CA2963815A1 - 14-membered ketolides and methods of their preparation and use - Google Patents

14-membered ketolides and methods of their preparation and use Download PDF

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Publication number
CA2963815A1
CA2963815A1 CA2963815A CA2963815A CA2963815A1 CA 2963815 A1 CA2963815 A1 CA 2963815A1 CA 2963815 A CA2963815 A CA 2963815A CA 2963815 A CA2963815 A CA 2963815A CA 2963815 A1 CA2963815 A1 CA 2963815A1
Authority
CA
Canada
Prior art keywords
optionally substituted
compound
alkyl
formula
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2963815A
Other languages
English (en)
French (fr)
Inventor
Andrew G. Myers
Ian Bass SEIPLE
Ziyang Zhang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Harvard University
Original Assignee
Harvard University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Harvard University filed Critical Harvard University
Publication of CA2963815A1 publication Critical patent/CA2963815A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
CA2963815A 2014-10-08 2015-10-08 14-membered ketolides and methods of their preparation and use Abandoned CA2963815A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462061571P 2014-10-08 2014-10-08
US62/061,571 2014-10-08
PCT/US2015/054700 WO2016057798A1 (en) 2014-10-08 2015-10-08 14-membered ketolides and methods of their preparation and use

Publications (1)

Publication Number Publication Date
CA2963815A1 true CA2963815A1 (en) 2016-04-14

Family

ID=55653777

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2963815A Abandoned CA2963815A1 (en) 2014-10-08 2015-10-08 14-membered ketolides and methods of their preparation and use

Country Status (7)

Country Link
US (3) US10633407B2 (enExample)
EP (1) EP3211997A4 (enExample)
JP (1) JP2017531663A (enExample)
CN (1) CN106998685A (enExample)
CA (1) CA2963815A1 (enExample)
HK (1) HK1242920A1 (enExample)
WO (1) WO2016057798A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
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JP2017531663A (ja) 2014-10-08 2017-10-26 プレジデント アンド フェローズ オブ ハーバード カレッジ １４員ケトライドならびにそれらの調製および使用の方法
WO2016154591A1 (en) 2015-03-25 2016-09-29 President And Fellows Of Harvard College Macrolides with modified desosamine sugars and uses thereof
US11673910B2 (en) 2017-04-28 2023-06-13 Zikani Therapeutics, Inc. Macrolides with modified desosamine sugars and uses thereof
IL283185B2 (en) 2018-11-19 2024-06-01 Zikani Therapeutics Inc Macrolides with 13 members converted to C10-cyclic and their uses
AU2019385333B2 (en) 2018-11-19 2025-04-17 President And Fellows Of Harvard College C10-alkylene substituted 13-membered macrolides and uses thereof
IL303173A (en) * 2023-05-23 2024-12-01 Yeda Res & Dev Active macrolide antibiotic compounds against pathogens
WO2025228440A1 (zh) * 2024-04-30 2025-11-06 苏州信诺维医药科技股份有限公司 大环内酯类化合物、其制备方法及其用途

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Also Published As

Publication number Publication date
CN106998685A (zh) 2017-08-01
HK1242920A1 (zh) 2018-07-06
EP3211997A1 (en) 2017-09-06
US11466046B2 (en) 2022-10-11
US10633407B2 (en) 2020-04-28
WO2016057798A1 (en) 2016-04-14
US20200361980A1 (en) 2020-11-19
EP3211997A4 (en) 2018-10-24
US20170305953A1 (en) 2017-10-26
JP2017531663A (ja) 2017-10-26
US20230109357A1 (en) 2023-04-06

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Legal Events

Date Code Title Description
FZDE Discontinued

Effective date: 20211229