JP2017531424A - ハイブリッド多元ステップ核酸増幅 - Google Patents

ハイブリッド多元ステップ核酸増幅 Download PDF

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Publication number
JP2017531424A
JP2017531424A JP2017514802A JP2017514802A JP2017531424A JP 2017531424 A JP2017531424 A JP 2017531424A JP 2017514802 A JP2017514802 A JP 2017514802A JP 2017514802 A JP2017514802 A JP 2017514802A JP 2017531424 A JP2017531424 A JP 2017531424A
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Prior art keywords
nucleic acid
primer
sample
amplification
reaction
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Withdrawn
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JP2017514802A
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Japanese (ja)
Inventor
プラナブ パテル，
プラナブ パテル，
インディラ ウー，
インディラ ウー，
アーロン リチャードソン，
アーロン リチャードソン，
カミラ ベルホシン，
カミラ ベルホシン，
ジョセフィン リー，
ジョセフィン リー，
スコット タバクマン，
スコット タバクマン，
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Theranos Inc
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Theranos Inc
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Priority claimed from PCT/US2014/056151 external-priority patent/WO2015076919A1/en
Application filed by Theranos Inc filed Critical Theranos Inc
Publication of JP2017531424A publication Critical patent/JP2017531424A/ja
Withdrawn legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701—Specific hybridization probes
    • C12Q1/706—Specific hybridization probes for hepatitis
    • C12Q1/707—Specific hybridization probes for hepatitis non-A, non-B Hepatitis, excluding hepatitis D
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M1/00—Apparatus for enzymology or microbiology
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6858—Allele-specific amplification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701—Specific hybridization probes
    • C12Q1/706—Specific hybridization probes for hepatitis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • C12Q1/689—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Sustainable Development (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
JP2017514802A 2014-09-17 2015-09-17 ハイブリッド多元ステップ核酸増幅 Withdrawn JP2017531424A (ja)

Applications Claiming Priority (13)

Application Number Priority Date Filing Date Title
US201462051912P 2014-09-17 2014-09-17
US201462051945P 2014-09-17 2014-09-17
PCT/US2014/056151 WO2015076919A1 (en) 2013-11-22 2014-09-17 Nucleic Acid Amplification
US62/051,945 2014-09-17
USPCT/US2014/056151 2014-09-17
US62/051,912 2014-09-17
US201462068603P 2014-10-24 2014-10-24
US201462068605P 2014-10-24 2014-10-24
US62/068,603 2014-10-24
US62/068,605 2014-10-24
US201562151358P 2015-04-22 2015-04-22
US62/151,358 2015-04-22
PCT/US2015/050822 WO2016044673A1 (en) 2014-09-17 2015-09-17 Hybrid multi-step nucleic acid amplification

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2020168379A Division JP2021006056A (ja) 2014-09-17 2020-10-05 ハイブリッド多元ステップ核酸増幅

Publications (1)

Publication Number Publication Date
JP2017531424A true JP2017531424A (ja) 2017-10-26

Family

ID=55533878

Family Applications (6)

Application Number Title Priority Date Filing Date
JP2017514802A Withdrawn JP2017531424A (ja) 2014-09-17 2015-09-17 ハイブリッド多元ステップ核酸増幅
JP2017514803A Withdrawn JP2017532030A (ja) 2014-09-17 2015-09-17 診断方法及び組成物
JP2020167791A Withdrawn JP2021000138A (ja) 2014-09-17 2020-10-02 診断方法及び組成物
JP2020168379A Withdrawn JP2021006056A (ja) 2014-09-17 2020-10-05 ハイブリッド多元ステップ核酸増幅
JP2022085319A Pending JP2022110152A (ja) 2014-09-17 2022-05-25 診断方法及び組成物
JP2022181727A Pending JP2023011943A (ja) 2014-09-17 2022-11-14 ハイブリッド多元ステップ核酸増幅

Family Applications After (5)

Application Number Title Priority Date Filing Date
JP2017514803A Withdrawn JP2017532030A (ja) 2014-09-17 2015-09-17 診断方法及び組成物
JP2020167791A Withdrawn JP2021000138A (ja) 2014-09-17 2020-10-02 診断方法及び組成物
JP2020168379A Withdrawn JP2021006056A (ja) 2014-09-17 2020-10-05 ハイブリッド多元ステップ核酸増幅
JP2022085319A Pending JP2022110152A (ja) 2014-09-17 2022-05-25 診断方法及び組成物
JP2022181727A Pending JP2023011943A (ja) 2014-09-17 2022-11-14 ハイブリッド多元ステップ核酸増幅

Country Status (8)

Country Link
US (3) US9909193B2 (cg-RX-API-DMAC7.html)
EP (2) EP3194590A4 (cg-RX-API-DMAC7.html)
JP (6) JP2017531424A (cg-RX-API-DMAC7.html)
CN (3) CN108026591B (cg-RX-API-DMAC7.html)
BR (1) BR112017005392A2 (cg-RX-API-DMAC7.html)
CA (2) CA2961209A1 (cg-RX-API-DMAC7.html)
MX (2) MX366113B (cg-RX-API-DMAC7.html)
WO (2) WO2016044664A1 (cg-RX-API-DMAC7.html)

Families Citing this family (4)

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EP3194590A4 (en) 2014-09-17 2018-05-09 Theranos, Inc. Hybrid multi-step nucleic acid amplification
US10822648B1 (en) 2016-07-29 2020-11-03 Labrador Diagnostics Llc Hybrid multi-step nucleic acid amplification
CA3046504A1 (en) 2016-12-15 2018-06-21 Meharry Medical College Antiviral agents
FI130673B1 (en) * 2020-11-24 2024-01-11 Mobidiag Oy Method and system for performing a cumulative nucleic acid amplification reaction

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EP3194590A1 (en) 2017-07-26
EP3194629A4 (en) 2018-03-07
US9909193B2 (en) 2018-03-06
JP2017532030A (ja) 2017-11-02
JP2023011943A (ja) 2023-01-24
MX366113B (es) 2019-06-26
JP2021006056A (ja) 2021-01-21
CN107002066A (zh) 2017-08-01
BR112017005392A2 (pt) 2017-12-12
JP2022110152A (ja) 2022-07-28
US20160201148A1 (en) 2016-07-14
US20180223381A1 (en) 2018-08-09
WO2016044664A1 (en) 2016-03-24
JP2021000138A (ja) 2021-01-07
CA2960859A1 (en) 2016-03-24
CN108026591A (zh) 2018-05-11
CN113736863A (zh) 2021-12-03
MX2017003473A (es) 2017-08-02
CN108026591B (zh) 2021-09-07
WO2016044673A1 (en) 2016-03-24
MX2017003475A (es) 2017-08-02
EP3194629A1 (en) 2017-07-26
CA2961209A1 (en) 2016-03-24
US20170342476A1 (en) 2017-11-30
EP3194590A4 (en) 2018-05-09

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