 (https=) |
| CA (1) | CA2970540A1 (https=) |
| HK (2) | HK1244444A1 (https=) |
| IL (1) | IL252528A0 (https=) |
| MX (1) | MX2017008748A (https=) |
| RU (1) | RU2017127182A (https=) |
| SG (1) | SG11201705598VA (https=) |
| WO (1) | WO2016112261A2 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN118359716A (zh) * | 2023-01-18 | 2024-07-19 | 江苏众红生物工程创药研究院有限公司 | 抗cd26抗体及其用途 |
| CN118791612A (zh) * | 2023-04-14 | 2024-10-18 | 江苏众红生物工程创药研究院有限公司 | 靶向cd26的抗原结合蛋白及其药物应用 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5681718A (en) | 1986-03-14 | 1997-10-28 | Celltech Limited | Methods for enhanced production of tissue plasminogen activator in cell culture using alkanoic acids or salts thereof |
| US5892019A (en) | 1987-07-15 | 1999-04-06 | The United States Of America, As Represented By The Department Of Health And Human Services | Production of a single-gene-encoded immunoglobulin |
| US7115555B2 (en) * | 1998-07-09 | 2006-10-03 | Baylor College Of Medicine | Hypohidrotic ectodermal dysplasia genes and proteins |
| US6573096B1 (en) * | 2000-04-01 | 2003-06-03 | The Research Foundation At State University Of New York | Compositions and methods for inhibition of cancer invasion and angiogenesis |
| EP1392361A4 (en) * | 2001-05-11 | 2009-08-05 | Univ Texas | ANTI-CD26 MONOCLONAL ANTIBODIES FOR THE TREATMENT OF DISEASES ASSOCIATED WITH CD26 EXPRESSIVE CELLS |
| GB0216648D0 (en) | 2002-07-18 | 2002-08-28 | Lonza Biologics Plc | Method of expressing recombinant protein in CHO cells |
| EP1631680A2 (en) | 2003-05-21 | 2006-03-08 | Bayer HealthCare AG | Diagnostics and therapeutics for diseases associated with dipeptidylpeptidase iv (dpp4) |
| GB0407315D0 (en) | 2003-07-15 | 2004-05-05 | Cambridge Antibody Tech | Human antibody molecules |
| WO2005075514A2 (en) | 2004-03-10 | 2005-08-18 | Lonza Ltd. | Method for producing antibodies |
| EP1907425B1 (en) * | 2005-07-22 | 2014-01-08 | Y's Therapeutics Co., Ltd. | Anti-cd26 antibodies and methods of use thereof |
| WO2008091814A2 (en) | 2007-01-22 | 2008-07-31 | Wyeth | Assessment of asthma and allergen-dependent gene expression |
| EP2631302A3 (en) | 2008-03-31 | 2014-01-08 | Genentech, Inc. | Compositions and methods for treating and diagnosing asthma |
| US20100221752A2 (en) | 2008-10-06 | 2010-09-02 | Somalogic, Inc. | Ovarian Cancer Biomarkers and Uses Thereof |
| US20130310266A1 (en) * | 2010-09-03 | 2013-11-21 | Immport Therapeutics, Inc. | Methods and Compositions For The Diagnosis And Treatment Of Cancer and Autoimmune Disorders |
| MX2013004212A (es) | 2010-10-15 | 2013-09-02 | Medimmune Ltd | Terapias para mejorar la funcion pulmonar. |
| TWI732259B (zh) | 2010-12-16 | 2021-07-01 | 美商建南德克公司 | 關於th2抑制作用之診斷及治療 |
| EP2710370A4 (en) | 2011-05-18 | 2015-01-07 | Medimmune Llc | METHODS OF DIAGNOSING AND TREATING PULMONARY DISEASES OR DISORDERS |
| US20160363591A1 (en) | 2014-01-27 | 2016-12-15 | Medimmune, Llc | Dipeptidyl peptidase-4 (dpp4/cd26) as a peripheral biomarker of il-13 activation in asthmatic lung |
-
2016
- 2016-01-08 US US14/991,160 patent/US10351630B2/en active Active
- 2016-01-08 HK HK18103970.8A patent/HK1244444A1/zh unknown
- 2016-01-08 AU AU2016205188A patent/AU2016205188A1/en not_active Abandoned
- 2016-01-08 CA CA2970540A patent/CA2970540A1/en not_active Abandoned
- 2016-01-08 RU RU2017127182A patent/RU2017127182A/ru not_active Application Discontinuation
- 2016-01-08 BR BR112017011724-0A patent/BR112017011724A2/pt not_active Application Discontinuation
- 2016-01-08 EP EP16735457.0A patent/EP3242686B1/en not_active Not-in-force
- 2016-01-08 WO PCT/US2016/012603 patent/WO2016112261A2/en not_active Ceased
- 2016-01-08 CN CN201680005264.3A patent/CN107206079A/zh active Pending
- 2016-01-08 KR KR1020177021858A patent/KR20170098941A/ko not_active Withdrawn
- 2016-01-08 JP JP2017536325A patent/JP2018502577A/ja active Pending
- 2016-01-08 HK HK18103568.6A patent/HK1243953A1/zh unknown
- 2016-01-08 MX MX2017008748A patent/MX2017008748A/es unknown
- 2016-01-08 SG SG11201705598VA patent/SG11201705598VA/en unknown
-
2017
- 2017-05-25 IL IL252528A patent/IL252528A0/en unknown
-
2019
- 2019-06-06 US US16/433,174 patent/US20190352425A1/en not_active Abandoned
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