JP2017532329A5 - - Google Patents
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- Publication number
- JP2017532329A5 JP2017532329A5 JP2017518431A JP2017518431A JP2017532329A5 JP 2017532329 A5 JP2017532329 A5 JP 2017532329A5 JP 2017518431 A JP2017518431 A JP 2017518431A JP 2017518431 A JP2017518431 A JP 2017518431A JP 2017532329 A5 JP2017532329 A5 JP 2017532329A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- alkyl
- solvent
- alken
- unsubstituted aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 0 C[C@](C([C@@](C([C@](C)O[C@](C[C@@](C([C@](C1)O)C(O)=O)OC1(CC(C1)OC(*)OC1C(CCC(C1)OC(*)OC1CC(O[C@@](C)[C@@]1C)=O)O)OC)C=CC=CC=CC=CC=CC=CC=C[C@](*)C1O)O)N)O)O Chemical compound C[C@](C([C@@](C([C@](C)O[C@](C[C@@](C([C@](C1)O)C(O)=O)OC1(CC(C1)OC(*)OC1C(CCC(C1)OC(*)OC1CC(O[C@@](C)[C@@]1C)=O)O)OC)C=CC=CC=CC=CC=CC=CC=C[C@](*)C1O)O)N)O)O 0.000 description 3
- YFMMNRNSTUPXBU-FLCNYULVSA-N C[C@H]([C@H]([C@@H]([C@H]1O)N)O)OC1OC(C[C@@H]([C@@H]([C@H](C1)O)C(O)=O)OC1(CC(CC(C(CCC(CC(CC(O[C@@H](C)C1)=O)O)O)O)O)O)O)/C=C\C=C/C=C\C=C/C=C\C=C/C=C\[C@H](C)[C@H]1O Chemical compound C[C@H]([C@H]([C@@H]([C@H]1O)N)O)OC1OC(C[C@@H]([C@@H]([C@H](C1)O)C(O)=O)OC1(CC(CC(C(CCC(CC(CC(O[C@@H](C)C1)=O)O)O)O)O)O)O)/C=C\C=C/C=C\C=C/C=C\C=C/C=C\[C@H](C)[C@H]1O YFMMNRNSTUPXBU-FLCNYULVSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462065330P | 2014-10-17 | 2014-10-17 | |
| US62/065,330 | 2014-10-17 | ||
| PCT/US2015/055899 WO2016061437A1 (en) | 2014-10-17 | 2015-10-16 | Scalable synthesis of reduced toxicity derivative of amphotericin b |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017532329A JP2017532329A (ja) | 2017-11-02 |
| JP2017532329A5 true JP2017532329A5 (https=) | 2018-11-22 |
| JP6755859B2 JP6755859B2 (ja) | 2020-09-16 |
Family
ID=55747385
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017518431A Active JP6755859B2 (ja) | 2014-10-17 | 2015-10-16 | アムホテリシンｂの毒性が低減された誘導体の規模変更可能な合成法 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US10087206B2 (https=) |
| EP (1) | EP3206695B1 (https=) |
| JP (1) | JP6755859B2 (https=) |
| AU (2) | AU2015331904B2 (https=) |
| WO (1) | WO2016061437A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6543272B2 (ja) * | 2014-05-16 | 2019-07-10 | ザ ボード オブ トラスティーズ オブ ザ ユニヴァーシティ オブ イリノイＴｈｅ Ｂｏａｒｄ Ｏｆ Ｔｒｕｓｔｅｅｓ Ｏｆ Ｔｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｉｌｌｉｎｏｉｓ | 低減された毒性を有するアンホテリシンｂ誘導体 |
| US10087206B2 (en) * | 2014-10-17 | 2018-10-02 | The Board Of Trustees Of The University Of Illinois | Scalable synthesis of reduced toxicity derivative of amphotericin B |
| CA3021061C (en) | 2015-04-15 | 2023-10-24 | Martin D. Burke | Derivatives of amphotericin b |
| KR20220058547A (ko) * | 2019-08-08 | 2022-05-09 | 더 보오드 오브 트러스티스 오브 더 유니버시티 오브 일리노이즈 | 감소된 독성을 갖는 하이브리드 암포테리신 b 유도체 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1008720A (en) | 1910-11-14 | 1911-11-14 | John Knape | Adjustable bracket. |
| EP0431874A1 (en) * | 1989-12-08 | 1991-06-12 | Beecham Group p.l.c. | Novel compounds |
| EP2371815A1 (en) * | 2003-12-30 | 2011-10-05 | XenoPort, Inc. | Sythesis of acyloxyalkyl carbamate prodrugs and intermediates thereof |
| WO2014059436A1 (en) * | 2012-10-12 | 2014-04-17 | The Board Of Trustees Of The University Of Illinois | Electronic tuning of site selectivity |
| WO2014165676A1 (en) * | 2013-04-03 | 2014-10-09 | The Board Of Trustees Of The University Of Illinois | Amphotericin b derivative with reduced toxicity |
| JP6543272B2 (ja) | 2014-05-16 | 2019-07-10 | ザ ボード オブ トラスティーズ オブ ザ ユニヴァーシティ オブ イリノイＴｈｅ Ｂｏａｒｄ Ｏｆ Ｔｒｕｓｔｅｅｓ Ｏｆ Ｔｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｉｌｌｉｎｏｉｓ | 低減された毒性を有するアンホテリシンｂ誘導体 |
| TWI702223B (zh) * | 2014-06-12 | 2020-08-21 | 日商塩野義製藥股份有限公司 | 多烯巨環內酯衍生物 |
| US10087206B2 (en) * | 2014-10-17 | 2018-10-02 | The Board Of Trustees Of The University Of Illinois | Scalable synthesis of reduced toxicity derivative of amphotericin B |
-
2015
- 2015-10-16 US US15/519,471 patent/US10087206B2/en active Active
- 2015-10-16 EP EP15851160.0A patent/EP3206695B1/en active Active
- 2015-10-16 JP JP2017518431A patent/JP6755859B2/ja active Active
- 2015-10-16 WO PCT/US2015/055899 patent/WO2016061437A1/en not_active Ceased
- 2015-10-16 AU AU2015331904A patent/AU2015331904B2/en active Active
-
2018
- 2018-10-01 US US16/148,255 patent/US10683318B2/en active Active
-
2021
- 2021-05-10 AU AU2021202949A patent/AU2021202949B2/en active Active
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