JP2017532961A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2017532961A5 JP2017532961A5 JP2017520449A JP2017520449A JP2017532961A5 JP 2017532961 A5 JP2017532961 A5 JP 2017532961A5 JP 2017520449 A JP2017520449 A JP 2017520449A JP 2017520449 A JP2017520449 A JP 2017520449A JP 2017532961 A5 JP2017532961 A5 JP 2017532961A5
- Authority
- JP
- Japan
- Prior art keywords
- smad7
- composition
- antisense oligonucleotide
- item
- ibd
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 101700026522 SMAD7 Proteins 0.000 claims description 69
- 102000049873 Smad7 Human genes 0.000 claims description 69
- 239000000074 antisense oligonucleotide Substances 0.000 claims description 44
- 238000012230 antisense oligonucleotides Methods 0.000 claims description 44
- 108091034117 Oligonucleotide Proteins 0.000 claims description 40
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims description 22
- 239000002773 nucleotide Substances 0.000 claims description 22
- 125000003729 nucleotide group Chemical group 0.000 claims description 22
- RYYWUUFWQRZTIU-UHFFFAOYSA-K thiophosphate Chemical compound [O-]P([O-])([O-])=S RYYWUUFWQRZTIU-UHFFFAOYSA-K 0.000 claims description 11
- 102000054765 polymorphisms of proteins Human genes 0.000 claims description 9
- LUCHPKXVUGJYGU-XLPZGREQSA-N 5-methyl-2'-deoxycytidine Chemical compound O=C1N=C(N)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 LUCHPKXVUGJYGU-XLPZGREQSA-N 0.000 claims description 8
- 150000007523 nucleic acids Chemical group 0.000 claims description 7
- 108020000948 Antisense Oligonucleotides Proteins 0.000 claims description 6
- 206010009900 Colitis ulcerative Diseases 0.000 claims description 4
- 208000011231 Crohn disease Diseases 0.000 claims description 4
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 4
- 201000006704 Ulcerative Colitis Diseases 0.000 claims description 4
- 239000008194 pharmaceutical composition Substances 0.000 claims description 4
- 102000039446 nucleic acids Human genes 0.000 claims description 3
- 108020004707 nucleic acids Proteins 0.000 claims description 3
- 108091028664 Ribonucleotide Proteins 0.000 claims description 2
- 239000002671 adjuvant Substances 0.000 claims description 2
- 230000000295 complement effect Effects 0.000 claims description 2
- 239000005547 deoxyribonucleotide Substances 0.000 claims description 2
- 239000008203 oral pharmaceutical composition Substances 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 239000002336 ribonucleotide Substances 0.000 claims description 2
- 125000002652 ribonucleotide group Chemical group 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 16
- 239000003814 drug Substances 0.000 claims 4
- 238000000034 method Methods 0.000 description 36
- 108060008682 Tumor Necrosis Factor Proteins 0.000 description 9
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 description 8
- 102100040247 Tumor necrosis factor Human genes 0.000 description 3
- 229930024421 Adenine Natural products 0.000 description 2
- GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical compound NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 description 2
- 229960000643 adenine Drugs 0.000 description 2
- UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical compound O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 description 2
- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 description 1
- 102000052567 Anaphase-Promoting Complex-Cyclosome Apc1 Subunit Human genes 0.000 description 1
- 238000001712 DNA sequencing Methods 0.000 description 1
- 101000611183 Homo sapiens Tumor necrosis factor Proteins 0.000 description 1
- 108090000144 Human Proteins Proteins 0.000 description 1
- 102000003839 Human Proteins Human genes 0.000 description 1
- 108091006463 SLC25A24 Proteins 0.000 description 1
- 206010054094 Tumour necrosis Diseases 0.000 description 1
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 1
- 238000001574 biopsy Methods 0.000 description 1
- 230000014509 gene expression Effects 0.000 description 1
- 238000011223 gene expression profiling Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 108020004999 messenger RNA Proteins 0.000 description 1
