JP2018016629A5 - - Google Patents
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- Publication number
- JP2018016629A5 JP2018016629A5 JP2017170106A JP2017170106A JP2018016629A5 JP 2018016629 A5 JP2018016629 A5 JP 2018016629A5 JP 2017170106 A JP2017170106 A JP 2017170106A JP 2017170106 A JP2017170106 A JP 2017170106A JP 2018016629 A5 JP2018016629 A5 JP 2018016629A5
- Authority
- JP
- Japan
- Prior art keywords
- fap
- proteasome inhibitor
- inhibitor according
- lower alkyl
- pharmaceutical composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161528824P | 2011-08-30 | 2011-08-30 | |
| US61/528,824 | 2011-08-30 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014528600A Division JP6207509B2 (ja) | 2011-08-30 | 2012-08-30 | 固形腫瘍を治療するためのｆａｐ活性化プロテアソーム阻害剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018016629A JP2018016629A (ja) | 2018-02-01 |
| JP2018016629A5 true JP2018016629A5 (enExample) | 2018-03-22 |
Family
ID=47757170
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014528600A Active JP6207509B2 (ja) | 2011-08-30 | 2012-08-30 | 固形腫瘍を治療するためのｆａｐ活性化プロテアソーム阻害剤 |
| JP2017170106A Pending JP2018016629A (ja) | 2011-08-30 | 2017-09-05 | 固形腫瘍を治療するためのｆａｐ活性化プロテアソーム阻害剤 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014528600A Active JP6207509B2 (ja) | 2011-08-30 | 2012-08-30 | 固形腫瘍を治療するためのｆａｐ活性化プロテアソーム阻害剤 |
Country Status (14)
| Country | Link |
|---|---|
| US (6) | US9597410B2 (enExample) |
| EP (3) | EP4706663A3 (enExample) |
| JP (2) | JP6207509B2 (enExample) |
| CN (2) | CN103945856A (enExample) |
| AU (2) | AU2012301810B2 (enExample) |
| CA (1) | CA2846852C (enExample) |
| DK (1) | DK2753334T3 (enExample) |
| ES (1) | ES2929179T3 (enExample) |
| HR (1) | HRP20221320T1 (enExample) |
| HU (1) | HUE060305T2 (enExample) |
| PL (1) | PL2753334T3 (enExample) |
| PT (1) | PT2753334T (enExample) |
| SI (1) | SI2753334T1 (enExample) |
| WO (1) | WO2013033396A2 (enExample) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4706663A3 (en) * | 2011-08-30 | 2026-05-20 | Trustees Of Tufts College | FAP-ACTIVATED PROTEASOME INHIBITORS USED TO TREAT SOLID TUMORS |
| EP2925746A1 (en) * | 2012-12-03 | 2015-10-07 | F. Hoffmann-La Roche AG | Substituted triazole and imidazole compounds |
| WO2014200969A2 (en) * | 2013-06-10 | 2014-12-18 | Millennium Pharmaceuticals, Inc. | Methods of treatment of cancer |
| WO2015076359A1 (ja) * | 2013-11-21 | 2015-05-28 | 国立大学法人北海道大学 | プロテアソーム阻害性化合物 |
| WO2015192124A1 (en) | 2014-06-13 | 2015-12-17 | Trustees Of Tufts College | Fap-activated therapeutic agents, and uses related thereto |
| IL325256A (en) * | 2014-06-13 | 2026-02-01 | Bach Biosciences Llc | FAP-activated medical materials and related uses |
| US10973920B2 (en) | 2014-06-30 | 2021-04-13 | Glykos Finland Oy | Saccharide derivative of a toxic payload and antibody conjugates thereof |
| WO2016011088A2 (en) * | 2014-07-14 | 2016-01-21 | Centrax International, Inc. | Epoxyketone compounds for enzyme inhibition |
| CN104231047B (zh) * | 2014-08-22 | 2017-06-16 | 亚飞（上海）生物医药科技有限公司 | 水溶性靶向激活的紫杉醇衍生物及其制备和用途 |
| CN106715457B (zh) | 2014-08-22 | 2021-09-28 | 亚飞（上海）生物医药科技有限公司 | 一种肿瘤微环境特异激活的小分子靶向偶联体及其用途 |
| WO2016210054A1 (en) * | 2015-06-23 | 2016-12-29 | The Board Of Trustees Of The Leland Stanford Junior University | Novel rhodol fluorophores for near-infrared imaging |
