JP2017535521A5 - - Google Patents
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- Publication number
- JP2017535521A5 JP2017535521A5 JP2017516516A JP2017516516A JP2017535521A5 JP 2017535521 A5 JP2017535521 A5 JP 2017535521A5 JP 2017516516 A JP2017516516 A JP 2017516516A JP 2017516516 A JP2017516516 A JP 2017516516A JP 2017535521 A5 JP2017535521 A5 JP 2017535521A5
- Authority
- JP
- Japan
- Prior art keywords
- weight
- modified release
- release formulation
- beta
- lactamase
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000009472 formulation Methods 0.000 claims 17
- 239000000203 mixture Substances 0.000 claims 17
- 108090000204 Dipeptidase 1 Proteins 0.000 claims 12
- 102000006635 beta-lactamase Human genes 0.000 claims 12
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 claims 8
- 239000008188 pellet Substances 0.000 claims 8
- 241000193163 Clostridioides difficile Species 0.000 claims 6
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims 4
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 4
- 229930006000 Sucrose Natural products 0.000 claims 4
- DOOTYTYQINUNNV-UHFFFAOYSA-N Triethyl citrate Chemical compound CCOC(=O)CC(O)(C(=O)OCC)CC(=O)OCC DOOTYTYQINUNNV-UHFFFAOYSA-N 0.000 claims 4
- 239000000337 buffer salt Substances 0.000 claims 4
- 229940075507 glyceryl monostearate Drugs 0.000 claims 4
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims 4
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims 4
- 239000001788 mono and diglycerides of fatty acids Substances 0.000 claims 4
- 229920000642 polymer Polymers 0.000 claims 4
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims 4
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims 4
- 229940068968 polysorbate 80 Drugs 0.000 claims 4
- 229920000053 polysorbate 80 Polymers 0.000 claims 4
- 239000005720 sucrose Substances 0.000 claims 4
- 239000001069 triethyl citrate Substances 0.000 claims 4
- VMYFZRTXGLUXMZ-UHFFFAOYSA-N triethyl citrate Natural products CCOC(=O)C(O)(C(=O)OCC)C(=O)OCC VMYFZRTXGLUXMZ-UHFFFAOYSA-N 0.000 claims 4
- 235000013769 triethyl citrate Nutrition 0.000 claims 4
- 206010009657 Clostridium difficile colitis Diseases 0.000 claims 3
- 125000003275 alpha amino acid group Chemical group 0.000 claims 3
- 230000003115 biocidal effect Effects 0.000 claims 3
- 239000011248 coating agent Substances 0.000 claims 3
- 238000000576 coating method Methods 0.000 claims 3
- 238000013270 controlled release Methods 0.000 claims 3
- 230000000694 effects Effects 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 claims 2
- 230000002411 adverse Effects 0.000 claims 2
- 229960001230 asparagine Drugs 0.000 claims 2
- 235000009582 asparagine Nutrition 0.000 claims 2
- 125000000613 asparagine group Chemical group N[C@@H](CC(N)=O)C(=O)* 0.000 claims 2
- 239000007771 core particle Substances 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 210000001035 gastrointestinal tract Anatomy 0.000 claims 2
- 208000004998 Abdominal Pain Diseases 0.000 claims 1
- 206010012735 Diarrhoea Diseases 0.000 claims 1
- -1 EUDRAGIT compound Chemical class 0.000 claims 1
- 229920003134 Eudragit® polymer Polymers 0.000 claims 1
- 208000003100 Pseudomembranous Enterocolitis Diseases 0.000 claims 1
- 206010037128 Pseudomembranous colitis Diseases 0.000 claims 1
- 206010037660 Pyrexia Diseases 0.000 claims 1
- 239000002775 capsule Substances 0.000 claims 1
- VAAUVRVFOQPIGI-SPQHTLEESA-N ceftriaxone Chemical compound S([C@@H]1[C@@H](C(N1C=1C(O)=O)=O)NC(=O)\C(=N/OC)C=2N=C(N)SC=2)CC=1CSC1=NC(=O)C(=O)NN1C VAAUVRVFOQPIGI-SPQHTLEESA-N 0.000 claims 1
- 229960004755 ceftriaxone Drugs 0.000 claims 1
- 206010009887 colitis Diseases 0.000 claims 1
- 230000018044 dehydration Effects 0.000 claims 1
- 238000006297 dehydration reaction Methods 0.000 claims 1
- 230000001419 dependent effect Effects 0.000 claims 1
- 239000003792 electrolyte Substances 0.000 claims 1
- 210000004051 gastric juice Anatomy 0.000 claims 1
- 230000007062 hydrolysis Effects 0.000 claims 1
- 238000006460 hydrolysis reaction Methods 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 230000000968 intestinal effect Effects 0.000 claims 1
- 210000000936 intestine Anatomy 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462061507P | 2014-10-08 | 2014-10-08 | |
| US62/061,507 | 2014-10-08 | ||
| US201562126556P | 2015-02-28 | 2015-02-28 | |
| US62/126,556 | 2015-02-28 | ||
| US201562205443P | 2015-08-14 | 2015-08-14 | |
| US62/205,443 | 2015-08-14 | ||
| PCT/US2015/054606 WO2016057744A1 (en) | 2014-10-08 | 2015-10-08 | Beta-lactamase formulations and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017535521A JP2017535521A (ja) | 2017-11-30 |
| JP2017535521A5 true JP2017535521A5 (enExample) | 2018-11-15 |
| JP6672277B2 JP6672277B2 (ja) | 2020-04-01 |
Family
ID=55653744
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017516516A Active JP6672277B2 (ja) | 2014-10-08 | 2015-10-08 | ベータラクタマーゼ製剤およびその使用 |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US10105322B2 (enExample) |
| EP (1) | EP3204495B1 (enExample) |
| JP (1) | JP6672277B2 (enExample) |
| KR (1) | KR102467968B1 (enExample) |
| CN (1) | CN107148473B (enExample) |
| AU (1) | AU2015330937B2 (enExample) |
| CA (1) | CA2962959C (enExample) |
| ES (1) | ES2806426T3 (enExample) |
| MX (1) | MX2017004473A (enExample) |
| WO (1) | WO2016057744A1 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2958755C (en) | 2014-08-28 | 2023-02-28 | Synthetic Biologics, Inc. | E. coli-based production of beta-lactamase |
| EP3236993B1 (en) | 2014-12-23 | 2023-09-13 | Theriva Biologics, Inc. | Methods and compositions for inhibiting or preventing adverse effects of oral antibiotics |
| WO2016137993A1 (en) | 2015-02-23 | 2016-09-01 | Synthetic Biologics, Inc. | Carbapenemases for use with antibiotics for the protection of the intestinal microbiome |
| EP3265119B1 (en) | 2015-03-06 | 2023-10-11 | Theriva Biologics, Inc. | Safe and effective beta-lactamase dosing for microbiome protection |
| WO2018005606A1 (en) * | 2016-06-28 | 2018-01-04 | Synthetic Biologics, Inc. | Microbiome protection from oral antibiotics |
| SG10201609137PA (en) * | 2016-11-01 | 2018-06-28 | Xylonix Ip Holdings Pte Ltd | Gamma-polyglutamic acid and zinc compositions |
| SG10201609131YA (en) | 2016-11-01 | 2018-06-28 | Xylonix Ip Holdings Pte Ltd | Zinc-pga compositions and methods for treating cancer |
| US20190275120A1 (en) * | 2016-11-01 | 2019-09-12 | Synthetic Biologics, Inc. | Methods and compositions for attenuating antibiotic resistance |
| WO2018175414A1 (en) * | 2017-03-21 | 2018-09-27 | Synthetic Biologics, Inc. | Beta-lactamase formulations |
| EP3701022B1 (en) * | 2017-10-25 | 2023-03-01 | Da Volterra | Beta-lactamase variants |
| US11541105B2 (en) | 2018-06-01 | 2023-01-03 | The Research Foundation For The State University Of New York | Compositions and methods for disrupting biofilm formation and maintenance |
| KR20210040395A (ko) * | 2018-08-05 | 2021-04-13 | 다 볼떼라 | 이식편 대 숙주 질환의 치료를 위한 조성물 |
| JP2022532162A (ja) * | 2019-05-06 | 2022-07-13 | シンセティック・バイオロジクス・インコーポレイテッド | 移植片対宿主病の処置のためのβ－ラクタマーゼ組成物 |
| CA3170780A1 (en) * | 2020-03-10 | 2021-09-16 | Sean Thomas Curtin | System and methods for mammalian transfer learning |
| CN112137984B (zh) * | 2020-10-30 | 2023-02-03 | 四川制药制剂有限公司 | 头孢克洛胶囊及其制备工艺 |
| WO2023168316A1 (en) * | 2022-03-04 | 2023-09-07 | Michael Ogburn | Enteric coated dry powdered cannabinoid formulations |
| CN116790567A (zh) * | 2022-12-30 | 2023-09-22 | 扬州大学 | 来源于土壤宏基因组的β-内酰胺酶及其应用 |
Family Cites Families (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL197650A (enExample) | 1954-05-29 | |||
| US2941995A (en) | 1957-08-02 | 1960-06-21 | Beecham Res Lab | Recovery of solid 6-aminopenicillanic acid |
| US2982696A (en) | 1959-05-01 | 1961-05-02 | Schenley Ind Inc | Ion-exchange procedures for the purification of penicillinase |
| US3070511A (en) | 1960-02-10 | 1962-12-25 | Lepetit Spa | Process for preparing 6-aminopenicillanic acid |
| US3150059A (en) | 1962-12-26 | 1964-09-22 | Lilly Co Eli | Penicillin deacylation via actinoplanaceae fermentation |
| US3239394A (en) | 1964-06-15 | 1966-03-08 | Merck & Co Inc | Process for producing 7-amino-cephalosporanic acid |
| US3499909A (en) | 1966-05-18 | 1970-03-10 | Koninklijke Gist Spiritus | Process for production of 6-aminopenicillanic acid |
| US3488729A (en) | 1966-08-22 | 1970-01-06 | Lilly Co Eli | Cephalothin ester |
| GB1241844A (en) | 1968-08-23 | 1971-08-04 | Beecham Group Ltd | Penicillins |
| GB1463513A (en) | 1974-08-13 | 1977-02-02 | Beecham Group Ltd | Enzymes |
| FI59265C (fi) | 1974-08-13 | 1981-07-10 | Beecham Group Ltd | Foerfarande foer framstaellning av 6-aminopenicillansyra |
| US4537776A (en) | 1983-06-21 | 1985-08-27 | The Procter & Gamble Company | Penetrating topical pharmaceutical compositions containing N-(2-hydroxyethyl) pyrrolidone |
| GB2199582A (en) | 1987-01-07 | 1988-07-13 | Bayer Ag | Analogues of pancreatic secretory trypsin inhibitor |
| FR2613624B1 (fr) | 1987-04-10 | 1990-11-23 | Roussy Inst Gustave | Composition pharmaceutique, administrable par voie orale, destinee a reduire les effets des b-lactamines |
| CA2007083A1 (en) | 1989-01-09 | 1990-07-09 | Nobuhiko Katunuma | Pharmaceutical use of trypstatin |
| JP2813809B2 (ja) * | 1989-06-19 | 1998-10-22 | 武田薬品工業株式会社 | 有核顆粒製剤およびその製造法 |
| CS275231B2 (en) | 1989-09-29 | 1992-02-19 | Ustav Makormolekularni Chemie | Medicine bottle |
| FI920206A0 (fi) * | 1992-01-17 | 1992-01-17 | Pekka Untamo Heino | Medicinsk anvaendning, medicinskt foerfarande och preparat. |
| WO1996001623A1 (en) * | 1994-07-08 | 1996-01-25 | Astra Aktiebolag | Multiple unit tableted dosage form i |
| JPH08143476A (ja) * | 1994-11-18 | 1996-06-04 | Japan Tobacco Inc | 薬物放出制御膜及び固形製剤 |
| AU6353896A (en) | 1995-07-07 | 1997-02-10 | Novo Nordisk A/S | Production of proteins using bacillus incapable of sporulation |
| CN1195500C (zh) * | 1998-05-18 | 2005-04-06 | 武田药品工业株式会社 | 可口腔崩解的片剂 |
| CA2581111A1 (en) * | 1998-07-28 | 2000-02-10 | Takeda Pharmaceutical Company Limited | Rapidly disintegrable solid preparation |
| FI4533U1 (fi) * | 2000-03-14 | 2000-08-10 | Finnzymes Oy | Entsyymikoostumus maidon käsittelemiseksi |
| WO2002097064A1 (en) | 2001-05-29 | 2002-12-05 | Kao Corporation | Host microorganisms |
| FI112666B (fi) | 2001-11-06 | 2003-12-31 | Ipsat Therapies Oy | Itiöimätön Bacillus subtilis, sen valmistus ja käyttö |
| FR2843302B1 (fr) | 2002-08-09 | 2004-10-22 | Centre Nat Rech Scient | Forme galenique pour la delivrance colique de principes actifs |
| JP4749660B2 (ja) * | 2002-10-16 | 2011-08-17 | 武田薬品工業株式会社 | 安定な固形製剤 |
| EP1564286A1 (en) | 2004-02-11 | 2005-08-17 | Université de Liège | Hybrid proteins of beta-lactamase class A |
| AR051946A1 (es) * | 2004-11-05 | 2007-02-21 | Wyeth Corp | Formulaciones de derivados de [1,4] diazepina [6,7,1-ij] quinolina |
| ES2429095T3 (es) | 2005-05-18 | 2013-11-13 | Da Volterra | Aporte colónico de adsorbentes |
| CN101410095B (zh) * | 2006-03-06 | 2015-07-01 | 波曾公司 | 施用组合药物的剂型 |
| FI119190B (fi) | 2006-06-21 | 2008-08-29 | Ipsat Therapies Oy | Modifioitu beta-laktamaasi ja menetelmä sen valmistamiseksi |
| US8273376B2 (en) * | 2006-11-17 | 2012-09-25 | Da Volterra | Colonic delivery of metallo-dependent enzymes |
| FI119678B (fi) * | 2006-11-28 | 2009-02-13 | Ipsat Therapies Oy | Beta-laktamaasin käyttö |
| US9023352B2 (en) | 2007-02-20 | 2015-05-05 | Tufts University | Methods, compositions and kits for treating a subject using a recombinant heteromultimeric neutralizing binding protein |
| EP2566466A1 (en) * | 2010-05-03 | 2013-03-13 | Aptalis Pharma Limited | Micropellet compositions comprising pancreatin containing digestive enzyme mixtures |
| FI20105572A0 (fi) * | 2010-05-24 | 2010-05-24 | Prevab R Lcc | Muokattu beeta-laktamaasi ja siihen liittyvät menetelmät ja käytöt |
| US9115079B2 (en) * | 2011-07-26 | 2015-08-25 | Meiji Seika Pharma Co., Ltd. | NDM inhibitor |
| CA2758556A1 (en) * | 2011-11-17 | 2013-05-17 | Pharmascience Inc. | Pharmaceutical composition of amphetamine mixed salts |
| US9433632B2 (en) * | 2011-11-30 | 2016-09-06 | Takeda Pharmaceutical Company Limited | Dry coated tablet |
| US20140128431A1 (en) | 2012-04-03 | 2014-05-08 | Hoffmann-Laroche Inc. | Pharmaceutical composition with improved bioavailability, safety and tolerability |
| AU2015247382B2 (en) * | 2014-04-17 | 2020-04-23 | Theriva Biologics, Inc. | Beta-lactamases with improved properties for therapy |
| EP3236993B1 (en) * | 2014-12-23 | 2023-09-13 | Theriva Biologics, Inc. | Methods and compositions for inhibiting or preventing adverse effects of oral antibiotics |
| EP3265119B1 (en) * | 2015-03-06 | 2023-10-11 | Theriva Biologics, Inc. | Safe and effective beta-lactamase dosing for microbiome protection |
-
2015
- 2015-10-08 ES ES15849110T patent/ES2806426T3/es active Active
- 2015-10-08 US US14/878,155 patent/US10105322B2/en active Active
- 2015-10-08 WO PCT/US2015/054606 patent/WO2016057744A1/en not_active Ceased
- 2015-10-08 CN CN201580059890.6A patent/CN107148473B/zh active Active
- 2015-10-08 MX MX2017004473A patent/MX2017004473A/es unknown
- 2015-10-08 JP JP2017516516A patent/JP6672277B2/ja active Active
- 2015-10-08 KR KR1020177012353A patent/KR102467968B1/ko active Active
- 2015-10-08 CA CA2962959A patent/CA2962959C/en active Active
- 2015-10-08 AU AU2015330937A patent/AU2015330937B2/en active Active
- 2015-10-08 EP EP15849110.0A patent/EP3204495B1/en active Active
-
2018
- 2018-08-24 US US16/111,477 patent/US10828260B2/en active Active
-
2020
- 2020-09-28 US US17/034,534 patent/US12178917B2/en active Active
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