JP2018500905A - ナノチューブを使用した核酸ポリメラーゼ立体構造変化の検出 - Google Patents

ナノチューブを使用した核酸ポリメラーゼ立体構造変化の検出 Download PDF

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JP2018500905A
JP2018500905A JP2017532800A JP2017532800A JP2018500905A JP 2018500905 A JP2018500905 A JP 2018500905A JP 2017532800 A JP2017532800 A JP 2017532800A JP 2017532800 A JP2017532800 A JP 2017532800A JP 2018500905 A JP2018500905 A JP 2018500905A
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nucleic acid
thio
nucleotide
molecule
acid polymerase
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JP2018500905A5 (enExample
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コリンズ，フィリップ・ジー
ワス，グレゴリー・エイ
チョイ，ヨンキ
オルセン，チボリ
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University of California
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University of California, San Diego
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C12Q1/485—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/07—Nucleotidyltransferases (2.7.7)
    • C12Y207/07007—DNA-directed DNA polymerase (2.7.7.7), i.e. DNA replicase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/403—Cells and electrode assemblies
    • G01N27/414—Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS
    • G01N27/4146—Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS involving nanosized elements, e.g. nanotubes, nanowires
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/48707—Physical analysis of biological material of liquid biological material by electrical means
    • G01N33/48721—Investigating individual macromolecules, e.g. by translocation through nanopores
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/91—Transferases (2.)
    • G01N2333/912—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • G01N2333/91205—Phosphotransferases in general
    • G01N2333/91245—Nucleotidyltransferases (2.7.7)
    • G01N2333/9125—Nucleotidyltransferases (2.7.7) with a definite EC number (2.7.7.-)
    • G01N2333/9126—DNA-directed DNA polymerase (2.7.7.7)

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Nanotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • Microelectronics & Electronic Packaging (AREA)
  • Biomedical Technology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
JP2017532800A 2014-12-18 2015-12-17 ナノチューブを使用した核酸ポリメラーゼ立体構造変化の検出 Pending JP2018500905A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462093671P 2014-12-18 2014-12-18
US62/093,671 2014-12-18
PCT/US2015/066321 WO2016100635A1 (en) 2014-12-18 2015-12-17 Detection of nucleic acid polymerase conformational changes using a nanotube

Publications (2)

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JP2018500905A true JP2018500905A (ja) 2018-01-18
JP2018500905A5 JP2018500905A5 (enExample) 2019-01-31

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US (1) US20180051316A1 (enExample)
EP (1) EP3234178A4 (enExample)
JP (1) JP2018500905A (enExample)
KR (1) KR20170091158A (enExample)
CN (2) CN107109466A (enExample)
AU (1) AU2015364602B2 (enExample)
CA (1) CA2971268A1 (enExample)
RU (1) RU2721965C2 (enExample)
SG (1) SG11201704862UA (enExample)
WO (2) WO2016100637A1 (enExample)

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JP2021524281A (ja) * 2018-05-17 2021-09-13 リンジー，スチュアート 酵素活性の直接電気測定用のデバイス、システムおよび方法
US12351855B2 (en) 2019-01-30 2025-07-08 Arizona Board Of Regents On Behalf Of Arizona State University Bioelectronic circuits, systems and methods for preparing and using them
US12509720B2 (en) 2020-04-30 2025-12-30 Arizona Board Of Regents On Behalf Of Arizona State University Methods for sequencing biopolymers
US12624389B2 (en) 2021-06-07 2026-05-12 Arizona Board Of Regents On Behalf Of Arizona State University Methods for sequencing biopolymers
US12637711B2 (en) 2019-06-20 2026-05-26 Arizona Board Of Regents On Behalf Of Arizona State University Direct electrical readout of nucleic acid sequences

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CN106244712B (zh) 2016-08-31 2019-11-19 北京大学 Dna测序方法
EP3545076A4 (en) * 2016-11-22 2020-07-29 Roswell Biotechnologies, Inc NUCLEIC ACID SEQUENCING DEVICE CONTAINING GRAPHEN
CN110431148A (zh) 2017-01-10 2019-11-08 罗斯威尔生命技术公司 用于dna数据存储的方法和系统
KR102685937B1 (ko) 2017-01-19 2024-07-17 로스웰 엠이 아이엔씨. 2차원 레이어 재료를 포함하는 솔리드 스테이트 시퀀싱 디바이스들
KR102692957B1 (ko) 2017-04-25 2024-08-06 로스웰 엠이 아이엔씨. 분자 센서들을 위한 효소 회로들
CN110651182B (zh) 2017-05-09 2022-12-30 罗斯威尔生命技术公司 用于分子传感器的结合探针电路
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HRP20231063T1 (hr) 2017-10-13 2023-12-22 Novo Nordisk Health Care Ag Postupci i pripravci namijenjeni inhibiranju eksprimiranja ldha
US20240011086A1 (en) 2018-11-15 2024-01-11 Omniome, Inc. Electronic detection of nucleic acid structure
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CN114641578A (zh) * 2019-03-01 2022-06-17 通用测序技术公司 用于生物聚合物鉴定的装置和方法
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CN116018413A (zh) 2020-05-29 2023-04-25 代表亚利桑那大学的亚利桑那校董事会 具有可编程适配子的生物电子装置
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JP2021524281A (ja) * 2018-05-17 2021-09-13 リンジー，スチュアート 酵素活性の直接電気測定用のデバイス、システムおよび方法
JP7433300B2 (ja) 2018-05-17 2024-02-19 レコグニション アナリティクス インコーポレイテッド 酵素活性の直接電気測定用のデバイス、システムおよび方法
US12480937B2 (en) 2018-05-17 2025-11-25 Recognition AnalytiX, Inc. Device, system and method for direct electrical measurement of enzyme activity
US12351855B2 (en) 2019-01-30 2025-07-08 Arizona Board Of Regents On Behalf Of Arizona State University Bioelectronic circuits, systems and methods for preparing and using them
US12637711B2 (en) 2019-06-20 2026-05-26 Arizona Board Of Regents On Behalf Of Arizona State University Direct electrical readout of nucleic acid sequences
US12509720B2 (en) 2020-04-30 2025-12-30 Arizona Board Of Regents On Behalf Of Arizona State University Methods for sequencing biopolymers
US12624389B2 (en) 2021-06-07 2026-05-12 Arizona Board Of Regents On Behalf Of Arizona State University Methods for sequencing biopolymers

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Publication number Publication date
AU2015364602B2 (en) 2021-12-09
RU2017125417A (ru) 2019-01-23
EP3234178A4 (en) 2018-07-11
RU2017125417A3 (enExample) 2019-05-27
RU2721965C2 (ru) 2020-05-25
CA2971268A1 (en) 2016-06-23
US20180051316A1 (en) 2018-02-22
WO2016100637A1 (en) 2016-06-23
KR20170091158A (ko) 2017-08-08
CN107109466A (zh) 2017-08-29
WO2016100635A1 (en) 2016-06-23
CN109517878A (zh) 2019-03-26
EP3234178A1 (en) 2017-10-25
SG11201704862UA (en) 2017-07-28
AU2015364602A1 (en) 2017-07-06

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Effective date: 20220418