| CN106588965A (zh) | 2015-10-15 | 2017-04-26 | 北京大学 | 脲拟肽硼酸化合物及其药物组合物、制备方法和用途 |
| CN105938123B (zh) * | 2015-12-18 | 2018-09-14 | 重庆两江药物研发中心有限公司 | 一种卡非佐米中间体中杂质的检测方法 |
| WO2017156071A1 (en) | 2016-03-09 | 2017-09-14 | Blade Therapeutics, Inc. | Cyclic keto-amide compounds as calpain modulators and methods of production and use thereof |
| JP7164521B2 (ja) | 2016-06-21 | 2022-11-01 | オリオン・オフサルモロジー・エルエルシー | 炭素環式プロリンアミド誘導体 |
| JP7179721B2 (ja) | 2016-06-21 | 2022-11-29 | オリオン・オフサルモロジー・エルエルシー | 複素環式プロリンアミド誘導体 |
| AU2017292646A1 (en) | 2016-07-05 | 2019-02-07 | Blade Therapeutics, Inc. | Calpain modulators and therapeutic uses thereof |
| US10934261B2 (en) | 2016-09-28 | 2021-03-02 | Blade Therapeutics, Inc. | Calpain modulators and therapeutic uses thereof |
| JP7162592B2 (ja) | 2016-12-14 | 2022-10-28 | パーデュー・リサーチ・ファウンデイション | 線維芽細胞活性化タンパク質（ｆａｐ）標的イメージングおよび治療 |
| WO2018129497A1 (en) | 2017-01-09 | 2018-07-12 | Bioxcel Therapeutics, Inc. | Predictive and diagnostic methods for prostate cancer |
| WO2018187418A1 (en) * | 2017-04-04 | 2018-10-11 | Genentech, Inc. | Substrates recognized by fibroblast activation protein (fap) and methods of using the same |
| GB201710973D0 (en) | 2017-07-07 | 2017-08-23 | Avacta Life Sciences Ltd | Scaffold proteins |
| KR102005030B1 (ko) * | 2017-10-31 | 2019-07-29 | 충북대학교 산학협력단 | 프로테아좀 억제제를 유효성분으로 포함하는 신경퇴행성 질환의 예방 또는 치료용 약학적 조성물 |
| CN108191957B (zh) * | 2017-12-30 | 2021-05-04 | 浙江大学 | 三肽大环衍生物及其制备方法和应用 |
| JP2021512165A (ja) | 2018-01-29 | 2021-05-13 | コグノス・セラピューティクス・インコーポレイテッド | ボルテゾミブの腫瘍内送達 |
| PH12020551205A1 (en) * | 2018-02-06 | 2021-04-19 | Univ Heidelberg | Fap inhibitors |
| US11466036B2 (en) * | 2018-08-02 | 2022-10-11 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Borate of azetidine derivative |
| WO2020033437A1 (en) | 2018-08-06 | 2020-02-13 | University Of Kentucky Research Foundation | Proteasome inhibitors |
| GB201820320D0 (en) * | 2018-12-13 | 2019-01-30 | Bicyclerd Ltd | Bicyclic peptide ligands specific for FAPalpha |
| US20240092831A1 (en) * | 2019-10-11 | 2024-03-21 | Mayo Foundation For Medical Education And Research | Proteasome Inhibitors |
| CN111235221B (zh) * | 2020-01-22 | 2022-08-05 | 北京大学第一医院 | 一种fap抑制剂的活性检测方法 |
| CZ309380B6 (cs) * | 2020-03-30 | 2022-10-26 | Ústav organické chemie a biochemie AV ČR v. v. i | Sloučeniny pro inhibici fibroblastového aktivačního proteinu |
| EP4706662A1 (en) * | 2020-06-17 | 2026-03-11 | University of Utah Research Foundation | Biomarker based patient selection for proteasome inhibitor treatment |
| UY39569A (es) | 2020-12-17 | 2022-07-29 | Astrazeneca Ab | N-(2-(4-cianotiazolidin-3-il)-2-oxoetil)- quinolin-4-carboxamidas |
| EP4262878A1 (en) * | 2020-12-17 | 2023-10-25 | Trustees Of Tufts College | Fap-activated radiotheranostics, and uses related thereto |
| JP2024510435A (ja) | 2021-03-18 | 2024-03-07 | シージェン インコーポレイテッド | 生体活性化合物の内部移行複合体からの選択的薬物放出 |
| US11806405B1 (en) | 2021-07-19 | 2023-11-07 | Zeno Management, Inc. | Immunoconjugates and methods |
| CA3224492A1 (en) | 2021-07-19 | 2023-01-26 | Xiaojun Han | Immunoconjugates and methods |
| TWI869142B (zh) * | 2022-12-27 | 2025-01-01 | 大陸商上海美悦生物科技發展有限公司 | 三肽環氧酮化合物、藥物組合物及其製備方法和用途 |
