JP2017531624A5 - - Google Patents
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- JP2017531624A5 JP2017531624A5 JP2017513748A JP2017513748A JP2017531624A5 JP 2017531624 A5 JP2017531624 A5 JP 2017531624A5 JP 2017513748 A JP2017513748 A JP 2017513748A JP 2017513748 A JP2017513748 A JP 2017513748A JP 2017531624 A5 JP2017531624 A5 JP 2017531624A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- unsubstituted
- nhc
- nhnh
- heteroaryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 125000001072 heteroaryl group Chemical group 0.000 claims 55
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 52
- 125000000217 alkyl group Chemical group 0.000 claims 48
- 125000003118 aryl group Chemical group 0.000 claims 48
- 125000000753 cycloalkyl group Chemical group 0.000 claims 48
- 125000004404 heteroalkyl group Chemical group 0.000 claims 48
- 229910052736 halogen Inorganic materials 0.000 claims 43
- 150000002367 halogens Chemical class 0.000 claims 43
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 38
- 150000001875 compounds Chemical class 0.000 claims 35
- 125000004474 heteroalkylene group Chemical group 0.000 claims 27
- -1 —OH Inorganic materials 0.000 claims 18
- 125000005549 heteroarylene group Chemical group 0.000 claims 16
- 229910052739 hydrogen Inorganic materials 0.000 claims 16
- 239000001257 hydrogen Substances 0.000 claims 16
- 150000002431 hydrogen Chemical class 0.000 claims 14
- 239000008194 pharmaceutical composition Substances 0.000 claims 14
- 125000002947 alkylene group Chemical group 0.000 claims 12
- 125000000732 arylene group Chemical group 0.000 claims 12
- 125000002993 cycloalkylene group Chemical group 0.000 claims 12
- 125000006588 heterocycloalkylene group Chemical group 0.000 claims 12
- 229910052757 nitrogen Inorganic materials 0.000 claims 10
- 150000003839 salts Chemical class 0.000 claims 9
- GVNVAWHJIKLAGL-UHFFFAOYSA-N 2-(cyclohexen-1-yl)cyclohexan-1-one Chemical compound O=C1CCCCC1C1=CCCCC1 GVNVAWHJIKLAGL-UHFFFAOYSA-N 0.000 claims 8
- 101150065749 Churc1 gene Proteins 0.000 claims 8
- 102100038239 Protein Churchill Human genes 0.000 claims 8
- QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 claims 8
- 201000010099 disease Diseases 0.000 claims 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 7
- 125000005647 linker group Chemical group 0.000 claims 6
- GYLDXIAOMVERTK-UHFFFAOYSA-N 5-(4-amino-1-propan-2-yl-3-pyrazolo[3,4-d]pyrimidinyl)-1,3-benzoxazol-2-amine Chemical compound C12=C(N)N=CN=C2N(C(C)C)N=C1C1=CC=C(OC(N)=N2)C2=C1 GYLDXIAOMVERTK-UHFFFAOYSA-N 0.000 claims 4
- 229910052799 carbon Inorganic materials 0.000 claims 4
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical class C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 claims 4
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 4
- 125000004043 oxo group Chemical group O=* 0.000 claims 4
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 4
