JP2017530692A5 - - Google Patents
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- JP2017530692A5 JP2017530692A5 JP2017506267A JP2017506267A JP2017530692A5 JP 2017530692 A5 JP2017530692 A5 JP 2017530692A5 JP 2017506267 A JP2017506267 A JP 2017506267A JP 2017506267 A JP2017506267 A JP 2017506267A JP 2017530692 A5 JP2017530692 A5 JP 2017530692A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- antigen
- binding fragment
- cancer
- disease
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 102000004965 antibodies Human genes 0.000 claims 69
- 108090001123 antibodies Proteins 0.000 claims 69
- 239000000427 antigen Substances 0.000 claims 65
- 102000038129 antigens Human genes 0.000 claims 65
- 108091007172 antigens Proteins 0.000 claims 65
- 210000004027 cells Anatomy 0.000 claims 19
- 201000010099 disease Diseases 0.000 claims 16
- 125000003275 alpha amino acid group Chemical group 0.000 claims 15
- 102000005740 Interleukin-1 Receptor Accessory Protein Human genes 0.000 claims 14
- 108010045623 Interleukin-1 Receptor Accessory Protein Proteins 0.000 claims 14
- 201000011510 cancer Diseases 0.000 claims 11
- 230000001613 neoplastic Effects 0.000 claims 10
- 230000011664 signaling Effects 0.000 claims 10
- 108010002352 Interleukin-1 Proteins 0.000 claims 6
- 102000000589 Interleukin-1 Human genes 0.000 claims 6
- 239000000523 sample Substances 0.000 claims 6
- 238000000338 in vitro Methods 0.000 claims 5
- 206010000880 Acute myeloid leukaemia Diseases 0.000 claims 4
- 208000008456 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Diseases 0.000 claims 4
- 208000007046 Leukemia, Myeloid, Acute Diseases 0.000 claims 4
- 201000006934 chronic myeloid leukemia Diseases 0.000 claims 4
- 230000002401 inhibitory effect Effects 0.000 claims 4
- 210000000130 stem cell Anatomy 0.000 claims 4
- 201000010874 syndrome Diseases 0.000 claims 4
- 206010025650 Malignant melanoma Diseases 0.000 claims 3
- 201000001441 melanoma Diseases 0.000 claims 3
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 229920001184 polypeptide Polymers 0.000 claims 3
- 210000001519 tissues Anatomy 0.000 claims 3
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- 230000035693 Fab Effects 0.000 claims 2
- 206010064570 Familial cold autoinflammatory syndrome Diseases 0.000 claims 2
- 206010016207 Familial mediterranean fever Diseases 0.000 claims 2
- 208000009471 Gastroesophageal Reflux Diseases 0.000 claims 2
- 206010017885 Gastrooesophageal reflux disease Diseases 0.000 claims 2
- 230000036499 Half live Effects 0.000 claims 2
- 208000005209 Hematologic Disease Diseases 0.000 claims 2
- 102000018297 Immunoglobulin subtype Human genes 0.000 claims 2
- 108050007411 Immunoglobulin subtype Proteins 0.000 claims 2
- 208000003456 Juvenile Arthritis Diseases 0.000 claims 2
- 206010059176 Juvenile idiopathic arthritis Diseases 0.000 claims 2
- 210000000265 Leukocytes Anatomy 0.000 claims 2
- 241000282567 Macaca fascicularis Species 0.000 claims 2
- 206010028576 Myeloproliferative disease Diseases 0.000 claims 2
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- 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 claims 2
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- 235000020824 obesity Nutrition 0.000 claims 2
