JP2017537130A5 - - Google Patents
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- Publication number
- JP2017537130A5 JP2017537130A5 JP2017531184A JP2017531184A JP2017537130A5 JP 2017537130 A5 JP2017537130 A5 JP 2017537130A5 JP 2017531184 A JP2017531184 A JP 2017531184A JP 2017531184 A JP2017531184 A JP 2017531184A JP 2017537130 A5 JP2017537130 A5 JP 2017537130A5
- Authority
- JP
- Japan
- Prior art keywords
- therapeutic agent
- hydrogel
- particles
- functional group
- xerogel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000463 material Substances 0.000 claims description 44
- 239000003814 drug Substances 0.000 claims description 36
- 229940124597 therapeutic agent Drugs 0.000 claims description 32
- 239000000017 hydrogel Substances 0.000 claims description 24
- 239000002245 particle Substances 0.000 claims description 22
- 239000002243 precursor Substances 0.000 claims description 19
- 125000000524 functional group Chemical group 0.000 claims description 18
- 239000007787 solid Substances 0.000 claims description 9
- 238000013268 sustained release Methods 0.000 claims description 8
- 239000012730 sustained-release form Substances 0.000 claims description 8
- 238000006065 biodegradation reaction Methods 0.000 claims description 5
- 230000003111 delayed effect Effects 0.000 claims description 4
- 229940079593 drug Drugs 0.000 claims description 4
- 238000011065 in-situ storage Methods 0.000 claims description 3
- 102000004169 proteins and genes Human genes 0.000 claims description 3
- 108090000623 proteins and genes Proteins 0.000 claims description 3
- 238000006243 chemical reaction Methods 0.000 claims description 2
- 230000000269 nucleophilic effect Effects 0.000 claims description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 2
- 229920001477 hydrophilic polymer Polymers 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 238000000034 method Methods 0.000 description 12
- 230000001934 delay Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462089994P | 2014-12-10 | 2014-12-10 | |
| US62/089,994 | 2014-12-10 | ||
| PCT/US2015/064975 WO2016094646A1 (en) | 2014-12-10 | 2015-12-10 | Hydrogel drug delivery implants |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020201207A Division JP2021046429A (ja) | 2014-12-10 | 2020-12-03 | ハイドロゲル薬物送達インプラント |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017537130A JP2017537130A (ja) | 2017-12-14 |
| JP2017537130A5 true JP2017537130A5 (cg-RX-API-DMAC7.html) | 2019-01-24 |
| JP7092502B2 JP7092502B2 (ja) | 2022-06-28 |
Family
ID=55070156
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017531184A Active JP7092502B2 (ja) | 2014-12-10 | 2015-12-10 | ハイドロゲル薬物送達インプラント |
| JP2020201207A Pending JP2021046429A (ja) | 2014-12-10 | 2020-12-03 | ハイドロゲル薬物送達インプラント |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020201207A Pending JP2021046429A (ja) | 2014-12-10 | 2020-12-03 | ハイドロゲル薬物送達インプラント |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20160166504A1 (cg-RX-API-DMAC7.html) |
| EP (2) | EP3858329A1 (cg-RX-API-DMAC7.html) |
| JP (2) | JP7092502B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR20170117384A (cg-RX-API-DMAC7.html) |
| CN (2) | CN120501693A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2015360469B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2969716C (cg-RX-API-DMAC7.html) |
| WO (1) | WO2016094646A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (37)
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| CA2939952C (en) | 2013-03-05 | 2022-03-22 | Morgan V. Fedorchak | Thermoresponsive hydrogel containing polymer microparticles for noninvasive ocular drug delivery |
| US20220118416A1 (en) * | 2020-10-18 | 2022-04-21 | Pathak Holdings Llc | Crosslinked multilayered material compositions, methods for their preparation and applications thereof |
| RU2729731C2 (ru) | 2014-12-15 | 2020-08-11 | Зе Джонс Хопкинс Юниверсити | Составы на основе сунитиниба и способы их применения для лечения глазных заболеваний |
| US9855317B2 (en) | 2015-04-27 | 2018-01-02 | Reflex Medical, Inc. | Systems and methods for sympathetic cardiopulmonary neuromodulation |
| EP3294212B1 (en) * | 2015-05-12 | 2023-10-25 | Incept, LLC | Drug delivery from hydrogels |
| WO2017062770A1 (en) | 2015-10-08 | 2017-04-13 | Silverberg Noah | Punctal plug and bioadhesives |
| EP3373978A4 (en) | 2015-11-12 | 2019-06-26 | Graybug Vision, Inc. | AGGREGATION OF MICROPARTICLES FOR THERAPY |
| US10420724B2 (en) | 2015-11-25 | 2019-09-24 | Incept, Llc | Shape changing drug delivery devices and methods |
| WO2017139487A1 (en) | 2016-02-09 | 2017-08-17 | Northwind Medical, Inc. | Methods, agents, and devices for local neuromodulation of autonomic nerves |
| US20190099365A1 (en) * | 2016-03-22 | 2019-04-04 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Thermoresponsive hydrogel containing polymer microparticles for noninvasive ocular biologic delivery |
| US11154547B2 (en) | 2016-06-29 | 2021-10-26 | Tulavi Therapeutics, Inc. | Treatment of sepsis and related inflammatory conditions by local neuromodulation of the autonomic nervous system |
| WO2018017899A1 (en) * | 2016-07-20 | 2018-01-25 | Emory University | Formulations for the suprachoroidal space of an eye and methods |
| KR20230053707A (ko) * | 2016-09-23 | 2023-04-21 | 인셉트, 엘엘씨 | 전안방내 약물 전달 데포 |
| WO2018209155A1 (en) | 2017-05-10 | 2018-11-15 | Graybug Vision, Inc. | Extended release microparticles and suspensions thereof for medical therapy |
| WO2019043699A1 (en) | 2017-08-30 | 2019-03-07 | Hadasit Medical Research Services And Development Ltd. | DEVICES, KITS AND METHODS FOR REDUCING AND / OR PREVENTING INTRA-ABDOMINAL ADHESIONS |
| WO2019088292A1 (ja) * | 2017-11-06 | 2019-05-09 | コニカミノルタ株式会社 | ハイドロゲル粒子およびその製造方法、ハイドロゲル粒子を内包する細胞または細胞構造体、ハイドロゲル粒子を用いた細胞活性の評価方法、並びにハイドロゲル粒子の徐放性製剤としての使用 |
| CN110392584B (zh) * | 2018-02-20 | 2023-05-12 | 先进美学科技公司 | 高浓度水凝胶及相关方法 |
| US20210315587A1 (en) | 2018-07-02 | 2021-10-14 | Tulavi Therapeutics, Inc. | Methods and devices for in situ formed nerve cap with rapid release |
| CN117599244A (zh) | 2018-07-02 | 2024-02-27 | 图拉维治疗股份有限公司 | 原位形成神经帽的方法和装置 |
| WO2020035819A1 (en) * | 2018-08-15 | 2020-02-20 | Microsert Ltd. | Sustained release component and corresponding drug delivery device with biodegradable material for flow path modification |
| CN110772376A (zh) * | 2019-11-20 | 2020-02-11 | 韩熠 | 一种用于婴幼儿及儿童的医用眼贴及其制备方法 |
| WO2021145325A1 (ja) * | 2020-01-14 | 2021-07-22 | 持田製薬株式会社 | アルギン酸塩を使用した対象の処置のための組合せ及び方法 |
| BR112022015533A2 (pt) | 2020-02-06 | 2022-09-27 | Ocular Therapeutix Inc | Composições e métodos para tratar doenças oculares |
| US20230136938A1 (en) * | 2020-03-25 | 2023-05-04 | Fukuoka University | Agent to be used in intraocular membrane detachment surgery |
| TW202202138A (zh) * | 2020-03-25 | 2022-01-16 | 美商歐克萊製藥公司 | 含有酪胺酸激酶抑制劑之眼用植入物 |
| WO2021222117A1 (en) * | 2020-04-27 | 2021-11-04 | Ocular Therapeutix, Inc. | Methods of treating allergic conjunctivitis |
| EP4149400A4 (en) * | 2020-05-15 | 2024-05-01 | Georgia Tech Research Corporation | METHODS AND COMPOSITIONS FOR REDUCING INTRAOCULAR PRESSURE |
| EP4216929A1 (en) | 2020-09-24 | 2023-08-02 | Ocular Therapeutix, Inc. | Sustained release biodegradable intracanalicular inserts comprising a hydrogel and an active agent |
| EP4344745A3 (en) | 2020-09-24 | 2024-10-09 | Ocular Therapeutix, Inc. | Sustained release biodegradable intracanalicular inserts comprising a hydrogel and cyclosporine |
| US12343454B2 (en) | 2020-11-12 | 2025-07-01 | Pramand LLC | Hydrogels formed in situ and composition design for intrauterine use |
| US20240122819A1 (en) * | 2021-02-05 | 2024-04-18 | Kao Corporation | Hydrogel structure |
| CN113230019A (zh) * | 2021-04-16 | 2021-08-10 | 南京佑羲医药科技有限公司 | 一种用于眼球玻璃体内植入的长效缓释给药装置 |
| WO2023150580A2 (en) * | 2022-02-01 | 2023-08-10 | Ocular Therapeutix, Inc. | A controlled release implant for biologics and corresponding methods of treatment |
| US12251466B2 (en) | 2022-04-20 | 2025-03-18 | Pramand LLC | Single solution hydrogels with covalent bonding formed in situ, composition design and medical procedures using the hydrogels |
| CN115671036A (zh) * | 2022-11-15 | 2023-02-03 | 上海交通大学医学院附属第九人民医院 | 用于治疗眼底和眼内疾病的凝胶药物 |
| CN120897764A (zh) | 2023-04-11 | 2025-11-04 | 视尔普斯眼科公司 | 包含阿西替尼多晶型物iv的眼部植入物 |
| CN116687840B (zh) * | 2023-08-03 | 2023-10-20 | 四川省医学科学院·四川省人民医院 | 一种用于治疗眼部病状的凝胶制剂及其制备方法 |
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| US3640741A (en) | 1970-02-24 | 1972-02-08 | Hollister Inc | Composition containing gel |
| US3865108A (en) | 1971-05-17 | 1975-02-11 | Ortho Pharma Corp | Expandable drug delivery device |
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| DE2437629C3 (de) | 1974-08-05 | 1978-09-21 | Basf Ag, 6700 Ludwigshafen | Verfahren zur Herstellung von unlöslichen in Wasser nur wenig quellbaren Polymerisaten von N-Vinyllactamen |
| US4014335A (en) | 1975-04-21 | 1977-03-29 | Alza Corporation | Ocular drug delivery device |
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| US5160745A (en) | 1986-05-16 | 1992-11-03 | The University Of Kentucky Research Foundation | Biodegradable microspheres as a carrier for macromolecules |
| US4741872A (en) | 1986-05-16 | 1988-05-03 | The University Of Kentucky Research Foundation | Preparation of biodegradable microspheres useful as carriers for macromolecules |
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| ATE203885T1 (de) * | 1994-09-08 | 2001-08-15 | Stryker Technologies Corp | Bandscheibenkern aus hydrogel |
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| AU743819B2 (en) | 1997-10-27 | 2002-02-07 | California Institute Of Technology | Methods and pharmaceutical compositions for the closure of retinal breaks |
| US6958212B1 (en) | 1999-02-01 | 2005-10-25 | Eidgenossische Technische Hochschule Zurich | Conjugate addition reactions for the controlled delivery of pharmaceutically active compounds |
| CA2438193A1 (en) | 2001-02-26 | 2002-09-06 | Duke University | Novel dendritic polymers and their biomedical uses |
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| EP3583960A1 (en) | 2009-12-15 | 2019-12-25 | Incept, LLC | Implants and biodegradable fiducial markers |
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| US10226417B2 (en) * | 2011-09-16 | 2019-03-12 | Peter Jarrett | Drug delivery systems and applications |
| JP6199883B2 (ja) * | 2011-12-05 | 2017-09-20 | インセプト・リミテッド・ライアビリティ・カンパニーＩｎｃｅｐｔ，Ｌｌｃ | 医療用オルガノゲルプロセス及び組成物 |
| US20150037422A1 (en) * | 2012-02-22 | 2015-02-05 | Trustees Of Tufts College | Compositions and methods for ocular delivery of a therapeutic agent |
| SG10201701773UA (en) * | 2012-09-06 | 2017-04-27 | Univ Nanyang Tech | Hyaluronic Acid-Based Drug Delivery Systems |
-
2015
- 2015-12-10 KR KR1020177018919A patent/KR20170117384A/ko not_active Ceased
- 2015-12-10 WO PCT/US2015/064975 patent/WO2016094646A1/en not_active Ceased
- 2015-12-10 JP JP2017531184A patent/JP7092502B2/ja active Active
- 2015-12-10 CN CN202510552462.2A patent/CN120501693A/zh active Pending
- 2015-12-10 AU AU2015360469A patent/AU2015360469B2/en active Active
- 2015-12-10 CN CN201580075658.1A patent/CN107205922A/zh active Pending
- 2015-12-10 CA CA2969716A patent/CA2969716C/en active Active
- 2015-12-10 EP EP20214440.8A patent/EP3858329A1/en active Pending
- 2015-12-10 EP EP15820375.2A patent/EP3229779B1/en active Active
- 2015-12-10 US US14/965,258 patent/US20160166504A1/en not_active Abandoned
-
2020
- 2020-12-03 JP JP2020201207A patent/JP2021046429A/ja active Pending
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