CN107206003B - 用于眼的交联治疗的系统、方法和组合物 - Google Patents

用于眼的交联治疗的系统、方法和组合物 Download PDF

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Publication number
CN107206003B
CN107206003B CN201580074913.0A CN201580074913A CN107206003B CN 107206003 B CN107206003 B CN 107206003B CN 201580074913 A CN201580074913 A CN 201580074913A CN 107206003 B CN107206003 B CN 107206003B
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riboflavin
light
corneal
solution
cornea
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Chinese (zh)
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CN107206003A (zh
Inventor
P·卡梅芙
M·弗里德曼
E·谢尔
S·M·彼得森
D·米勒
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Avedro Inc
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Avedro Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007—Methods or devices for eye surgery
    • A61F9/0079—Methods or devices for eye surgery using non-laser electromagnetic radiation, e.g. non-coherent light or microwaves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/525—Isoalloxazines, e.g. riboflavins, vitamin B2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/26—Iron; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0613—Apparatus adapted for a specific treatment
    • A61N5/062—Photodynamic therapy, i.e. excitation of an agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/16—Materials or treatment for tissue regeneration for reconstruction of eye parts, e.g. intraocular lens, cornea

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Ophthalmology & Optometry (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Surgery (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Radiology & Medical Imaging (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Optics & Photonics (AREA)
  • Electromagnetism (AREA)
  • Physics & Mathematics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201580074913.0A 2014-12-02 2015-12-02 用于眼的交联治疗的系统、方法和组合物 Active CN107206003B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462086572P 2014-12-02 2014-12-02
US62/086,572 2014-12-02
PCT/US2015/063466 WO2016090016A1 (en) 2014-12-02 2015-12-02 Systems, methods, and compositions for cross-linking treatments of an eye

Publications (2)

Publication Number Publication Date
CN107206003A CN107206003A (zh) 2017-09-26
CN107206003B true CN107206003B (zh) 2021-10-26

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CN201580074913.0A Active CN107206003B (zh) 2014-12-02 2015-12-02 用于眼的交联治疗的系统、方法和组合物

Country Status (6)

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US (2) US20160175442A1 (enExample)
EP (2) EP4082547B1 (enExample)
JP (1) JP6674462B2 (enExample)
KR (1) KR102606740B1 (enExample)
CN (1) CN107206003B (enExample)
WO (1) WO2016090016A1 (enExample)

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WO2011116306A2 (en) 2010-03-19 2011-09-22 Avedro, Inc. Systems and methods for applying and monitoring eye therapy
US9622911B2 (en) 2010-09-30 2017-04-18 Cxl Ophthalmics, Llc Ophthalmic treatment device, system, and method of use
WO2012167260A2 (en) 2011-06-02 2012-12-06 Avedro, Inc. Systems and methods for monitoring time based photo active agent delivery or photo active marker presence
EP4420725A3 (en) 2012-03-29 2025-04-16 Epion Therapeutics, Inc. Ocular treatment solutions, delivery devices and delivery augmentation methods
US9566301B2 (en) 2012-03-29 2017-02-14 Cxl Ophthalmics, Llc Compositions and methods for treating or preventing diseases associated with oxidative stress
EP3212140B1 (en) 2014-10-27 2021-12-01 Avedro, Inc. Systems for cross-linking treatments of an eye
US10114205B2 (en) 2014-11-13 2018-10-30 Avedro, Inc. Multipass virtually imaged phased array etalon
EP3827792A1 (en) 2015-04-24 2021-06-02 Avedro, Inc. Systems and methods for photoactivating a photosensitizer applied to an eye
EP4483884A3 (en) 2015-05-22 2025-03-05 Avedro Inc. Systems for monitoring cross-linking activity for corneal treatments
WO2017015471A1 (en) 2015-07-21 2017-01-26 Avedro, Inc. Systems and methods for treaments of an eye with a photosensitizer
US10342697B2 (en) 2016-04-13 2019-07-09 Avedro, Inc. Systems and methods for delivering drugs to an eye
CN115282494B (zh) 2016-05-31 2026-01-30 西达-赛奈医疗中心 用于体内紫外线疗法的胶囊和系统以及使用该系统的方法
US10932864B2 (en) 2018-11-28 2021-03-02 Rxsight, Inc. Tracking-based illumination control system
US11013593B2 (en) 2018-12-02 2021-05-25 Rxsight, Inc. Light adjustable lens tracking system and method
WO2020117974A1 (en) 2018-12-04 2020-06-11 Avedro, Inc. Compounds and compositions for eye treatments
US12344598B2 (en) 2019-01-25 2025-07-01 Avedro, Inc. Bis(diazirine) derivatives as photo-crosslinker for treating corneal ectatic disorders
KR102234258B1 (ko) * 2019-01-28 2021-03-31 경북대학교 산학협력단 안압이 상승된 동물 모델, 그의 제조방법 및 그를 이용한 녹내장 치료제의 스크리닝 방법
CN114848817A (zh) * 2019-05-17 2022-08-05 北京厚燊维康科技有限责任公司 二酮类化合物在光动力治疗或诊断中的用途
US11179575B2 (en) 2019-10-15 2021-11-23 Cedars-Sinai Medical Center Internal ultraviolet therapy
AU2021324983A1 (en) 2020-08-13 2023-03-02 Cedars-Sinai Medical Center Internal ultraviolet therapy
CN113096074B (zh) * 2021-03-19 2025-02-18 深圳市定视生物医疗科技有限公司 一种个性化角膜交联系统
CN114920203A (zh) * 2022-05-20 2022-08-19 杭州诺莘科技有限责任公司 一种利用核黄素类化合物产生过氧化氢的方法

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JPH1085303A (ja) * 1996-09-17 1998-04-07 Taisho Pharmaceut Co Ltd 一体成形型点眼剤用容器
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Also Published As

Publication number Publication date
JP6674462B2 (ja) 2020-04-01
JP2018501216A (ja) 2018-01-18
US20200046835A1 (en) 2020-02-13
US20160175442A1 (en) 2016-06-23
EP3226871B1 (en) 2022-07-13
EP3226871A4 (en) 2018-07-25
EP3226871A1 (en) 2017-10-11
KR20170088977A (ko) 2017-08-02
CN107206003A (zh) 2017-09-26
WO2016090016A1 (en) 2016-06-09
EP4082547B1 (en) 2026-02-04
KR102606740B1 (ko) 2023-11-24
EP4082547A1 (en) 2022-11-02

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