- 238000010208 microarray analysis Methods 0.000 description 1
- 238000007481 next generation sequencing Methods 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462065598P | 2014-10-17 | 2014-10-17 | |
| US62/065,598 | 2014-10-17 | ||
| PCT/EP2015/074066 WO2016059239A1 (en) | 2014-10-17 | 2015-10-16 | Methods and compositions for treating a subject with a smad7 antisense oligonucleotide |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017532961A JP2017532961A (ja) | 2017-11-09 |
| JP2017532961A5 true JP2017532961A5 (https=) | 2018-11-29 |
Family
ID=54330761
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017520449A Pending JP2017532961A (ja) | 2014-10-17 | 2015-10-16 | Ｓｍａｄ７アンチセンスオリゴヌクレオチドによる対象を処置するための方法および組成物 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US10337004B2 (https=) |
| EP (1) | EP3207136A1 (https=) |
| JP (1) | JP2017532961A (https=) |
| KR (1) | KR20170069262A (https=) |
| CN (1) | CN107406851A (https=) |
| AU (1) | AU2015332624A1 (https=) |
| CA (1) | CA2964667A1 (https=) |
| EA (1) | EA201790867A1 (https=) |
| IL (1) | IL251717A0 (https=) |
| MA (1) | MA43331A (https=) |
| MX (1) | MX2017004973A (https=) |
| WO (1) | WO2016059239A1 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITRM20030149A1 (it) | 2003-04-02 | 2004-10-03 | Giuliani Spa | Oligonucleotidi (odn) antisenso per smad7 e loro usi in campo medico |
| ES2627745T3 (es) | 2008-11-13 | 2017-07-31 | Nogra Pharma Limited | Composiciones antisentido, y procedimientos de fabricación y uso de las mismas |
| ES2617200T3 (es) | 2011-09-15 | 2017-06-15 | Nogra Pharma Limited | Procedimientos para supervisar la capacidad de respuesta al tratamiento anti-SMAD7 |
| US10081809B2 (en) | 2012-04-18 | 2018-09-25 | University Of Miami | Methods of treating diabetes and/or promoting survival of pancreatic islets after transplantation |
| US10006029B2 (en) | 2013-03-15 | 2018-06-26 | Nogra Pharma Limited | Methods of treating colorectal cancer |
| AU2015257589A1 (en) | 2014-05-09 | 2016-11-24 | Nogra Pharma Limited | Methods for treating inflammatory bowel disease |
| US20170233736A1 (en) * | 2014-10-17 | 2017-08-17 | Nogra Pharma Limited | Methods for dosing and monitoring smad7 antisense oligonucleotide treatment using biomarker levels |
| WO2016059239A1 (en) | 2014-10-17 | 2016-04-21 | Nogra Pharma Limited | Methods and compositions for treating a subject with a smad7 antisense oligonucleotide |
| JP2019505598A (ja) | 2016-02-23 | 2019-02-28 | セルジーン アルパイン インベストメント カンパニー Ｉｉ， エルエルシー | Ｓｍａｄ７の阻害を用いて、腸線維症を治療する方法 |
| JP2020503327A (ja) * | 2016-12-30 | 2020-01-30 | ノグラ ファーマ リミテッド | Ｓｍａｄ７アンチセンスオリゴヌクレオチドの組成物および乾癬を処置するまたは予防する方法 |
| AU2021260967A1 (en) * | 2020-04-24 | 2022-10-20 | Nogra Pharma Limited | Compositions of SMAD7 antisense oligonucleotides (ASO) and methods of using the same |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT1456380E (pt) | 2001-11-02 | 2012-07-23 | Giuliani Int Ltd | Inibidores smad7 para o tratamento de doenças do snc |
| ITRM20030149A1 (it) | 2003-04-02 | 2004-10-03 | Giuliani Spa | Oligonucleotidi (odn) antisenso per smad7 e loro usi in campo medico |
| ES2627745T3 (es) | 2008-11-13 | 2017-07-31 | Nogra Pharma Limited | Composiciones antisentido, y procedimientos de fabricación y uso de las mismas |
| US9062311B2 (en) * | 2009-01-26 | 2015-06-23 | Academisch Ziekenhuis Leiden H.O.D.N. Lumc | Means and methods for modulating NOTCH3 protein expression and/or the coding region of NOTCH3; compositions and use thereof in the treatment of CADASIL |
| EP3628750A1 (en) * | 2010-02-08 | 2020-04-01 | Ionis Pharmaceuticals, Inc. | Selective reduction of allelic variants |
| ES2617200T3 (es) * | 2011-09-15 | 2017-06-15 | Nogra Pharma Limited | Procedimientos para supervisar la capacidad de respuesta al tratamiento anti-SMAD7 |
| US10081809B2 (en) | 2012-04-18 | 2018-09-25 | University Of Miami | Methods of treating diabetes and/or promoting survival of pancreatic islets after transplantation |
| US10006029B2 (en) | 2013-03-15 | 2018-06-26 | Nogra Pharma Limited | Methods of treating colorectal cancer |
| RU2674147C2 (ru) | 2013-03-15 | 2018-12-05 | Ногра Фарма Лимитед | Способы лечения колоректального рака |
