JP2017531682A - 医薬製剤の粘度低下 - Google Patents

医薬製剤の粘度低下 Download PDF

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Publication number
JP2017531682A
JP2017531682A JP2017522169A JP2017522169A JP2017531682A JP 2017531682 A JP2017531682 A JP 2017531682A JP 2017522169 A JP2017522169 A JP 2017522169A JP 2017522169 A JP2017522169 A JP 2017522169A JP 2017531682 A JP2017531682 A JP 2017531682A
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viscosity
excipient
protein
concentration
formulation
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JP2017522169A
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Japanese (ja)
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JP2017531682A5 (enExample
Inventor
スローイー，クリストファー・ジェイムズ
カナプラン，セカール
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アムジエン・インコーポレーテツド
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=54427875&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JP2017531682(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by アムジエン・インコーポレーテツド filed Critical アムジエン・インコーポレーテツド
Publication of JP2017531682A publication Critical patent/JP2017531682A/ja
Publication of JP2017531682A5 publication Critical patent/JP2017531682A5/ja
Priority to JP2019191701A priority Critical patent/JP6965321B2/ja
Priority to JP2021170676A priority patent/JP7411615B2/ja
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Endocrinology (AREA)
  • Dermatology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2017522169A 2014-10-23 2015-10-22 医薬製剤の粘度低下 Pending JP2017531682A (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2019191701A JP6965321B2 (ja) 2014-10-23 2019-10-21 医薬製剤の粘度低下
JP2021170676A JP7411615B2 (ja) 2014-10-23 2021-10-19 医薬製剤の粘度低下

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462067637P 2014-10-23 2014-10-23
US62/067,637 2014-10-23
PCT/US2015/056972 WO2016065181A1 (en) 2014-10-23 2015-10-22 Reducing viscosity of pharmaceutical formulations

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2019191701A Division JP6965321B2 (ja) 2014-10-23 2019-10-21 医薬製剤の粘度低下

Publications (2)

Publication Number Publication Date
JP2017531682A true JP2017531682A (ja) 2017-10-26
JP2017531682A5 JP2017531682A5 (enExample) 2018-09-27

Family

ID=54427875

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2017522169A Pending JP2017531682A (ja) 2014-10-23 2015-10-22 医薬製剤の粘度低下
JP2019191701A Active JP6965321B2 (ja) 2014-10-23 2019-10-21 医薬製剤の粘度低下
JP2021170676A Active JP7411615B2 (ja) 2014-10-23 2021-10-19 医薬製剤の粘度低下

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2019191701A Active JP6965321B2 (ja) 2014-10-23 2019-10-21 医薬製剤の粘度低下
JP2021170676A Active JP7411615B2 (ja) 2014-10-23 2021-10-19 医薬製剤の粘度低下

Country Status (17)

Country Link
US (3) US11813328B2 (enExample)
EP (2) EP3209332B1 (enExample)
JP (3) JP2017531682A (enExample)
KR (1) KR102534017B1 (enExample)
CN (2) CN107206070B (enExample)
AU (2) AU2015335743B2 (enExample)
BR (1) BR112017008125B1 (enExample)
CA (1) CA2964786C (enExample)
CL (2) CL2017000984A1 (enExample)
EA (3) EA038462B1 (enExample)
ES (1) ES2964713T3 (enExample)
IL (2) IL287947B2 (enExample)
MA (1) MA54716A (enExample)
MX (2) MX388858B (enExample)
SG (1) SG11201703152RA (enExample)
WO (1) WO2016065181A1 (enExample)
ZA (1) ZA201702762B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023513312A (ja) * 2020-02-13 2023-03-30 アムジェン インコーポレイテッド ヒト抗ｔｓｌｐ抗体の製剤及び炎症性疾患を治療する方法

