JP2018500905A5 - - Google Patents

Download PDF

Info

Publication number
JP2018500905A5
JP2018500905A5 JP2017532800A JP2017532800A JP2018500905A5 JP 2018500905 A5 JP2018500905 A5 JP 2018500905A5 JP 2017532800 A JP2017532800 A JP 2017532800A JP 2017532800 A JP2017532800 A JP 2017532800A JP 2018500905 A5 JP2018500905 A5 JP 2018500905A5
Authority
JP
Japan
Prior art keywords
thio
substitution
nucleic acid
nucleotide
alpha
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2017532800A
Other languages
English (en)
Japanese (ja)
Other versions
JP2018500905A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2015/066321 external-priority patent/WO2016100635A1/en
Publication of JP2018500905A publication Critical patent/JP2018500905A/ja
Publication of JP2018500905A5 publication Critical patent/JP2018500905A5/ja
Pending legal-status Critical Current

Links

JP2017532800A 2014-12-18 2015-12-17 ナノチューブを使用した核酸ポリメラーゼ立体構造変化の検出 Pending JP2018500905A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462093671P 2014-12-18 2014-12-18
US62/093,671 2014-12-18
PCT/US2015/066321 WO2016100635A1 (en) 2014-12-18 2015-12-17 Detection of nucleic acid polymerase conformational changes using a nanotube

Publications (2)

Publication Number Publication Date
JP2018500905A JP2018500905A (ja) 2018-01-18
JP2018500905A5 true JP2018500905A5 (https=) 2019-01-31

Family

ID=56127582

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2017532800A Pending JP2018500905A (ja) 2014-12-18 2015-12-17 ナノチューブを使用した核酸ポリメラーゼ立体構造変化の検出

Country Status (10)