- 229920001223 polyethylene glycol Polymers 0.000 claims 2
- 206010000496 Acne Diseases 0.000 claims 1
- 208000009746 Adult T-Cell Leukemia-Lymphoma Diseases 0.000 claims 1
- 208000002496 Adult-Onset Still's Disease Diseases 0.000 claims 1
- 206010002556 Ankylosing spondylitis Diseases 0.000 claims 1
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- 210000004556 Brain Anatomy 0.000 claims 1
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- 206010007559 Cardiac failure congestive Diseases 0.000 claims 1
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- 206010008342 Cervix carcinoma Diseases 0.000 claims 1
- 208000009863 Chronic Kidney Failure Diseases 0.000 claims 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 1
- 206010009900 Colitis ulcerative Diseases 0.000 claims 1
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- 229920002307 Dextran Polymers 0.000 claims 1
- 206010012601 Diabetes mellitus Diseases 0.000 claims 1
- SHZGCJCMOBCMKK-DHVFOXMCSA-N Fucose Chemical group C[C@@H]1OC(O)[C@@H](O)[C@H](O)[C@@H]1O SHZGCJCMOBCMKK-DHVFOXMCSA-N 0.000 claims 1
- 206010017758 Gastric cancer Diseases 0.000 claims 1
- 208000007882 Gastritis Diseases 0.000 claims 1
- 206010018651 Graft versus host disease Diseases 0.000 claims 1
- 208000009329 Graft vs Host Disease Diseases 0.000 claims 1
- 241000589989 Helicobacter Species 0.000 claims 1
- 208000005176 Hepatitis C Diseases 0.000 claims 1
- 206010048595 Histiocytosis haematophagic Diseases 0.000 claims 1
- 102000008100 Human Serum Albumin Human genes 0.000 claims 1
- 108091006822 Human Serum Albumin Proteins 0.000 claims 1
- 206010020751 Hypersensitivity Diseases 0.000 claims 1
- 101000242783 IL1RAP Proteins 0.000 claims 1
- 206010021972 Inflammatory bowel disease Diseases 0.000 claims 1
- 208000002551 Irritable Bowel Syndrome Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 206010025135 Lupus erythematosus Diseases 0.000 claims 1
- 206010025323 Lymphomas Diseases 0.000 claims 1
- 208000004987 Macrophage Activation Syndrome Diseases 0.000 claims 1
- 206010027253 Meningitis pneumococcal Diseases 0.000 claims 1
- 208000001145 Metabolic Syndrome Diseases 0.000 claims 1
- 208000010125 Myocardial Infarction Diseases 0.000 claims 1
- 241000588653 Neisseria Species 0.000 claims 1
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims 1
- 206010025310 Other lymphomas Diseases 0.000 claims 1
- 210000001672 Ovary Anatomy 0.000 claims 1
- 208000008443 Pancreatic Carcinoma Diseases 0.000 claims 1
- 206010055006 Pancreatic sarcoma Diseases 0.000 claims 1
- 206010034277 Pemphigoid Diseases 0.000 claims 1
- 241001442654 Percnon planissimum Species 0.000 claims 1
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 208000004593 Pneumococcal Meningitis Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000009954 Pyoderma Gangrenosum Diseases 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 206010063837 Reperfusion injury Diseases 0.000 claims 1
- 206010039073 Rheumatoid arthritis Diseases 0.000 claims 1
- 201000010848 Schnitzler syndrome Diseases 0.000 claims 1
- 206010040070 Septic shock Diseases 0.000 claims 1
- 102000005632 Single-Chain Antibodies Human genes 0.000 claims 1
- 108010070144 Single-Chain Antibodies Proteins 0.000 claims 1