| US20250186630A1 (en) | 2023-12-12 | 2025-06-12 | Viewpoint Molecular Targeting, Inc. | Fibroblast activation protein targeting peptides |
| WO2025159301A1 (ko) * | 2024-01-24 | 2025-07-31 | 서울대학교산학협력단 | 섬유아세포 활성화 단백질에 의해 활성화되는 프로드러그 화합물 |
| WO2025259682A1 (en) * | 2024-06-10 | 2025-12-18 | Trustees Of Tufts College | Enzyme-activated prodrugs with small molecule-mediated extended serum half-life |
| WO2026060338A1 (en) * | 2024-09-13 | 2026-03-19 | Case Western Reserve University | Anticancer mtor activator |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4499082A (en) | 1983-12-05 | 1985-02-12 | E. I. Du Pont De Nemours And Company | α-Aminoboronic acid peptides |
| ZA86746B (en) | 1985-02-04 | 1986-09-24 | Merrell Dow Pharma | Novel peptidase inhibitors |
| US4935493A (en) | 1987-10-06 | 1990-06-19 | E. I. Du Pont De Nemours And Company | Protease inhibitors |
| US5462928A (en) | 1990-04-14 | 1995-10-31 | New England Medical Center Hospitals, Inc. | Inhibitors of dipeptidyl-aminopeptidase type IV |
| US6825169B1 (en) | 1991-10-22 | 2004-11-30 | Trustees Of Tufts College | Inhibitors of dipeptidyl-aminopeptidase type IV |
| DE69535019T2 (de) | 1994-03-11 | 2007-01-04 | Wilson Greatbatch, Ltd. | Elektromagnetische pumpe mit geringem vermögen |
| US5580979A (en) | 1994-03-15 | 1996-12-03 | Trustees Of Tufts University | Phosphotyrosine peptidomimetics for inhibiting SH2 domain interactions |
| US6083903A (en) * | 1994-10-28 | 2000-07-04 | Leukosite, Inc. | Boronic ester and acid compounds, synthesis and uses |
| US6180402B1 (en) | 1996-11-20 | 2001-01-30 | Qlt Inc. | Method for inhibiting apoptosis induced by photodynamic therapy using a cysteine or serine protease inhibitor |
| JP2001518290A (ja) | 1997-09-29 | 2001-10-16 | ポイント セラピューティクス， インコーポレイテッド | インビトロでの造血細胞の刺激 |
| EP1052994A2 (en) | 1998-02-02 | 2000-11-22 | Trustees Of Tufts College | Use of dipeptidylpetidase inhibitors to regulate glucose metabolism |
| US6300314B1 (en) | 1998-05-04 | 2001-10-09 | Point Therapeutics, Inc. | Hematopoietic stimulation |
| AU765370B2 (en) | 1998-06-05 | 2003-09-18 | Point Therapeutics, Inc. | Cyclic boroproline compounds |
| US6979697B1 (en) | 1998-08-21 | 2005-12-27 | Point Therapeutics, Inc. | Regulation of substrate activity |
| WO2000048302A1 (en) | 1999-02-11 | 2000-08-17 | Battelle Memorial Institute | Power supply |
| US6890904B1 (en) | 1999-05-25 | 2005-05-10 | Point Therapeutics, Inc. | Anti-tumor agents |
| EP2769715A3 (en) | 2001-11-26 | 2014-09-17 | Trustees Of Tufts College | Methods for treating autoimmune disorders, and reagents related thereto |
| JP4771661B2 (ja) | 2001-11-26 | 2011-09-14 | トラスティーズ オブ タフツ カレッジ | Ｐｏｓｔ−プロリン開裂酵素の擬ペプチド性阻害剤 |
| US7691967B2 (en) * | 2002-04-30 | 2010-04-06 | Trustees Of Tufts College | Smart pro-drugs of serine protease inhibitors |
| WO2004004661A2 (en) | 2002-07-09 | 2004-01-15 | Point Therapeutics, Inc. | Boroproline compound combination therapy |
| EP1633384B1 (en) | 2003-05-15 | 2012-03-14 | Trustees Of Tufts College | Stable analogs of glp-1 |
| AU2005216970B2 (en) | 2004-02-23 | 2011-07-07 | Trustees Of Tufts College | Inhibitors of dipeptidylpeptidase IV for regulating glucose metabolism |
| US20060063719A1 (en) | 2004-09-21 | 2006-03-23 | Point Therapeutics, Inc. | Methods for treating diabetes |
