JP2017535521A5 - - Google Patents
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- Publication number
- JP2017535521A5 JP2017535521A5 JP2017516516A JP2017516516A JP2017535521A5 JP 2017535521 A5 JP2017535521 A5 JP 2017535521A5 JP 2017516516 A JP2017516516 A JP 2017516516A JP 2017516516 A JP2017516516 A JP 2017516516A JP 2017535521 A5 JP2017535521 A5 JP 2017535521A5
- Authority
- JP
- Japan
- Prior art keywords
- weight
- modified release
- release formulation
- beta
- lactamase
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000009472 formulation Methods 0.000 claims 17
- 239000000203 mixture Substances 0.000 claims 17
- 108090000204 Dipeptidase 1 Proteins 0.000 claims 12
- 102000006635 beta-lactamase Human genes 0.000 claims 12
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 claims 8
- 239000008188 pellet Substances 0.000 claims 8
- 241000193163 Clostridioides difficile Species 0.000 claims 6
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims 4
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 4
- 229930006000 Sucrose Natural products 0.000 claims 4
- DOOTYTYQINUNNV-UHFFFAOYSA-N Triethyl citrate Chemical compound CCOC(=O)CC(O)(C(=O)OCC)CC(=O)OCC DOOTYTYQINUNNV-UHFFFAOYSA-N 0.000 claims 4
- 239000000337 buffer salt Substances 0.000 claims 4
- 229940075507 glyceryl monostearate Drugs 0.000 claims 4
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims 4
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims 4
- 239000001788 mono and diglycerides of fatty acids Substances 0.000 claims 4
- 229920000642 polymer Polymers 0.000 claims 4
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims 4
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims 4
- 229940068968 polysorbate 80 Drugs 0.000 claims 4
- 229920000053 polysorbate 80 Polymers 0.000 claims 4
- 239000005720 sucrose Substances 0.000 claims 4
- 239000001069 triethyl citrate Substances 0.000 claims 4
- VMYFZRTXGLUXMZ-UHFFFAOYSA-N triethyl citrate Natural products CCOC(=O)C(O)(C(=O)OCC)C(=O)OCC VMYFZRTXGLUXMZ-UHFFFAOYSA-N 0.000 claims 4
- 235000013769 triethyl citrate Nutrition 0.000 claims 4
- 206010009657 Clostridium difficile colitis Diseases 0.000 claims 3
- 125000003275 alpha amino acid group Chemical group 0.000 claims 3
- 230000003115 biocidal effect Effects 0.000 claims 3
- 239000011248 coating agent Substances 0.000 claims 3
- 238000000576 coating method Methods 0.000 claims 3
- 238000013270 controlled release Methods 0.000 claims 3
- 230000000694 effects Effects 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 claims 2
- 230000002411 adverse Effects 0.000 claims 2
- 229960001230 asparagine Drugs 0.000 claims 2
- 235000009582 asparagine Nutrition 0.000 claims 2
- 125000000613 asparagine group Chemical group N[C@@H](CC(N)=O)C(=O)* 0.000 claims 2
- 239000007771 core particle Substances 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 210000001035 gastrointestinal tract Anatomy 0.000 claims 2
- 208000004998 Abdominal Pain Diseases 0.000 claims 1
- 206010012735 Diarrhoea Diseases 0.000 claims 1
- -1 EUDRAGIT compound Chemical class 0.000 claims 1
- 229920003134 Eudragit® polymer Polymers 0.000 claims 1
- 208000003100 Pseudomembranous Enterocolitis Diseases 0.000 claims 1
- 206010037128 Pseudomembranous colitis Diseases 0.000 claims 1
- 206010037660 Pyrexia Diseases 0.000 claims 1
- 239000002775 capsule Substances 0.000 claims 1