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JP7275027B2 (ja) * 2016-10-06 2023-05-17 アムジェン インコーポレイテッド 粘度低下タンパク質医薬製剤
JP7377596B2 (ja) 2017-02-22 2023-11-10 アムジエン・インコーポレーテツド 低粘度、高濃度エボロクマブ製剤及びそれらの製造方法
US12103979B2 (en) * 2017-04-28 2024-10-01 Amgen Inc. N-acetylated and non-acetylated dipeptides containing arginine to reduce the viscosity of viscous compositions of therapeutic polypeptides
MA48461A (fr) 2017-04-28 2020-03-04 Amgen Inc Excipients pour réduire la viscosité de formulations d'anticorps et compositions de formulation
US10646569B2 (en) 2017-05-16 2020-05-12 Bhami's Research Laboratory, Pvt. Ltd. High concentration protein formulations with reduced viscosity
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US20200289621A1 (en) * 2017-09-22 2020-09-17 Asahi Kasei Pharma Corporation Teriparatide-containing liquid pharmaceutical composition having excellent stability
WO2019106206A1 (en) 2017-12-01 2019-06-06 Fyb 202 Project Gmbh Stable, low viscosity, high concentration liquid formulations of an anti-il-12/23p40 antibody
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EP3628683A1 (en) * 2018-09-28 2020-04-01 Zealand Pharma A/S Formulations of glucagon-like-peptide-2 (glp-2) analogues
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KR102746418B1 (ko) * 2020-12-03 2024-12-26 동국대학교 산학협력단 N-아세틸-l-아르기닌을 포함하는 단백질 응집 억제용 조성물
EP4674865A3 (en) * 2021-03-09 2026-03-25 GI Innovation, Inc. Formulation of fusion protein including extracellular domain of alpha subunit of ige fc receptor
CA3214867A1 (en) * 2021-04-09 2022-10-13 Courtney O'DELL Performance-enhancing excipients and methods of reducing viscosity and increasing stability of biologic formulations
TW202600593A (zh) * 2024-02-16 2026-01-01 美商再生元醫藥公司 製造濃縮配製包括蛋白質之藥品物質之方法，以及該方法製造之濃縮配製之藥品物質

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Patent Citations (5)

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Publication number Priority date Publication date Assignee Title
JP2001522814A (ja) * 1997-11-07 2001-11-20 カイロン コーポレイション 増大されたｉｇｆ−ｉ溶解性を提供する組成物
WO2007074880A1 (ja) * 2005-12-28 2007-07-05 Chugai Seiyaku Kabushiki Kaisha 抗体含有安定化製剤
JP2011067202A (ja) * 2009-08-31 2011-04-07 Sanyo Chem Ind Ltd タンパク質水溶液の安定化剤、この安定化剤を含有するタンパク質水溶液及びタンパク質の安定化方法
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023513312A (ja) * 2020-02-13 2023-03-30 アムジェン インコーポレイテッド ヒト抗ｔｓｌｐ抗体の製剤及び炎症性疾患を治療する方法

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US12318447B2 (en) 2025-06-03
CA2964786A1 (en) 2016-04-28
EP3909611B1 (en) 2023-08-30
US20170333559A1 (en) 2017-11-23
ZA201702762B (en) 2022-12-21
JP7411615B2 (ja) 2024-01-11
BR112017008125B1 (pt) 2023-11-21
EA038462B1 (ru) 2021-08-31
US11813328B2 (en) 2023-11-14
EP3209332A1 (en) 2017-08-30
IL287947A (en) 2022-01-01
MA54716A (fr) 2021-11-17
AU2015335743B2 (en) 2020-12-24
US20250345421A1 (en) 2025-11-13
JP2020037559A (ja) 2020-03-12
EA201790787A1 (ru) 2017-08-31
MX2017005243A (es) 2017-08-18
BR112017008125A2 (pt) 2018-06-19
CN114569716A (zh) 2022-06-03
CN107206070B (zh) 2022-01-18
SG11201703152RA (en) 2017-05-30
AU2015335743A1 (en) 2017-05-04
JP6965321B2 (ja) 2021-11-10
EP3209332B1 (en) 2021-05-26
CL2019002190A1 (es) 2019-11-22
IL251726A0 (en) 2017-06-29
MX388858B (es) 2025-03-20
IL287947B2 (en) 2024-08-01
KR20170071518A (ko) 2017-06-23
US20240066124A1 (en) 2024-02-29
CA2964786C (en) 2023-10-17
EP3909611A1 (en) 2021-11-17
CL2017000984A1 (es) 2018-01-05
KR102534017B1 (ko) 2023-05-19
AU2021200990A1 (en) 2021-03-11
JP2022009223A (ja) 2022-01-14
IL287947B1 (en) 2024-04-01
WO2016065181A1 (en) 2016-04-28
AU2021200990B2 (en) 2023-02-16
EA201991447A1 (ru) 2019-11-29
CN107206070A (zh) 2017-09-26
ES2964713T3 (es) 2024-04-09
MX2021015789A (es) 2022-01-27
IL251726B (en) 2021-12-01
EA202191513A1 (ru) 2021-11-30
EA033444B1 (ru) 2019-10-31

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