- 208000006011 Stroke Diseases 0.000 claims 1
- 102000003298 Tumor Necrosis Factor Receptors Human genes 0.000 claims 1
- 108060008683 Tumor Necrosis Factor Receptors Proteins 0.000 claims 1
- 208000001072 Type 2 Diabetes Mellitus Diseases 0.000 claims 1
- 206010046766 Uterine cancer Diseases 0.000 claims 1
- 206010046996 Varicose vein Diseases 0.000 claims 1
- 201000006966 adult T-cell leukemia Diseases 0.000 claims 1
- 201000005794 allergic hypersensitivity disease Diseases 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 239000000969 carrier Substances 0.000 claims 1
- 201000010881 cervical cancer Diseases 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 201000000522 chronic kidney disease Diseases 0.000 claims 1
- 235000009508 confectionery Nutrition 0.000 claims 1
- 201000006233 congestive heart failure Diseases 0.000 claims 1
- 230000001809 detectable Effects 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 235000014113 dietary fatty acids Nutrition 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 201000004101 esophageal cancer Diseases 0.000 claims 1
- 239000000194 fatty acid Substances 0.000 claims 1
- 150000004665 fatty acids Chemical class 0.000 claims 1
- 201000009846 fatty liver disease Diseases 0.000 claims 1
- 238000005755 formation reaction Methods 0.000 claims 1
- 201000005569 gout Diseases 0.000 claims 1
- 102000021212 human IL1RAP protein Human genes 0.000 claims 1
- 201000001431 hyperuricemia Diseases 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 200000000018 inflammatory disease Diseases 0.000 claims 1
- 201000002215 juvenile rheumatoid arthritis Diseases 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 201000007270 liver cancer Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000003068 molecular probe Substances 0.000 claims 1
- 201000009251 multiple myeloma Diseases 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 230000035772 mutation Effects 0.000 claims 1
- 201000008482 osteoarthritis Diseases 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 230000000737 periodic Effects 0.000 claims 1
- 201000001245 periodontitis Diseases 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 201000010065 polycystic ovary syndrome Diseases 0.000 claims 1
- 229920000023 polynucleotide Polymers 0.000 claims 1
- 239000002157 polynucleotide Substances 0.000 claims 1
- 201000004681 psoriasis Diseases 0.000 claims 1
- 201000000306 sarcoidosis Diseases 0.000 claims 1
- 230000036303 septic shock Effects 0.000 claims 1
- CHIBHAOESMLHPV-YQVAFVGVSA-M sodium;[(2R)-3-hexadecanoyloxy-2-[(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoyl]oxypropyl] hydrogen phosphate Chemical compound [Na+].CCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)([O-])=O)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC CHIBHAOESMLHPV-YQVAFVGVSA-M 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims 1
- 201000008827 tuberculosis Diseases 0.000 claims 1
- 201000006704 ulcerative colitis Diseases 0.000 claims 1
- 230000002485 urinary Effects 0.000 claims 1
- 201000005112 urinary bladder cancer Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1413913.3 | 2014-08-06 | ||
| GBGB1413913.3A GB201413913D0 (en) | 2014-08-06 | 2014-08-06 | Novel antibodies and uses thereof |