- VAAUVRVFOQPIGI-SPQHTLEESA-N ceftriaxone Chemical compound S([C@@H]1[C@@H](C(N1C=1C(O)=O)=O)NC(=O)\C(=N/OC)C=2N=C(N)SC=2)CC=1CSC1=NC(=O)C(=O)NN1C VAAUVRVFOQPIGI-SPQHTLEESA-N 0.000 claims 1
- 229960004755 ceftriaxone Drugs 0.000 claims 1
- 206010009887 colitis Diseases 0.000 claims 1
- 230000018044 dehydration Effects 0.000 claims 1
- 238000006297 dehydration reaction Methods 0.000 claims 1
- 230000001419 dependent effect Effects 0.000 claims 1
- 239000003792 electrolyte Substances 0.000 claims 1
- 210000004051 gastric juice Anatomy 0.000 claims 1
- 230000007062 hydrolysis Effects 0.000 claims 1
- 238000006460 hydrolysis reaction Methods 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 230000000968 intestinal effect Effects 0.000 claims 1
- 210000000936 intestine Anatomy 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462061507P | 2014-10-08 | 2014-10-08 | |
| US62/061,507 | 2014-10-08 | ||
| US201562126556P | 2015-02-28 | 2015-02-28 | |
| US62/126,556 | 2015-02-28 | ||
| US201562205443P | 2015-08-14 | 2015-08-14 | |
| US62/205,443 | 2015-08-14 | ||
| PCT/US2015/054606 WO2016057744A1 (en) | 2014-10-08 | 2015-10-08 | Beta-lactamase formulations and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017535521A JP2017535521A (ja) | 2017-11-30 |
| JP2017535521A5 true JP2017535521A5 (enExample) | 2018-11-15 |
| JP6672277B2 JP6672277B2 (ja) | 2020-04-01 |
Family
ID=55653744
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017516516A Active JP6672277B2 (ja) | 2014-10-08 | 2015-10-08 | ベータラクタマーゼ製剤およびその使用 |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US10105322B2 (enExample) |
| EP (1) | EP3204495B1 (enExample) |
| JP (1) | JP6672277B2 (enExample) |
| KR (1) | KR102467968B1 (enExample) |
| CN (1) | CN107148473B (enExample) |
| AU (1) | AU2015330937B2 (enExample) |
| CA (1) | CA2962959C (enExample) |
| ES (1) | ES2806426T3 (enExample) |
| MX (1) | MX2017004473A (enExample) |
| WO (1) | WO2016057744A1 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11034966B2 (en) | 2014-08-28 | 2021-06-15 | Synthetic Biologics, Inc. | E. coli-based production of beta-lactamase |
| WO2016105498A1 (en) | 2014-12-23 | 2016-06-30 | Synthetic Biologics, Inc. | Methods and compositions for inhibiting or preventing adverse effects of oral antibiotics |
| WO2016137993A1 (en) | 2015-02-23 | 2016-09-01 | Synthetic Biologics, Inc. | Carbapenemases for use with antibiotics for the protection of the intestinal microbiome |
| KR20170122776A (ko) | 2015-03-06 | 2017-11-06 | 신세틱 바이오로직스, 인코퍼레이티드 | 마이크로바이옴 보호를 위한 안전하고 유효한 베타-락타마제 투약 |
| CN109562147B (zh) * | 2016-06-28 | 2023-09-01 | 特里瓦生物制剂有限公司 | 保护微生物组免受口服抗生素 |
| SG10201609131YA (en) | 2016-11-01 | 2018-06-28 | Xylonix Ip Holdings Pte Ltd | Zinc-pga compositions and methods for treating cancer |
| US20190275120A1 (en) * | 2016-11-01 | 2019-09-12 | Synthetic Biologics, Inc. | Methods and compositions for attenuating antibiotic resistance |
| SG10201609137PA (en) * | 2016-11-01 | 2018-06-28 | Xylonix Ip Holdings Pte Ltd | Gamma-polyglutamic acid and zinc compositions |
| US20200108130A1 (en) * | 2017-03-21 | 2020-04-09 | Synthetic Biologics, Inc. | Beta-lactamase formulations |
| KR20200074982A (ko) * | 2017-10-25 | 2020-06-25 | 다 볼떼라 | 베타-락타마아제 변이체 |
| US11541105B2 (en) | 2018-06-01 | 2023-01-03 | The Research Foundation For The State University Of New York | Compositions and methods for disrupting biofilm formation and maintenance |
