JP2017534646A5 - - Google Patents
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- Publication number
- JP2017534646A5 JP2017534646A5 JP2017525023A JP2017525023A JP2017534646A5 JP 2017534646 A5 JP2017534646 A5 JP 2017534646A5 JP 2017525023 A JP2017525023 A JP 2017525023A JP 2017525023 A JP2017525023 A JP 2017525023A JP 2017534646 A5 JP2017534646 A5 JP 2017534646A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- antibody
- acid sequence
- seq
- humanized antibody
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001413 amino acids Chemical group 0.000 claims 13
- 125000000539 amino acid group Chemical group 0.000 claims 7
- 239000003814 drug Substances 0.000 claims 5
- 239000000427 antigen Substances 0.000 claims 4
- 102000036639 antigens Human genes 0.000 claims 4
- 108091007433 antigens Proteins 0.000 claims 4
- 230000035772 mutation Effects 0.000 claims 4
- 101001033249 Homo sapiens Interleukin-1 beta Proteins 0.000 claims 3
- 108090000193 Interleukin-1 beta Proteins 0.000 claims 2
- 102000003777 Interleukin-1 beta Human genes 0.000 claims 2
- 102000019223 Interleukin-1 receptor Human genes 0.000 claims 2
- 108050006617 Interleukin-1 receptor Proteins 0.000 claims 2
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims 2
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 2
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims 2
- 238000005734 heterodimerization reaction Methods 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 239000004474 valine Substances 0.000 claims 2
- NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 claims 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 1
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims 1
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims 1
- 208000014245 Ocular vascular disease Diseases 0.000 claims 1
- 235000004279 alanine Nutrition 0.000 claims 1
- 230000004071 biological effect Effects 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000003993 interaction Effects 0.000 claims 1
- 229960000310 isoleucine Drugs 0.000 claims 1
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 claims 1
- 208000002780 macular degeneration Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14192523.0 | 2014-11-10 | ||
| EP14192523 | 2014-11-10 | ||
| PCT/EP2015/075875 WO2016075034A1 (en) | 2014-11-10 | 2015-11-06 | ANTI-IL-1beta ANTIBODIES AND METHODS OF USE |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017534646A JP2017534646A (ja) | 2017-11-24 |
| JP2017534646A5 true JP2017534646A5 (esLanguage) | 2018-12-06 |
| JP6787888B2 JP6787888B2 (ja) | 2020-11-18 |
Family
ID=51868114
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017525023A Expired - Fee Related JP6787888B2 (ja) | 2014-11-10 | 2015-11-06 | 抗ｉｌ−１ベータ抗体及び使用方法 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US10344085B2 (esLanguage) |
| EP (1) | EP3218402A1 (esLanguage) |
| JP (1) | JP6787888B2 (esLanguage) |
| KR (1) | KR20170081253A (esLanguage) |
| CN (1) | CN107074942A (esLanguage) |
| AR (1) | AR102594A1 (esLanguage) |
| AU (1) | AU2015345320A1 (esLanguage) |
| BR (1) | BR112017009817A2 (esLanguage) |
| CA (1) | CA2963719A1 (esLanguage) |
| IL (1) | IL251165A0 (esLanguage) |
| MX (1) | MX2017005987A (esLanguage) |
| RU (1) | RU2017120358A (esLanguage) |
| SG (1) | SG11201702550WA (esLanguage) |
| TW (1) | TW201632552A (esLanguage) |
| WO (1) | WO2016075034A1 (esLanguage) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2417156B1 (en) | 2009-04-07 | 2015-02-11 | Roche Glycart AG | Trivalent, bispecific antibodies |
