JP2017537157A5 - - Google Patents
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- Publication number
- JP2017537157A5 JP2017537157A5 JP2017547370A JP2017547370A JP2017537157A5 JP 2017537157 A5 JP2017537157 A5 JP 2017537157A5 JP 2017547370 A JP2017547370 A JP 2017547370A JP 2017547370 A JP2017547370 A JP 2017547370A JP 2017537157 A5 JP2017537157 A5 JP 2017537157A5
- Authority
- JP
- Japan
- Prior art keywords
- phenyl
- alkyl
- formula
- compound
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 15
- 150000003839 salts Chemical class 0.000 claims 11
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 9
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 5
- 229910052801 chlorine Inorganic materials 0.000 claims 5
- 239000000460 chlorine Substances 0.000 claims 5
- 230000002265 prevention Effects 0.000 claims 5
- 125000004093 cyano group Chemical group *C#N 0.000 claims 4
- 229910052736 halogen Inorganic materials 0.000 claims 4
- 150000002367 halogens Chemical class 0.000 claims 4
- 125000004043 oxo group Chemical group O=* 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 208000002193 Pain Diseases 0.000 claims 3
- 125000001070 dihydroindolyl group Chemical group N1(CCC2=CC=CC=C12)* 0.000 claims 3
- 125000001041 indolyl group Chemical group 0.000 claims 3
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims 2
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 2
- 208000034972 Sudden Infant Death Diseases 0.000 claims 2
- 206010042440 Sudden infant death syndrome Diseases 0.000 claims 2
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims 2
- 229910052794 bromium Inorganic materials 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 239000003085 diluting agent Substances 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 229910052731 fluorine Inorganic materials 0.000 claims 2
- 239000011737 fluorine Substances 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims 1
- 229940100578 Acetylcholinesterase inhibitor Drugs 0.000 claims 1
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 206010002329 Aneurysm Diseases 0.000 claims 1
- 201000001320 Atherosclerosis Diseases 0.000 claims 1
- 208000000094 Chronic Pain Diseases 0.000 claims 1
- 206010020843 Hyperthermia Diseases 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 201000002481 Myositis Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 208000001294 Nociceptive Pain Diseases 0.000 claims 1
- 230000001154 acute effect Effects 0.000 claims 1
- 208000005298 acute pain Diseases 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 239000002260 anti-inflammatory agent Substances 0.000 claims 1
- 229940121363 anti-inflammatory agent Drugs 0.000 claims 1
- 208000008784 apnea Diseases 0.000 claims 1
- 206010003246 arthritis Diseases 0.000 claims 1
- 239000003693 atypical antipsychotic agent Substances 0.000 claims 1
- 229940127236 atypical antipsychotics Drugs 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 239000000544 cholinesterase inhibitor Substances 0.000 claims 1
- 239000002475 cognitive enhancer Substances 0.000 claims 1
- 125000004966 cyanoalkyl group Chemical group 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- ZCRZCMUDOWDGOB-UHFFFAOYSA-N ethanesulfonimidic acid Chemical compound CCS(N)(=O)=O ZCRZCMUDOWDGOB-UHFFFAOYSA-N 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 230000036031 hyperthermia Effects 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 239000003695 memory enhancer Substances 0.000 claims 1
- 208000004296 neuralgia Diseases 0.000 claims 1
- 208000021722 neuropathic pain Diseases 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- -1 phenoxyphenyl Chemical group 0.000 claims 1
- 229920006395 saturated elastomer Polymers 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE1451434-3 | 2014-11-27 | ||
| SE1451434 | 2014-11-27 | ||
| PCT/SE2015/051261 WO2016085391A1 (en) | 2014-11-27 | 2015-11-24 | Bis(sulfonamide) derivatives and their use as mpges inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017537157A JP2017537157A (ja) | 2017-12-14 |
| JP2017537157A5 true JP2017537157A5 (https=) | 2018-09-27 |
Family
ID=56074770
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017547370A Pending JP2017537157A (ja) | 2014-11-27 | 2015-11-24 | ビス（スルホンアミド）誘導体およびｍＰＧＥＳ阻害薬としてのその使用 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US10227296B2 (https=) |
| EP (1) | EP3224241A4 (https=) |
| JP (1) | JP2017537157A (https=) |
| CN (1) | CN107001251A (https=) |
| WO (1) | WO2016085391A1 (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SMT202000024T1 (it) * | 2014-11-27 | 2020-03-13 | Gesynta Pharma Ab | Derivati di bis (solfonammide) e loro uso come inibitori di mpges |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6211197B1 (en) * | 1998-10-07 | 2001-04-03 | Merck Frosst Canada & Co. | Prostaglandin receptor ligands |
| CN101284773A (zh) * | 2001-08-09 | 2008-10-15 | 小野药品工业株式会社 | 羧酸衍生物及以它为活性成分的药剂 |
| JP4054369B2 (ja) * | 2004-05-04 | 2008-02-27 | ファイザー株式会社 | オルト置換アリールまたはヘテロアリールアミド化合物 |
| CA2620363A1 (en) | 2005-10-13 | 2007-04-19 | Biolipox Ab | Naphthalene-disulfonamides useful for the treatment of inflammation |
| WO2008129276A1 (en) | 2007-04-19 | 2008-10-30 | Boehringer Ingelheim International Gmbh | Disulfonamides useful in the treatment of inflammation |
| WO2008129288A2 (en) | 2007-04-19 | 2008-10-30 | Boehringer Ingelheim International Gmbh | Disulfonamides useful in the treatment of inflammation |
| TW200930369A (en) | 2007-11-15 | 2009-07-16 | Astrazeneca Ab | Bis-(sulfonylamino) derivatives in therapy |
| TW200930368A (en) * | 2007-11-15 | 2009-07-16 | Astrazeneca Ab | Bis-(sulfonylamino) derivatives in therapy |
| US20090163586A1 (en) | 2007-12-20 | 2009-06-25 | Astrazeneca Ab | Bis-(Sulfonylamino) Derivatives in Therapy 205 |
| CA2747835A1 (en) * | 2009-01-19 | 2010-07-22 | Abbott Laboratories | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases |
| US20100292279A1 (en) | 2009-05-14 | 2010-11-18 | Astrazeneca Ab | Bis-(Sulfonylamino) Derivatives in Therapy |
-
2015
- 2015-11-24 WO PCT/SE2015/051261 patent/WO2016085391A1/en not_active Ceased
- 2015-11-24 CN CN201580064771.XA patent/CN107001251A/zh active Pending
- 2015-11-24 JP JP2017547370A patent/JP2017537157A/ja active Pending
- 2015-11-24 EP EP15863225.7A patent/EP3224241A4/en not_active Withdrawn
- 2015-11-24 US US15/529,701 patent/US10227296B2/en not_active Expired - Fee Related
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