JP2017528416A5 - - Google Patents
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- Publication number
- JP2017528416A5 JP2017528416A5 JP2016571722A JP2016571722A JP2017528416A5 JP 2017528416 A5 JP2017528416 A5 JP 2017528416A5 JP 2016571722 A JP2016571722 A JP 2016571722A JP 2016571722 A JP2016571722 A JP 2016571722A JP 2017528416 A5 JP2017528416 A5 JP 2017528416A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- heteroaryl
- aryl
- cycloalkyl
- heterocycloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 125
- 125000001072 heteroaryl group Chemical group 0.000 claims description 124
- 125000003118 aryl group Chemical group 0.000 claims description 114
- 125000000217 alkyl group Chemical group 0.000 claims description 96
- 229910052739 hydrogen Inorganic materials 0.000 claims description 92
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims description 90
- 239000001257 hydrogen Substances 0.000 claims description 88
- 150000002431 hydrogen Chemical class 0.000 claims description 86
- 125000000304 alkynyl group Chemical group 0.000 claims description 72
- 125000003342 alkenyl group Chemical group 0.000 claims description 65
- 229910052736 halogen Inorganic materials 0.000 claims description 55
- 150000002367 halogens Chemical class 0.000 claims description 55
- 125000003545 alkoxy group Chemical group 0.000 claims description 53
- 125000004104 aryloxy group Chemical group 0.000 claims description 48
- 230000008685 targeting Effects 0.000 claims description 47
- 230000002708 enhancing effect Effects 0.000 claims description 43
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 39
- 150000003839 salts Chemical class 0.000 claims description 35
- 239000002243 precursor Substances 0.000 claims description 26
- 229910052760 oxygen Inorganic materials 0.000 claims description 25
- 229910052717 sulfur Inorganic materials 0.000 claims description 25
- UGFAIRIUMAVXCW-UHFFFAOYSA-N Carbon monoxide Chemical compound [O+]#[C-] UGFAIRIUMAVXCW-UHFFFAOYSA-N 0.000 claims description 23
- 229910002091 carbon monoxide Inorganic materials 0.000 claims description 23
- 150000001875 compounds Chemical class 0.000 claims description 20
- 125000004404 heteroalkyl group Chemical group 0.000 claims description 20
- -1 heteroalkynyl Chemical group 0.000 claims description 19
- 239000000203 mixture Substances 0.000 claims description 17
- 230000004962 physiological condition Effects 0.000 claims description 15
- 125000000623 heterocyclic group Chemical group 0.000 claims description 14
- 125000005647 linker group Chemical group 0.000 claims description 12
- 238000006352 cycloaddition reaction Methods 0.000 claims description 11
- 230000001681 protective effect Effects 0.000 claims description 11
- 150000001993 dienes Chemical class 0.000 claims description 8
- 238000006243 chemical reaction Methods 0.000 claims description 6
- 238000001727 in vivo Methods 0.000 claims description 6
- 239000008194 pharmaceutical composition Substances 0.000 claims description 6
- 239000000654 additive Substances 0.000 claims description 4
- 125000004122 cyclic group Chemical group 0.000 claims description 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 2
- 229910052799 carbon Inorganic materials 0.000 claims 1
- CHNUOJQWGUIOLD-NFZZJPOKSA-N epalrestat Chemical compound C=1C=CC=CC=1\C=C(/C)\C=C1/SC(=S)N(CC(O)=O)C1=O CHNUOJQWGUIOLD-NFZZJPOKSA-N 0.000 claims 1
- 238000000034 method Methods 0.000 description 88
- 150000001336 alkenes Chemical class 0.000 description 4
- 150000001720 carbohydrates Chemical class 0.000 description 4
- 235000014633 carbohydrates Nutrition 0.000 description 4
- 150000004678 hydrides Chemical class 0.000 description 4
- 206010028980 Neoplasm Diseases 0.000 description 3
- 201000011510 cancer Diseases 0.000 description 3
- 0 *C1=C(*)C(I)=C(*)C1=O Chemical compound *C1=C(*)C(I)=C(*)C1=O 0.000 description 2
- 102100041003 Glutamate carboxypeptidase 2 Human genes 0.000 description 2
- 101000892862 Homo sapiens Glutamate carboxypeptidase 2 Proteins 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 150000004676 glycans Chemical class 0.000 description 2
- 150000002772 monosaccharides Chemical class 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 229920001282 polysaccharide Polymers 0.000 description 2
- 239000005017 polysaccharide Substances 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 125000000547 substituted alkyl group Chemical group 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- IYMAXBFPHPZYIK-BQBZGAKWSA-N Arg-Gly-Asp Chemical compound NC(N)=NCCC[C@H](N)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(O)=O IYMAXBFPHPZYIK-BQBZGAKWSA-N 0.000 description 1
- WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 description 1
- SRBFZHDQGSBBOR-IOVATXLUSA-N D-xylopyranose Chemical group O[C@@H]1COC(O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-IOVATXLUSA-N 0.000 description 1
- 229920002307 Dextran Polymers 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 108010072041 arginyl-glycyl-aspartic acid Proteins 0.000 description 1
