JP2018193364A - 内服組成物、甘味の後引きを改善する方法および変色を抑制する方法 - Google Patents
内服組成物、甘味の後引きを改善する方法および変色を抑制する方法 Download PDFInfo
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- JP2018193364A JP2018193364A JP2018092241A JP2018092241A JP2018193364A JP 2018193364 A JP2018193364 A JP 2018193364A JP 2018092241 A JP2018092241 A JP 2018092241A JP 2018092241 A JP2018092241 A JP 2018092241A JP 2018193364 A JP2018193364 A JP 2018193364A
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Abstract
Description
なお、本発明の内服組成物には、飲食品(飲料および食品)、医薬部外品および医薬品が含まれる。
クロセチンは、通常、カロテノイド系の黄色色素であるクロシン(クロセチンのジゲンチオビオースエステル)を加水分解することにより得られる。上記クロシンは、アカネ科クチナシ(Gardenia augusta MERRIL var.grandiflora HORT.,Gardenia jasminoides ELLIS)の果実、サフランの柱頭の乾燥物等に含まれており、工業的原料としてはクチナシの果実が好ましく用いられる。
後記の表1〜5に示す組成のとおり、内服組成物(実施例1〜19、比較例1〜9、いずれも粉末状)を調製した。すなわち、各材料を準備し、これらを一度に混合して、粉末状の内服組成物を調製した。なお、クロセチンについては、クロセチン製剤であるクロビットP(クロセチン含量75wt%、理研ビタミン社製)を使用した。
官能検査について訓練を受けたパネラー5名により、内服組成物の甘味の質(甘味や雑味の後引き)を評価した。すなわち、各パネラーは、表1〜3に示す組成のとおり調製した内服組成物を、ミクロスパーテル1さじ分をすくい取って口内に含み、その甘味の質(甘味や雑味の後引き)を下記の基準に基づいて採点した。そして、パネラー5名の採点の合計点を下記の指標にあてはめ、各内服組成物の評価とした。
[採点基準]
2点(非常によい):不快な甘みおよび雑味が全く残らない。
1点(よい):不快な甘みおよび雑味がごくわずかに残るが、気にならない。
−1点(悪い):不快な甘みおよび雑味が残るが、口内を水ですすげば取り除くことができる。
−2点(非常に悪い):不快な甘みおよび雑味が残り、口内を水ですすいでも取り除くことができない。
[評価指標]
◎(非常によい):6点以上
〇(よい):3点以上6点未満
×(悪い):0点以上3点未満
××(非常に悪い):0点未満
表4および5に示す組成の通り調製した内服組成物をガラス瓶に約0.5gずつ入れて密封し、調製直後と40℃で一日(24時間)保管した後の内服組成物の色差を測定した。色差は色差計(日本電色工業社製、品番:GC 5000)を用いて測定し、下記の式1を用いて求めた。その結果を表4および5に併せて示す。
式1:色差(ΔE*ab)=[(Δa*)2+(Δb*)2+(ΔL*)2]1/2
Δa*:保存後の内服組成物のa値−保存前の内服組成物のa値
Δb*:保存後の内服組成物のb値−保存前の内服組成物のb値
ΔL*:保存後の内服組成物のL値−保存前の内服組成物のL値
一方、クロセチンのみが含有され、甘味料を含有していない比較例9は、保存前後の色差が大きく、クロセチンに由来する黄色が変色し、外観の変化が目立つという結果であった。
下記の表6〜10に示す材料を用いて、本発明の内服組成物(製剤例1〜27)を調製した。製剤例1〜9(表6参照)はチュアブルの形状とし、製剤例10〜15(表7参照)は錠剤の形状とし、製剤例16〜19(表8参照)はドリンクとし、製剤例20〜23(表9参照)はゼリーの形状とし、製剤例24〜27(表10参照)はグミの形状とした。なお、製剤例1〜27の材料として、クロセチンについては、実施例1〜19で用いたものを用い、その他の材料は食品原料又は食品添加物規格のものを用いている。これらの内服組成物は眼精疲労、近視予防等の視機能改善効果に優れている。
Claims (8)
- クロセチンおよび甘味料を含有することを特徴とする内服組成物。
- 上記甘味料に対するクロセチンの質量比が、0.0001〜10である請求項1記載の内服組成物。
- 上記甘味料が、非糖質系甘味料、糖アルコールおよびこれらの混合物からなる群から選ばれた少なくとも一つである請求項1又は2記載の内服組成物。
- 上記非糖質系甘味料が、アスパルテーム、ネオテーム、スクラロース、アセスルファムカリウムおよびステビア抽出物からなる群から選ばれた少なくとも一つである請求項3記載の内服組成物。
- 上記糖アルコールが、キシリトール、ソルビトール、エリスリトール、マルチトールおよびイソマルツロース還元物からなる群から選ばれた少なくとも一つである請求項3記載の内服組成物。
- 上記内服組成物が、口腔内崩壊錠、チュアブル錠、顆粒剤、散剤、トローチ錠、ゼリー剤、グミ剤、ガム剤、液剤およびシロップ剤のいずれかの形状である請求項1〜5のいずれか一項に記載の内服組成物。
- 甘味料とクロセチンとを併用することを特徴とする、甘味料を含有する内服組成物の甘味の後引きを改善する方法。
- 甘味料とクロセチンとを併用することを特徴とする、クロセチンを含有する内服組成物の変色を抑制する方法。
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