JP2018501216A5 - - Google Patents
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- Publication number
- JP2018501216A5 JP2018501216A5 JP2017529360A JP2017529360A JP2018501216A5 JP 2018501216 A5 JP2018501216 A5 JP 2018501216A5 JP 2017529360 A JP2017529360 A JP 2017529360A JP 2017529360 A JP2017529360 A JP 2017529360A JP 2018501216 A5 JP2018501216 A5 JP 2018501216A5
- Authority
- JP
- Japan
- Prior art keywords
- cornea
- cross
- composition
- light
- applying
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims 12
- 210000004087 cornea Anatomy 0.000 claims 7
- 239000000654 additive Substances 0.000 claims 6
- 229910052742 iron Inorganic materials 0.000 claims 6
- 239000000203 mixture Substances 0.000 claims 6
- 238000000034 method Methods 0.000 claims 5
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 claims 4
- 230000000996 additive effect Effects 0.000 claims 4
- 239000007979 citrate buffer Substances 0.000 claims 4
- 239000003431 cross linking reagent Substances 0.000 claims 4
- 238000004132 cross linking Methods 0.000 claims 3
- 230000000694 effects Effects 0.000 claims 3
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 claims 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 239000001301 oxygen Substances 0.000 claims 2
- 229960002477 riboflavin Drugs 0.000 claims 2
- 235000019192 riboflavin Nutrition 0.000 claims 2
- 239000002151 riboflavin Substances 0.000 claims 2
- 230000002186 photoactivation Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462086572P | 2014-12-02 | 2014-12-02 | |
| US62/086,572 | 2014-12-02 | ||
| PCT/US2015/063466 WO2016090016A1 (en) | 2014-12-02 | 2015-12-02 | Systems, methods, and compositions for cross-linking treatments of an eye |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018501216A JP2018501216A (ja) | 2018-01-18 |
| JP2018501216A5 true JP2018501216A5 (enExample) | 2018-03-15 |
| JP6674462B2 JP6674462B2 (ja) | 2020-04-01 |
Family
ID=56092400
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017529360A Active JP6674462B2 (ja) | 2014-12-02 | 2015-12-02 | 眼の架橋処置のためのシステム、方法及び組成物 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US20160175442A1 (enExample) |
| EP (2) | EP4082547B1 (enExample) |
| JP (1) | JP6674462B2 (enExample) |
| KR (1) | KR102606740B1 (enExample) |
| CN (1) | CN107206003B (enExample) |
| WO (1) | WO2016090016A1 (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011116306A2 (en) | 2010-03-19 | 2011-09-22 | Avedro, Inc. | Systems and methods for applying and monitoring eye therapy |
| US9622911B2 (en) | 2010-09-30 | 2017-04-18 | Cxl Ophthalmics, Llc | Ophthalmic treatment device, system, and method of use |
| WO2012167260A2 (en) | 2011-06-02 | 2012-12-06 | Avedro, Inc. | Systems and methods for monitoring time based photo active agent delivery or photo active marker presence |
| EP4420725A3 (en) | 2012-03-29 | 2025-04-16 | Epion Therapeutics, Inc. | Ocular treatment solutions, delivery devices and delivery augmentation methods |
| US9566301B2 (en) | 2012-03-29 | 2017-02-14 | Cxl Ophthalmics, Llc | Compositions and methods for treating or preventing diseases associated with oxidative stress |
| EP3212140B1 (en) | 2014-10-27 | 2021-12-01 | Avedro, Inc. | Systems for cross-linking treatments of an eye |
| US10114205B2 (en) | 2014-11-13 | 2018-10-30 | Avedro, Inc. | Multipass virtually imaged phased array etalon |
| EP3827792A1 (en) | 2015-04-24 | 2021-06-02 | Avedro, Inc. | Systems and methods for photoactivating a photosensitizer applied to an eye |
| EP4483884A3 (en) | 2015-05-22 | 2025-03-05 | Avedro Inc. | Systems for monitoring cross-linking activity for corneal treatments |