- 125000000168 pyrrolyl group Chemical group 0.000 claims 4
- ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 claims 4
- 229950009216 sapanisertib Drugs 0.000 claims 4
- 229960002930 sirolimus Drugs 0.000 claims 4
- 125000001424 substituent group Chemical group 0.000 claims 4
- 102000008135 Mechanistic Target of Rapamycin Complex 1 Human genes 0.000 claims 3
- 108010035196 Mechanistic Target of Rapamycin Complex 1 Proteins 0.000 claims 3
- 230000000694 effects Effects 0.000 claims 3
- 125000002883 imidazolyl group Chemical group 0.000 claims 3
- 125000000335 thiazolyl group Chemical group 0.000 claims 3
- SVNJBEMPMKWDCO-KCHLEUMXSA-N (2s)-2-[[(2s)-3-carboxy-2-[[2-[[(2s)-5-(diaminomethylideneamino)-2-[[4-oxo-4-[[4-(4-oxo-8-phenylchromen-2-yl)morpholin-4-ium-4-yl]methoxy]butanoyl]amino]pentanoyl]amino]acetyl]amino]propanoyl]amino]-3-hydroxypropanoate Chemical compound C=1C(=O)C2=CC=CC(C=3C=CC=CC=3)=C2OC=1[N+]1(COC(=O)CCC(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C([O-])=O)CCOCC1 SVNJBEMPMKWDCO-KCHLEUMXSA-N 0.000 claims 2
- 125000006587 (C5-C10) heteroarylene group Chemical group 0.000 claims 2
- DWZAEMINVBZMHQ-UHFFFAOYSA-N 1-[4-[4-(dimethylamino)piperidine-1-carbonyl]phenyl]-3-[4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl]urea Chemical compound C1CC(N(C)C)CCN1C(=O)C(C=C1)=CC=C1NC(=O)NC1=CC=C(C=2N=C(N=C(N=2)N2CCOCC2)N2CCOCC2)C=C1 DWZAEMINVBZMHQ-UHFFFAOYSA-N 0.000 claims 2
- RGJOJUGRHPQXGF-INIZCTEOSA-N 1-ethyl-3-[4-[4-[(3s)-3-methylmorpholin-4-yl]-7-(oxetan-3-yl)-6,8-dihydro-5h-pyrido[3,4-d]pyrimidin-2-yl]phenyl]urea Chemical compound C1=CC(NC(=O)NCC)=CC=C1C(N=C1N2[C@H](COCC2)C)=NC2=C1CCN(C1COC1)C2 RGJOJUGRHPQXGF-INIZCTEOSA-N 0.000 claims 2
- XDLYKKIQACFMJG-UHFFFAOYSA-N 2-amino-8-[4-(2-hydroxyethoxy)cyclohexyl]-6-(6-methoxypyridin-3-yl)-4-methylpyrido[2,3-d]pyrimidin-7-one Chemical compound C1=NC(OC)=CC=C1C(C1=O)=CC2=C(C)N=C(N)N=C2N1C1CCC(OCCO)CC1 XDLYKKIQACFMJG-UHFFFAOYSA-N 0.000 claims 2
- JUSFANSTBFGBAF-IRXDYDNUSA-N 3-[2,4-bis[(3s)-3-methylmorpholin-4-yl]pyrido[2,3-d]pyrimidin-7-yl]-n-methylbenzamide Chemical compound CNC(=O)C1=CC=CC(C=2N=C3N=C(N=C(C3=CC=2)N2[C@H](COCC2)C)N2[C@H](COCC2)C)=C1 JUSFANSTBFGBAF-IRXDYDNUSA-N 0.000 claims 2
- KVLFRAWTRWDEDF-IRXDYDNUSA-N AZD-8055 Chemical compound C1=C(CO)C(OC)=CC=C1C1=CC=C(C(=NC(=N2)N3[C@H](COCC3)C)N3[C@H](COCC3)C)C2=N1 KVLFRAWTRWDEDF-IRXDYDNUSA-N 0.000 claims 2
- YUXMAKUNSXIEKN-BTJKTKAUSA-N BGT226 Chemical compound OC(=O)\C=C/C(O)=O.C1=NC(OC)=CC=C1C1=CC=C(N=CC2=C3N(C=4C=C(C(N5CCNCC5)=CC=4)C(F)(F)F)C(=O)N2C)C3=C1 YUXMAKUNSXIEKN-BTJKTKAUSA-N 0.000 claims 2
- UFKLYTOEMRFKAD-SHTZXODSSA-N C1C[C@@H](OC)CC[C@@H]1N1C2=NC(C=3C=NC(=CC=3)C(C)(C)O)=CN=C2NCC1=O Chemical compound C1C[C@@H](OC)CC[C@@H]1N1C2=NC(C=3C=NC(=CC=3)C(C)(C)O)=CN=C2NCC1=O UFKLYTOEMRFKAD-SHTZXODSSA-N 0.000 claims 2
