BR112017011724A2 - ensaio para detectar dpp-4 humana - Google Patents
ensaio para detectar dpp-4 humanaInfo
- Publication number
- BR112017011724A2 BR112017011724A2 BR112017011724-0A BR112017011724A BR112017011724A2 BR 112017011724 A2 BR112017011724 A2 BR 112017011724A2 BR 112017011724 A BR112017011724 A BR 112017011724A BR 112017011724 A2 BR112017011724 A2 BR 112017011724A2
- Authority
- BR
- Brazil
- Prior art keywords
- assay
- dpp
- detect human
- human dpp
- antibodies
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
esta invenção fornece um ensaio robusto, sensível, e específico para a detecção e medição de níveis de dpp-4 em amostras obtidas de pacientes humanos. a invenção fornece ainda novos anticorpos monoclonais anti-dpp-4 que reconhecem dpp-4 humana, e kits de ensaio compreendendo um ou mais destes anticorpos.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562101697P | 2015-01-09 | 2015-01-09 | |
US62/101,697 | 2015-01-09 | ||
PCT/US2016/012603 WO2016112261A2 (en) | 2015-01-09 | 2016-01-08 | Assay to detect human dpp-4 |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112017011724A2 true BR112017011724A2 (pt) | 2018-05-15 |
Family
ID=56356576
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112017011724-0A BR112017011724A2 (pt) | 2015-01-09 | 2016-01-08 | ensaio para detectar dpp-4 humana |
Country Status (14)
Country | Link |
---|---|
US (2) | US10351630B2 (pt) |
EP (1) | EP3242686B1 (pt) |
JP (1) | JP2018502577A (pt) |
KR (1) | KR20170098941A (pt) |
CN (1) | CN107206079A (pt) |
AU (1) | AU2016205188A1 (pt) |
BR (1) | BR112017011724A2 (pt) |
CA (1) | CA2970540A1 (pt) |
HK (2) | HK1243953A1 (pt) |
IL (1) | IL252528A0 (pt) |
MX (1) | MX2017008748A (pt) |
RU (1) | RU2017127182A (pt) |
SG (1) | SG11201705598VA (pt) |
WO (1) | WO2016112261A2 (pt) |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5681718A (en) | 1986-03-14 | 1997-10-28 | Celltech Limited | Methods for enhanced production of tissue plasminogen activator in cell culture using alkanoic acids or salts thereof |
US5892019A (en) | 1987-07-15 | 1999-04-06 | The United States Of America, As Represented By The Department Of Health And Human Services | Production of a single-gene-encoded immunoglobulin |
US7115555B2 (en) * | 1998-07-09 | 2006-10-03 | Baylor College Of Medicine | Hypohidrotic ectodermal dysplasia genes and proteins |
US6573096B1 (en) * | 2000-04-01 | 2003-06-03 | The Research Foundation At State University Of New York | Compositions and methods for inhibition of cancer invasion and angiogenesis |
WO2002092127A1 (en) * | 2001-05-11 | 2002-11-21 | Board Of Regents, The University Of Texas System | Anti-cd26 monoclonal antibodies as therapy for diseases associated with cells expressing cd26 |
GB0216648D0 (en) | 2002-07-18 | 2002-08-28 | Lonza Biologics Plc | Method of expressing recombinant protein in CHO cells |
EP1631680A2 (en) | 2003-05-21 | 2006-03-08 | Bayer HealthCare AG | Diagnostics and therapeutics for diseases associated with dipeptidylpeptidase iv (dpp4) |
GB0407315D0 (en) | 2003-07-15 | 2004-05-05 | Cambridge Antibody Tech | Human antibody molecules |
EP1725585A2 (en) | 2004-03-10 | 2006-11-29 | Lonza Ltd | Method for producing antibodies |
KR20080039929A (ko) * | 2005-07-22 | 2008-05-07 | 와이스 테라퓨틱스 가부시키가이샤 | 항-cd26 항체 및 이들의 사용 방법 |