| WO2016075036A1 (en) | 2014-11-10 | 2016-05-19 | F. Hoffmann-La Roche Ag | Anti-pdgf-b antibodies and methods of use |
| BR112017009790A2 (pt) | 2014-11-10 | 2017-12-19 | Hoffmann La Roche | anticorpos direcionados ao anti-ang2 e métodos de uso |
| JP6787888B2 (ja) | 2014-11-10 | 2020-11-18 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 抗ｉｌ−１ベータ抗体及び使用方法 |
| CN107074941A (zh) | 2014-11-10 | 2017-08-18 | 豪夫迈·罗氏有限公司 | 双特异性抗体和用于眼科学的方法 |
| JP6721590B2 (ja) | 2014-12-03 | 2020-07-15 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 多重特異性抗体 |
| TWI679052B (zh) * | 2017-05-16 | 2019-12-11 | 南韓商Ｃｊ醫藥健康股份有限公司 | 使用親和力層析術純化抗體或其抗體片段的方法 |
| WO2018212556A1 (en) * | 2017-05-16 | 2018-11-22 | Cj Healthcare Corporation | A method for purifying an antibody or an antibody fragment thereof using affinity chromatography |
| CN118994394A (zh) | 2017-06-12 | 2024-11-22 | 蓝鳍生物医药公司 | 抗-il1rap抗体和抗体药物缀合物 |
| CN111788221B (zh) * | 2018-01-26 | 2026-02-13 | 建新公司 | 具有与FcRn增强的结合及延长的半衰期的Fc变体 |
| CN110818793A (zh) * | 2018-08-14 | 2020-02-21 | 中山康方生物医药有限公司 | 抗IL-1β的抗体、其药物组合物及其用途 |
| CN113195531B (zh) * | 2018-12-21 | 2025-03-04 | 豪夫迈·罗氏有限公司 | 与VEGF和IL-1β结合的抗体及其使用方法 |
| CN115028723B (zh) * | 2019-03-07 | 2023-08-29 | 瑞阳(苏州)生物科技有限公司 | 人IL-1β蛋白结合分子及其编码基因和应用 |
| JP7387196B2 (ja) | 2019-06-11 | 2023-11-28 | バイオアトラ インコーポレイテッド | 条件付きで活性な抗ｅｐｃａｍ抗体、抗体フラグメント、それらのイムノコンジュゲート、及びそれらの使用 |
| CN114524875B (zh) * | 2021-11-11 | 2023-07-25 | 江苏莱森生物科技研究院有限公司 | 偶联IL-1β单克隆抗体的纳米硅球及应用 |
| CN117126278B (zh) * | 2023-10-26 | 2024-01-05 | 中国科学院苏州纳米技术与纳米仿生研究所 | 一种单克隆抗体及其应用 |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4935343A (en) * | 1986-08-08 | 1990-06-19 | Syntex (U.S.A.) Inc. | Monoclonal antibodies for interleukin-1β |
| EP1481010A2 (en) * | 2002-02-28 | 2004-12-01 | Eli Lilly And Company | Anti-interleukin-1 beta analogs |
| AU2003244817B2 (en) | 2002-06-28 | 2010-08-26 | Domantis Limited | Antigen-binding immunoglobulin single variable domains and dual-specific constructs |
| MXPA05007853A (es) * | 2003-01-24 | 2006-02-10 | Applied Molecular Evolution | Antagonistas de il-1 beta humana. |
| WO2005052002A2 (en) * | 2003-11-20 | 2005-06-09 | Massachusetts Institute Of Technology | Single-domain antibodies and uses thereof |
| WO2005087812A1 (en) | 2004-03-05 | 2005-09-22 | Ludwig Institute For Cancer Research | Multivalent antibody materials and methods for vegf/pdgf family of growth factors |
| US7612181B2 (en) | 2005-08-19 | 2009-11-03 | Abbott Laboratories | Dual variable domain immunoglobulin and uses thereof |
| US8268314B2 (en) | 2008-10-08 | 2012-09-18 | Hoffmann-La Roche Inc. | Bispecific anti-VEGF/anti-ANG-2 antibodies |
| RU2011135768A (ru) * | 2009-01-29 | 2013-03-10 | Эбботт Лэборетриз | Белки, связывающие il-1 |
| AU2010306681A1 (en) * | 2009-10-15 | 2012-04-19 | Abbvie Inc. | IL-1 binding proteins |
| AR080794A1 (es) | 2010-03-26 | 2012-05-09 | Hoffmann La Roche | Anticuerpos bivalentes biespecificos anti- vegf/ anti-ang-2 |
| BR112013003279A2 (pt) * | 2010-08-13 | 2016-06-14 | Genentech In | “métodos para tratar uma doença, método para neutralizar ou bloquear a atividade de il-1ß e/ou il-18, anticorpo, usos de um anticorpo e usos de um anticorpo monoclonal” |
| JP5866130B2 (ja) * | 2010-09-10 | 2016-02-17 | アペクシジェン， インコーポレイテッド | 抗ＩＬ−１β抗体およびその使用方法 |
| EP2655417A2 (en) * | 2010-12-21 | 2013-10-30 | AbbVie Inc. | Il-1 -alpha and -beta bispecific dual variable domain immunoglobulins and their use |
| CA2840212A1 (en) | 2011-06-29 | 2013-01-03 | Amgen Inc. | Predictive biomarker of survival in the treatment of renal cell carcinoma |