- 125000000041 C6-C10 aryl group Chemical group 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- TUVCWJQQGGETHL-UHFFFAOYSA-N PI-103 Chemical compound OC1=CC=CC(C=2N=C3C4=CC=CN=C4OC3=C(N3CCOCC3)N=2)=C1 TUVCWJQQGGETHL-UHFFFAOYSA-N 0.000 claims 2
- NVRXTLZYXZNATH-UHFFFAOYSA-N PP121 Chemical compound N1=C(C=2C=C3C=CNC3=NC=2)C=2C(N)=NC=NC=2N1C1CCCC1 NVRXTLZYXZNATH-UHFFFAOYSA-N 0.000 claims 2
- 208000031481 Pathologic Constriction Diseases 0.000 claims 2
- 125000002047 benzodioxolyl group Chemical group O1OC(C2=C1C=CC=C2)* 0.000 claims 2
- 125000000499 benzofuranyl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 claims 2
- 125000005874 benzothiadiazolyl group Chemical group 0.000 claims 2
- 125000001164 benzothiazolyl group Chemical group S1C(=NC2=C1C=CC=C2)* 0.000 claims 2
- 125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 claims 2
- 125000003354 benzotriazolyl group Chemical group N1N=NC2=C1C=CC=C2* 0.000 claims 2
- 125000004541 benzoxazolyl group Chemical group O1C(=NC2=C1C=CC=C2)* 0.000 claims 2
- 235000010290 biphenyl Nutrition 0.000 claims 2
- 239000004305 biphenyl Substances 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 238000006243 chemical reaction Methods 0.000 claims 2
- 229950006418 dactolisib Drugs 0.000 claims 2
- JOGKUKXHTYWRGZ-UHFFFAOYSA-N dactolisib Chemical compound O=C1N(C)C2=CN=C3C=CC(C=4C=C5C=CC=CC5=NC=4)=CC3=C2N1C1=CC=C(C(C)(C)C#N)C=C1 JOGKUKXHTYWRGZ-UHFFFAOYSA-N 0.000 claims 2
- 125000002720 diazolyl group Chemical group 0.000 claims 2
- 125000002541 furyl group Chemical group 0.000 claims 2
- 125000004857 imidazopyridinyl group Chemical group N1C(=NC2=C1C=CC=N2)* 0.000 claims 2
- 125000003453 indazolyl group Chemical group N1N=C(C2=C1C=CC=C2)* 0.000 claims 2
- 125000001041 indolyl group Chemical group 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 125000005956 isoquinolyl group Chemical group 0.000 claims 2
- 125000001786 isothiazolyl group Chemical group 0.000 claims 2
- 125000000842 isoxazolyl group Chemical group 0.000 claims 2
- 229940124302 mTOR inhibitor Drugs 0.000 claims 2
- 239000003628 mammalian target of rapamycin inhibitor Substances 0.000 claims 2
- VDOCQQKGPJENHJ-UHFFFAOYSA-N methyl n-[4-[4-morpholin-4-yl-1-[1-(pyridin-3-ylmethyl)piperidin-4-yl]pyrazolo[3,4-d]pyrimidin-6-yl]phenyl]carbamate Chemical compound C1=CC(NC(=O)OC)=CC=C1C1=NC(N2CCOCC2)=C(C=NN2C3CCN(CC=4C=NC=CC=4)CC3)C2=N1 VDOCQQKGPJENHJ-UHFFFAOYSA-N 0.000 claims 2
- 125000001624 naphthyl group Chemical group 0.000 claims 2
- 125000001715 oxadiazolyl group Chemical group 0.000 claims 2
- 125000002971 oxazolyl group Chemical group 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 125000000561 purinyl group Chemical group N1=C(N=C2N=CNC2=C1)* 0.000 claims 2
- 125000003373 pyrazinyl group Chemical group 0.000 claims 2
- 125000003226 pyrazolyl group Chemical group 0.000 claims 2
- 125000004076 pyridyl group Chemical group 0.000 claims 2
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 claims 2
- 125000005493 quinolyl group Chemical group 0.000 claims 2
