JP2017532068A5 - - Google Patents
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- JP2017532068A5 JP2017532068A5 JP2017539525A JP2017539525A JP2017532068A5 JP 2017532068 A5 JP2017532068 A5 JP 2017532068A5 JP 2017539525 A JP2017539525 A JP 2017539525A JP 2017539525 A JP2017539525 A JP 2017539525A JP 2017532068 A5 JP2017532068 A5 JP 2017532068A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- neural stem
- human neural
- igf
- fetal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 210000001178 neural stem cell Anatomy 0.000 claims 26
- 101000599951 Homo sapiens Insulin-like growth factor I Proteins 0.000 claims 21
- 102100037852 Insulin-like growth factor I Human genes 0.000 claims 21
- 230000001605 fetal effect Effects 0.000 claims 16
- 239000002157 polynucleotide Substances 0.000 claims 14
- 102000040430 polynucleotide Human genes 0.000 claims 14
- 108091033319 polynucleotide Proteins 0.000 claims 14
- 210000004556 brain Anatomy 0.000 claims 11
- 210000004027 cell Anatomy 0.000 claims 8
- 230000004069 differentiation Effects 0.000 claims 8
- 239000003102 growth factor Substances 0.000 claims 8
- 102000001708 Protein Isoforms Human genes 0.000 claims 6
- 108010029485 Protein Isoforms Proteins 0.000 claims 6
- 208000020431 spinal cord injury Diseases 0.000 claims 5
- 102000004219 Brain-derived neurotrophic factor Human genes 0.000 claims 4
- 108090000715 Brain-derived neurotrophic factor Proteins 0.000 claims 4
- 102000034615 Glial cell line-derived neurotrophic factor Human genes 0.000 claims 4
- 108091010837 Glial cell line-derived neurotrophic factor Proteins 0.000 claims 4
- 102000004230 Neurotrophin 3 Human genes 0.000 claims 4
- 108090000742 Neurotrophin 3 Proteins 0.000 claims 4
- 229940077737 brain-derived neurotrophic factor Drugs 0.000 claims 4
- 208000015122 neurodegenerative disease Diseases 0.000 claims 4
- 229940032018 neurotrophin 3 Drugs 0.000 claims 4
- 210000003754 fetus Anatomy 0.000 claims 3
- 210000001320 hippocampus Anatomy 0.000 claims 3
- 239000002773 nucleotide Substances 0.000 claims 3
- 125000003729 nucleotide group Chemical group 0.000 claims 3
- 208000024827 Alzheimer disease Diseases 0.000 claims 2
- 108010025020 Nerve Growth Factor Proteins 0.000 claims 2
- 102000007072 Nerve Growth Factors Human genes 0.000 claims 2
- 102100037935 Polyubiquitin-C Human genes 0.000 claims 2
- 208000030886 Traumatic Brain injury Diseases 0.000 claims 2
- 108010056354 Ubiquitin C Proteins 0.000 claims 2
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims 2
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims 2
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims 2
- 206010012601 diabetes mellitus Diseases 0.000 claims 2
- 230000004770 neurodegeneration Effects 0.000 claims 2
- 239000003900 neurotrophic factor Substances 0.000 claims 2
- 208000033808 peripheral neuropathy Diseases 0.000 claims 2
- 210000000130 stem cell Anatomy 0.000 claims 2
- 230000009529 traumatic brain injury Effects 0.000 claims 2
- 210000003556 vascular endothelial cell Anatomy 0.000 claims 2
- 102000013455 Amyloid beta-Peptides Human genes 0.000 claims 1
- 108010090849 Amyloid beta-Peptides Proteins 0.000 claims 1
- 230000007082 Aβ accumulation Effects 0.000 claims 1
- 206010012289 Dementia Diseases 0.000 claims 1
- 101000579123 Homo sapiens Phosphoglycerate kinase 1 Proteins 0.000 claims 1
- 102000001435 Synapsin Human genes 0.000 claims 1
- 108050009621 Synapsin Proteins 0.000 claims 1
- 210000003169 central nervous system Anatomy 0.000 claims 1
