JP6674462B2 - 眼の架橋処置のためのシステム、方法及び組成物 - Google Patents

眼の架橋処置のためのシステム、方法及び組成物 Download PDF

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Publication number
JP6674462B2
JP6674462B2 JP2017529360A JP2017529360A JP6674462B2 JP 6674462 B2 JP6674462 B2 JP 6674462B2 JP 2017529360 A JP2017529360 A JP 2017529360A JP 2017529360 A JP2017529360 A JP 2017529360A JP 6674462 B2 JP6674462 B2 JP 6674462B2
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riboflavin
corneal
fluorescence
cornea
light
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Japanese (ja)
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JP2018501216A (ja
JP2018501216A5 (enExample
Inventor
カマエフ，パベル
フリードマン，マーク
シェア，エヴァン
ピーターソン，サラ・エム
ミューラー，デイビッド
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Avedro Inc
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Avedro Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007—Methods or devices for eye surgery
    • A61F9/0079—Methods or devices for eye surgery using non-laser electromagnetic radiation, e.g. non-coherent light or microwaves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/525—Isoalloxazines, e.g. riboflavins, vitamin B2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/26—Iron; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0613—Apparatus adapted for a specific treatment
    • A61N5/062—Photodynamic therapy, i.e. excitation of an agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/16—Materials or treatment for tissue regeneration for reconstruction of eye parts, e.g. intraocular lens, cornea

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Ophthalmology & Optometry (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Surgery (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Radiology & Medical Imaging (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Optics & Photonics (AREA)
  • Electromagnetism (AREA)
  • Physics & Mathematics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2017529360A 2014-12-02 2015-12-02 眼の架橋処置のためのシステム、方法及び組成物 Active JP6674462B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462086572P 2014-12-02 2014-12-02
US62/086,572 2014-12-02
PCT/US2015/063466 WO2016090016A1 (en) 2014-12-02 2015-12-02 Systems, methods, and compositions for cross-linking treatments of an eye

Publications (3)

Publication Number Publication Date
JP2018501216A JP2018501216A (ja) 2018-01-18
JP2018501216A5 JP2018501216A5 (enExample) 2018-03-15
JP6674462B2 true JP6674462B2 (ja) 2020-04-01

Family

ID=56092400

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2017529360A Active JP6674462B2 (ja) 2014-12-02 2015-12-02 眼の架橋処置のためのシステム、方法及び組成物

Country Status (6)