- 125000001567 quinoxalinyl group Chemical group N1=C(C=NC2=CC=CC=C12)* 0.000 claims 2
- 208000037804 stenosis Diseases 0.000 claims 2
- 230000036262 stenosis Effects 0.000 claims 2
- 125000003831 tetrazolyl group Chemical group 0.000 claims 2
- 125000001544 thienyl group Chemical group 0.000 claims 2
- AKCRNFFTGXBONI-UHFFFAOYSA-N torin 1 Chemical compound C1CN(C(=O)CC)CCN1C1=CC=C(N2C(C=CC3=C2C2=CC(=CC=C2N=C3)C=2C=C3C=CC=CC3=NC=2)=O)C=C1C(F)(F)F AKCRNFFTGXBONI-UHFFFAOYSA-N 0.000 claims 2
- GUXXEUUYCAYESJ-UHFFFAOYSA-N torin 2 Chemical compound C1=NC(N)=CC=C1C1=CC=C(N=CC2=C3N(C=4C=C(C=CC=4)C(F)(F)F)C(=O)C=C2)C3=C1 GUXXEUUYCAYESJ-UHFFFAOYSA-N 0.000 claims 2
- MFAQYJIYDMLAIM-UHFFFAOYSA-N torkinib Chemical compound C12=C(N)N=CN=C2N(C(C)C)N=C1C1=CC2=CC(O)=CC=C2N1 MFAQYJIYDMLAIM-UHFFFAOYSA-N 0.000 claims 2
- 125000001425 triazolyl group Chemical group 0.000 claims 2
- 125000001313 C5-C10 heteroaryl group Chemical group 0.000 claims 1
- 208000024172 Cardiovascular disease Diseases 0.000 claims 1
- 208000026372 Congenital cystic kidney disease Diseases 0.000 claims 1
- 208000026292 Cystic Kidney disease Diseases 0.000 claims 1
- 206010017533 Fungal infection Diseases 0.000 claims 1
- 208000031888 Mycoses Diseases 0.000 claims 1
- 206010052779 Transplant rejections Diseases 0.000 claims 1
- 230000002159 abnormal effect Effects 0.000 claims 1
- 230000032683 aging Effects 0.000 claims 1
- 230000005784 autoimmunity Effects 0.000 claims 1
- 125000003785 benzimidazolyl group Chemical class N1=C(NC2=C1C=CC=C2)* 0.000 claims 1
- 125000004603 benzisoxazolyl group Chemical group O1N=C(C2=C1C=CC=C2)* 0.000 claims 1
- 208000016097 disease of metabolism Diseases 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 208000030159 metabolic disease Diseases 0.000 claims 1
- 230000004770 neurodegeneration Effects 0.000 claims 1
- 208000015122 neurodegenerative disease Diseases 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 230000035755 proliferation Effects 0.000 claims 1
- 208000037803 restenosis Diseases 0.000 claims 1
- 125000001113 thiadiazolyl group Chemical group 0.000 claims 1
- 125000005559 triazolylene group Chemical group 0.000 claims 1
- VMXMBPPFDJEVAB-UHFFFAOYSA-P CC(CC(CCC1OCCOCC(N=N)=C[NH2+]CCOCCOCCOCCOCCOCCOCCOCCOCCC(NCCCC[NH2+]c2ncnc(N)c2C(c2ccc3[o]c(N)nc3c2)=N)=O)CC1OC)C(CC(C(C)C=C(C)C(C(C(C(C)CC(C)C=CC=CC=C(C)C(CC(CCC1C)OC1(C(C(N1C2CCCC1)=O)=O)O)OC)=O)OC)O)=O)OC2=O Chemical compound CC(CC(CCC1OCCOCC(N=N)=C[NH2+]CCOCCOCCOCCOCCOCCOCCOCCOCCC(NCCCC[NH2+]c2ncnc(N)c2C(c2ccc3[o]c(N)nc3c2)=N)=O)CC1OC)C(CC(C(C)C=C(C)C(C(C(C(C)CC(C)C=CC=CC=C(C)C(CC(CCC1C)OC1(C(C(N1C2CCCC1)=O)=O)O)OC)=O)OC)O)=O)OC2=O VMXMBPPFDJEVAB-UHFFFAOYSA-P 0.000 description 1
- 0 C[C@](C[C@](CC[C@@]1O)(C[C@]1OC)I#C)[C@](CC([C@](C)C=C(C)[C@@](*)[C@](C([C@](C)C[C@](C)C=CC=CC=C(C)[C@](C[C@@](CC[C@]1C)(C#C)OC1(C(C(*(CCCC1)[C@@]11C=C)=O)=O)OC)OC)=O)OC)=O)OC1=O Chemical compound C[C@](C[C@](CC[C@@]1O)(C[C@]1OC)I#C)[C@](CC([C@](C)C=C(C)[C@@](*)[C@](C([C@](C)C[C@](C)C=CC=CC=C(C)[C@](C[C@@](CC[C@]1C)(C#C)OC1(C(C(*(CCCC1)[C@@]11C=C)=O)=O)OC)OC)=O)OC)=O)OC1=O 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462049186P | 2014-09-11 | 2014-09-11 | |