| WO2017015471A1 (en) | 2015-07-21 | 2017-01-26 | Avedro, Inc. | Systems and methods for treaments of an eye with a photosensitizer |
| US10342697B2 (en) | 2016-04-13 | 2019-07-09 | Avedro, Inc. | Systems and methods for delivering drugs to an eye |
| CN115282494B (zh) | 2016-05-31 | 2026-01-30 | 西达-赛奈医疗中心 | 用于体内紫外线疗法的胶囊和系统以及使用该系统的方法 |
| US10932864B2 (en) | 2018-11-28 | 2021-03-02 | Rxsight, Inc. | Tracking-based illumination control system |
| US11013593B2 (en) | 2018-12-02 | 2021-05-25 | Rxsight, Inc. | Light adjustable lens tracking system and method |
| WO2020117974A1 (en) | 2018-12-04 | 2020-06-11 | Avedro, Inc. | Compounds and compositions for eye treatments |
| US12344598B2 (en) | 2019-01-25 | 2025-07-01 | Avedro, Inc. | Bis(diazirine) derivatives as photo-crosslinker for treating corneal ectatic disorders |
| KR102234258B1 (ko) * | 2019-01-28 | 2021-03-31 | 경북대학교 산학협력단 | 안압이 상승된 동물 모델, 그의 제조방법 및 그를 이용한 녹내장 치료제의 스크리닝 방법 |
| CN114848817A (zh) * | 2019-05-17 | 2022-08-05 | 北京厚燊维康科技有限责任公司 | 二酮类化合物在光动力治疗或诊断中的用途 |
| US11179575B2 (en) | 2019-10-15 | 2021-11-23 | Cedars-Sinai Medical Center | Internal ultraviolet therapy |
| AU2021324983A1 (en) | 2020-08-13 | 2023-03-02 | Cedars-Sinai Medical Center | Internal ultraviolet therapy |
| CN113096074B (zh) * | 2021-03-19 | 2025-02-18 | 深圳市定视生物医疗科技有限公司 | 一种个性化角膜交联系统 |
| CN114920203A (zh) * | 2022-05-20 | 2022-08-19 | 杭州诺莘科技有限责任公司 | 一种利用核黄素类化合物产生过氧化氢的方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH02262518A (ja) * | 1989-04-03 | 1990-10-25 | Kaken Pharmaceut Co Ltd | 眼圧調整剤 |
| JPH1085303A (ja) * | 1996-09-17 | 1998-04-07 | Taisho Pharmaceut Co Ltd | 一体成形型点眼剤用容器 |
| US6153582A (en) * | 1998-11-05 | 2000-11-28 | Bausch & Lomb Surgical, Inc. | Defined serumfree medical solution for ophthalmology |
| FR2849383B1 (fr) * | 2002-12-26 | 2005-09-30 | Jean Noel Thorel | Composition trophique en milieu aqueux, et ses applications, notamment en ophtalmologie |
| MXPA03011987A (es) * | 2003-12-19 | 2005-06-23 | Osio Sancho Alberto | Metodo para el tratamiento de la presbicia induciendo cambios en el poder y fisiologia corneal. |
| JP2009256281A (ja) * | 2008-04-21 | 2009-11-05 | Teika Seiyaku Kk | イソプロピルウノプロストン含有点眼剤組成物 |
| WO2011050164A1 (en) | 2009-10-21 | 2011-04-28 | Avedro, Inc. | Eye therapy |
| US20130245536A1 (en) | 2009-10-21 | 2013-09-19 | Avedro, Inc. | Systems and methods for corneal cross-linking with pulsed light |
| WO2011116306A2 (en) | 2010-03-19 | 2011-09-22 | Avedro, Inc. | Systems and methods for applying and monitoring eye therapy |
| US20120215155A1 (en) | 2010-03-19 | 2012-08-23 | Avedro Inc. | Controlled cross-linking initiation and corneal topography feedback systems for directing cross-linking |
| JP2014503552A (ja) * | 2011-01-12 | 2014-02-13 | ソーフト イタリア エスピーエー | 円錐角膜の処置のためのイオン導入による架橋剤の角膜送達および関連眼科組成物 |
| EP2872081B2 (en) | 2012-07-16 | 2025-07-16 | Avedro, Inc. | Systems for corneal cross-linking with pulsed light |
| US20140343480A1 (en) * | 2013-05-19 | 2014-11-20 | Avedro, Inc. | Systems, methods, and compositions for cross-linking |
-
2015
- 2015-12-02 KR KR1020177017789A patent/KR102606740B1/ko active Active
- 2015-12-02 EP EP22178453.1A patent/EP4082547B1/en active Active
- 2015-12-02 EP EP15864372.6A patent/EP3226871B1/en active Active
- 2015-12-02 CN CN201580074913.0A patent/CN107206003B/zh active Active
- 2015-12-02 JP JP2017529360A patent/JP6674462B2/ja active Active
- 2015-12-02 US US14/957,187 patent/US20160175442A1/en not_active Abandoned
- 2015-12-02 WO PCT/US2015/063466 patent/WO2016090016A1/en not_active Ceased
-
2019
- 2019-10-16 US US16/655,208 patent/US20200046835A1/en not_active Abandoned
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