JP2007511210A5 - - Google Patents

Info

Publication number

JP2007511210A5

JP2007511210A5 JP2006538375A JP2006538375A JP2007511210A5 JP 2007511210 A5 JP2007511210 A5 JP 2007511210A5 JP 2006538375 A JP2006538375 A JP 2006538375A JP 2006538375 A JP2006538375 A JP 2006538375A JP 2007511210 A5 JP2007511210 A5 JP 2007511210A5

Authority

JP

Japan

Prior art keywords

seq

oligonucleotide

nrp

sequence

use according

Prior art date

2004-11-01

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 108091034117 Oligonucleotide Proteins 0.000 claims 12
• 210000005036 nerve Anatomy 0.000 claims 10
• 125000003275 alpha amino acid group Chemical group 0.000 claims 7
• 230000008929 regeneration Effects 0.000 claims 6
• 238000011069 regeneration method Methods 0.000 claims 6
• 239000003814 drug Substances 0.000 claims 3
• 210000003757 neuroblast Anatomy 0.000 claims 3
• 108090000765 processed proteins & peptides Proteins 0.000 claims 3
• 210000000130 stem cell Anatomy 0.000 claims 3
• 238000001356 surgical procedure Methods 0.000 claims 3
• 208000028389 Nerve injury Diseases 0.000 claims 2
• 210000004351 coronary vessel Anatomy 0.000 claims 2
• 230000004069 differentiation Effects 0.000 claims 2
• 230000002068 genetic effect Effects 0.000 claims 2
• 208000015181 infectious disease Diseases 0.000 claims 2
• 238000004519 manufacturing process Methods 0.000 claims 2
• 238000000034 method Methods 0.000 claims 2
• 230000008764 nerve damage Effects 0.000 claims 2
• 230000035755 proliferation Effects 0.000 claims 2
• 230000001737 promoting effect Effects 0.000 claims 2
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical group C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• 208000007848 Alcoholism Diseases 0.000 claims 1
• 208000024827 Alzheimer disease Diseases 0.000 claims 1
• 206010012289 Dementia Diseases 0.000 claims 1
• 208000016192 Demyelinating disease Diseases 0.000 claims 1
• 208000023105 Huntington disease Diseases 0.000 claims 1
• 206010021143 Hypoxia Diseases 0.000 claims 1
• 208000002720 Malnutrition Diseases 0.000 claims 1
• 208000018737 Parkinson disease Diseases 0.000 claims 1
• 208000006011 Stroke Diseases 0.000 claims 1
• 208000030886 Traumatic Brain injury Diseases 0.000 claims 1
• 201000007930 alcohol dependence Diseases 0.000 claims 1
• 210000003050 axon Anatomy 0.000 claims 1
• 208000029028 brain injury Diseases 0.000 claims 1
• 210000004027 cell Anatomy 0.000 claims 1
• 230000030833 cell death Effects 0.000 claims 1
• 230000012292 cell migration Effects 0.000 claims 1
• 208000026106 cerebrovascular disease Diseases 0.000 claims 1
• 238000002512 chemotherapy Methods 0.000 claims 1
• 230000000295 complement effect Effects 0.000 claims 1
• 229940079593 drug Drugs 0.000 claims 1
• 239000013604 expression vector Substances 0.000 claims 1
• 230000007954 hypoxia Effects 0.000 claims 1
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• 208000028867 ischemia Diseases 0.000 claims 1
• 230000001071 malnutrition Effects 0.000 claims 1
• 235000000824 malnutrition Nutrition 0.000 claims 1
• 208000030159 metabolic disease Diseases 0.000 claims 1
• 230000005012 migration Effects 0.000 claims 1
• 238000013508 migration Methods 0.000 claims 1
• 210000000653 nervous system Anatomy 0.000 claims 1
• 230000001537 neural effect Effects 0.000 claims 1
• 210000002241 neurite Anatomy 0.000 claims 1
• 230000004770 neurodegeneration Effects 0.000 claims 1
• 230000014511 neuron projection development Effects 0.000 claims 1
• 208000015380 nutritional deficiency disease Diseases 0.000 claims 1
• 208000033808 peripheral neuropathy Diseases 0.000 claims 1
• 239000008194 pharmaceutical composition Substances 0.000 claims 1
• 229920001184 polypeptide Polymers 0.000 claims 1
• 102000004196 processed proteins & peptides Human genes 0.000 claims 1
• 238000001959 radiotherapy Methods 0.000 claims 1
• 208000020431 spinal cord injury Diseases 0.000 claims 1
• 239000000126 substance Substances 0.000 claims 1
• 238000006467 substitution reaction Methods 0.000 claims 1
• 230000004083 survival effect Effects 0.000 claims 1
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• 230000008733 trauma Effects 0.000 claims 1
• 230000009529 traumatic brain injury Effects 0.000 claims 1