| US62/049,186 | 2014-09-11 | ||
| PCT/US2015/049693 WO2016040806A1 (en) | 2014-09-11 | 2015-09-11 | mTORC1 INHIBITORS |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020072118A Division JP7057798B2 (ja) | 2014-09-11 | 2020-04-14 | ｍＴＯＲＣ１阻害剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017531624A JP2017531624A (ja) | 2017-10-26 |
| JP2017531624A5 true JP2017531624A5 (enExample) | 2019-03-28 |
| JP6692798B2 JP6692798B2 (ja) | 2020-05-13 |
Family
ID=55459613
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017513748A Active JP6692798B2 (ja) | 2014-09-11 | 2015-09-11 | ｍＴＯＲＣ１阻害剤 |
| JP2020072118A Active JP7057798B2 (ja) | 2014-09-11 | 2020-04-14 | ｍＴＯＲＣ１阻害剤 |
| JP2022064349A Pending JP2022091995A (ja) | 2014-09-11 | 2022-04-08 | ｍＴＯＲＣ１阻害剤 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020072118A Active JP7057798B2 (ja) | 2014-09-11 | 2020-04-14 | ｍＴＯＲＣ１阻害剤 |
| JP2022064349A Pending JP2022091995A (ja) | 2014-09-11 | 2022-04-08 | ｍＴＯＲＣ１阻害剤 |
Country Status (7)
| Country | Link |
|---|---|
| US (5) | US10117945B2 (enExample) |
| EP (1) | EP3193902A4 (enExample) |
| JP (3) | JP6692798B2 (enExample) |
| CN (2) | CN113620978A (enExample) |
| CA (1) | CA2960992C (enExample) |
| MX (2) | MX2017001981A (enExample) |
| WO (1) | WO2016040806A1 (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016040806A1 (en) | 2014-09-11 | 2016-03-17 | The Regents Of The University Of California | mTORC1 INHIBITORS |
| US20180141897A1 (en) | 2014-12-08 | 2018-05-24 | The Research Foundation For The State University Of New York | Anti-fungals targeting the synthesis of fungal shingolipids |
| US10683308B2 (en) * | 2015-09-11 | 2020-06-16 | Navitor Pharmaceuticals, Inc. | Rapamycin analogs and uses thereof |
| IL303660A (en) * | 2017-05-02 | 2023-08-01 | Revolution Medicines Inc | Rapamycin analogs as mtor inhibitors |
| WO2018232298A1 (en) | 2017-06-16 | 2018-12-20 | The Research Foundation For The State University Of New York | Anti-fungals compounds targeting the synthesis of fungal sphingolipids |
| CN110945129B (zh) * | 2017-07-20 | 2024-02-02 | 株式会社库利金 | 同时抑制雄激素受体基因及哺乳动物雷帕霉素靶蛋白基因的表达的核酸 |
| WO2019178536A1 (en) * | 2018-03-16 | 2019-09-19 | The Regents Of The University Of California | Mtor inhibitors and uses thereof |
| CN118978535A (zh) * | 2018-05-01 | 2024-11-19 | 锐新医药公司 | 作为mTOR抑制剂的C40-、C28-及C-32连接的雷帕霉素类似物 |
| CA3098698A1 (en) * | 2018-05-01 | 2019-11-07 | Revolution Medicines, Inc. | C26-linked rapamycin analogs as mtor inhibitors |
| CN108676882B (zh) * | 2018-05-30 | 2022-02-22 | 中山大学肿瘤防治中心（中山大学附属肿瘤医院、中山大学肿瘤研究所） | NOP14基因及其蛋白作为肿瘤对mTOR抑制剂敏感性的标志物的应用 |
| IL314362A (en) | 2018-06-15 | 2024-09-01 | Janssen Pharmaceutica Nv | Rapamycin analogs and their uses |