Country Link
US (2) US20160175442A1 (enExample)
EP (2) EP4082547B1 (enExample)
JP (1) JP6674462B2 (enExample)
KR (1) KR102606740B1 (enExample)
CN (1) CN107206003B (enExample)
WO (1) WO2016090016A1 (enExample)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011116306A2 (en) 2010-03-19 2011-09-22 Avedro, Inc. Systems and methods for applying and monitoring eye therapy
US9622911B2 (en) 2010-09-30 2017-04-18 Cxl Ophthalmics, Llc Ophthalmic treatment device, system, and method of use
WO2012167260A2 (en) 2011-06-02 2012-12-06 Avedro, Inc. Systems and methods for monitoring time based photo active agent delivery or photo active marker presence
EP4420725A3 (en) 2012-03-29 2025-04-16 Epion Therapeutics, Inc. Ocular treatment solutions, delivery devices and delivery augmentation methods
US9566301B2 (en) 2012-03-29 2017-02-14 Cxl Ophthalmics, Llc Compositions and methods for treating or preventing diseases associated with oxidative stress
EP3212140B1 (en) 2014-10-27 2021-12-01 Avedro, Inc. Systems for cross-linking treatments of an eye
US10114205B2 (en) 2014-11-13 2018-10-30 Avedro, Inc. Multipass virtually imaged phased array etalon
EP3827792A1 (en) 2015-04-24 2021-06-02 Avedro, Inc. Systems and methods for photoactivating a photosensitizer applied to an eye
EP4483884A3 (en) 2015-05-22 2025-03-05 Avedro Inc. Systems for monitoring cross-linking activity for corneal treatments
WO2017015471A1 (en) 2015-07-21 2017-01-26 Avedro, Inc. Systems and methods for treaments of an eye with a photosensitizer
US10342697B2 (en) 2016-04-13 2019-07-09 Avedro, Inc. Systems and methods for delivering drugs to an eye
CN115282494B (zh) 2016-05-31 2026-01-30 西达-赛奈医疗中心 用于体内紫外线疗法的胶囊和系统以及使用该系统的方法
US10932864B2 (en) 2018-11-28 2021-03-02 Rxsight, Inc. Tracking-based illumination control system
US11013593B2 (en) 2018-12-02 2021-05-25 Rxsight, Inc. Light adjustable lens tracking system and method
WO2020117974A1 (en) 2018-12-04 2020-06-11 Avedro, Inc. Compounds and compositions for eye treatments
US12344598B2 (en) 2019-01-25 2025-07-01 Avedro, Inc. Bis(diazirine) derivatives as photo-crosslinker for treating corneal ectatic disorders
KR102234258B1 (ko) * 2019-01-28 2021-03-31 경북대학교 산학협력단 안압이 상승된 동물 모델, 그의 제조방법 및 그를 이용한 녹내장 치료제의 스크리닝 방법
CN114848817A (zh) * 2019-05-17 2022-08-05 北京厚燊维康科技有限责任公司 二酮类化合物在光动力治疗或诊断中的用途
US11179575B2 (en) 2019-10-15 2021-11-23 Cedars-Sinai Medical Center Internal ultraviolet therapy
AU2021324983A1 (en) 2020-08-13 2023-03-02 Cedars-Sinai Medical Center Internal ultraviolet therapy
CN113096074B (zh) * 2021-03-19 2025-02-18 深圳市定视生物医疗科技有限公司 一种个性化角膜交联系统
CN114920203A (zh) * 2022-05-20 2022-08-19 杭州诺莘科技有限责任公司 一种利用核黄素类化合物产生过氧化氢的方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
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JPH02262518A (ja) * 1989-04-03 1990-10-25 Kaken Pharmaceut Co Ltd 眼圧調整剤
JPH1085303A (ja) * 1996-09-17 1998-04-07 Taisho Pharmaceut Co Ltd 一体成形型点眼剤用容器
US6153582A (en) * 1998-11-05 2000-11-28 Bausch & Lomb Surgical, Inc. Defined serumfree medical solution for ophthalmology
FR2849383B1 (fr) * 2002-12-26 2005-09-30 Jean Noel Thorel Composition trophique en milieu aqueux, et ses applications, notamment en ophtalmologie
MXPA03011987A (es) * 2003-12-19 2005-06-23 Osio Sancho Alberto Metodo para el tratamiento de la presbicia induciendo cambios en el poder y fisiologia corneal.
JP2009256281A (ja) * 2008-04-21 2009-11-05 Teika Seiyaku Kk イソプロピルウノプロストン含有点眼剤組成物
WO2011050164A1 (en) 2009-10-21 2011-04-28 Avedro, Inc. Eye therapy
US20130245536A1 (en) 2009-10-21 2013-09-19 Avedro, Inc. Systems and methods for corneal cross-linking with pulsed light
WO2011116306A2 (en) 2010-03-19 2011-09-22 Avedro, Inc. Systems and methods for applying and monitoring eye therapy
US20120215155A1 (en) 2010-03-19 2012-08-23 Avedro Inc. Controlled cross-linking initiation and corneal topography feedback systems for directing cross-linking
JP2014503552A (ja) * 2011-01-12 2014-02-13 ソーフト イタリア エスピーエー 円錐角膜の処置のためのイオン導入による架橋剤の角膜送達および関連眼科組成物
EP2872081B2 (en) 2012-07-16 2025-07-16 Avedro, Inc. Systems for corneal cross-linking with pulsed light
US20140343480A1 (en) * 2013-05-19 2014-11-20 Avedro, Inc. Systems, methods, and compositions for cross-linking

Also Published As

Publication number Publication date
JP2018501216A (ja) 2018-01-18
US20200046835A1 (en) 2020-02-13
US20160175442A1 (en) 2016-06-23
EP3226871B1 (en) 2022-07-13
EP3226871A4 (en) 2018-07-25
EP3226871A1 (en) 2017-10-11
KR20170088977A (ko) 2017-08-02
CN107206003A (zh) 2017-09-26
WO2016090016A1 (en) 2016-06-09
EP4082547B1 (en) 2026-02-04
KR102606740B1 (ko) 2023-11-24
EP4082547A1 (en) 2022-11-02
CN107206003B (zh) 2021-10-26

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