Country Link
US (1) US20180051316A1 (https=)
EP (1) EP3234178A4 (https=)
JP (1) JP2018500905A (https=)
KR (1) KR20170091158A (https=)
CN (2) CN107109466A (https=)
AU (1) AU2015364602B2 (https=)
CA (1) CA2971268A1 (https=)
RU (1) RU2721965C2 (https=)
SG (1) SG11201704862UA (https=)
WO (2) WO2016100637A1 (https=)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113985017A (zh) 2016-01-14 2022-01-28 罗斯韦尔生物技术股份有限公司 分子传感器及相关方法
CN109071212A (zh) 2016-01-28 2018-12-21 罗斯韦尔生物技术股份有限公司 使用大规模分子电子传感器阵列测量分析物的方法和装置
KR102763291B1 (ko) 2016-01-28 2025-02-04 로스웰 엠이 아이엔씨. 대량 병렬 dna 시퀀싱 장치
CA3053103A1 (en) 2016-02-09 2017-08-17 Roswell Biotechnologies, Inc. Electronic label-free dna and genome sequencing
US10597767B2 (en) 2016-02-22 2020-03-24 Roswell Biotechnologies, Inc. Nanoparticle fabrication
US9829456B1 (en) 2016-07-26 2017-11-28 Roswell Biotechnologies, Inc. Method of making a multi-electrode structure usable in molecular sensing devices
CN106244712B (zh) 2016-08-31 2019-11-19 北京大学 Dna测序方法
EP3545076A4 (en) * 2016-11-22 2020-07-29 Roswell Biotechnologies, Inc NUCLEIC ACID SEQUENCING DEVICE CONTAINING GRAPHEN
CN110431148A (zh) 2017-01-10 2019-11-08 罗斯威尔生命技术公司 用于dna数据存储的方法和系统
CA3052140A1 (en) * 2017-01-19 2018-07-26 Roswell Biotechnologies, Inc. Solid state sequencing devices comprising two dimensional layer materials
US10508296B2 (en) 2017-04-25 2019-12-17 Roswell Biotechnologies, Inc. Enzymatic circuits for molecular sensors
EP3615685B1 (en) 2017-04-25 2025-02-19 Roswell Biotechnologies, Inc Enzymatic circuits for molecular sensors
EP3622086A4 (en) 2017-05-09 2021-04-21 Roswell Biotechnologies, Inc BINDING PROBE CIRCUITS FOR MOLECULAR SENSORS
CN111373049A (zh) 2017-08-30 2020-07-03 罗斯威尔生命技术公司 用于dna数据存储的进行性酶分子电子传感器
JP2020530257A (ja) 2017-09-15 2020-10-22 イルミナ インコーポレイテッド 配列検出システム
CA3067230A1 (en) 2017-09-15 2019-03-21 Illumina, Inc. Tuning and calibration features of a sequence-detection system
EP3694990A4 (en) 2017-10-10 2022-06-15 Roswell Biotechnologies, Inc. METHODS, DEVICE AND SYSTEMS FOR AMPLIFICATION-FREE DNA DATA STORAGE
HRP20231063T1 (hr) * 2017-10-13 2023-12-22 Novo Nordisk Health Care Ag Postupci i pripravci namijenjeni inhibiranju eksprimiranja ldha
SG11202011394WA (en) * 2018-05-17 2020-12-30 Stuart Lindsay Device, system and method for direct electrical measurement of enzyme activity
US20240011086A1 (en) 2018-11-15 2024-01-11 Omniome, Inc. Electronic detection of nucleic acid structure
CN211311477U (zh) 2018-12-04 2020-08-21 欧姆尼欧美公司 测序系统
WO2020160300A2 (en) 2019-01-30 2020-08-06 Stuart Lindsay Bioelectronic circuits, systems and methods for preparing and using them
US11499189B2 (en) 2019-02-14 2022-11-15 Pacific Biosciences Of California, Inc. Mitigating adverse impacts of detection systems on nucleic acids and other biological analytes
CN114641578A (zh) * 2019-03-01 2022-06-17 通用测序技术公司 用于生物聚合物鉴定的装置和方法
US20220251638A1 (en) * 2019-05-27 2022-08-11 Universal Sequencing Technology Corporation Methods to Identify Components in Nucleic Acid Sequences
EP4028407B1 (en) 2019-09-10 2023-08-16 Pacific Biosciences of California, Inc. Reversible modification of nucleotides
DE202019106694U1 (de) 2019-12-02 2020-03-19 Omniome, Inc. System zur Sequenzierung von Nukleinsäuren in Fluidschaum
WO2021158511A1 (en) 2020-02-04 2021-08-12 Omniome, Inc. Flow cells and methods for their manufacture and use
KR20220147602A (ko) * 2020-02-28 2022-11-03 아리조나 보드 오브 리젠츠 온 비하프 오브 아리조나 스테이트 유니버시티 생체고분자를 시퀀싱하는 방법
WO2021211950A1 (en) 2020-04-17 2021-10-21 Arizona Board Of Regents On Behalf Of Arizona State University Single-molecule electronic sequence detector and methods of use
KR20230005866A (ko) 2020-04-30 2023-01-10 아리조나 보드 오브 리젠츠 온 비하프 오브 아리조나 스테이트 유니버시티 바이오폴리머 시퀀싱 방법
EP4158063A4 (en) 2020-05-29 2024-05-29 Arizona Board of Regents on behalf of Arizona State University BIOELECTRONIC DEVICES WITH PROGRAMMABLE ADAPTERS
AU2021288692A1 (en) 2020-06-11 2023-02-02 Nautilus Subsidiary, Inc. Methods and systems for computational decoding of biological, chemical, and physical entities
CA3196729A1 (en) 2020-11-11 2022-05-19 Tural AKSEL Affinity reagents having enhanced binding and detection characteristics
EP4281775B1 (en) 2021-01-21 2026-04-29 Nautilus Subsidiary, Inc. Systems and methods for biomolecule preparation
IL305336B2 (en) 2021-03-11 2025-09-01 Nautilus Subsidiary Inc Systems and methods for preserving biomolecules
CA3227872A1 (en) 2021-09-09 2023-03-16 James Henry JOLY Characterization and localization of protein modifications
CA3227592A1 (en) 2021-09-22 2023-03-30 Gregory KAPP Methods and systems for determining polypeptide interactions
US20230149883A1 (en) 2021-11-03 2023-05-18 Nautilus Biotechnology, Inc. Systems and methods for surface structuring
US12092578B2 (en) 2022-03-29 2024-09-17 Nautilus Subsidiary, Inc. Integrated arrays for single-analyte processes
CN117174183B (zh) * 2022-05-27 2025-11-25 中国科学院大连化学物理研究所 基于多尺度分子动力学模拟的rna结构预测方法
EP4544077A1 (en) 2022-06-21 2025-04-30 Nautilus Subsidiary, Inc. Method for detecting analytes at sites of optically non-resolvable distances
WO2024073599A1 (en) 2022-09-29 2024-04-04 Nautilus Subsidiary, Inc. Preparation of array surfaces for single-analyte processes
WO2024124073A1 (en) 2022-12-09 2024-06-13 Nautilus Subsidiary, Inc. A method comprising performing on a single-analyte array at least 50 cycles of a process
US20240201182A1 (en) 2022-12-15 2024-06-20 Nautilus Subsidiary, Inc. Inhibition of photon phenomena on single molecule arrays
EP4689173A1 (en) 2023-03-24 2026-02-11 Nautilus Subsidiary, Inc. Improved transfer of nanoparticles to array surfaces
US20240394902A1 (en) 2023-05-24 2024-11-28 Nautilus Subsidiary, Inc. Systems and methods for machine vision
US20250066841A1 (en) 2023-08-24 2025-02-27 Nautilus Subsidiary, Inc. Compositions and methods for detecting binding interactions under equilibrium or non-equilibrium conditions
US20250189519A1 (en) 2023-12-11 2025-06-12 Nautilus Subsidiary, Inc. Methods and compositions of particle-based arrays
WO2025137166A1 (en) 2023-12-20 2025-06-26 Nautilus Subsidiary, Inc. Fluidic devices for single-analyte assays
US20250298016A1 (en) 2024-03-22 2025-09-25 Nautilus Subsidiary, Inc. Plasmonic particle systems for single-analyte assays
WO2025212338A1 (en) 2024-04-01 2025-10-09 Nautilus Subsidiary, Inc. Nanostructures for modulation of analyte conformation