| EP4272825A3 (en) * | 2019-01-22 | 2023-12-06 | Aeovian Pharmaceuticals, Inc. | Mtorc modulators and uses thereof |
| US12594275B2 (en) * | 2019-02-07 | 2026-04-07 | The Regents Of The University Of California | Immunophilin binding agents and uses thereof |
| WO2020163598A1 (en) * | 2019-02-07 | 2020-08-13 | The Regents Of The University Of California | Immunophilin-dependent inhibitors and uses thereof |
| CN110152004B (zh) * | 2019-07-08 | 2021-09-03 | 天津医科大学 | 甘氨酸在制备药物递送增强剂及细胞移植试剂方面的用途 |
| BR112022010754A2 (pt) | 2019-12-05 | 2022-08-23 | Anakuria Therapeutics Inc | Análogos de rapamicina e usos dos mesmos |
| MX2022011964A (es) | 2020-03-27 | 2022-12-02 | Aeovian Pharmaceuticals Inc | Moduladores de mtorc1 y usos de los mismos. |
| KR20230042600A (ko) | 2020-06-18 | 2023-03-28 | 레볼루션 메디슨즈, 인크. | Ras 억제제에 대한 획득된 저항성을 지연, 예방, 및 치료하는 방법 |
| CN116322677B (zh) * | 2020-07-21 | 2025-09-23 | 艾奥维安制药公司 | Mtorc1调节剂及其用途 |
| CN114507236A (zh) * | 2022-02-28 | 2022-05-17 | 山东中医药大学 | mTOR蛋白降解靶向嵌合体及其制备方法和应用 |
| JP2025522296A (ja) | 2022-05-25 | 2025-07-15 | レヴォリューション・メディスンズ，インコーポレイテッド | ｍＴＯＲ阻害剤によりがんを処置する方法 |
| WO2026010866A1 (en) * | 2024-07-01 | 2026-01-08 | Apertor Pharmaceuticals, Inc. | Hetero-bifunctional molecules |
| CN119462690B (zh) * | 2024-11-08 | 2026-02-06 | 西安交通大学 | 一类基于自噬-溶酶体途径的选择性mTORC1降解剂及其制备方法和应用 |
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|---|---|---|---|---|
| ZA737247B (en) | 1972-09-29 | 1975-04-30 | Ayerst Mckenna & Harrison | Rapamycin and process of preparation |
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-
2015
- 2015-09-11 WO PCT/US2015/049693 patent/WO2016040806A1/en not_active Ceased
- 2015-09-11 MX MX2017001981A patent/MX2017001981A/es unknown
- 2015-09-11 CA CA2960992A patent/CA2960992C/en active Active
- 2015-09-11 CN CN202111002275.5A patent/CN113620978A/zh active Pending
- 2015-09-11 EP EP15840163.8A patent/EP3193902A4/en active Pending
- 2015-09-11 CN CN201580057417.4A patent/CN107073066B/zh active Active
- 2015-09-11 JP JP2017513748A patent/JP6692798B2/ja active Active
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2017
- 2017-02-13 MX MX2022013114A patent/MX2022013114A/es unknown
- 2017-03-10 US US15/455,727 patent/US10117945B2/en active Active
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2018
- 2018-09-10 US US16/126,210 patent/US10646577B2/en active Active
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2020
- 2020-03-24 US US16/828,774 patent/US11452780B2/en active Active
- 2020-04-14 JP JP2020072118A patent/JP7057798B2/ja active Active
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2022
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- 2023-02-28 US US18/176,335 patent/US12097262B2/en active Active
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- 2024-08-12 US US18/801,301 patent/US20250099597A1/en active Pending
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