| CN112689506A (zh) * | 2018-08-05 | 2021-04-20 | 达·沃尔泰拉公司 | 用于治疗移植物抗宿主疾病的组合物 |
| US20220218800A1 (en) * | 2019-05-06 | 2022-07-14 | Synthetic Biologics, Inc. | Beta-lactamase compositions for treatment of graft versus host disease |
| CN115298702A (zh) * | 2020-03-10 | 2022-11-04 | Ai:On创新公司 | 用于哺乳动物迁移学习的系统和方法 |
| CN112137984B (zh) * | 2020-10-30 | 2023-02-03 | 四川制药制剂有限公司 | 头孢克洛胶囊及其制备工艺 |
| WO2023168316A1 (en) * | 2022-03-04 | 2023-09-07 | Michael Ogburn | Enteric coated dry powdered cannabinoid formulations |
| CN116790567A (zh) * | 2022-12-30 | 2023-09-22 | 扬州大学 | 来源于土壤宏基因组的β-内酰胺酶及其应用 |
Family Cites Families (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL89987C (enExample) | 1954-05-29 | |||
| US2941995A (en) | 1957-08-02 | 1960-06-21 | Beecham Res Lab | Recovery of solid 6-aminopenicillanic acid |
| US2982696A (en) | 1959-05-01 | 1961-05-02 | Schenley Ind Inc | Ion-exchange procedures for the purification of penicillinase |
| US3070511A (en) | 1960-02-10 | 1962-12-25 | Lepetit Spa | Process for preparing 6-aminopenicillanic acid |
| US3150059A (en) | 1962-12-26 | 1964-09-22 | Lilly Co Eli | Penicillin deacylation via actinoplanaceae fermentation |
| US3239394A (en) | 1964-06-15 | 1966-03-08 | Merck & Co Inc | Process for producing 7-amino-cephalosporanic acid |
| US3499909A (en) | 1966-05-18 | 1970-03-10 | Koninklijke Gist Spiritus | Process for production of 6-aminopenicillanic acid |
| US3488729A (en) | 1966-08-22 | 1970-01-06 | Lilly Co Eli | Cephalothin ester |
| GB1241844A (en) | 1968-08-23 | 1971-08-04 | Beecham Group Ltd | Penicillins |
| FI59265C (fi) | 1974-08-13 | 1981-07-10 | Beecham Group Ltd | Foerfarande foer framstaellning av 6-aminopenicillansyra |
| GB1463513A (en) | 1974-08-13 | 1977-02-02 | Beecham Group Ltd | Enzymes |
| US4537776A (en) | 1983-06-21 | 1985-08-27 | The Procter & Gamble Company | Penetrating topical pharmaceutical compositions containing N-(2-hydroxyethyl) pyrrolidone |
| GB2199582A (en) | 1987-01-07 | 1988-07-13 | Bayer Ag | Analogues of pancreatic secretory trypsin inhibitor |
| FR2613624B1 (fr) | 1987-04-10 | 1990-11-23 | Roussy Inst Gustave | Composition pharmaceutique, administrable par voie orale, destinee a reduire les effets des b-lactamines |
| CA2007083A1 (en) | 1989-01-09 | 1990-07-09 | Nobuhiko Katunuma | Pharmaceutical use of trypstatin |
| JP2813809B2 (ja) * | 1989-06-19 | 1998-10-22 | 武田薬品工業株式会社 | 有核顆粒製剤およびその製造法 |
| CS275231B2 (en) | 1989-09-29 | 1992-02-19 | Ustav Makormolekularni Chemie | Medicine bottle |
| FI920206A0 (fi) | 1992-01-17 | 1992-01-17 | Pekka Untamo Heino | Medicinsk anvaendning, medicinskt foerfarande och preparat. |
| WO1996001623A1 (en) * | 1994-07-08 | 1996-01-25 | Astra Aktiebolag | Multiple unit tableted dosage form i |
| JPH08143476A (ja) * | 1994-11-18 | 1996-06-04 | Japan Tobacco Inc | 薬物放出制御膜及び固形製剤 |
| CN1190434A (zh) | 1995-07-07 | 1998-08-12 | 诺沃挪第克公司 | 用不能形成芽孢的芽孢杆菌生产蛋白质的方法 |
| WO1999059544A2 (en) * | 1998-05-18 | 1999-11-25 | Takeda Chemical Industries, Ltd. | Orally disintegrable tablets |
| ATE481090T1 (de) * | 1998-07-28 | 2010-10-15 | Takeda Pharmaceutical | Leicht zerfallende feste zubereitung |
| FI4533U1 (fi) * | 2000-03-14 | 2000-08-10 | Finnzymes Oy | Entsyymikoostumus maidon käsittelemiseksi |