US20090155784A1 (en) | 2007-01-22 | 2009-06-18 | Wyeth | Assessment of asthma and allergen-dependent gene expression |
AU2009231733B2 (en) | 2008-03-31 | 2015-12-24 | Genentech, Inc. | Compositions and methods for treating and diagnosing asthma |
US20100221752A2 (en) | 2008-10-06 | 2010-09-02 | Somalogic, Inc. | Ovarian Cancer Biomarkers and Uses Thereof |
US20130310266A1 (en) * | 2010-09-03 | 2013-11-21 | Immport Therapeutics, Inc. | Methods and Compositions For The Diagnosis And Treatment Of Cancer and Autoimmune Disorders |
CN103328506A (zh) | 2010-10-15 | 2013-09-25 | 米迪缪尼有限公司 | 用于改善肺功能的疗法 |
BR112013013460A8 (pt) | 2010-12-16 | 2019-02-12 | Genentech Inc | métodos de identificação de um paciente com asma, método de monitoramento de um paciente com asma, uso de um kit de detecção de periostina total, kit de medição da periostina total, uso de um anticorpo anti-il-13, uso de uma quantidade terapeuticamente eficaz de lebrikizumab, uso de um inibidor da via de th2, método de avaliação de eventos adversos, anticorpo anti-periostina e teste de periostina total |
US8961965B2 (en) | 2011-05-18 | 2015-02-24 | Medimmune, Llc | Methods of diagnosing and treating pulmonary diseases or disorders |
BR112016017192A2 (pt) | 2014-01-27 | 2017-10-10 | Medimmune Llc | dipeptidil peptidase-4 (dpp4/cd26) como um biomarcador periférico da ativação de il-13 no pulmão asmático |
-
2016
- 2016-01-08 CA CA2970540A patent/CA2970540A1/en not_active Abandoned
- 2016-01-08 MX MX2017008748A patent/MX2017008748A/es unknown
- 2016-01-08 SG SG11201705598VA patent/SG11201705598VA/en unknown
- 2016-01-08 KR KR1020177021858A patent/KR20170098941A/ko unknown
- 2016-01-08 WO PCT/US2016/012603 patent/WO2016112261A2/en active Application Filing
- 2016-01-08 BR BR112017011724-0A patent/BR112017011724A2/pt not_active Application Discontinuation
- 2016-01-08 JP JP2017536325A patent/JP2018502577A/ja active Pending
- 2016-01-08 CN CN201680005264.3A patent/CN107206079A/zh active Pending
- 2016-01-08 RU RU2017127182A patent/RU2017127182A/ru not_active Application Discontinuation
- 2016-01-08 US US14/991,160 patent/US10351630B2/en active Active
- 2016-01-08 EP EP16735457.0A patent/EP3242686B1/en active Active
- 2016-01-08 AU AU2016205188A patent/AU2016205188A1/en not_active Abandoned
-
2017
- 2017-05-25 IL IL252528A patent/IL252528A0/en unknown
-
2018
- 2018-03-14 HK HK18103568.6A patent/HK1243953A1/zh unknown
- 2018-03-22 HK HK18103970.8A patent/HK1244444A1/zh unknown
-
2019
- 2019-06-06 US US16/433,174 patent/US20190352425A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
CA2970540A1 (en) | 2016-07-14 |
US20160200832A1 (en) | 2016-07-14 |
AU2016205188A1 (en) | 2017-06-22 |
RU2017127182A (ru) | 2019-02-11 |
EP3242686B1 (en) | 2020-07-08 |
HK1243953A1 (zh) | 2018-07-27 |
CN107206079A (zh) | 2017-09-26 |
WO2016112261A2 (en) | 2016-07-14 |
SG11201705598VA (en) | 2017-08-30 |
US20190352425A1 (en) | 2019-11-21 |
EP3242686A2 (en) | 2017-11-15 |
MX2017008748A (es) | 2017-11-17 |
IL252528A0 (en) | 2017-07-31 |
US10351630B2 (en) | 2019-07-16 |
JP2018502577A (ja) | 2018-02-01 |
WO2016112261A3 (en) | 2016-09-01 |
KR20170098941A (ko) | 2017-08-30 |
HK1244444A1 (zh) | 2018-08-10 |
EP3242686A4 (en) | 2018-06-06 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |