JP2016510719A5 - - Google Patents
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- JP2016510719A5 JP2016510719A5 JP2015542108A JP2015542108A JP2016510719A5 JP 2016510719 A5 JP2016510719 A5 JP 2016510719A5 JP 2015542108 A JP2015542108 A JP 2015542108A JP 2015542108 A JP2015542108 A JP 2015542108A JP 2016510719 A5 JP2016510719 A5 JP 2016510719A5
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- JP
- Japan
- Prior art keywords
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- Prior art date
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- 125000005843 halogen group Chemical group 0.000 claims 13
- 150000003839 salts Chemical class 0.000 claims 12
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 8
- 150000001875 compounds Chemical class 0.000 claims 8
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 8
- 125000006376 (C3-C10) cycloalkyl group Chemical group 0.000 claims 6
- UHOVQNZJYSORNB-UHFFFAOYSA-N monobenzene Natural products C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 claims 6
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims 5
- 239000003814 drug Substances 0.000 claims 4
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 3
- 125000001424 substituent group Chemical group 0.000 claims 3
- 125000005915 C6-C14 aryl group Chemical group 0.000 claims 2
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 claims 2
- 125000006615 aromatic heterocyclic group Chemical group 0.000 claims 2
- 125000002950 monocyclic group Chemical group 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- DTXZCJGBZLDJAZ-UHFFFAOYSA-N 1-[2-[[3,5-diethoxy-4-(4-fluorophenyl)phenyl]methyl]-5-oxa-2,6-diazaspiro[3.4]oct-6-en-7-yl]-4-methylpiperidine-4-carboxylic acid Chemical compound C=1C(OCC)=C(C=2C=CC(F)=CC=2)C(OCC)=CC=1CN(C1)CC1(ON=1)CC=1N1CCC(C)(C(O)=O)CC1 DTXZCJGBZLDJAZ-UHFFFAOYSA-N 0.000 claims 1
- DJCPYTGQXWYAQU-UHFFFAOYSA-N 1-[2-[[3-chloro-5-cyclopropyl-4-(4-fluorophenyl)-2-methoxyphenyl]methyl]-5-oxa-2,6-diazaspiro[3.4]oct-6-en-7-yl]-4-methylpiperidine-4-carboxylic acid Chemical compound C1=C(C2CC2)C(C=2C=CC(F)=CC=2)=C(Cl)C(OC)=C1CN(C1)CC1(ON=1)CC=1N1CCC(C)(C(O)=O)CC1 DJCPYTGQXWYAQU-UHFFFAOYSA-N 0.000 claims 1
- WYKLKEOTXNGJOY-UHFFFAOYSA-N 1-[2-[[5-cyclopropyl-3-fluoro-4-(4-fluorophenyl)-2-methoxyphenyl]methyl]-5-oxa-2,6-diazaspiro[3.4]oct-6-en-7-yl]-4-methylpiperidine-4-carboxylic acid Chemical compound C1=C(C2CC2)C(C=2C=CC(F)=CC=2)=C(F)C(OC)=C1CN(C1)CC1(ON=1)CC=1N1CCC(C)(C(O)=O)CC1 WYKLKEOTXNGJOY-UHFFFAOYSA-N 0.000 claims 1
- 229940123829 Somatostatin receptor 5 antagonist Drugs 0.000 claims 1
- 125000002029 aromatic hydrocarbon group Chemical group 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 125000006574 non-aromatic ring group Chemical group 0.000 claims 1
- 125000003386 piperidinyl group Chemical group 0.000 claims 1
- 230000000069 prophylactic effect Effects 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2015542108A JP6247697B2 (ja) | 2013-03-14 | 2014-03-13 | スピロアゼチジンイソキサゾール誘導体及びそのｓｓｔｒ５アンタゴニストとしての使用 |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2013052482 | 2013-03-14 | ||
| JP2013052482 | 2013-03-14 | ||
| JP2015542108A JP6247697B2 (ja) | 2013-03-14 | 2014-03-13 | スピロアゼチジンイソキサゾール誘導体及びそのｓｓｔｒ５アンタゴニストとしての使用 |
| PCT/JP2014/058144 WO2014142363A1 (en) | 2013-03-14 | 2014-03-13 | Spiro azetidine isoxazole derivatives and their use as sstr5 antagonists |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016510719A JP2016510719A (ja) | 2016-04-11 |
| JP2016510719A5 true JP2016510719A5 (https=) | 2017-02-23 |
| JP6247697B2 JP6247697B2 (ja) | 2017-12-13 |
Family
ID=50478533
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015542108A Expired - Fee Related JP6247697B2 (ja) | 2013-03-14 | 2014-03-13 | スピロアゼチジンイソキサゾール誘導体及びそのｓｓｔｒ５アンタゴニストとしての使用 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US9605000B2 (https=) |
| EP (1) | EP2970331B1 (https=) |
| JP (1) | JP6247697B2 (https=) |
| ES (1) | ES2629729T3 (https=) |
| WO (1) | WO2014142363A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2907820B1 (ja) | 1998-06-19 | 1999-06-21 | 有限会社アシスト | 樹脂フィルム等の成形方法 |
| JO3442B1 (ar) | 2013-10-07 | 2019-10-20 | Takeda Pharmaceuticals Co | مضادات ذات نوع فرعي من مستقبل سوماتوستاتين 5 (sstr5) |
| SMT201900101T1 (it) | 2013-10-29 | 2019-02-28 | Takeda Pharmaceuticals Co | Composto eterociclico |
| TW201712012A (zh) | 2015-06-16 | 2017-04-01 | 美國禮來大藥廠 | ２－側氧基－１，３，８－三氮雜螺［４．５］癸－３－基羧酸衍生物 |
| US10879420B2 (en) | 2018-07-09 | 2020-12-29 | University Of Iowa Research Foundation | Cascaded superlattice LED system |
| CN116354961B (zh) * | 2021-12-27 | 2025-07-25 | 中国科学院上海药物研究所 | 生长抑素受体5拮抗剂及其药物组合物及用途 |
| CN120752056A (zh) | 2023-03-27 | 2025-10-03 | 思可海雅药品株式会社 | 生长激素分泌促进剂 |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU6944296A (en) | 1995-09-13 | 1997-04-01 | Takeda Chemical Industries Ltd. | Benzoxazepine compounds, their production and use as lipid lowering agents |
| AR035016A1 (es) | 1999-08-25 | 2004-04-14 | Takeda Chemical Industries Ltd | Composicion de azol promotor de produccion/secrecion de neurotrofina, compuesto prodroga del mismo, composicion farmaceutica que lo comprende y uso del mismo para preparar esta ultima. |
| EP1285651B1 (en) | 2000-04-28 | 2010-09-01 | Takeda Pharmaceutical Company Limited | Melanin concentrating hormone antagonists |
| US7229986B2 (en) | 2000-05-16 | 2007-06-12 | Takeda Pharmaceutical Company Ltd. | Melanin-concentrating hormone antagonist |
| WO2002006234A1 (en) | 2000-07-17 | 2002-01-24 | Takeda Chemical Industries, Ltd. | Sulfone derivatives, process for their production and use thereof |
| NZ540381A (en) | 2002-11-01 | 2007-11-30 | Takeda Pharmaceutical | 5-membered aromatic heterocycle derivatives as prophylactic and therapeutic agents for treating neuropathy |
| AU2003277576A1 (en) | 2002-11-08 | 2004-06-07 | Takeda Pharmaceutical Company Limited | Receptor function controlling agent |
| AU2003284596A1 (en) | 2002-11-22 | 2004-06-18 | Takeda Pharmaceutical Company Limited | Imidazole derivative, process for producing the same, and use |
| EP1630152A4 (en) | 2003-05-30 | 2009-09-23 | Takeda Pharmaceutical | CONDENSED CYCLIC COMPOUND |
| US7534887B2 (en) | 2003-09-30 | 2009-05-19 | Takeda Pharmaceutical Company Limited | Thiazoline derivative and use of the same |