| US7585674B2 (en) | 2001-05-29 | 2009-09-08 | Kao Corporation | Host microorganisms |
| FI112666B (fi) | 2001-11-06 | 2003-12-31 | Ipsat Therapies Oy | Itiöimätön Bacillus subtilis, sen valmistus ja käyttö |
| FR2843302B1 (fr) | 2002-08-09 | 2004-10-22 | Centre Nat Rech Scient | Forme galenique pour la delivrance colique de principes actifs |
| JP4749660B2 (ja) * | 2002-10-16 | 2011-08-17 | 武田薬品工業株式会社 | 安定な固形製剤 |
| EP1564286A1 (en) | 2004-02-11 | 2005-08-17 | Université de Liège | Hybrid proteins of beta-lactamase class A |
| AR051946A1 (es) * | 2004-11-05 | 2007-02-21 | Wyeth Corp | Formulaciones de derivados de [1,4] diazepina [6,7,1-ij] quinolina |
| WO2006122835A1 (en) | 2005-05-18 | 2006-11-23 | Da Volterra | Colonic delivery of adsorbents |
| EP1993518A4 (en) * | 2006-03-06 | 2012-12-12 | Pozen Inc | DOSAGE FORMS FOR THE ADMINISTRATION OF MEDICINAL COMBINATIONS |
| FI119190B (fi) | 2006-06-21 | 2008-08-29 | Ipsat Therapies Oy | Modifioitu beta-laktamaasi ja menetelmä sen valmistamiseksi |
| US8273376B2 (en) * | 2006-11-17 | 2012-09-25 | Da Volterra | Colonic delivery of metallo-dependent enzymes |
| FI119678B (fi) * | 2006-11-28 | 2009-02-13 | Ipsat Therapies Oy | Beta-laktamaasin käyttö |
| US9023352B2 (en) | 2007-02-20 | 2015-05-05 | Tufts University | Methods, compositions and kits for treating a subject using a recombinant heteromultimeric neutralizing binding protein |
| JP2013525488A (ja) * | 2010-05-03 | 2013-06-20 | アプタリス ファーマ リミテッド | 消化酵素混合物を含有するパンクレアチンを含むマイクロペレット組成物 |
| FI20105572A0 (fi) * | 2010-05-24 | 2010-05-24 | Prevab R Lcc | Muokattu beeta-laktamaasi ja siihen liittyvät menetelmät ja käytöt |
| WO2013015388A1 (ja) * | 2011-07-26 | 2013-01-31 | Ｍｅｉｊｉ Ｓｅｉｋａファルマ株式会社 | Ｎｄｍ阻害剤 |
| CA2758556A1 (en) * | 2011-11-17 | 2013-05-17 | Pharmascience Inc. | Pharmaceutical composition of amphetamine mixed salts |
| KR101952478B1 (ko) * | 2011-11-30 | 2019-02-26 | 다케다 야쿠힌 고교 가부시키가이샤 | 유핵정 |
| US20140128431A1 (en) | 2012-04-03 | 2014-05-08 | Hoffmann-Laroche Inc. | Pharmaceutical composition with improved bioavailability, safety and tolerability |
| US9290754B2 (en) * | 2014-04-17 | 2016-03-22 | Synthetic Biologics Inc. | Beta-lactamases with improved properties for therapy |
| WO2016105498A1 (en) * | 2014-12-23 | 2016-06-30 | Synthetic Biologics, Inc. | Methods and compositions for inhibiting or preventing adverse effects of oral antibiotics |
| KR20170122776A (ko) * | 2015-03-06 | 2017-11-06 | 신세틱 바이오로직스, 인코퍼레이티드 | 마이크로바이옴 보호를 위한 안전하고 유효한 베타-락타마제 투약 |
-
2015
- 2015-10-08 KR KR1020177012353A patent/KR102467968B1/ko active Active
- 2015-10-08 CA CA2962959A patent/CA2962959C/en active Active
- 2015-10-08 ES ES15849110T patent/ES2806426T3/es active Active
- 2015-10-08 US US14/878,155 patent/US10105322B2/en active Active
- 2015-10-08 AU AU2015330937A patent/AU2015330937B2/en active Active
- 2015-10-08 CN CN201580059890.6A patent/CN107148473B/zh active Active
- 2015-10-08 JP JP2017516516A patent/JP6672277B2/ja active Active
- 2015-10-08 WO PCT/US2015/054606 patent/WO2016057744A1/en not_active Ceased
- 2015-10-08 MX MX2017004473A patent/MX2017004473A/es unknown
- 2015-10-08 EP EP15849110.0A patent/EP3204495B1/en active Active
-
2018
- 2018-08-24 US US16/111,477 patent/US10828260B2/en active Active
-
2020
- 2020-09-28 US US17/034,534 patent/US12178917B2/en active Active
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