| AU2015257589A1 (en) | 2014-05-09 | 2016-11-24 | Nogra Pharma Limited | Methods for treating inflammatory bowel disease |
| US20170233736A1 (en) | 2014-10-17 | 2017-08-17 | Nogra Pharma Limited | Methods for dosing and monitoring smad7 antisense oligonucleotide treatment using biomarker levels |
| WO2016059239A1 (en) | 2014-10-17 | 2016-04-21 | Nogra Pharma Limited | Methods and compositions for treating a subject with a smad7 antisense oligonucleotide |
| WO2015011694A2 (en) | 2014-10-17 | 2015-01-29 | Celgene Corporation | Isotopologues of smad7 antisense oligonucleotides |
| MA41271A (fr) | 2014-12-26 | 2017-10-31 | Celgene Alpine Invest Company Ii Llc | Méthodes d'utilisation d'oligonucléotides antisens ciblant smad7 |
| MX2018003699A (es) | 2015-09-30 | 2018-08-01 | Celgene Alpine Invest Company Ii Llc | Moduladores de tlr y metodos de uso. |
| EP3355896A2 (en) | 2015-09-30 | 2018-08-08 | Nogra Pharma Limited | Methods of using smad7 antisense oligonucleotides based on biomarker expression |
-
2015
- 2015-10-16 WO PCT/EP2015/074066 patent/WO2016059239A1/en not_active Ceased
- 2015-10-16 EP EP15781642.2A patent/EP3207136A1/en not_active Withdrawn
- 2015-10-16 AU AU2015332624A patent/AU2015332624A1/en not_active Abandoned
- 2015-10-16 MX MX2017004973A patent/MX2017004973A/es unknown
- 2015-10-16 JP JP2017520449A patent/JP2017532961A/ja active Pending
- 2015-10-16 CN CN201580069041.9A patent/CN107406851A/zh active Pending
- 2015-10-16 US US15/519,468 patent/US10337004B2/en not_active Expired - Fee Related
- 2015-10-16 EA EA201790867A patent/EA201790867A1/ru unknown
- 2015-10-16 KR KR1020177012839A patent/KR20170069262A/ko not_active Withdrawn
- 2015-10-16 CA CA2964667A patent/CA2964667A1/en not_active Abandoned
- 2015-10-16 MA MA043331A patent/MA43331A/fr unknown
-
2017
- 2017-04-13 IL IL251717A patent/IL251717A0/en unknown
-
2019
- 2019-05-21 US US16/418,108 patent/US20190338283A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2017532961A5 (https=) | ||
| Jenner et al. | Insights into host responses against pathogens from transcriptional profiling | |
| CN101892311B (zh) | 高血压易感基因的单核苷酸多态性位点rs7550536的检测方法及检测试剂盒 | |
| AU2017224226A1 (en) | Compositions and methods of using piRNAs in cancer diagnostics and therapeutics | |
| CN102586408B (zh) | 高血压易感基因Mfn2单核苷酸多态性位点rs3820189的检测方法及检测试剂盒 | |
| CN101892302B (zh) | 高血压易感基因的rs2336384位点的用途及检测试剂盒 | |
| Truelove et al. | Evaluation of IL10, IL19 and IL20 gene polymorphisms and chronic hepatitis B infection outcome | |
| CN109414448A (zh) | 用于减少PAPD5或PAPD7 mRNA治疗乙型肝炎感染的核酸分子 | |
| FI3384049T3 (fi) | Menetelmiä geenimuunnosten liittämiseksi kliiniseen tulokseen potilailla, jotka kärsivät silmänpohjan ikärappeumasta ja joita on hoidettu anti-VEGF:llä | |
| US10337004B2 (en) | Methods and compositions for treating a subject with a SMAD7 antisense oligonucleotide | |
| JP2018517704A5 (https=) | ||
| US20180263979A1 (en) | Combination of raf inhibitors and aurora kinase inhibitors | |
| Chen et al. | CD55 variant associated with pegylated-interferon α therapy response in HBeAg-positive chronic hepatitis B patients | |
| CN101892297B (zh) | 高血压易感基因单核苷酸多态性位点的检测方法及其试剂盒 | |
| Yang et al. | Fibronectin is essential for hepatitis B virus propagation in vitro: may be a potential cellular target? | |
| JP2005500029A5 (https=) | ||
| JP5787337B2 (ja) | Ｃ型肝炎の治療効果を予測するためのマーカー群、検査方法及び検査用キット | |
| Day et al. | Unsaturated fatty acid regulation of AraC/XylS transcription factors | |
| JP7498448B2 (ja) | ＳＮＨＧ１２遺伝子に由来するｎｃＲＮＡの発現抑制剤を有効成分とするがん増殖抑制剤 | |
| CN118265529A (zh) | 使用camp应答元件结合蛋白3样3(creb3l3)抑制剂的肝病治疗 | |
| AU2024335101A1 (en) | Treatment of muscle disorder with folliculin interacting protein 1 (fnip1) inhibitors and/or folliculin (flcn) inhibitors | |
| Wang | Construction and analysis of competing endogenous RNA | |
| WO2025090721A1 (en) | Treatment of osteoarthritis with procollagen galactosyl transferase 2 (colgalt2) inhibitors | |
| CN121844049A (zh) | 使用软骨中间层蛋白2 (cilp2)抑制剂治疗骨关节炎 | |
| CA3210481A1 (en) | Treatment of liver disease with mitochondrial glycerol-3-phosphate acyltransferase (gpam) inhibitors |