- XRWSZZJLZRKHHD-WVWIJVSJSA-N asunaprevir Chemical compound O=C([C@@H]1C[C@H](CN1C(=O)[C@@H](NC(=O)OC(C)(C)C)C(C)(C)C)OC1=NC=C(C2=CC=C(Cl)C=C21)OC)N[C@]1(C(=O)NS(=O)(=O)C2CC2)C[C@H]1C=C XRWSZZJLZRKHHD-WVWIJVSJSA-N 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 229940125961 compound 24 Drugs 0.000 description 1
- 150000002016 disaccharides Chemical class 0.000 description 1
- 229940014144 folate Drugs 0.000 description 1
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical group C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 description 1
- 235000019152 folic acid Nutrition 0.000 description 1
- 239000011724 folic acid Substances 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 229920001542 oligosaccharide Polymers 0.000 description 1
- 150000002482 oligosaccharides Chemical class 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462009451P | 2014-06-09 | 2014-06-09 | |
| US62/009,451 | 2014-06-09 | ||
| PCT/US2015/034948 WO2015191616A1 (en) | 2014-06-09 | 2015-06-09 | Carbon monoxide-releasing molecules for therapeutic applications and methods of making and using thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017528416A JP2017528416A (ja) | 2017-09-28 |
| JP2017528416A5 true JP2017528416A5 (enExample) | 2018-07-19 |
| JP6670763B2 JP6670763B2 (ja) | 2020-03-25 |
Family
ID=54834205
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016571722A Active JP6670763B2 (ja) | 2014-06-09 | 2015-06-09 | 治療用途のための一酸化炭素放出分子ならびにその作製および使用の方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US10300069B2 (enExample) |
| EP (1) | EP3151919B1 (enExample) |
| JP (1) | JP6670763B2 (enExample) |
| KR (1) | KR20170007857A (enExample) |
| CN (1) | CN106794362B (enExample) |
| AU (1) | AU2015274767B2 (enExample) |
| CA (1) | CA2950007A1 (enExample) |
| WO (1) | WO2015191616A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106794362B (zh) | 2014-06-09 | 2021-07-06 | 乔治亚州立大学研究基金会股份有限公司 | 用于治疗应用的一氧化碳-释放分子及其制备和使用方法 |
| WO2018093924A1 (en) * | 2016-11-16 | 2018-05-24 | Georgia State University Research Foundation, Inc. | Carbon monoxide-releasing molecules and therapeutic applications thereof |
| KR102373273B1 (ko) * | 2017-04-18 | 2022-03-15 | 기초과학연구원 | 고분자형 젤과 이의 제조방법, 및 이를 포함하는 물품 |
| CN110944629B (zh) * | 2017-06-12 | 2024-04-09 | 乔治亚州立大学研究基金会股份有限公司 | 酶触发的一氧化碳释放分子 |
| US20180369278A1 (en) * | 2017-06-23 | 2018-12-27 | The Regents Of The University Of Michigan | Carbon monoxide-based therapies and implantable devices for the treatment of vascular disease |
| WO2019032879A1 (en) * | 2017-08-09 | 2019-02-14 | Georgia State University Research Foundation, Inc. | CARBON MONOXIDE RELEASE MOLECULES DISCHARGED BY PHYSIOLOGICAL STIMULI |
| WO2019084323A1 (en) * | 2017-10-25 | 2019-05-02 | Georgia State University Research Foundation, Inc. | CHEMICAL RELEASE SYSTEM DELIVERED BY ENRICHMENT |
| CN109306049B (zh) * | 2018-09-28 | 2020-12-01 | 中国热带农业科学院农产品加工研究所 | 植物油-壳聚糖基可生物降解pua及其制备方法和应用 |
| WO2020081723A1 (en) | 2018-10-16 | 2020-04-23 | Georgia State University Research Foundation, Inc. | Carbon monoxide prodrugs for the treatment of medical disorders |
| CN113559071B (zh) * | 2021-08-18 | 2022-12-27 | 苏州大学 | 一种co靶向递送系统及其构建方法与应用 |
| EP4275682A1 (en) * | 2022-05-12 | 2023-11-15 | Institut National De La Sante Et De La Recherche Medicale - Inserm | Carbon monoxide-releasing molecule (corm) or composition thereof for use in the treatment or the prevention of an intestinal dysbiosis in a subject |
| WO2025090901A1 (en) * | 2023-10-26 | 2025-05-01 | Georgia State University Research Foundation, Inc. | Ros-activated co prodrugs for cancer treatment |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5670664A (en) * | 1995-09-08 | 1997-09-23 | University Of Maryland Biotechnology Institute | Photosensitive organic compounds that release carbon monoxide upon illumination |
| JP2005519928A (ja) | 2002-02-04 | 2005-07-07 | ハース，ベルナー | Ｃｏ放出能力を有する化合物の投与によって哺乳動物を治療する方法と、ｃｏ放出能力を有する化合物ならびにその医薬組成物 |
| PT1812031E (pt) | 2004-11-01 | 2015-10-01 | Univ California | Composições e métodos para modificação de biomoléculas |
| US8519122B2 (en) | 2010-02-12 | 2013-08-27 | The Regents Of The University Of California | Compositions and methods for modification of biomolecules |
| CN106794362B (zh) | 2014-06-09 | 2021-07-06 | 乔治亚州立大学研究基金会股份有限公司 | 用于治疗应用的一氧化碳-释放分子及其制备和使用方法 |
-
2015
- 2015-06-09 CN CN201580042734.9A patent/CN106794362B/zh active Active
- 2015-06-09 EP EP15807244.7A patent/EP3151919B1/en active Active
- 2015-06-09 WO PCT/US2015/034948 patent/WO2015191616A1/en not_active Ceased
- 2015-06-09 JP JP2016571722A patent/JP6670763B2/ja active Active
- 2015-06-09 KR KR1020177000227A patent/KR20170007857A/ko not_active Withdrawn
- 2015-06-09 AU AU2015274767A patent/AU2015274767B2/en not_active Ceased
- 2015-06-09 US US15/317,705 patent/US10300069B2/en active Active
- 2015-06-09 CA CA2950007A patent/CA2950007A1/en not_active Abandoned
-
2019
- 2019-05-27 US US16/423,094 patent/US10751344B2/en active Active
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