JP2017531663A - １４員ケトライドならびにそれらの調製および使用の方法 - Google Patents

１４員ケトライドならびにそれらの調製および使用の方法 Download PDF

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Publication number
JP2017531663A
JP2017531663A JP2017519264A JP2017519264A JP2017531663A JP 2017531663 A JP2017531663 A JP 2017531663A JP 2017519264 A JP2017519264 A JP 2017519264A JP 2017519264 A JP2017519264 A JP 2017519264A JP 2017531663 A JP2017531663 A JP 2017531663A
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optionally substituted
alkyl
certain embodiments
hydrogen
formula
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Japanese (ja)
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JP2017531663A5 (enExample
Inventor
マイヤーズ，アンドリュー，ジー．
セイプル，イアン，バス
ツァン，ジヤン
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Harvard University
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Harvard University
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Publication of JP2017531663A publication Critical patent/JP2017531663A/ja
Publication of JP2017531663A5 publication Critical patent/JP2017531663A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
JP2017519264A 2014-10-08 2015-10-08 １４員ケトライドならびにそれらの調製および使用の方法 Pending JP2017531663A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462061571P 2014-10-08 2014-10-08
US62/061,571 2014-10-08
PCT/US2015/054700 WO2016057798A1 (en) 2014-10-08 2015-10-08 14-membered ketolides and methods of their preparation and use

Publications (2)

Publication Number Publication Date
JP2017531663A true JP2017531663A (ja) 2017-10-26
JP2017531663A5 JP2017531663A5 (enExample) 2018-11-15

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JP2017519264A Pending JP2017531663A (ja) 2014-10-08 2015-10-08 １４員ケトライドならびにそれらの調製および使用の方法

Country Status (7)

Country Link
US (3) US10633407B2 (enExample)
EP (1) EP3211997A4 (enExample)
JP (1) JP2017531663A (enExample)
CN (1) CN106998685A (enExample)
CA (1) CA2963815A1 (enExample)
HK (1) HK1242920A1 (enExample)
WO (1) WO2016057798A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4095146A1 (en) 2013-04-04 2022-11-30 President And Fellows Of Harvard College Macrolides and methods of their preparation and use
JP2017531663A (ja) 2014-10-08 2017-10-26 プレジデント アンド フェローズ オブ ハーバード カレッジ １４員ケトライドならびにそれらの調製および使用の方法
WO2016154591A1 (en) 2015-03-25 2016-09-29 President And Fellows Of Harvard College Macrolides with modified desosamine sugars and uses thereof
US11673910B2 (en) 2017-04-28 2023-06-13 Zikani Therapeutics, Inc. Macrolides with modified desosamine sugars and uses thereof
IL283185B2 (en) 2018-11-19 2024-06-01 Zikani Therapeutics Inc Macrolides with 13 members converted to C10-cyclic and their uses
AU2019385333B2 (en) 2018-11-19 2025-04-17 President And Fellows Of Harvard College C10-alkylene substituted 13-membered macrolides and uses thereof
IL303173A (en) * 2023-05-23 2024-12-01 Yeda Res & Dev Active macrolide antibiotic compounds against pathogens
WO2025228440A1 (zh) * 2024-04-30 2025-11-06 苏州信诺维医药科技股份有限公司 大环内酯类化合物、其制备方法及其用途

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JP2002519032A (ja) * 1998-06-29 2002-07-02 バイオティカ テクノロジー リミティド ポリケチドとその合成
JP2005511752A (ja) * 2001-12-05 2005-04-28 オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド 抗バクテリア剤として有効なエリスロマイシンの６−Ｏ−アシルケトーリド（ｋｅｔｏｌｉｄｅ）誘導体
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Also Published As

Publication number Publication date
CN106998685A (zh) 2017-08-01
CA2963815A1 (en) 2016-04-14
HK1242920A1 (zh) 2018-07-06
EP3211997A1 (en) 2017-09-06
US11466046B2 (en) 2022-10-11
US10633407B2 (en) 2020-04-28
WO2016057798A1 (en) 2016-04-14
US20200361980A1 (en) 2020-11-19
EP3211997A4 (en) 2018-10-24
US20170305953A1 (en) 2017-10-26
US20230109357A1 (en) 2023-04-06

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