| JP4769082B2 (ja) | 2003-12-17 | 2011-09-07 | 武田薬品工業株式会社 | ウレア誘導体、その製造法及び用途 |
| AU2004309271A1 (en) | 2003-12-25 | 2005-07-14 | Takeda Pharmaceutical Company Limited | 3-(4-benzyloxyphenyl)propanoic acid derivatives |
| EP1698624B1 (en) | 2003-12-26 | 2012-06-27 | Takeda Pharmaceutical Company Limited | Phenylpropanoic acid derivatives |
| US7786165B2 (en) | 2004-03-15 | 2010-08-31 | Takeda Pharmaceutical Company Limited | Aminophenylpropanoic acid derivative |
| JP4859665B2 (ja) | 2004-03-30 | 2012-01-25 | 武田薬品工業株式会社 | アルコキシフェニルプロパン酸誘導体 |
| TWI396686B (zh) | 2004-05-21 | 2013-05-21 | Takeda Pharmaceutical | 環狀醯胺衍生物、以及其製品和用法 |
| EP2308839B1 (en) | 2005-04-20 | 2017-03-01 | Takeda Pharmaceutical Company Limited | Fused heterocyclic compounds |
| JP5084503B2 (ja) | 2005-07-29 | 2012-11-28 | 武田薬品工業株式会社 | シクロプロパンカルボン酸化合物 |
| JPWO2007013694A1 (ja) | 2005-07-29 | 2009-02-12 | 武田薬品工業株式会社 | フェノキシアルカン酸化合物 |
| KR20080033524A (ko) | 2005-08-10 | 2008-04-16 | 다케다 야쿠힌 고교 가부시키가이샤 | 당뇨병 치료제 |
| JP2007063225A (ja) | 2005-09-01 | 2007-03-15 | Takeda Chem Ind Ltd | イミダゾピリジン化合物 |
| BRPI0713378A8 (pt) | 2006-06-27 | 2018-01-02 | Takeda Pharmaceutical | composto, pró-droga, modulador da função do receptor gpr40, agente farmacêutico uso do composto, e, método de produção de uma forma opticamente ativa de um composto |
| EP2077267A4 (en) | 2006-10-18 | 2010-04-07 | Takeda Pharmaceutical | CONDENSED HETEROCYCLIC COMPOUND |
| US7652133B2 (en) | 2006-10-19 | 2010-01-26 | Takeda Pharmaceutical Company Limited | Indole compound |
| WO2008093639A1 (ja) | 2007-01-29 | 2008-08-07 | Takeda Pharmaceutical Company Limited | ピラゾール化合物 |
| EP2118066A1 (en) | 2007-02-09 | 2009-11-18 | Takeda Pharmaceutical Company Limited | Fused ring compounds as partial agonists of ppar-gamma |
| JPWO2008136428A1 (ja) | 2007-04-27 | 2010-07-29 | 武田薬品工業株式会社 | 含窒素５員複素環化合物 |
| EP2157859A4 (en) | 2007-06-19 | 2011-01-12 | Takeda Pharmaceutical | INDAZOL COMPOUNDS FOR THE ACTIVATION OF GLUCCOKINASE |
| US20110166124A1 (en) * | 2008-07-23 | 2011-07-07 | Mccormick Kevin D | Tricyclic spirocycle derivatives and methods of use |
| EP2427465A1 (en) * | 2009-05-07 | 2012-03-14 | Merck Sharp & Dohme Corp. | Substituted spirocyclic amines useful as antidiabetic compounds |
| CA2799414A1 (en) | 2010-05-18 | 2011-11-24 | Merck Sharp & Dohme Corp. | Spiro isoxazoline compounds as sstr5 antagonists |
| US8742110B2 (en) * | 2010-08-18 | 2014-06-03 | Merck Sharp & Dohme Corp. | Spiroxazolidinone compounds |
| JO3442B1 (ar) * | 2013-10-07 | 2019-10-20 | Takeda Pharmaceuticals Co | مضادات ذات نوع فرعي من مستقبل سوماتوستاتين 5 (sstr5) |
| SMT201900101T1 (it) | 2013-10-29 | 2019-02-28 | Takeda Pharmaceuticals Co | Composto eterociclico |
-
2014
- 2014-03-13 WO PCT/JP2014/058144 patent/WO2014142363A1/en not_active Ceased
- 2014-03-13 ES ES14716647.4T patent/ES2629729T3/es active Active
- 2014-03-13 JP JP2015542108A patent/JP6247697B2/ja not_active Expired - Fee Related
- 2014-03-13 EP EP14716647.4A patent/EP2970331B1/en not_active Not-in-force
- 2014-03-13 US US14/775,265 patent/US9605000B2/en not_active Expired - Fee Related