JP2016515827A5 - - Google Patents
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- Publication number
- JP2016515827A5 JP2016515827A5 JP2016506666A JP2016506666A JP2016515827A5 JP 2016515827 A5 JP2016515827 A5 JP 2016515827A5 JP 2016506666 A JP2016506666 A JP 2016506666A JP 2016506666 A JP2016506666 A JP 2016506666A JP 2016515827 A5 JP2016515827 A5 JP 2016515827A5
- Authority
- JP
- Japan
- Prior art keywords
- chimeric
- probe
- rna
- region
- label
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 239000000523 sample Substances 0.000 claims description 134
- 238000000034 method Methods 0.000 claims description 47
- 239000002773 nucleotide Substances 0.000 claims description 42
- 125000003729 nucleotide group Chemical group 0.000 claims description 42
- 238000001514 detection method Methods 0.000 claims description 39
- 150000007523 nucleic acids Chemical class 0.000 claims description 22
- 102000039446 nucleic acids Human genes 0.000 claims description 22
- 108020004707 nucleic acids Proteins 0.000 claims description 22
- 230000000295 complement effect Effects 0.000 claims description 20
- 239000007787 solid Substances 0.000 claims description 20
- 239000000758 substrate Substances 0.000 claims description 20
- 238000004220 aggregation Methods 0.000 claims description 10
- 230000009870 specific binding Effects 0.000 claims description 10
- 230000004931 aggregating effect Effects 0.000 claims description 8
- 230000002776 aggregation Effects 0.000 claims description 8
- 241000894006 Bacteria Species 0.000 claims description 6
- 241000700605 Viruses Species 0.000 claims description 6
- 125000003277 amino group Chemical group 0.000 claims description 6
- 244000005700 microbiome Species 0.000 claims description 6
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims description 4
- 102000006382 Ribonucleases Human genes 0.000 claims description 4
- 108010083644 Ribonucleases Proteins 0.000 claims description 4
- 108010090804 Streptavidin Proteins 0.000 claims description 4
- 230000027455 binding Effects 0.000 claims description 4
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 claims description 4
- 229910052737 gold Inorganic materials 0.000 claims description 4
- 239000010931 gold Substances 0.000 claims description 4
- 239000003795 chemical substances by application Substances 0.000 claims description 3
- 102000004594 DNA Polymerase I Human genes 0.000 claims description 2
- 108010017826 DNA Polymerase I Proteins 0.000 claims description 2
- 102000016928 DNA-directed DNA polymerase Human genes 0.000 claims description 2
- 108010014303 DNA-directed DNA polymerase Proteins 0.000 claims description 2
- 102100034343 Integrase Human genes 0.000 claims description 2
- 101710203526 Integrase Proteins 0.000 claims description 2
- FOIXSVOLVBLSDH-UHFFFAOYSA-N Silver ion Chemical compound [Ag+] FOIXSVOLVBLSDH-UHFFFAOYSA-N 0.000 claims description 2
- 229960002685 biotin Drugs 0.000 claims description 2
- 235000020958 biotin Nutrition 0.000 claims description 2
- 239000011616 biotin Substances 0.000 claims description 2
- 239000002105 nanoparticle Substances 0.000 claims description 2
- 229910052709 silver Inorganic materials 0.000 claims description 2
- 239000004332 silver Substances 0.000 claims description 2
- 230000001404 mediated effect Effects 0.000 claims 1
- 125000005647 linker group Chemical group 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 230000004520 agglutination Effects 0.000 description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361808447P | 2013-04-04 | 2013-04-04 | |
| US61/808,447 | 2013-04-04 | ||
| PCT/US2014/033062 WO2014165814A1 (en) | 2013-04-04 | 2014-04-04 | Rna microchip detection using nanoparticle-assisted signal amplification |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016515827A JP2016515827A (ja) | 2016-06-02 |
| JP2016515827A5 true JP2016515827A5 (https=) | 2017-05-18 |
Family
ID=51023017
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016506666A Ceased JP2016515827A (ja) | 2013-04-04 | 2014-04-04 | ナノ粒子支援シグナル増幅を使用するｒｎａマイクロチップ検出 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20160068894A1 (https=) |