| PCT/EP2015/068208 WO2016020502A1 (en) | 2014-08-06 | 2015-08-06 | Novel antibodies and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017530692A JP2017530692A (ja) | 2017-10-19 |
| JP2017530692A5 true JP2017530692A5 (US20040106767A1-20040603-C00005.png) | 2018-08-30 |
| JP6827411B2 JP6827411B2 (ja) | 2021-02-10 |
Family
ID=51587804
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017506267A Active JP6827411B2 (ja) | 2014-08-06 | 2015-08-06 | 新規の抗体及びその使用 |
Country Status (11)
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7307083B2 (ja) | 2017-11-23 | 2023-07-11 | エタブリスマン フランセ デュ サン | Ｉｌ－１ｒａｐを標的とするｃａｒ－ｔ細胞及びその使用 |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2472856B (en) | 2009-08-21 | 2012-07-11 | Cantargia Ab | IL1-RAP modulators and uses thereof |
| JP5940093B2 (ja) | 2011-01-19 | 2016-06-29 | カンタージア アクチエボラーグ | 抗ｉｌ−１ｒａｐ抗体及びヒトを処置するためのそれらの使用 |
| GB201403875D0 (en) | 2014-03-05 | 2014-04-16 | Cantargia Ab | Novel antibodies and uses thereof |
| EP3218515B1 (en) | 2014-11-10 | 2023-04-26 | F. Hoffmann-La Roche AG | Therapeutic and diagnostic methods for il-33-mediated disorders |
| CR20170240A (es) | 2014-11-10 | 2018-04-03 | Genentech Inc | Anticuerpos anti-interleucina-33 y sus usos |
| EP3313887A2 (en) | 2015-06-26 | 2018-05-02 | MAB Discovery GmbH | Monoclonal anti-il-1racp antibodies |
| WO2017181790A1 (zh) * | 2016-04-19 | 2017-10-26 | 南京中硼联康医疗科技有限公司 | 用于消除β淀粉样蛋白沉积斑块的中子捕获治疗系统 |
| EP3241845A1 (en) | 2016-05-06 | 2017-11-08 | MAB Discovery GmbH | Humanized anti-il-1r3 antibodies |
| US11359025B2 (en) | 2016-10-16 | 2022-06-14 | Cantargia Ab | Anti-IL1-RAP antibodies |
| MY191926A (en) | 2016-12-01 | 2022-07-18 | Regeneron Pharma | Radiolabeled anti-pd-l1 antibodies for immuno-pet imaging |
| KR20240058959A (ko) | 2017-02-10 | 2024-05-07 | 리제너론 파마슈티칼스 인코포레이티드 | 면역-pet 이미지화를 위한 방사선 라벨링된 항-lag3 항체 |
| EP3401332A1 (en) * | 2017-05-08 | 2018-11-14 | MAB Discovery GmbH | Anti-il-1r3 antibodies for use in inflammatory conditions |
| US11248054B2 (en) | 2017-06-12 | 2022-02-15 | Bluefin Biomedicine, Inc. | Anti-IL1RAP antibodies and antibody drug conjugates |
| CA3070796A1 (en) | 2017-07-24 | 2019-01-31 | Regeneron Pharmaceuticals, Inc. | Anti-cd8 antibodies and uses thereof |
| WO2019028190A1 (en) * | 2017-08-01 | 2019-02-07 | City Of Hope | ANTI-IL1RAP ANTIBODIES |
| EP3752630A4 (en) * | 2018-02-14 | 2022-01-05 | Yale University | COMPOSITIONS FOR THE MODULATION OF A TREM OR TREML PROTEIN AND METHOD OF USE |
| EP3837283B1 (en) | 2018-08-16 | 2024-04-17 | Cantargia AB | Anti-il1rap antibody compositions |
| TW202021618A (zh) * | 2018-08-17 | 2020-06-16 | 美商２３與我有限公司 | 抗ｉｌ１ｒａｐ抗體及其使用方法 |
| WO2021148884A1 (en) * | 2020-01-24 | 2021-07-29 | Tychan Pte. Ltd. | Anti-wuhan coronavirus antibodies |
| WO2021183849A1 (en) | 2020-03-13 | 2021-09-16 | Genentech, Inc. | Anti-interleukin-33 antibodies and uses thereof |
| PE20231575A1 (es) | 2020-09-14 | 2023-10-04 | Ichnos Sciences SA | Anticuerpos que se unen a il1rap y usos de estos |
| AR124414A1 (es) | 2020-12-18 | 2023-03-22 | Century Therapeutics Inc | Sistema de receptor de antígeno quimérico con especificidad de receptor adaptable |
| EP4341290A1 (en) | 2021-05-21 | 2024-03-27 | LEO Pharma A/S | Anti il-1 receptor accessory protein antibodies |