| CA2606785A1 (en) | 2005-05-19 | 2006-11-23 | Genentech, Inc. | Fibroblast activation protein inhibitor compounds and methods |
| CN101247799B (zh) * | 2005-07-05 | 2013-03-27 | 塔夫茨大学信托人 | 成纤维细胞活化蛋白α的抑制剂 |
| AU2006201635A1 (en) * | 2005-10-20 | 2007-05-10 | Ludwig Institute For Cancer Research | Novel inhibitors and methods for their preparation |
| CN101379069A (zh) * | 2005-12-19 | 2009-03-04 | 塔夫茨大学信托人 | 软蛋白酶抑制剂及其前软形式 |
| CA2656393A1 (en) * | 2006-06-30 | 2008-01-10 | Schering Corporation | Method of using substituted piperidines that increase p53 activity |
| US20100184706A1 (en) * | 2007-03-20 | 2010-07-22 | Bachovchin William W | Fap-activated chemotherapeutic compounds, and methods of use thereof |
| CA2681351A1 (en) | 2007-03-20 | 2008-09-25 | Trustees Of Tufts College | Inhibitors of fibroblast activation protein, and methods of use thereof |
| WO2009006473A2 (en) * | 2007-07-05 | 2009-01-08 | Trustees Of Tufts College | Pro-soft polypeptide proteasome inhibitors, and methods of use thereof |
| KR20140042933A (ko) * | 2007-08-06 | 2014-04-07 | 밀레니엄 파머슈티컬스 인코퍼레이티드 | 프로테아좀 억제제 |
| NZ600126A (en) * | 2007-08-17 | 2013-12-20 | Boehringer Ingelheim Int | Purine derivatives for use in the treatment of fap-related diseases |
| AU2009221976B2 (en) * | 2008-03-03 | 2014-02-27 | Kansas State University Research Foundation | Protease assay |
| JP5801585B2 (ja) | 2011-03-30 | 2015-10-28 | 株式会社ケーヒン | 燃料噴射制御システム |
| EP4706663A3 (en) | 2011-08-30 | 2026-05-20 | Trustees Of Tufts College | FAP-ACTIVATED PROTEASOME INHIBITORS USED TO TREAT SOLID TUMORS |
-
2012
- 2012-08-30 EP EP25213800.3A patent/EP4706663A3/en active Pending
- 2012-08-30 EP EP12827686.2A patent/EP2753334B1/en active Active
- 2012-08-30 CN CN201280052940.4A patent/CN103945856A/zh active Pending
- 2012-08-30 CA CA2846852A patent/CA2846852C/en active Active
- 2012-08-30 WO PCT/US2012/053140 patent/WO2013033396A2/en not_active Ceased
- 2012-08-30 CN CN201810059355.6A patent/CN108383893A/zh active Pending
- 2012-08-30 EP EP22201696.6A patent/EP4144354B1/en active Active
- 2012-08-30 US US14/241,666 patent/US9597410B2/en active Active
- 2012-08-30 HR HRP20221320TT patent/HRP20221320T1/hr unknown
- 2012-08-30 JP JP2014528600A patent/JP6207509B2/ja active Active
- 2012-08-30 HU HUE12827686A patent/HUE060305T2/hu unknown
- 2012-08-30 DK DK12827686.2T patent/DK2753334T3/da active
- 2012-08-30 PL PL12827686.2T patent/PL2753334T3/pl unknown
- 2012-08-30 PT PT128276862T patent/PT2753334T/pt unknown
- 2012-08-30 AU AU2012301810A patent/AU2012301810B2/en active Active
- 2012-08-30 SI SI201232012T patent/SI2753334T1/sl unknown
- 2012-08-30 ES ES12827686T patent/ES2929179T3/es active Active
-
2016
- 2016-05-27 US US15/167,109 patent/US9956297B2/en active Active
-
2017
- 2017-06-19 AU AU2017204121A patent/AU2017204121A1/en not_active Abandoned
- 2017-09-05 JP JP2017170106A patent/JP2018016629A/ja active Pending
-
2018
- 2018-04-13 US US15/952,648 patent/US10517955B2/en active Active
-
2019
- 2019-11-19 US US16/688,574 patent/US11065339B2/en active Active
-
2021
- 2021-06-15 US US17/348,043 patent/US12214047B2/en active Active
-
2025
- 2025-02-03 US US19/044,150 patent/US20250367304A1/en active Pending
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