| EP (1) | EP2981622A1 (https=) |
| JP (1) | JP2016515827A (https=) |
| KR (1) | KR20150139582A (https=) |
| CN (1) | CN105283561A (https=) |
| HK (1) | HK1220236A1 (https=) |
| WO (1) | WO2014165814A1 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016130811A1 (en) * | 2015-02-11 | 2016-08-18 | Biogen Ma Inc. | Methods and compositions for detecting therapeutic nucleic acids |
| US10472666B2 (en) | 2016-02-15 | 2019-11-12 | Roche Sequencing Solutions, Inc. | System and method for targeted depletion of nucleic acids |
| WO2017140659A1 (en) * | 2016-02-15 | 2017-08-24 | F. Hoffmann-La Roche Ag | System and method for targeted depletion of nucleic acids |
| KR102066148B1 (ko) * | 2016-09-22 | 2020-01-14 | 고려대학교 산학협력단 | 나노 플라즈모닉 바이오센서 및 이를 이용한 발병 표지 인자의 검출방법 |
| CN107828861B (zh) * | 2017-11-21 | 2021-06-04 | 湖南工程学院 | 基于微流控芯片和g-四链体-血红素dna酶检测循环核酸用试剂盒及其制备方法和应用 |
| CA3168815A1 (en) * | 2020-03-03 | 2021-09-10 | Universiteit Gent | Hydrolysis-based probe and method for str genotyping |
| CN118957050A (zh) * | 2022-04-01 | 2024-11-15 | 海南医学院 | 一种登革病毒ns1基因片段裸眼检测平台在制备登革病毒感染筛查的试剂盒中的应用 |
| CN116004765B (zh) * | 2022-08-09 | 2025-11-21 | 合肥工业大学 | 一种功能性核酸探针及其制备方法与应用 |
| WO2024130098A1 (en) * | 2022-12-16 | 2024-06-20 | Cz Biohub Sf, Llc | Microbeads with ratiometric lanthanide encoding for drug screening |
| KR102667684B1 (ko) * | 2023-07-10 | 2024-06-10 | 한국화학연구원 | 형광이 표지된 유전자 프로브의 형광 신호를 증폭하는 은나노 산화아연 복합 나노구조체, 이의 제조방법 및 형광신호 검출방법 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE68927417T2 (de) | 1988-04-27 | 1997-03-20 | Isis Pharmaceutical Inc | Oligoribonukleotid-Derivate und ihre Anwendung als antivirale Mittel |
| US5001050A (en) | 1989-03-24 | 1991-03-19 | Consejo Superior Investigaciones Cientificas | PHφ29 DNA polymerase |
| US5198543A (en) | 1989-03-24 | 1993-03-30 | Consejo Superior Investigaciones Cientificas | PHI29 DNA polymerase |
| US5871928A (en) | 1989-06-07 | 1999-02-16 | Fodor; Stephen P. A. | Methods for nucleic acid analysis |
| DE69103627T2 (de) | 1990-05-07 | 1995-03-30 | Anchor Hocking Packaging | Zusammengesetzter Verschluss. |
| DE4216134A1 (de) | 1991-06-20 | 1992-12-24 | Europ Lab Molekularbiolog | Synthetische katalytische oligonukleotidstrukturen |
| AU659482B2 (en) | 1991-06-28 | 1995-05-18 | Massachusetts Institute Of Technology | Localized oligonucleotide therapy |
| IL108206A0 (en) | 1993-01-06 | 1994-04-12 | Univ Johns Hopkins | Oligomers having improved stability at acid ph |
| US5429807A (en) | 1993-10-28 | 1995-07-04 | Beckman Instruments, Inc. | Method and apparatus for creating biopolymer arrays on a solid support surface |
| EP0746614A1 (en) | 1994-02-23 | 1996-12-11 | Ribozyme Pharmaceuticals, Inc. | Method and reagent for inhibiting the expression of disease related genes |
| US5604097A (en) | 1994-10-13 | 1997-02-18 | Spectragen, Inc. | Methods for sorting polynucleotides using oligonucleotide tags |
| US5599695A (en) | 1995-02-27 | 1997-02-04 | Affymetrix, Inc. | Printing molecular library arrays using deprotection agents solely in the vapor phase |
| AU5429399A (en) | 1998-08-08 | 2000-02-28 | Imperial Cancer Research Technology Limited | Fluorescent assay for biological systems |
| JP2000300267A (ja) * | 1999-04-21 | 2000-10-31 | Technol Res Assoc Of Medical & Welfare Apparatus | 核酸の測定方法及びそのためのキット |
| CA2719072A1 (en) * | 2008-03-26 | 2009-10-01 | Indevr, Inc. | Nanoparticle-mediated signal amplification |
| WO2011049964A1 (en) * | 2009-10-19 | 2011-04-28 | Lab Scientific Group | Rna detection and quantitation |
-
2014
- 2014-04-04 US US14/782,346 patent/US20160068894A1/en not_active Abandoned
- 2014-04-04 JP JP2016506666A patent/JP2016515827A/ja not_active Ceased
- 2014-04-04 WO PCT/US2014/033062 patent/WO2014165814A1/en not_active Ceased
- 2014-04-04 HK HK16108342.0A patent/HK1220236A1/zh unknown
- 2014-04-04 CN CN201480031785.7A patent/CN105283561A/zh active Pending
- 2014-04-04 EP EP14733750.5A patent/EP2981622A1/en not_active Withdrawn
- 2014-04-04 KR KR1020157031699A patent/KR20150139582A/ko not_active Withdrawn