| US20240059744A1 (en) * | 2022-07-25 | 2024-02-22 | Interius Biotherapeutics, Inc. | Mutated polypeptides, compositions comprising the same, and uses thereof |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4235871A (en) | 1978-02-24 | 1980-11-25 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| SE459005B (sv) | 1985-07-12 | 1989-05-29 | Aake Rikard Lindahl | Saett att framstaella sfaeriska polymerpartiklar |
| PE64396A1 (es) | 1995-01-23 | 1997-01-28 | Hoffmann La Roche | Proteina accesoria del receptor de la interleucina 1 |
| CA2192782C (en) | 1995-12-15 | 2008-10-14 | Nobuyuki Takechi | Production of microspheres |
| US20030215453A1 (en) | 2002-05-14 | 2003-11-20 | Dedera Douglas A. | Methods of therapy and diagnosis using immunotargeting of cells expressing VpreB1 protein |
| US7960512B2 (en) | 2003-01-09 | 2011-06-14 | Macrogenics, Inc. | Identification and engineering of antibodies with variant Fc regions and methods of using same |
| EP2481814A3 (en) | 2003-06-09 | 2012-10-10 | The Regents of the University of Michigan | Compositions and methods for treating and diagnosing cancer |
| GB0316294D0 (en) | 2003-07-11 | 2003-08-13 | Polytherics Ltd | Conjugated biological molecules and their preparation |
| CA2573192C (en) | 2004-08-04 | 2013-09-10 | Applied Molecular Evolution Inc. | Variant fc regions |
| ES2796085T3 (es) | 2008-01-15 | 2020-11-25 | Univ Leland Stanford Junior | Marcadores de células madre de leucemia mieloide aguda |
| CN102046660A (zh) | 2008-03-26 | 2011-05-04 | 塞勒兰特治疗公司 | 骨髓性血液学增殖性病症相关的免疫球蛋白和/或toll样受体蛋白及其用途 |
| GB2472856B (en) * | 2009-08-21 | 2012-07-11 | Cantargia Ab | IL1-RAP modulators and uses thereof |
| JP5940093B2 (ja) | 2011-01-19 | 2016-06-29 | カンタージア アクチエボラーグ | 抗ｉｌ−１ｒａｐ抗体及びヒトを処置するためのそれらの使用 |
| CN103077969B (zh) | 2011-10-26 | 2016-03-30 | 中国科学院微电子研究所 | 一种mos器件及其制造方法 |
| EP3313887A2 (en) | 2015-06-26 | 2018-05-02 | MAB Discovery GmbH | Monoclonal anti-il-1racp antibodies |
| BR112018008908A2 (pt) | 2015-11-02 | 2018-11-27 | Janssen Pharmaceutica Nv | anticorpos anti-il1rap, moléculas de ligação ao antígeno biespecíficas que se ligam il1rap e cd3, e seus usos |
-
2014
- 2014-08-06 GB GBGB1413913.3A patent/GB201413913D0/en not_active Ceased
-
2015
- 2015-08-06 CN CN201580042011.9A patent/CN107074946B/zh active Active
- 2015-08-06 US US15/501,710 patent/US10100119B2/en active Active
- 2015-08-06 BR BR112017002342A patent/BR112017002342A2/pt not_active Application Discontinuation
- 2015-08-06 AU AU2015298852A patent/AU2015298852A1/en not_active Abandoned
- 2015-08-06 MX MX2017001599A patent/MX2017001599A/es unknown
- 2015-08-06 CA CA2955056A patent/CA2955056A1/en not_active Abandoned
- 2015-08-06 JP JP2017506267A patent/JP6827411B2/ja active Active
- 2015-08-06 KR KR1020177004417A patent/KR20170039685A/ko not_active Application Discontinuation
- 2015-08-06 EP EP15747487.5A patent/EP3193926B1/en active Active
- 2015-08-06 WO PCT/EP2015/068208 patent/WO2016020502A1/en active Application Filing
-
2018
- 2018-08-22 US US16/109,017 patent/US10562971B2/en active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7307083B2 (ja) | 2017-11-23 | 2023-07-11 | エタブリスマン フランセ デュ サン | Ｉｌ－１ｒａｐを標的とするｃａｒ－ｔ細胞及びその使用 |