| KR20150023957A (ko) | 2012-06-28 | 2015-03-05 | 몰리큘라 파트너스 아게 | 혈소판-유래 성장인자에 결합하는 설계된 안키린 반복 단백질 |
| DK3495387T3 (da) | 2012-07-13 | 2021-11-08 | Roche Glycart Ag | Bispecifikke anti-VEGF-/anti-ANG-2-antistoffer og deres anvendelse ved behandling af okulære vaskulære sygdomme |
| US20140093499A1 (en) | 2012-09-28 | 2014-04-03 | Boehringer Ingelheim International Gmbh | Pharmaceutical combinations comprising dual angiopoietin-2 / dll4 binders and anti-vegf agents |
| BR112015006363A2 (pt) | 2012-09-28 | 2017-08-08 | Boehringer Ingelheim Int | combinações farmacêuticas compreendendo ligantes angiopoietina-2/dll4 duplos e agentes anti-vegf-r |
| WO2014074823A1 (en) | 2012-11-08 | 2014-05-15 | Clearside Biomedical, Inc. | Methods and devices for the treatment of ocular diseases in human subjects |
| KR20150082503A (ko) | 2012-11-09 | 2015-07-15 | 화이자 인코포레이티드 | 혈소판 유래 성장 인자 b 특이적 항체, 및 그의 조성물 및 용도 |
| JO3405B1 (ar) | 2013-01-09 | 2019-10-20 | Regeneron Pharma | الأجسام المضادة لمضاد مستقبل عامل النمو المشتق من الصفائح الدموية - بيتا واستخداماتها |
| CA2904448A1 (en) * | 2013-03-15 | 2014-09-18 | Tariq Ghayur | Dual specific binding proteins directed against il-1.beta. and/or il-17 |
| PE20151807A1 (es) * | 2013-04-29 | 2015-12-02 | Hoffmann La Roche | Anticuerpos modificados de union a fcrn humano y metodo de utilizacion |
| MX2016008099A (es) | 2013-12-20 | 2016-10-13 | Hoffmann La Roche | Terapia combinada con un anticuerpo anti-ang2 y un agonista de cd40. |
| CA2931986A1 (en) | 2014-01-15 | 2015-07-23 | F. Hoffmann-La Roche Ag | Fc-region variants with modified fcrn- and maintained protein a-binding properties |
| CN107074941A (zh) | 2014-11-10 | 2017-08-18 | 豪夫迈·罗氏有限公司 | 双特异性抗体和用于眼科学的方法 |
| JP6787888B2 (ja) | 2014-11-10 | 2020-11-18 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 抗ｉｌ−１ベータ抗体及び使用方法 |
| WO2016075036A1 (en) | 2014-11-10 | 2016-05-19 | F. Hoffmann-La Roche Ag | Anti-pdgf-b antibodies and methods of use |
| BR112017009790A2 (pt) | 2014-11-10 | 2017-12-19 | Hoffmann La Roche | anticorpos direcionados ao anti-ang2 e métodos de uso |
| WO2016209972A1 (en) | 2015-06-26 | 2016-12-29 | Amgen Inc. | Biomarker of survival in the treatment of renal cell carcinoma with a vegfr inhibitor and an ang2 inhibitor |
| BR112019022074A2 (pt) | 2017-06-02 | 2020-05-12 | Boehringer Ingelheim International Gmbh | Terapia de combinação anticâncer |
-
2015
- 2015-11-06 JP JP2017525023A patent/JP6787888B2/ja not_active Expired - Fee Related
- 2015-11-06 WO PCT/EP2015/075875 patent/WO2016075034A1/en not_active Ceased
- 2015-11-06 CN CN201580060880.4A patent/CN107074942A/zh active Pending
- 2015-11-06 CA CA2963719A patent/CA2963719A1/en not_active Abandoned
- 2015-11-06 BR BR112017009817A patent/BR112017009817A2/pt not_active Application Discontinuation
- 2015-11-06 RU RU2017120358A patent/RU2017120358A/ru not_active Application Discontinuation
- 2015-11-06 KR KR1020177015590A patent/KR20170081253A/ko not_active Withdrawn
- 2015-11-06 AU AU2015345320A patent/AU2015345320A1/en not_active Abandoned
- 2015-11-06 MX MX2017005987A patent/MX2017005987A/es unknown
- 2015-11-06 EP EP15790945.8A patent/EP3218402A1/en not_active Withdrawn
- 2015-11-06 SG SG11201702550WA patent/SG11201702550WA/en unknown
- 2015-11-09 TW TW104136907A patent/TW201632552A/zh unknown
- 2015-11-09 AR ARP150103647A patent/AR102594A1/es unknown
-
2017
- 2017-03-14 IL IL251165A patent/IL251165A0/en unknown
- 2017-05-09 US US15/590,161 patent/US10344085B2/en not_active Expired - Fee Related
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