- 210000001638 cerebellum Anatomy 0.000 claims 1
- 210000002932 cholinergic neuron Anatomy 0.000 claims 1
- 230000019771 cognition Effects 0.000 claims 1
- 208000010877 cognitive disease Diseases 0.000 claims 1
- 230000008021 deposition Effects 0.000 claims 1
- 210000001222 gaba-ergic neuron Anatomy 0.000 claims 1
- 102000045429 human PGK1 Human genes 0.000 claims 1
- 230000000302 ischemic effect Effects 0.000 claims 1
- 210000001161 mammalian embryo Anatomy 0.000 claims 1
- 210000001259 mesencephalon Anatomy 0.000 claims 1
- 208000027061 mild cognitive impairment Diseases 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 210000005036 nerve Anatomy 0.000 claims 1
- 210000002569 neuron Anatomy 0.000 claims 1
- 201000001119 neuropathy Diseases 0.000 claims 1
- 230000007823 neuropathy Effects 0.000 claims 1
- 230000002062 proliferating effect Effects 0.000 claims 1
- 230000002207 retinal effect Effects 0.000 claims 1
- 210000001202 rhombencephalon Anatomy 0.000 claims 1
- 210000000278 spinal cord Anatomy 0.000 claims 1
- 210000003594 spinal ganglia Anatomy 0.000 claims 1
- 210000000225 synapse Anatomy 0.000 claims 1
- 210000001103 thalamus Anatomy 0.000 claims 1
- 230000000472 traumatic effect Effects 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462066174P | 2014-10-20 | 2014-10-20 | |
| US62/066,174 | 2014-10-20 | ||
| US201562147950P | 2015-04-15 | 2015-04-15 | |
| US62/147,950 | 2015-04-15 | ||
| PCT/US2015/056226 WO2016064737A1 (en) | 2014-10-20 | 2015-10-19 | Stable neural stem cells comprising an exogenous polynucleotide coding for a growth factor and methods of use thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020201316A Division JP2021045156A (ja) | 2014-10-20 | 2020-12-03 | 成長因子をコードする外因性ポリヌクレオチドを含む安定な神経幹細胞およびその使用の方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017532068A JP2017532068A (ja) | 2017-11-02 |
| JP2017532068A5 true JP2017532068A5 (https=) | 2018-10-11 |
| JP6983069B2 JP6983069B2 (ja) | 2021-12-17 |
Family
ID=55761367
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017539525A Active JP6983069B2 (ja) | 2014-10-20 | 2015-10-19 | 成長因子をコードする外因性ポリヌクレオチドを含む安定な神経幹細胞およびその使用の方法 |
| JP2020201316A Pending JP2021045156A (ja) | 2014-10-20 | 2020-12-03 | 成長因子をコードする外因性ポリヌクレオチドを含む安定な神経幹細胞およびその使用の方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020201316A Pending JP2021045156A (ja) | 2014-10-20 | 2020-12-03 | 成長因子をコードする外因性ポリヌクレオチドを含む安定な神経幹細胞およびその使用の方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US9750769B2 (https=) |
| EP (1) | EP3209306B1 (https=) |
| JP (2) | JP6983069B2 (https=) |
| KR (2) | KR20190060016A (https=) |
| CN (1) | CN107148275A (https=) |
| AU (2) | AU2015336194B2 (https=) |
| CA (1) | CA2964927C (https=) |
| MX (1) | MX382488B (https=) |
| WO (1) | WO2016064737A1 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20250022877A (ko) * | 2017-01-31 | 2025-02-17 | 리젠엑스바이오 인크. | 완전히-인간 글리코실화된 인간 알파-l-이두로니다아제(idua)를 이용한 뮤코다당증 1형의 치료 |
| KR102245539B1 (ko) | 2018-02-12 | 2021-04-29 | 주식회사 지앤피바이오사이언스 | 코어-쉘 구조의 마이크로 입자를 유효성분으로 포함하는 성장인자 유전자 발현 증가용 조성물 |
| WO2019165306A1 (en) * | 2018-02-23 | 2019-08-29 | Regeneration Biomedical, Inc. | Methods, apparatuses and systems for instilling stem cells and pharmaceuticals into the human ventricular system |
| CN112469732A (zh) * | 2018-07-17 | 2021-03-09 | 赫利世弥斯株式会社 | 使用胰岛素样生长因子1-加密脱氧核糖核酸构建体及肝细胞生长因子-加密脱氧核糖核酸构建体的神经病变治疗 |
| EP3823981A4 (en) * | 2018-07-17 | 2022-04-06 | Neuromyon Inc. | TREATMENT OF NEUROPATHY WITH DNA CONSTRUCTS EXPRESSING IGF-1 ISOFORMS |