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8911972B2 (en) * 2009-12-16 2014-12-16 Pacific Biosciences Of California, Inc. Sequencing methods using enzyme conformation
US20110287432A1 (en) * 2010-05-21 2011-11-24 454 Life Science Corporation System and method for tailoring nucleotide concentration to enzymatic efficiencies in dna sequencing technologies
US8884251B2 (en) * 2010-06-03 2014-11-11 Element Six Limited Diamond tools
CN103620403B (zh) * 2011-01-11 2016-08-10 纽约市哥伦比亚大学理事会 使用纳米管监测单分子的系统和方法
US9164053B2 (en) * 2011-09-26 2015-10-20 The Regents Of The University Of California Electronic device for monitoring single molecule dynamics
WO2013096692A1 (en) * 2011-12-21 2013-06-27 Illumina, Inc. Apparatus and methods for kinetic analysis and determination of nucleic acid sequences
US9950001B2 (en) * 2012-08-20 2018-04-24 The Regents Of The University Of California Polynucleotides having bioreversible groups

Similar Documents

Publication Publication Date Title
JP2018500905A5 (https=)
RU2017125417A (ru) Обнаружение изменений конформации полимеразы нуклеиновых кислот с помощью нанотрубки
Farimani et al. DNA base detection using a single-layer MoS2
Shukla et al. Prospects of graphene–hBN heterostructure nanogap for DNA sequencing
CN108700535B (zh) 用于核酸检测和鉴别的纳米传感器
US9377431B2 (en) Heterojunction nanopore for sequencing
Rangnekar et al. Building DNA nanostructures for molecular computation, templated assembly, and biological applications
JP2015504661A5 (https=)
WO2014152397A3 (en) Selective purification of rna and rna-bound molecular complexes
JP2016526876A5 (https=)
JP2015525077A5 (https=)
JP2017002079A5 (https=)
WO2016187284A8 (en) Methods and composition for determining ph
JP7612659B2 (ja) 標的分子を評価するためのシステム及び方法
JP2016515827A5 (https=)
Ahmed et al. Next-generation epigenetic detection technique: identifying methylated cytosine using graphene nanopore
Kumawat et al. Extended topological line defects in graphene for individual identification of DNA nucleobases
Tyagi et al. Revealing the mechanism of DNA passing through graphene and boron nitride nanopores
US9965586B2 (en) Noise reduction methods for nucleic acid and macromolecule sequencing
JP2021536261A (ja) ナノ細孔デバイスを使用して分子を検出するためのセンシング組成物、方法、およびデバイス
Russell et al. Formation of silver nanostructures by rolling circle amplification using boranephosphonate-modified nucleotides
Liu et al. Self-aligning nanojunctions for integrated single-molecule circuits
Mittal et al. A step toward amino acid-labeled DNA sequencing: boosting transmission sensitivity of graphene nanogap
WO2016094294A1 (en) Quantum molecular sequencing (qm-seq): identification of unique nanoelectronic tunneling spectroscopy fingerprints for dna, rna, and single nucleotide modifications
US9528153B2 (en) Base-by-base ratcheting of DNA/RNA in a Y-shaped nanochannel