AU2015331904B2 - Scalable synthesis of reduced toxicity derivative of amphotericin B - Google Patents

Scalable synthesis of reduced toxicity derivative of amphotericin B Download PDF

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Publication number
AU2015331904B2
AU2015331904B2 AU2015331904A AU2015331904A AU2015331904B2 AU 2015331904 B2 AU2015331904 B2 AU 2015331904B2 AU 2015331904 A AU2015331904 A AU 2015331904A AU 2015331904 A AU2015331904 A AU 2015331904A AU 2015331904 B2 AU2015331904 B2 AU 2015331904B2
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certain embodiments
solvent
alkyl
alken
group
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AU2015331904A
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AU2015331904A1 (en
Inventor
Martin D. Burke
Souvik RAKSHIT
Brice E. Uno
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University of Illinois System
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University of Illinois at Urbana Champaign
University of Illinois System
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AU2015331904A 2014-10-17 2015-10-16 Scalable synthesis of reduced toxicity derivative of amphotericin B Active AU2015331904B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2021202949A AU2021202949B2 (en) 2014-10-17 2021-05-10 Scalable synthesis of reduced toxicity derivative of amphotericin B

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462065330P 2014-10-17 2014-10-17
US62/065,330 2014-10-17
PCT/US2015/055899 WO2016061437A1 (en) 2014-10-17 2015-10-16 Scalable synthesis of reduced toxicity derivative of amphotericin b

Related Child Applications (1)

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AU2021202949A Division AU2021202949B2 (en) 2014-10-17 2021-05-10 Scalable synthesis of reduced toxicity derivative of amphotericin B

Publications (2)

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AU2015331904A1 AU2015331904A1 (en) 2017-05-25
AU2015331904B2 true AU2015331904B2 (en) 2021-02-11

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AU2015331904A Active AU2015331904B2 (en) 2014-10-17 2015-10-16 Scalable synthesis of reduced toxicity derivative of amphotericin B
AU2021202949A Active AU2021202949B2 (en) 2014-10-17 2021-05-10 Scalable synthesis of reduced toxicity derivative of amphotericin B

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AU2021202949A Active AU2021202949B2 (en) 2014-10-17 2021-05-10 Scalable synthesis of reduced toxicity derivative of amphotericin B

Country Status (5)

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US (2) US10087206B2 (https=)
EP (1) EP3206695B1 (https=)
JP (1) JP6755859B2 (https=)
AU (2) AU2015331904B2 (https=)
WO (1) WO2016061437A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6543272B2 (ja) * 2014-05-16 2019-07-10 ザ ボード オブ トラスティーズ オブ ザ ユニヴァーシティ オブ イリノイＴｈｅ Ｂｏａｒｄ Ｏｆ Ｔｒｕｓｔｅｅｓ Ｏｆ Ｔｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｉｌｌｉｎｏｉｓ 低減された毒性を有するアンホテリシンｂ誘導体
US10087206B2 (en) * 2014-10-17 2018-10-02 The Board Of Trustees Of The University Of Illinois Scalable synthesis of reduced toxicity derivative of amphotericin B
CA3021061C (en) 2015-04-15 2023-10-24 Martin D. Burke Derivatives of amphotericin b
KR20220058547A (ko) * 2019-08-08 2022-05-09 더 보오드 오브 트러스티스 오브 더 유니버시티 오브 일리노이즈 감소된 독성을 갖는 하이브리드 암포테리신 b 유도체

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6284736B1 (en) * 1989-12-08 2001-09-04 Beecham Group, Plc Amphotericin derivatives
WO2015175875A1 (en) * 2014-05-16 2015-11-19 The Board Of Trustees Of The University Of Illinois Amphotericin b derivative with reduced toxicity

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1008720A (en) 1910-11-14 1911-11-14 John Knape Adjustable bracket.
EP2371815A1 (en) * 2003-12-30 2011-10-05 XenoPort, Inc. Sythesis of acyloxyalkyl carbamate prodrugs and intermediates thereof
WO2014059436A1 (en) * 2012-10-12 2014-04-17 The Board Of Trustees Of The University Of Illinois Electronic tuning of site selectivity
WO2014165676A1 (en) * 2013-04-03 2014-10-09 The Board Of Trustees Of The University Of Illinois Amphotericin b derivative with reduced toxicity
TWI702223B (zh) * 2014-06-12 2020-08-21 日商塩野義製藥股份有限公司 多烯巨環內酯衍生物
US10087206B2 (en) * 2014-10-17 2018-10-02 The Board Of Trustees Of The University Of Illinois Scalable synthesis of reduced toxicity derivative of amphotericin B

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6284736B1 (en) * 1989-12-08 2001-09-04 Beecham Group, Plc Amphotericin derivatives
WO2015175875A1 (en) * 2014-05-16 2015-11-19 The Board Of Trustees Of The University Of Illinois Amphotericin b derivative with reduced toxicity

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
MITCHELL P. CROATT ET AL, "Probing the Role of the Mycosamine C2'-OH on the Activity of Amphotericin B", ORGANIC LETTERS, (2011-03-18), vol. 13, no. 6, doi:10.1021/ol2000765, ISSN 1523-7060, pages 1390 - 1393 *
PALACIOS et al., "A Post-PKS Oxidation of the Amphotericin B Skeleton Predicted to be Critical for Channel Formation is Not Required for Potent Antifungal Activity", J Am Chem Soc., (2007), vol. 129, no. 45, pages 13804 - 13805. *
WILCOCK et al., "Electronic tuning of site-selectivity", NATURE CHEMISTRY, (2012), vol. 4, pages 996 - 1003. *

Also Published As

Publication number Publication date
EP3206695A1 (en) 2017-08-23
US10087206B2 (en) 2018-10-02
JP2017532329A (ja) 2017-11-02
EP3206695B1 (en) 2026-04-29
AU2021202949B2 (en) 2023-07-13
EP3206695A4 (en) 2018-06-20
US20190127412A1 (en) 2019-05-02
AU2021202949A1 (en) 2021-06-03
AU2015331904A1 (en) 2017-05-25
WO2016061437A1 (en) 2016-04-21
JP6755859B2 (ja) 2020-09-16
US20170233427A1 (en) 2017-08-17
US10683318B2 (en) 2020-06-16

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