| EP3852771A4 (en) | 2018-09-19 | 2022-06-08 | Regeneration Biomedical, Inc. | WNT-ACTIVATED ADI-DERIVED STEM CELL DEVICES, METHODS AND SYSTEMS |
| KR20210077634A (ko) * | 2019-12-17 | 2021-06-25 | 코아스템(주) | 인간 만능 줄기세포로부터 3d 오가노이드를 이용하여 미세교세포를 다량 확보하는 미세교세포의 분화방법 |
| CN111388654A (zh) * | 2020-05-22 | 2020-07-10 | 南通大学 | 治疗脊髓损伤的药物、药物试剂盒及方法 |
| WO2023158214A1 (ko) * | 2022-02-15 | 2023-08-24 | 주식회사 헬릭스미스 | 인슐린-유사 성장인자-1의 이형체를 이용한 근감소증 예방 또는 치료용 조성물 |
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| AU623922B2 (en) | 1988-08-04 | 1992-05-28 | Amrad Operations Pty. Limited | In vitro propagation of embryonic stem cells |
| US5082670A (en) | 1988-12-15 | 1992-01-21 | The Regents Of The University Of California | Method of grafting genetically modified cells to treat defects, disease or damage or the central nervous system |
| US4980174A (en) | 1988-12-23 | 1990-12-25 | Jacqueline Sagen | Method for alleviating depression |
| US5093317A (en) * | 1989-06-05 | 1992-03-03 | Cephalon, Inc. | Treating disorders by application of insulin-like growth factor |
| AU6174490A (en) | 1989-08-04 | 1991-03-11 | Board Of Regents, The University Of Texas System | Methods and compositions; purified preparation of neural progenitor regulatory factor |
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| US5411883A (en) | 1989-12-26 | 1995-05-02 | Somatix Therapy Corporation | Proliferated neuron progenitor cell product and process |
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| US6294346B1 (en) | 1991-07-08 | 2001-09-25 | Neurospheres Holdings, Ltd. | Use of multipotent neural stem cells and their progeny for the screening of drugs and other biological agents |
| US5750376A (en) * | 1991-07-08 | 1998-05-12 | Neurospheres Holdings Ltd. | In vitro growth and proliferation of genetically modified multipotent neural stem cells and their progeny |
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| WO2010018996A2 (ko) * | 2008-08-12 | 2010-02-18 | 연세대학교 산학협력단 | 인간 신경줄기세포 및 이를 이용한 중추 또는 말초 신경계 질환 및 손상 치료용 약학적 조성물 |
| US9657329B2 (en) * | 2011-11-07 | 2017-05-23 | The Broad Institute Inc. | Propeptide-luciferase fusion proteins and methods of use thereof |
| CN102604894B (zh) * | 2012-02-29 | 2014-07-30 | 中国科学院广州生物医药与健康研究院 | 用于制备神经干细胞的培养基及其用途 |
| WO2014138003A1 (en) * | 2013-03-04 | 2014-09-12 | Neuralstem, Inc. | Compositions comprising an immunosuppressive drug and/or neural stem cells and methods of using same for the treatment of neurodegenerative diseases and/or disorders |
-
2015
- 2015-10-19 WO PCT/US2015/056226 patent/WO2016064737A1/en not_active Ceased
- 2015-10-19 AU AU2015336194A patent/AU2015336194B2/en active Active
- 2015-10-19 US US14/886,272 patent/US9750769B2/en active Active
- 2015-10-19 KR KR1020197015061A patent/KR20190060016A/ko not_active Withdrawn
- 2015-10-19 KR KR1020177013001A patent/KR102100021B1/ko active Active
- 2015-10-19 CA CA2964927A patent/CA2964927C/en active Active
- 2015-10-19 JP JP2017539525A patent/JP6983069B2/ja active Active
- 2015-10-19 MX MX2017005186A patent/MX382488B/es unknown
- 2015-10-19 EP EP15852516.2A patent/EP3209306B1/en active Active
- 2015-10-19 CN CN201580057196.0A patent/CN107148275A/zh active Pending
-
2017
- 2017-06-16 US US15/624,959 patent/US10702555B2/en active Active
-
2018
- 2018-12-14 AU AU2018279014A patent/AU2018279014A1/en not_active Abandoned
-
2020
- 2020-12-03 JP JP2020201316A patent/JP2021045156A/ja active Pending
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